YU1302A - Derivati aminotiazola i njihova primena kao liganada crf receptora - Google Patents
Derivati aminotiazola i njihova primena kao liganada crf receptoraInfo
- Publication number
- YU1302A YU1302A YU1302A YUP1302A YU1302A YU 1302 A YU1302 A YU 1302A YU 1302 A YU1302 A YU 1302A YU P1302 A YUP1302 A YU P1302A YU 1302 A YU1302 A YU 1302A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- receptor ligands
- crf receptor
- aminothiazole derivatives
- aminothiazole
- derivatives
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/06—Antimigraine agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
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- A61P27/00—Drugs for disorders of the senses
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
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- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
- A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Reproductive Health (AREA)
- Hematology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Psychology (AREA)
- Emergency Medicine (AREA)
- Pregnancy & Childbirth (AREA)
- Anesthesiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Ophthalmology & Optometry (AREA)
- Gynecology & Obstetrics (AREA)
Abstract
Pronalazak se odnosi na jedinjenja formule (I), gde R1, R2, R3, R4, R5 i R6, R7 su kao što je definisano u zahtevu 1. Pomenuta jedinjenja poseduju afinitet za CRF receptore.[The invention concerns compounds of formula (I) wherein: R1, R2, R3, R4, R5, R6 and R7 are as defined in Claim 1. Said compounds have an affinity for CRF receptors.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9909144A FR2796380B3 (fr) | 1999-07-15 | 1999-07-15 | Nouveaux derives d'aminothiazoles, leur preparation et les compositions pharmaceutiques les contenant |
Publications (2)
Publication Number | Publication Date |
---|---|
YU1302A true YU1302A (sh) | 2005-03-15 |
RS50443B RS50443B (sr) | 2010-03-02 |
Family
ID=9548107
Country Status (36)
Country | Link |
---|---|
US (2) | US6586456B1 (sh) |
EP (1) | EP1200419B1 (sh) |
JP (1) | JP4949582B2 (sh) |
KR (1) | KR100707320B1 (sh) |
CN (1) | CN1167692C (sh) |
AR (1) | AR024747A1 (sh) |
AT (1) | ATE264315T1 (sh) |
AU (1) | AU772683B2 (sh) |
BR (1) | BR0012478B1 (sh) |
CA (1) | CA2378792C (sh) |
CO (1) | CO5200792A1 (sh) |
CZ (1) | CZ300937B6 (sh) |
DE (1) | DE60009911T2 (sh) |
DK (1) | DK1200419T3 (sh) |
EA (1) | EA005159B1 (sh) |
EE (1) | EE05004B1 (sh) |
ES (1) | ES2220504T3 (sh) |
FR (1) | FR2796380B3 (sh) |
HK (1) | HK1045692B (sh) |
HU (1) | HU229069B1 (sh) |
IL (2) | IL147282A0 (sh) |
IS (1) | IS2314B (sh) |
ME (1) | MEP26608A (sh) |
MX (1) | MXPA02000545A (sh) |
NO (1) | NO324352B1 (sh) |
NZ (1) | NZ516397A (sh) |
PL (1) | PL206515B1 (sh) |
PT (1) | PT1200419E (sh) |
RS (1) | RS50443B (sh) |
SI (1) | SI1200419T1 (sh) |
SK (1) | SK287069B6 (sh) |
TR (1) | TR200200125T2 (sh) |
TW (1) | TWI278453B (sh) |
UA (1) | UA73125C2 (sh) |
WO (1) | WO2001005776A1 (sh) |
ZA (1) | ZA200200221B (sh) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU9625501A (en) * | 2000-09-21 | 2002-04-02 | Bristol Myers Squibb Co | Substituted azole derivatives as inhibitors of corticotropin releasing factor |
EP1423113A4 (en) * | 2001-08-13 | 2007-04-18 | Phenex Pharmaceuticals Ag | NR1H4 NUCLEAR RECEPTOR BINDING COMPOUNDS |
WO2003033128A2 (en) | 2001-10-12 | 2003-04-24 | Duke University | Methods for image analysis of high-density synthetic dna microarrays |
AU2005250056A1 (en) | 2004-06-03 | 2005-12-15 | Athlomics Pty Ltd | Agents and methods for diagnosing stress |
CA2575466A1 (en) * | 2004-08-13 | 2006-02-23 | Genentech, Inc. | Thiazole based inhibitors of atp-utilizing enzymes |
EP1834641A1 (en) * | 2006-03-16 | 2007-09-19 | Sanofi-Aventis | Use of CRF1 receptor antagonists for preparing a drug for treating metabolic syndrome and/or obesity and/or dyslipoproteinemia |
HUP0900267A2 (en) * | 2009-04-30 | 2011-03-28 | Sanofi Aventis | Process for preparing of thiazole amines and intermediates thereof |
EP2841068B8 (en) * | 2012-04-23 | 2019-03-06 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Crhr1 antagonists for use in the treatment of patients having crh overactivity |
GB201210686D0 (en) | 2012-06-15 | 2012-08-01 | Holsboermaschmeyer Neurochemie Gmbh | V1B receptor antagonist for use in the treatment of patients having an elevated AVP level and/or an elevated copeptin level |
