YU60198A - Supstituisani derivati indazola i njihova upotreba kao fosfodiesteraze (pde) tipa iv i inhibitora faktora nekroze tumora (tnf) - Google Patents
Supstituisani derivati indazola i njihova upotreba kao fosfodiesteraze (pde) tipa iv i inhibitora faktora nekroze tumora (tnf)Info
- Publication number
- YU60198A YU60198A YU60198A YU60198A YU60198A YU 60198 A YU60198 A YU 60198A YU 60198 A YU60198 A YU 60198A YU 60198 A YU60198 A YU 60198A YU 60198 A YU60198 A YU 60198A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- pde
- tnf
- type
- necrosis factor
- tumor necrosis
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Obesity (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Ovaj pronalazak se odnosi na formulu (I) i njene farmaceutski prihvatljive soli gde su R, R1 i R2 kao što je definisano, ovaj pronalazak se dalje odnosi na farmaceutske smeše koje sadrže i postupke za uzpotrebu jedinjenja formule (I) ili njene farmaceutski prihvatljive soli za inhibiciju fosfodiasteraeze (PDE) tipa IV ili javljanja faktora nekroze tumora (TNF) kod sisara.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2038596P | 1996-06-25 | 1996-06-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
YU60198A true YU60198A (sh) | 1999-09-27 |
Family
ID=21798354
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YU60198A YU60198A (sh) | 1996-06-25 | 1998-12-24 | Supstituisani derivati indazola i njihova upotreba kao fosfodiesteraze (pde) tipa iv i inhibitora faktora nekroze tumora (tnf) |
Country Status (43)
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997048697A1 (en) | 1996-06-19 | 1997-12-24 | Rhone-Poulenc Rorer Limited | Substituted azabicylic compounds and their use as inhibitors of the production of tnf and cyclic amp phosphodiesterase |
YU11299A (sh) * | 1996-09-04 | 2001-07-10 | Pfizer Inc. | Derivati indazola |
US6248746B1 (en) | 1998-01-07 | 2001-06-19 | Euro-Celtique S.A. | 3-(arylalkyl) xanthines |
CA2309175A1 (en) * | 1997-11-04 | 1999-05-14 | Pfizer Products Inc. | Therapeutically active compounds based on indazole bioisostere replacement of catechol in pde4 inhibitors |
ATE290002T1 (de) * | 1999-12-23 | 2005-03-15 | Icos Corp | Cyclische amp spezifische phosphodiesterase inhibitoren |
US6362213B1 (en) | 1999-12-23 | 2002-03-26 | Icos Corporation | Cyclic AMP-specific phosphodiesterase inhibitors |
US6953774B2 (en) | 2000-08-11 | 2005-10-11 | Applied Research Systems Ars Holding N.V. | Methods of inducing ovulation |
US7205320B2 (en) | 2001-01-22 | 2007-04-17 | Memory Pharmaceuticals Corp. | Phosphodiesterase 4 inhibitors |
US7153871B2 (en) | 2001-01-22 | 2006-12-26 | Memory Pharmaceuticals Corporation | Phosphodiesterase 4 inhibitors, including aminoindazole and aminobenzofuran analogs |
US6982274B2 (en) * | 2001-04-16 | 2006-01-03 | Eisai Co., Ltd. | 1H-indazole compound |
PT1908463E (pt) | 2001-12-14 | 2011-12-19 | Merck Serono Sa | Método para induzir a ovulação utilizando um modulador de nível camp não polipeptídico |
BR0313000A (pt) | 2002-07-19 | 2005-07-12 | Memory Pharm Corp | Compostos, composição farmacêutica e método para efetuar a inibição da enzima pde4, realçar a cognição e/ou tratar a psicose em um paciente |
NZ537724A (en) | 2002-07-19 | 2006-10-27 | Memory Pharm Corp | Phosphodiesterase 4 inhibitors, including N-substituted aniline and diphenylamine analogs |
BR0315705A (pt) * | 2002-11-19 | 2005-09-06 | Memory Pharm Corp | Inibidores de fosfodiesterase-4 |
