YU46903A - Derivati difenil-azetidinona,postupak za njihovu proizvodnju lekovi koji sadrže ova jedinjenja i njihova primena - Google Patents
Derivati difenil-azetidinona,postupak za njihovu proizvodnju lekovi koji sadrže ova jedinjenja i njihova primenaInfo
- Publication number
- YU46903A YU46903A YU46903A YUP46903A YU46903A YU 46903 A YU46903 A YU 46903A YU 46903 A YU46903 A YU 46903A YU P46903 A YUP46903 A YU P46903A YU 46903 A YU46903 A YU 46903A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- compounds
- production
- medicaments containing
- azetidinone derivatives
- diphenyl azetidinone
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Pronalazak se odnosi na difenil-azetidinone, postupak za njihovu proizvodnju, lekove koji sasdrže ova jedinjenja i njihovu primenu. Pronalazak se odnosi na jedinjenja formule I, u kojima R1, R2, R3, R4, R5 i R6 imaju navedena značenja, kao i na njihove farmaceutski prihvatljive soli. Jedinjenja su pogodna, na primer, kao hipolipidemijska sredstva.[The invention relates to novel diphenyl azetidinones, to a method for the production thereof, to medicaments containing these compounds, and to their use. The invention concerns compounds of formula (I), wherein R1, R2, R3, R4, R5 and R6 have the cited meanings, and concerns the physiologically compatible salts thereof. The compounds are suited for use e.g. as hypolipidemic drugs.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10064402A DE10064402A1 (de) | 2000-12-21 | 2000-12-21 | Diphenylazetidinonderivate, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung |
DE2001154520 DE10154520A1 (de) | 2001-11-07 | 2001-11-07 | Diphenylazetidinonderivate, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung |
Publications (1)
Publication Number | Publication Date |
---|---|
YU46903A true YU46903A (sh) | 2006-05-25 |
Family
ID=26008045
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YU46903A YU46903A (sh) | 2000-12-21 | 2001-12-11 | Derivati difenil-azetidinona,postupak za njihovu proizvodnju lekovi koji sadrže ova jedinjenja i njihova primena |
Country Status (24)
Country | Link |
---|---|
US (1) | US6498156B2 (sh) |
EP (1) | EP1345932B1 (sh) |
JP (1) | JP2004516293A (sh) |
KR (1) | KR20030061462A (sh) |
CN (1) | CN1222522C (sh) |
AR (1) | AR034282A1 (sh) |
AT (1) | ATE342899T1 (sh) |
AU (2) | AU2002219173B2 (sh) |
BR (1) | BR0116482A (sh) |
CA (1) | CA2431985A1 (sh) |
CZ (1) | CZ20031731A3 (sh) |
DE (1) | DE50111293D1 (sh) |
EE (1) | EE200300237A (sh) |
HK (1) | HK1059936A1 (sh) |
HR (1) | HRP20030499A2 (sh) |
HU (1) | HUP0401067A2 (sh) |
IL (1) | IL156552A0 (sh) |
MX (1) | MXPA03005018A (sh) |
NO (1) | NO20032733L (sh) |
NZ (1) | NZ526592A (sh) |
PL (1) | PL362173A1 (sh) |
SK (1) | SK7812003A3 (sh) |
WO (1) | WO2002050068A1 (sh) |
YU (1) | YU46903A (sh) |
Families Citing this family (61)
Publication number | Priority date | Publication date | Assignee | Title |
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ATE349425T1 (de) * | 2000-12-21 | 2007-01-15 | Sanofi Aventis Deutschland | Neue diphenzylazetidinone, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung zur behandlung von lipidstoffwechselstörungen |
CZ20032031A3 (cs) * | 2001-01-26 | 2003-12-17 | Schering Corporation | Farmaceutický prostředek |
DE60221798T2 (de) * | 2001-01-26 | 2008-06-05 | Schering Corp. | Kombinationen von gallensäure sequestriermitteln und hemmern der sterol absorption zur behandlung von kardiovaskulären indikationen |
WO2002058734A2 (en) * | 2001-01-26 | 2002-08-01 | Schering Corporation | Combinations of sterol absorption inhibitor(s) with blood modifier(s) for treating vascular conditions |