GB201310782D0 (en) | 2013-06-17 | 2013-07-31 | Max Planck Innovation Gmbh | Method for predicting a treatment response to a CRHR1 antagonist and/or V1B antagonist in a patient with depressive and/or anxiety symptoms |
KR20210064407A (ko) | 2014-01-21 | 2021-06-02 | 뉴로크린 바이오사이언시즈 인코퍼레이티드 | 선천성 부신 과형성 치료를 위한 crf1 수용체 길항제 |
MA56226A (fr) | 2018-12-07 | 2022-04-20 | Neurocrine Biosciences Inc | Antagoniste du récepteur crf1, formulations pharmaceutiques et ses formes solides pour le traitement de l'hyperplasie surrénale congénitale |
US20220409592A1 (en) * | 2019-09-27 | 2022-12-29 | Neurocrine Biosciences, Inc. | Crf receptor antagonists and methods of use |
CA3181084A1 (en) | 2020-06-10 | 2021-12-16 | Robert H. FARBER | Crf1 receptor antagonist for the treatment of congenital adrenal hyperplasia |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2692893B1 (fr) * | 1992-06-24 | 1994-09-02 | Sanofi Elf | Dérivés alkylamino ramifiés du thiazole, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent. |
FR2714059B1 (fr) * | 1993-12-21 | 1996-03-08 | Sanofi Elf | Dérivés amino ramifiés du thiazole, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent. |
FR2735777B1 (fr) * | 1995-06-21 | 1997-09-12 | Sanofi Sa | Derives de 4-phenylaminothiazole, leur procede de preparation et les compositions pharmaceutiques les contenant |
FR2754258B1 (fr) * | 1996-10-08 | 1998-12-31 | Sanofi Sa | Derives d'aminothiazole, leur procede de preparation et les compositions pharmaceutiques les contenant |
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1999
- 1999-07-15 FR FR9909144A patent/FR2796380B3/fr not_active Expired - Lifetime
-
2000
- 2000-07-11 HU HU0202387A patent/HU229069B1/hu not_active IP Right Cessation
- 2000-07-11 EE EEP200200022A patent/EE05004B1/xx not_active IP Right Cessation
- 2000-07-11 NZ NZ516397A patent/NZ516397A/xx not_active IP Right Cessation
- 2000-07-11 AU AU64521/00A patent/AU772683B2/en not_active Ceased
- 2000-07-11 MX MXPA02000545A patent/MXPA02000545A/es active IP Right Grant
- 2000-07-11 ME MEP-266/08A patent/MEP26608A/xx unknown
- 2000-07-11 EA EA200101234A patent/EA005159B1/ru not_active IP Right Cessation
- 2000-07-11 WO PCT/FR2000/001995 patent/WO2001005776A1/fr active IP Right Grant
- 2000-07-11 CN CNB008116911A patent/CN1167692C/zh not_active Expired - Fee Related
- 2000-07-11 PT PT00951647T patent/PT1200419E/pt unknown
- 2000-07-11 ES ES00951647T patent/ES2220504T3/es not_active Expired - Lifetime
- 2000-07-11 AT AT00951647T patent/ATE264315T1/de active
- 2000-07-11 US US10/031,038 patent/US6586456B1/en not_active Expired - Lifetime
- 2000-07-11 KR KR1020027000549A patent/KR100707320B1/ko not_active IP Right Cessation
- 2000-07-11 SI SI200030377T patent/SI1200419T1/xx unknown
- 2000-07-11 BR BRPI0012478-8B1A patent/BR0012478B1/pt not_active IP Right Cessation
- 2000-07-11 DE DE60009911T patent/DE60009911T2/de not_active Expired - Lifetime
- 2000-07-11 IL IL14728200A patent/IL147282A0/xx active IP Right Grant
- 2000-07-11 PL PL352901A patent/PL206515B1/pl unknown
- 2000-07-11 JP JP2001511437A patent/JP4949582B2/ja not_active Expired - Lifetime
- 2000-07-11 DK DK00951647T patent/DK1200419T3/da active
- 2000-07-11 CZ CZ20020137A patent/CZ300937B6/cs not_active IP Right Cessation
- 2000-07-11 TR TR2002/00125T patent/TR200200125T2/xx unknown
- 2000-07-11 EP EP00951647A patent/EP1200419B1/fr not_active Expired - Lifetime
- 2000-07-11 CA CA002378792A patent/CA2378792C/en not_active Expired - Fee Related
- 2000-07-11 RS YUP-13/02A patent/RS50443B/sr unknown
- 2000-07-11 SK SK38-2002A patent/SK287069B6/sk not_active IP Right Cessation
- 2000-07-13 CO CO00052852A patent/CO5200792A1/es active IP Right Grant
- 2000-07-14 AR ARP000103626A patent/AR024747A1/es not_active Application Discontinuation
- 2000-07-14 TW TW089114114A patent/TWI278453B/zh not_active IP Right Cessation
- 2000-11-07 UA UA2001129084A patent/UA73125C2/uk unknown
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2001
- 2001-12-24 IL IL147282A patent/IL147282A/en not_active IP Right Cessation
-
2002
- 2002-01-03 IS IS6219A patent/IS2314B/is unknown
- 2002-01-10 ZA ZA200200221A patent/ZA200200221B/en unknown
- 2002-01-11 NO NO20020155A patent/NO324352B1/no not_active IP Right Cessation
- 2002-10-04 HK HK02107310.6A patent/HK1045692B/zh not_active IP Right Cessation
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2007
- 2007-04-25 US US11/740,001 patent/US8420679B2/en not_active Expired - Lifetime
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