WO2004094411A1 (en) * | 2003-04-18 | 2004-11-04 | Memory Pharmaceuticals Corporation | Pyrazole derivatives as phosphodiesterase 4 inhibitors |
US20090048255A1 (en) * | 2003-07-21 | 2009-02-19 | Schumacher Richard A | Phosphodiesterase 4 inhibitors, including n-substituted aniline and diphenylamine analogs |
MY141255A (en) * | 2003-12-11 | 2010-03-31 | Memory Pharm Corp | Phosphodiesterase 4 inhibitors, including n-substituted diarylamine analogs |
WO2006044528A1 (en) * | 2004-10-15 | 2006-04-27 | Memory Pharmaceuticals Corporation | Pyrazole derivatives as phosphodiesterase 4 inhibitors |
US7601847B2 (en) | 2004-10-26 | 2009-10-13 | Wyeth | Preparation and purification of 4-(indazol-3-yl)phenols |
WO2006129158A2 (en) * | 2005-05-30 | 2006-12-07 | Ranbaxy Laboratories Limited | 3 - indazolyl - isoxazoline derivatives as inhibitors of phosphodiesterase type - i |
EP2258359A3 (en) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation with sabcomelin |
JP2009506069A (ja) | 2005-08-26 | 2009-02-12 | ブレインセルス,インコーポレイティド | ムスカリン性受容体調節による神経発生 |
US7781460B2 (en) | 2005-09-05 | 2010-08-24 | Ranbaxy Laboratories Limited | Substituted indazoles as inhibitors of phosphodiesterase type-IV |
WO2007031838A1 (en) | 2005-09-16 | 2007-03-22 | Ranbaxy Laboratories Limited | Substituted pyrazolo [3,4-b] pyridines as phosphodiesterase inhibitors |
CA2625153A1 (en) | 2005-10-21 | 2007-04-26 | Braincells, Inc. | Modulation of neurogenesis by pde inhibition |
US20070112017A1 (en) | 2005-10-31 | 2007-05-17 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
EP2377531A2 (en) | 2006-05-09 | 2011-10-19 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
MX2009009793A (es) | 2007-03-14 | 2009-10-16 | Ranbaxy Lab Ltd | Derivados de pirazolo (3,4-b) piridina como inhibidores de fosfodiesterasa. |
US20100029689A1 (en) * | 2008-07-02 | 2010-02-04 | Memory Pharmaceuticals Corporation | Phosphodiesterase 4 inhibitors |
US20100216805A1 (en) | 2009-02-25 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
NZ599597A (en) * | 2009-10-30 | 2013-05-31 | Janssen Pharmaceutica Nv | IMIDAZO[1,2-b]PYRIDAZINE DERIVATIVES AND THEIR USE AS PDE10 INHIBITORS |
WO2013106547A1 (en) | 2012-01-10 | 2013-07-18 | President And Fellows Of Harvard College | Beta-cell replication promoting compounds and methods of their use |
US20150125438A1 (en) * | 2012-07-20 | 2015-05-07 | Sang Jae Kim | Anti-Inflammatory Peptides and Composition Comprising the Same |
WO2015166370A1 (en) | 2014-04-28 | 2015-11-05 | Pfizer Inc. | Heteroaromatic compounds and their use as dopamine d1 ligands |
KR20220167441A (ko) * | 2021-06-11 | 2022-12-21 | 주식회사 메타센테라퓨틱스 | 신규한 인돌 유도체 및 이의 최종당화산물 관련 질환의 치료 용도 |
KR20220167804A (ko) * | 2021-06-11 | 2022-12-22 | 주식회사 메타센테라퓨틱스 | 인돌 유도체를 포함하는 최종당화산물 관련 질환의 치료용 조성물 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB753573A (en) * | 1953-06-17 | 1956-07-25 | Ici Ltd | New dyestuffs intermediates |
GB8707051D0 (en) * | 1986-04-15 | 1987-04-29 | Ici America Inc | Heterocyclic carboxamides |
PT100441A (pt) * | 1991-05-02 | 1993-09-30 | Smithkline Beecham Corp | Pirrolidinonas, seu processo de preparacao, composicoes farmaceuticas que as contem e uso |
TW223004B (sh) * | 1991-11-25 | 1994-05-01 | Sumitomo Chemical Co | |
US5444038A (en) * | 1992-03-09 | 1995-08-22 | Zeneca Limited | Arylindazoles and their use as herbicides |
AU677776B2 (en) * | 1992-04-02 | 1997-05-08 | Smithkline Beecham Corporation | Compounds useful for treating allergic and inflammatory diseases |