US20020183305A1 (en) * | 2001-01-26 | 2002-12-05 | Schering Corporation | Combinations of nicotinic acid and derivatives thereof and sterol absorption inhibitor(s) and treatments for vascular indications |
ES2290562T3 (es) * | 2001-01-26 | 2008-02-16 | Schering Corporation | Combinaciones del activador del receptor activado por el proliferador de los peroxisomas (ppar) fenofibrato con el inhibidor de la absorcion de esteroles ezetimiba para indicaciones vasculares. |
DE50212937D1 (de) * | 2001-08-22 | 2008-12-04 | Sanofi Aventis Deutschland | Kombinationspräparate von 1,4- benzothiepin-1,1-dioxidderivaten mit weiteren wirkstoffen und deren verwendung |
US7053080B2 (en) * | 2001-09-21 | 2006-05-30 | Schering Corporation | Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors |
US20030119808A1 (en) * | 2001-09-21 | 2003-06-26 | Schering Corporation | Methods of treating or preventing cardiovascular conditions while preventing or minimizing muscular degeneration side effects |
EP1429756B1 (en) * | 2001-09-21 | 2006-11-22 | Schering Corporation | Treatment of xanthoma with azetidinone derivatives as sterol absorption inhibitors |
US7056906B2 (en) | 2001-09-21 | 2006-06-06 | Schering Corporation | Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women |
DE10227508A1 (de) * | 2002-06-19 | 2004-01-08 | Aventis Pharma Deutschland Gmbh | Säuregruppen-substituierte Diphenylazetidinone, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung |
DE10227507A1 (de) * | 2002-06-19 | 2004-01-08 | Aventis Pharma Deutschland Gmbh | Kationisch substituierte Diphenylazetidinone, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung |
US7671047B2 (en) | 2002-06-19 | 2010-03-02 | Sanofi-Aventis Deutschland Gmbh | Cationically substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use |
US7176194B2 (en) | 2002-06-19 | 2007-02-13 | Sanofi-Aventis Deutschland Gmbh | Ring-substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use |
US7176193B2 (en) | 2002-06-19 | 2007-02-13 | Sanofi-Aventis Deutschland Gmbh | Acid-group-substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use |
GB0215579D0 (en) | 2002-07-05 | 2002-08-14 | Astrazeneca Ab | Chemical compounds |
WO2004010948A2 (en) * | 2002-07-30 | 2004-02-05 | Karykion Inc. | Compositions of ezetimibe and methods for the treatment of cholesterol-associated benign and malignant tumors |
US7208486B2 (en) | 2003-03-07 | 2007-04-24 | Schering Corporation | Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof |
WO2004081002A1 (en) | 2003-03-07 | 2004-09-23 | Schering Corporation | Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia |
EP1626711A4 (en) * | 2003-05-09 | 2010-10-06 | Univ Pennsylvania | COMPOSITIONS AND METHOD FOR THE TREATMENT OF CANCER |
US20070072812A1 (en) * | 2003-08-25 | 2007-03-29 | Microbia, Inc. | Quaternary salt derivatives of 1,4-diphenylazetidin-2-ones |
US8987322B2 (en) * | 2003-11-04 | 2015-03-24 | Circ Pharma Research And Development Limited | Pharmaceutical formulations for carrier-mediated transport statins and uses thereof |
EP1918000A2 (en) | 2003-11-05 | 2008-05-07 | Schering Corporation | Combinations of lipid modulating agents and substituted azetidinones and treatments for vascular conditions |
US7871998B2 (en) | 2003-12-23 | 2011-01-18 | Astrazeneca Ab | Diphenylazetidinone derivatives possessing cholesterol absorption inhibitory activity |
EA010373B1 (ru) * | 2004-01-20 | 2008-08-29 | Панацея Биотек Лтд. | Фармацевтические композиции, содержащие высшие первичные спирты и эзетимиб, и способ их получения |
AU2005221656B2 (en) | 2004-03-05 | 2011-06-23 | The Trustees Of The University Of Pennsylvania | Methods for treating disorders or diseases associated with hyperlipidemia and hypercholesterolemia while minimizing side-effects |
