YU3103A - 2,2-disupstituisani 1,3-dioksolani kao sredstva protiv kašlja - Google Patents
2,2-disupstituisani 1,3-dioksolani kao sredstva protiv kašljaInfo
- Publication number
- YU3103A YU3103A YU3103A YUP3103A YU3103A YU 3103 A YU3103 A YU 3103A YU 3103 A YU3103 A YU 3103A YU P3103 A YUP3103 A YU P3103A YU 3103 A YU3103 A YU 3103A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- dioxolanes
- disubstituted
- antitussive agents
- piperazinyl
- phenyl
- Prior art date
Links
- -1 2,2-disubstituted 1,3-dioxolanes Chemical class 0.000 title abstract 2
- 239000003434 antitussive agent Substances 0.000 title 1
- 229940124584 antitussives Drugs 0.000 title 1
- PTVWPYVOOKLBCG-UHFFFAOYSA-N 3-(4-phenyl-1-piperazinyl)propane-1,2-diol Chemical compound C1CN(CC(O)CO)CCN1C1=CC=CC=C1 PTVWPYVOOKLBCG-UHFFFAOYSA-N 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- PTVWPYVOOKLBCG-ZDUSSCGKSA-N levodropropizine Chemical compound C1CN(C[C@H](O)CO)CCN1C1=CC=CC=C1 PTVWPYVOOKLBCG-ZDUSSCGKSA-N 0.000 abstract 1
- 229960002265 levodropropizine Drugs 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/28—Radicals substituted by nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Holo Graphy (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Hydrogenated Pyridines (AREA)
- Secondary Cells (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
- Fats And Perfumes (AREA)
- Liquid Crystal Substances (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Compounds Of Alkaline-Earth Elements, Aluminum Or Rare-Earth Metals (AREA)
- Glass Compositions (AREA)
Abstract
Opisani su ciklični acetali (S)-3-(4-fenil-1-piperazinil)-1,2- propandiola koji se koriste kao sredstva protiv kašlja i kao intermedijeri za dobijanje levodropropizina i njegovih soli, kao i procesa za dobijanje pomenutih actala.[3-(4-Phenyl-1-piperazinyl)-1,2-propanediol cyclic acetals, a process for the optical resolution thereof and their use as intermediates for the prepartion of (-) 3-(4-phenyl-1-piperazinyl)-1,2-propanediol (levodropropizine) and salts thereof
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2000MI001735A IT1318651B1 (it) | 2000-07-28 | 2000-07-28 | Sintesi di (+-)1,3-diossolani e loro risoluzione ottica. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| YU3103A true YU3103A (sh) | 2006-05-25 |
| RS50862B RS50862B (sr) | 2010-08-31 |
Family
ID=11445592
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US6916926B2 (sh) |
| EP (1) | EP1307440B1 (sh) |
| JP (1) | JP5015403B2 (sh) |
| KR (1) | KR100788532B1 (sh) |
| CN (1) | CN1216053C (sh) |
| AT (1) | ATE290533T1 (sh) |
| AU (1) | AU2001281992A1 (sh) |
| BR (1) | BR0112802A (sh) |
| CZ (1) | CZ301039B6 (sh) |
| DE (1) | DE60109299T2 (sh) |
| EE (1) | EE05159B1 (sh) |
| ES (1) | ES2237589T3 (sh) |
| HK (1) | HK1058798A1 (sh) |
| HU (1) | HU229801B1 (sh) |
| IL (2) | IL153502A0 (sh) |
| IT (1) | IT1318651B1 (sh) |
| MX (1) | MXPA02012922A (sh) |
| PL (1) | PL206308B1 (sh) |
| PT (1) | PT1307440E (sh) |
| RS (1) | RS50862B (sh) |
| RU (1) | RU2269522C2 (sh) |
| SI (1) | SI21041B (sh) |
| SK (1) | SK286795B6 (sh) |
| UA (1) | UA73790C2 (sh) |
