YU5199A - Farmaceutski proizvodi za lečenje i sprečavanje bolesti nastalih od oštećenja vaskularnih endotelialnih ćelija - Google Patents
Farmaceutski proizvodi za lečenje i sprečavanje bolesti nastalih od oštećenja vaskularnih endotelialnih ćelijaInfo
- Publication number
- YU5199A YU5199A YU5199A YU5199A YU5199A YU 5199 A YU5199 A YU 5199A YU 5199 A YU5199 A YU 5199A YU 5199 A YU5199 A YU 5199A YU 5199 A YU5199 A YU 5199A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- group
- refers
- general formula
- carbon atoms
- normal
- Prior art date
Links
- 201000010099 disease Diseases 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 229940127557 pharmaceutical product Drugs 0.000 title 1
- 210000003556 vascular endothelial cell Anatomy 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 229910052757 nitrogen Inorganic materials 0.000 abstract 3
- 125000002252 acyl group Chemical group 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 230000006806 disease prevention Effects 0.000 abstract 1
- 210000002889 endothelial cell Anatomy 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 150000002443 hydroxylamines Chemical class 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/15—Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Pronalazak se odnosi na izvesne derivate hidroksilamina u lecenju ili sprecavanju bolesti koje nastaju od ostecenja endotelijalnih celija. Drugi predmet pronalaska je upotreba istih jedinjenja u dobijanju farmaceutskih kompozicija protiv gornjih bolesti. U opstim formulama (I) i (II) R1 i R2 se nezavisno odnose na atom vodonika ili normalnu ili razgranatu alkil grupu od 1 do 6 atoma ugljenika, ili R1 i R2 zajedno sa atomom azota koji se nalazi izmedju obrazuju zasicenu 5-7 clanu heterociklicnu grupu, koja opciono sadrzi dalje heteroatome azota i/ili kiseonika. A se odnosi na normalnu ili razgranatu alkil grupu od 4 do 12 atoma ugljenika, fenil grupu, supstituisanu ili nesupstituisanu, koja sadrzi prvenstveno alkil-halogenalkil- ili nitro grupu kao supstituent, ili 5-6 clani heteroaromaticni prsten koji sadrzi azot, kiseonik ili sumpor, u opstoj formuli (I), Z se odnosi na kovalentnu vezu, a u opstoj formuli (II) na kovalentnu vezu ili =NH grupu, u opstoj formuli (I), X se odnosi na atom halogena ili -NR3R4 grupu, gde se R3 i R4 nezavisno odnose na atom vodonika ili normalnu ili razgranatu alkil grupu od 1 do 6 atoma ugljenika, dok se u opstoj formuli (II) X odnosi na atom kiseonika, u opstoj formuli (II), R' se odnosi na atom vodonika ili normalnu ili razgranatu alkil grupu od 1 do 6 ugljenikovih atoma, i u opstim formulama (I) i (II), Y se odnosi na atom vodonika, hidroksilnu grupu ili aciloksi grupu koja sadrzi prvenstveno acil deo masne kiseline dugackog niza od 8 do 22 atoma ugljenika, ili ciklicnu aromaticnu karboksilnu kiselinu kao njenu acil komponentu, i u jedinjenjima opste formule (I), gde se X odnosi na -NR3R4 grupu i Y se odnosi na hidroksilnu grupu, X grupa se kondenzuje sa Y supstituentom i obrazuju intramolekularni prsten predstavljen opstom formulom (III) u kojoj formuli A, Z, R1 i R2 imaju iste reference kao gore.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU9602204A HUP9602204D0 (en) | 1996-08-09 | 1996-08-09 | Pharmaceutical compositions for treating diseases connected with the disfunction of the vascular endothelial cells |