JP2008514718A (ja) * | 2004-09-29 | 2008-05-08 | シェーリング コーポレイション | 置換アゼチドノンおよびcb1アンタゴニストの組み合わせ |
CA2580690A1 (en) * | 2004-10-21 | 2006-05-04 | Transtech Pharma, Inc. | Bissulfonamide compounds as agonists of galr1, compositions, and methods of use |
ES2435790T3 (es) | 2004-12-03 | 2013-12-23 | Intervet International B.V. | Piperazinas sustituidas como antagonistas de CB1 |
TW200726746A (en) * | 2005-05-06 | 2007-07-16 | Microbia Inc | Processes for production of 4-biphenylylazetidin-2-ones |
BRPI0611531A2 (pt) * | 2005-05-09 | 2010-09-21 | Microbia Inc | agentes de acoplamento de benzenofosfonato de organometal e método de geração de ligação carbono-carbono |
EA200702464A1 (ru) * | 2005-05-11 | 2008-04-28 | Майкробиа, Инк. | Способы получения фенольных 4-бифенилилазетидин-2-онов |
AU2006249905A1 (en) * | 2005-05-25 | 2006-11-30 | Microbia, Inc. | Processes for production of 4-(biphenylyl)azetidin-2-one phosphonic acids |
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RU2009108280A (ru) | 2006-08-08 | 2010-09-20 | Санофи-Авентис (Fr) | Ариламиноарилалкилзамещенные имидазолидин-2,4-дионы, способы их получения, содержащие эти соединения лекарственные средства и их применение |
WO2008030382A1 (en) * | 2006-09-05 | 2008-03-13 | Schering Corporation | Pharmaceutical combinations for lipid management and in the treatment of atherosclerosis and hepatic steatosis |
WO2008039829A2 (en) * | 2006-09-26 | 2008-04-03 | Ironwood Pharmaceuticals, Inc. | Diphenylheterocycle cholesterol absorption inhibitors |
DE102007002260A1 (de) | 2007-01-16 | 2008-07-31 | Sanofi-Aventis | Verwendung von substituierten Pyranonsäurederivaten zur Herstellung von Medikamenten zur Behandlung des Metabolischen Syndroms |
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EP2170847A2 (en) * | 2007-06-28 | 2010-04-07 | Intervet International BV | Substituted piperazines as cb1 antagonists |
KR20100051625A (ko) * | 2007-06-28 | 2010-05-17 | 인터벳 인터내셔널 비.브이. | Cb1 길항제로서의 치환된 피페라진 |
EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
DE102007054497B3 (de) | 2007-11-13 | 2009-07-23 | Sanofi-Aventis Deutschland Gmbh | Neue kristalline Diphenylazetidinonhydrate und Verfahren zu deren Herstellung |
US20090312302A1 (en) * | 2008-06-17 | 2009-12-17 | Ironwood Pharmaceuticals, Inc. | Compositions and methods for treating nonalcoholic fatty liver disease-associated disorders |
UY31968A (es) | 2008-07-09 | 2010-01-29 | Sanofi Aventis | Nuevos derivados heterocíclicos, sus procesos para su preparación, y sus usos terapéuticos |
WO2010068601A1 (en) | 2008-12-08 | 2010-06-17 | Sanofi-Aventis | A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof |
US9212175B2 (en) | 2009-03-06 | 2015-12-15 | Lipideon Biotechnology Ag | Pharmaceutical hypocholesterolemic compositions |
CN101993403B (zh) | 2009-08-11 | 2012-07-11 | 浙江海正药业股份有限公司 | 氮杂环丁酮类化合物及医药应用 |
SG178880A1 (en) | 2009-08-26 | 2012-04-27 | Sanofi Sa | Novel crystalline heteroaromatic fluoroglycoside hydrates, pharmaceuticals comprising these compounds and their use |
WO2011157827A1 (de) | 2010-06-18 | 2011-12-22 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
US8828995B2 (en) | 2011-03-08 | 2014-09-09 | Sanofi | Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
US8871758B2 (en) | 2011-03-08 | 2014-10-28 | Sanofi | Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof |
WO2012120054A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
WO2012120052A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
EP2683699B1 (de) | 2011-03-08 | 2015-06-24 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
CN102746249B (zh) * | 2012-07-07 | 2013-12-25 | 山东诚创医药技术开发有限公司 | 一种依折麦布中间体的纯化精制方法 |