| WO (1) | WO2002010150A1 (sh) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1318650B1 (it) * | 2000-07-28 | 2003-08-27 | Dompe Spa | 1,3-diossolani ad attivita' antitosse. |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4049660A (en) * | 1971-06-18 | 1977-09-20 | Delalande S.A. | N-substituted derivatives of 4 (N-piperazinylmethyl) spiro dibenzocycloheptadi- (or tri-) ene-5, 2-dioxolane (1,3) their method of preparation and their application in therapeutics |
| IT1210639B (it) * | 1981-02-25 | 1989-09-14 | Menarini Sas | Prodotto: 3(4-fenil1piperazinio-1-il)-1,2-propandiolo 3(teofillin-7-il)-1propansolfonato,utilizzabile in terapia,e relativo procedimento di fabbricazione |
| IT1203721B (it) * | 1983-12-29 | 1989-02-23 | Dompe Farmaceutici Spa | Composti otticamente attivi ad attivita' antitosse e sedativa centrale,procedimento per la preparazione e composizioni che li contengono |
| SE449516B (sv) * | 1984-10-16 | 1987-05-04 | Skf Nova Ab | Klemring med reglerbar halomkrets |
| IT1254452B (it) * | 1992-02-14 | 1995-09-25 | Dompe Farmaceutici Spa | N-ossidi ed n,n'-diossidi di 3-(piperazin-1-il)-propan-1,2-dioli |
| IL111730A (en) * | 1993-11-29 | 1998-12-06 | Fujisawa Pharmaceutical Co | Piperazine derivatives, processes for their preparation and pharmaceutical preparations containing them |
| IT1318650B1 (it) * | 2000-07-28 | 2003-08-27 | Dompe Spa | 1,3-diossolani ad attivita' antitosse. |
-
2000
- 2000-07-28 IT IT2000MI001735A patent/IT1318651B1/it active
-
2001
- 2001-07-18 AU AU2001281992A patent/AU2001281992A1/en not_active Abandoned
- 2001-07-18 AT AT01960513T patent/ATE290533T1/de active
- 2001-07-18 MX MXPA02012922A patent/MXPA02012922A/es active IP Right Grant
- 2001-07-18 SK SK90-2003A patent/SK286795B6/sk not_active IP Right Cessation
- 2001-07-18 UA UA2003021768A patent/UA73790C2/uk unknown
- 2001-07-18 EE EEP200300035A patent/EE05159B1/xx not_active IP Right Cessation
- 2001-07-18 CN CN018134572A patent/CN1216053C/zh not_active Expired - Fee Related
- 2001-07-18 KR KR1020037000943A patent/KR100788532B1/ko not_active IP Right Cessation
- 2001-07-18 CZ CZ20030269A patent/CZ301039B6/cs not_active IP Right Cessation
- 2001-07-18 BR BR0112802-7A patent/BR0112802A/pt not_active Application Discontinuation
- 2001-07-18 RU RU2003105692/04A patent/RU2269522C2/ru not_active IP Right Cessation
- 2001-07-18 US US10/312,290 patent/US6916926B2/en not_active Expired - Fee Related
- 2001-07-18 PL PL361173A patent/PL206308B1/pl unknown
- 2001-07-18 EP EP01960513A patent/EP1307440B1/en not_active Expired - Lifetime
- 2001-07-18 DE DE60109299T patent/DE60109299T2/de not_active Expired - Lifetime
- 2001-07-18 JP JP2002515881A patent/JP5015403B2/ja not_active Expired - Fee Related
- 2001-07-18 IL IL15350201A patent/IL153502A0/xx active IP Right Grant
- 2001-07-18 HU HU0301473A patent/HU229801B1/hu not_active IP Right Cessation
- 2001-07-18 SI SI200120037A patent/SI21041B/sl not_active IP Right Cessation
- 2001-07-18 ES ES01960513T patent/ES2237589T3/es not_active Expired - Lifetime
- 2001-07-18 RS YUP-31/03A patent/RS50862B/sr unknown
- 2001-07-18 WO PCT/EP2001/008305 patent/WO2002010150A1/en active IP Right Grant
- 2001-07-18 PT PT01960513T patent/PT1307440E/pt unknown
-
2002
- 2002-12-17 IL IL153502A patent/IL153502A/en not_active IP Right Cessation
-
2004
- 2004-03-05 HK HK04101654A patent/HK1058798A1/xx not_active IP Right Cessation
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