| HU9701349A HUP9701349A1 (hu) | 1997-08-04 | 1997-08-04 | Gyógyászati készítmények a vaszkuláris endoteliális sejtek rendellenes működésével összefüggő betegségek gyógyítására vagy megelőzésére |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| YU5199A true YU5199A (sh) | 2000-10-30 |
| RS49719B RS49719B (sr) | 2007-12-31 |
Family
ID=90014231
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US6143741A (sh) |
| EP (1) | EP0966283B1 (sh) |
| JP (1) | JP2001504446A (sh) |
| AT (1) | ATE329592T1 (sh) |
| AU (1) | AU739614B2 (sh) |
| BG (1) | BG64456B1 (sh) |
| CA (1) | CA2262997C (sh) |
| CZ (1) | CZ298542B6 (sh) |
| DE (1) | DE69736130T2 (sh) |
| DK (1) | DK0966283T3 (sh) |
| EE (1) | EE04044B1 (sh) |
| ES (1) | ES2267148T3 (sh) |
| HK (1) | HK1025506A1 (sh) |
| IL (1) | IL128256A (sh) |
| NO (1) | NO325109B1 (sh) |
| PT (1) | PT966283E (sh) |
| RS (1) | RS49719B (sh) |
| SK (1) | SK284301B6 (sh) |
| UA (1) | UA64716C2 (sh) |
| WO (1) | WO1998006400A2 (sh) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU9701081D0 (en) | 1997-06-23 | 1997-08-28 | Gene Research Lab Inc N | Pharmaceutical composition of antitumoral activity |
| HU226617B1 (en) * | 1998-12-14 | 2009-04-28 | Cytrx Corp | Optically active pyridyl-4h-1,2,4-oxadiazine derivatives, and pharmaceutical composition containing the compound as active ingredient |
| HUP9900475D0 (en) * | 1999-02-26 | 1999-04-28 | Biorex Kutato Fejlesztoe Kft | O-(3-piperidino-2-hydroxy-1-propyl)-hiyroximic acid-halogenid derivative, it's use for treating insulin resistance, and pharmaceutical compositions containing them as active component |
| IL162941A0 (en) | 2002-01-11 | 2005-11-20 | Biorex Kutato Fejlesztoe Kft | Carboxamidine derivatives and their use in the treatment of vascular diseases |
| HUP0303584A3 (en) | 2003-10-30 | 2009-12-28 | Cytrx Corp | Use of a hydroximic acid halide derivative in the treatment of neurodegenerative diseases |
| WO2008039514A1 (en) * | 2006-09-26 | 2008-04-03 | Cytrx Corporation | Pharmaceutical compositions and methods for treating diseases associated with neurodegeneration |
| JP2010511622A (ja) * | 2006-12-01 | 2010-04-15 | シトルックス コーポレイション | 発作の回復 |
| TW200901958A (en) * | 2007-05-04 | 2009-01-16 | Cytrx Corp | Diabetic wound healing |
| JP5429865B2 (ja) * | 2009-09-15 | 2014-02-26 | 学校法人日本大学 | 生体外創傷治癒試験用用具または創傷作製方法 |
| HUP1100535A2 (en) * | 2011-09-26 | 2013-04-29 | Bracelia Invest Ltd | Pharmaceutical composition for enhancement of stem cell treatment |
| WO2016201168A1 (en) * | 2015-06-10 | 2016-12-15 | Forum Pharmceuticals Inc. | Oxadiazine compounds and methods of use thereof |
| CA3202568A1 (en) | 2020-11-19 | 2022-05-27 | Zevra Denmark A/S | Processes for preparing arimoclomol citrate and intermediates thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4187220A (en) * | 1977-08-30 | 1980-02-05 | Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara R.T. | New O-(3-amino-2-hydroxy-propyl)-amidoxime derivatives, process for the preparation thereof and pharmaceutical compositions containing same |
| HU207988B (en) * | 1988-10-20 | 1993-07-28 | Biorex Kutato Fejlesztoe Kft | Process for producing halogenides of o-/3-amino-2-hydroxy-propyl/hydroximic acid and pharmaceutical compositions containing them as active components |