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US5631365A (en) * | 1993-09-21 | 1997-05-20 | Schering Corporation | Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents |
JPH10501811A (ja) * | 1994-06-20 | 1998-02-17 | シェーリング コーポレイション | 低コレステロール化剤として有用な置換アゼチジノン化合物 |
ES2155136T3 (es) * | 1994-09-13 | 2001-05-01 | Monsanto Co | Nuevas benzotiepinas que tienen actividad como inhibidores del transporte de acido biliar iliaco y la captacion de taurocolato. |
US5994391A (en) * | 1994-09-13 | 1999-11-30 | G.D. Searle And Company | Benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
US5656624A (en) * | 1994-12-21 | 1997-08-12 | Schering Corporation | 4-[(heterocycloalkyl or heteroaromatic)-substituted phenyl]-2-azetidinones useful as hypolipidemic agents |
US5756470A (en) | 1996-10-29 | 1998-05-26 | Schering Corporation | Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents |
-
2000
- 2000-12-11 IL IL15655200A patent/IL156552A0/xx unknown
-
2001
- 2001-12-11 NZ NZ526592A patent/NZ526592A/en unknown
- 2001-12-11 SK SK781-2003A patent/SK7812003A3/sk unknown
- 2001-12-11 CA CA002431985A patent/CA2431985A1/en not_active Abandoned
- 2001-12-11 JP JP2002551564A patent/JP2004516293A/ja not_active Abandoned
- 2001-12-11 BR BR0116482-1A patent/BR0116482A/pt not_active IP Right Cessation
- 2001-12-11 PL PL01362173A patent/PL362173A1/xx not_active Application Discontinuation
- 2001-12-11 AU AU2002219173A patent/AU2002219173B2/en not_active Expired - Fee Related
- 2001-12-11 AT AT01271371T patent/ATE342899T1/de not_active IP Right Cessation
- 2001-12-11 EE EEP200300237A patent/EE200300237A/xx unknown
- 2001-12-11 CN CNB018210449A patent/CN1222522C/zh not_active Expired - Fee Related
- 2001-12-11 YU YU46903A patent/YU46903A/sh unknown
- 2001-12-11 KR KR10-2003-7008330A patent/KR20030061462A/ko not_active Application Discontinuation
- 2001-12-11 AU AU1917302A patent/AU1917302A/xx active Pending
- 2001-12-11 WO PCT/EP2001/014532 patent/WO2002050068A1/de not_active Application Discontinuation
- 2001-12-11 EP EP01271371A patent/EP1345932B1/de not_active Expired - Lifetime
- 2001-12-11 DE DE50111293T patent/DE50111293D1/de not_active Expired - Lifetime
- 2001-12-11 MX MXPA03005018A patent/MXPA03005018A/es active IP Right Grant
- 2001-12-11 HU HU0401067A patent/HUP0401067A2/hu unknown
- 2001-12-11 CZ CZ20031731A patent/CZ20031731A3/cs unknown
- 2001-12-19 AR ARP010105906A patent/AR034282A1/es unknown
- 2001-12-19 US US10/021,028 patent/US6498156B2/en not_active Expired - Lifetime
-
2003
- 2003-06-16 NO NO20032733A patent/NO20032733L/no not_active Application Discontinuation
- 2003-06-18 HR HR20030499A patent/HRP20030499A2/hr not_active Application Discontinuation
-
2004
- 2004-04-22 HK HK04102849A patent/HK1059936A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP1345932A1 (de) | 2003-09-24 |
HUP0401067A2 (hu) | 2004-09-28 |
CZ20031731A3 (cs) | 2003-09-17 |
US20020128252A1 (en) | 2002-09-12 |
CA2431985A1 (en) | 2002-06-27 |
SK7812003A3 (en) | 2004-01-08 |
EE200300237A (et) | 2003-08-15 |
BR0116482A (pt) | 2004-02-03 |
NZ526592A (en) | 2004-11-26 |
AU2002219173B2 (en) | 2006-06-22 |
AR034282A1 (es) | 2004-02-18 |
MXPA03005018A (es) | 2003-09-25 |
AU1917302A (en) | 2002-07-01 |
ATE342899T1 (de) | 2006-11-15 |
HK1059936A1 (en) | 2004-07-23 |
WO2002050068A1 (de) | 2002-06-27 |
IL156552A0 (en) | 2004-01-04 |
PL362173A1 (en) | 2004-10-18 |
EP1345932B1 (de) | 2006-10-18 |
CN1481381A (zh) | 2004-03-10 |
HRP20030499A2 (en) | 2005-04-30 |
DE50111293D1 (de) | 2006-11-30 |
JP2004516293A (ja) | 2004-06-03 |
NO20032733L (no) | 2003-08-14 |
KR20030061462A (ko) | 2003-07-18 |
NO20032733D0 (no) | 2003-06-16 |
US6498156B2 (en) | 2002-12-24 |
CN1222522C (zh) | 2005-10-12 |
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