US5612360A (en) * | 1992-06-03 | 1997-03-18 | Eli Lilly And Company | Angiotensin II antagonists |
US5554620A (en) * | 1993-09-14 | 1996-09-10 | Sterling Winthrop Inc. | Substituted 6,11-ethano-6,11-dihydrobenzo[b] quinolizinium salts and compositions and methods of use thereof |
JPH07215952A (ja) * | 1993-12-06 | 1995-08-15 | Otsuka Pharmaceut Factory Inc | カテコール誘導体 |
WO1996012720A1 (en) * | 1994-10-20 | 1996-05-02 | Pfizer Inc. | Bicyclic tetrahydro pyrazolopyridines and their use as medicaments |
-
1997
- 1997-06-02 TR TR1998/02685T patent/TR199802685T2/xx unknown
- 1997-06-02 KR KR1019980710961A patent/KR20000022516A/ko active IP Right Grant
- 1997-06-02 IL IL12703697A patent/IL127036A/en not_active IP Right Cessation
- 1997-06-02 DE DE69723447T patent/DE69723447T2/de not_active Expired - Fee Related
- 1997-06-02 EP EP97921992A patent/EP0912558B1/en not_active Expired - Lifetime
- 1997-06-02 CN CN97195846A patent/CN1080260C/zh not_active Expired - Fee Related
- 1997-06-02 SK SK1765-98A patent/SK176598A3/sk unknown
- 1997-06-02 CZ CZ984233A patent/CZ423398A3/cs unknown
- 1997-06-02 HU HU9903009A patent/HUP9903009A3/hu unknown
- 1997-06-02 PL PL97330974A patent/PL330974A1/xx unknown
- 1997-06-02 DK DK97921992T patent/DK0912558T3/da active
- 1997-06-02 ES ES97921992T patent/ES2201299T3/es not_active Expired - Lifetime
- 1997-06-02 SI SI9730553T patent/SI0912558T1/xx unknown
- 1997-06-02 EA EA199801047A patent/EA002274B1/ru not_active IP Right Cessation
- 1997-06-02 WO PCT/IB1997/000630 patent/WO1997049702A1/en not_active Application Discontinuation
- 1997-06-02 AT AT97921992T patent/ATE244713T1/de not_active IP Right Cessation
- 1997-06-02 JP JP50258998A patent/JP3152940B2/ja not_active Expired - Fee Related
- 1997-06-02 AU AU27857/97A patent/AU716376B2/en not_active Ceased
- 1997-06-02 BR BR9712782-5A patent/BR9712782A/pt not_active Application Discontinuation
- 1997-06-02 CA CA002258285A patent/CA2258285C/en not_active Expired - Fee Related
- 1997-06-02 PT PT97921992T patent/PT912558E/pt unknown
- 1997-06-05 HN HN1997000079A patent/HN1997000079A/es unknown
- 1997-06-05 US US08/869,358 patent/US6040329A/en not_active Expired - Fee Related
- 1997-06-10 PA PA19978432301A patent/PA8432301A1/es unknown
- 1997-06-12 GT GT199700075A patent/GT199700075A/es unknown
- 1997-06-19 AP APAP/P/1997/001020A patent/AP1025A/en active
- 1997-06-20 TW TW086108723A patent/TW434237B/zh not_active IP Right Cessation
- 1997-06-23 MY MYPI97002820A patent/MY116915A/en unknown
- 1997-06-23 AR ARP970102755A patent/AR007456A1/es unknown
- 1997-06-24 ZA ZA975581A patent/ZA975581B/xx unknown
- 1997-06-24 DZ DZ970104A patent/DZ2254A1/fr active
- 1997-06-24 ID IDP972170A patent/ID18579A/id unknown
- 1997-06-24 TN TNTNSN97108A patent/TNSN97108A1/fr unknown
- 1997-06-25 MA MA24679A patent/MA24225A1/fr unknown
- 1997-06-25 HR HR970350A patent/HRP970350B1/xx not_active Application Discontinuation
- 1997-06-25 CO CO97035540A patent/CO4900056A1/es unknown
-
1998
- 1998-11-27 IS IS4910A patent/IS4910A/is unknown
- 1998-12-11 OA OA9800235A patent/OA10934A/en unknown
- 1998-12-23 NZ NZ332752A patent/NZ332752A/en unknown
- 1998-12-23 NO NO986103A patent/NO986103D0/no not_active Application Discontinuation
- 1998-12-24 YU YU60198A patent/YU60198A/sh unknown
-
1999
- 1999-01-07 BG BG103056A patent/BG64052B1/bg unknown
- 1999-08-31 HK HK99103733A patent/HK1018700A1/xx not_active IP Right Cessation
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