| GB9017351D0 (en) * | 1990-08-08 | 1990-09-19 | Wellcome Found | Medicaments for treatment of atherosclerosis |
| RO115873B1 (ro) * | 1994-05-06 | 2000-07-28 | Biorex Kutato Es Fejleszto Rt. | Derivaţi de acid hidroximic, procedee de obţinere a acestora, intermediari pentru realizarea unuia dintre procedee şi compoziţie farmaceutică |
| HU218480B (hu) * | 1995-06-15 | 2000-09-28 | BIOREX Kutató és Fejlesztő Rt. | Hidroxilaminszármazékok, eljárás előállításukra és a vegyületeket tartalmazó gyógyszerkészítmények |
| HU222994B1 (hu) * | 1995-11-02 | 2004-01-28 | BIOREX Kutató és Fejlesztő Rt. | Hidroxilaminszármazékok és azok alkalmazása sejtek molekuláris chaperon-termelésének fokozására alkalmas gyógyszerkészítmények előállítására |
-
1997
- 1997-06-08 UA UA99020697A patent/UA64716C2/uk unknown
- 1997-08-06 EP EP97933813A patent/EP0966283B1/en not_active Expired - Lifetime
- 1997-08-06 RS YUP-51/99A patent/RS49719B/sr unknown
- 1997-08-06 AU AU37049/97A patent/AU739614B2/en not_active Ceased
- 1997-08-06 AT AT97933813T patent/ATE329592T1/de active
- 1997-08-06 PT PT97933813T patent/PT966283E/pt unknown
- 1997-08-06 CZ CZ0043599A patent/CZ298542B6/cs not_active IP Right Cessation
- 1997-08-06 IL IL12825697A patent/IL128256A/en not_active IP Right Cessation
- 1997-08-06 US US09/230,941 patent/US6143741A/en not_active Expired - Fee Related
- 1997-08-06 ES ES97933813T patent/ES2267148T3/es not_active Expired - Lifetime
- 1997-08-06 DE DE69736130T patent/DE69736130T2/de not_active Expired - Lifetime
- 1997-08-06 CA CA002262997A patent/CA2262997C/en not_active Expired - Fee Related
- 1997-08-06 WO PCT/HU1997/000044 patent/WO1998006400A2/en active IP Right Grant
- 1997-08-06 EE EEP199900044A patent/EE04044B1/xx not_active IP Right Cessation
- 1997-08-06 SK SK154-99A patent/SK284301B6/sk not_active IP Right Cessation
- 1997-08-06 DK DK97933813T patent/DK0966283T3/da active
- 1997-08-06 JP JP50952798A patent/JP2001504446A/ja not_active Ceased
-
1999
- 1999-02-05 NO NO19990547A patent/NO325109B1/no not_active IP Right Cessation
- 1999-02-22 BG BG103194A patent/BG64456B1/bg unknown
-
2000
- 2000-06-28 HK HK00103903A patent/HK1025506A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CZ43599A3 (cs) | 1999-07-14 |
| EP0966283B1 (en) | 2006-06-14 |
| RS49719B (sr) | 2007-12-31 |
| IL128256A0 (en) | 2000-02-17 |
| AU3704997A (en) | 1998-03-06 |
| UA64716C2 (en) | 2004-03-15 |
| SK15499A3 (en) | 2000-02-14 |
| DE69736130T2 (de) | 2007-01-04 |
| NO990547L (no) | 1999-03-25 |
| WO1998006400A2 (en) | 1998-02-19 |
| AU739614B2 (en) | 2001-10-18 |
| CA2262997C (en) | 2008-07-29 |
| EE04044B1 (et) | 2003-06-16 |
| BG64456B1 (bg) | 2005-03-31 |
| ES2267148T3 (es) | 2007-03-01 |
| SK284301B6 (sk) | 2005-01-03 |
| JP2001504446A (ja) | 2001-04-03 |
| NO325109B1 (no) | 2008-02-04 |
| US6143741A (en) | 2000-11-07 |
| IL128256A (en) | 2004-05-12 |
| BG103194A (en) | 1999-09-30 |
| PT966283E (pt) | 2006-08-31 |
| DK0966283T3 (da) | 2006-10-09 |
| CZ298542B6 (cs) | 2007-10-31 |
| EE9900044A (et) | 1999-08-16 |
| WO1998006400A3 (en) | 1998-03-26 |
| ATE329592T1 (de) | 2006-07-15 |
| HK1025506A1 (en) | 2000-11-17 |
| NO990547D0 (no) | 1999-02-05 |
| DE69736130D1 (de) | 2006-07-27 |
| CA2262997A1 (en) | 1998-02-19 |
| EP0966283A2 (en) | 1999-12-29 |
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