WO2023213325A1 - Boisson hautement énergétique préparée par combinaison et raffinage synergique d'un composé octacosanol-flavonoïde de très grande pureté et d'eau deutérée, et son procédé de préparation - Google Patents
Boisson hautement énergétique préparée par combinaison et raffinage synergique d'un composé octacosanol-flavonoïde de très grande pureté et d'eau deutérée, et son procédé de préparation Download PDFInfo
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- WO2023213325A1 WO2023213325A1 PCT/CN2023/092553 CN2023092553W WO2023213325A1 WO 2023213325 A1 WO2023213325 A1 WO 2023213325A1 CN 2023092553 W CN2023092553 W CN 2023092553W WO 2023213325 A1 WO2023213325 A1 WO 2023213325A1
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- octacosanol
- purity
- deuterated water
- flavonoids
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/38—Other non-alcoholic beverages
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
- A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Definitions
- the invention relates to the technical field of food processing, and specifically designs a high-energy beverage that is synergistically refined with an ultra-high-purity octacosanol-flavonoid composite deuterated water combination and a preparation method thereof.
- 1.Octacosanol is a natural higher fatty alcohol with good biodegradability and easy to be absorbed by the human body.
- octacosanol has the function of lowering blood lipids.
- Qi Xiaoming and others proposed that the hypolipidemia effect of octacosanol is related to the dosage. Higher dosages of this substance can significantly reduce the TG, TC and LDL-C content in the serum; while low dosages only have an effect on the serum lipid levels.
- TC concentration has an impact.
- Research by DevK.Singh et al. proposed that octacosanol reduces cholesterol content in serum by activating enzyme activity through phosphorylation of AMP-kinase, thereby reducing HMG-CoA enzyme activity and controlling cholesterol synthesis in serum. Purpose;
- Octacosanol can reduce excess calcium and fat content in the blood and is a promoter of calcitonin formation.
- octacosanol is known as a compound that can relieve physical fatigue and has good biological activity. Research shows that this substance can improve the human body's endurance, quickly restore physical strength, and improve related physiological indicators in body fluids after activity;
- octacosanol has a very small dosage but significant physiological activity. It can quickly eliminate fatigue and enhance physical strength and endurance. It is a world-recognized anti-fatigue functional substance. According to reports from Nippon Oils and Fats Co., Ltd., usually 0.2 mg of octacosanol is taken orally per person per day to eliminate fatigue; in order to enhance physical strength and endurance, the daily oral dosage is about 0.5 mg; and for therapeutic purposes The dosage is 5mg;
- bamboo leaf flavonoids are a type of plant flavonoids, and the active ingredients are flavonoid glycosides and coumarin lactones. In addition to flavonoids, its components also include phenolic acids, anthraquinones, aromatic components, and trace elements such as manganese, zinc, and tin. Together, they form the basis for the extensive physiological and pharmacological activities of bamboo leaf flavonoids.
- It has the functions of scavenging oxygen free radicals, resisting aging, preventing Alzheimer's disease, preventing vascular sclerosis, resisting vascular proliferation, resisting myocardial ischemia, lowering blood pressure, lowering blood lipids, and protecting cardiovascular and cerebrovascular diseases. It can be used to prevent and treat cardiovascular and cerebrovascular diseases. If it can reduce The fragility of blood vessels, dilating blood vessels and improving blood vessel permeability, preventing arteriosclerosis, lowering blood lipids and cholesterol, preventing and treating hypertension in the elderly, cerebral hemorrhage, coronary heart disease, angina pectoris, dilating coronary blood vessels, increasing coronary flow, lowering blood sugar, etc. good effect;
- liver protection liver detoxification, treatment of acute and chronic hepatitis, liver cirrhosis, improvement of body immunity, diarrhea, cough relieving, expectoration, asthma, antispasmodic, anti-allergic, anti-allergic and anti-viral, etc. pharmacological effects;
- Oxidative stress has been shown to contribute to chronic fatigue through increased release of pro-inflammatory cytokines such as tumor necrosis factor- ⁇ (TNF- ⁇ ), interleukin-6 (IL-6), and IL-1 ⁇ ;
- TNF- ⁇ tumor necrosis factor- ⁇
- IL-6 interleukin-6
- IL-1 ⁇ pro-inflammatory cytokines
- LN lutein-6-c-neohesperidin luteolin-6-c-neohesperidin
- bamboo leaf flavonoids can prevent or delay the oxidation of food, improve the stability of food and extend the storage period;
- the current main raw materials for extracting octacosanol are sugarcane, bran wax, insecticide, and wheat germ oil, it is insoluble in water and soluble in organic solvents.
- the structure of the existing substance is relatively complex. Therefore, how to extract it from natural substances? Efficient, economical and environmentally friendly extraction is a problem that should be solved in the production of a large amount of high-quality such substances.
- the raw materials are saponified and extracted with organic solvents (n-hexane, acetone, etc.), a A white or light yellow powdery product.
- This powdery crystal is a natural high-grade alkanol mixture (containing higher alkanols with 24-34 carbon atoms).
- the content of octadecane in this mixture is 50-70%. , and the relevant pharmacological experiments in the data were also conducted on extracts with this content.
- the product technology is only that the conventional extraction purity of octacosanol can only reach 40-80%, such as: a sports drink and its manufacturing method - 200510036559.0 (no rights - no annual fee paid) claim 5.
- the sports drink is characterized in that: the purity of the octacosanol used is greater than 80% .
- wheat germ beverage and its preparation method-201010615889.6 no rights-unpaid annual fee
- the described octacosanol is first extracted from wheat germ using a supercritical CO2 extraction method to obtain white flake crystals of octacosanol, in which the octacosanol content is 42.1 to 43.5% ;
- Flavonoids have very different solubility properties due to their different structures and sources. Therefore, appropriate solvents should be selected for extraction based on their polarity and water solubility. With the continuous deepening of research, there are more and more extraction methods for bamboo leaf flavonoids. According to the literature, the common extraction methods of bamboo flavonoids include hot water extraction, organic solvent extraction, microwave extraction, ultrasonic extraction, Supercritical fluid extraction, enzyme extraction, crushing extraction and other methods;
- the extracts obtained by the above-mentioned single methods have good stability in the pH range of 6 to 7. Conditions above 50°C and strong natural light are not conducive to the preservation and use of the extracts;
- a bamboo leaf flavonoid beverage characterized in that it includes the following components by weight: moso bamboo leaf flavonoid extraction with a mass fraction of more than 50% 10 to 20 parts of liquid , 20 to 40 parts of bis-depleted apple juice, 3 to 5 parts of lemon juice concentrate, and 40 to 60 parts of water; the moso bamboo leaf flavonoid extract also contains moso bamboo leaf polysaccharide with a mass fraction of 5% to 7% ;
- the present invention studies a high-energy beverage made by synergistically refining ultra-high-purity octacosanol-flavonoid compound deuterated water combination and its preparation method, which has strong application value.
- bamboo leaf flavonoids or octacosanol alone in beverage processing technology.
- the excellent properties of bamboo leaf flavonoids or octacosanol themselves are self-evident, and their combined use
- An ultra-high-purity octacosanol-flavonoid composite deuterated water combination synergistically refined high-energy drink and its preparation method including the following components: 0.05 to 0.1 parts of octacosanol, 0.12 to 0.2 parts of flavonoids, and deuterated water. 900 to 1000 parts of water, 0.1 to 0.3 parts of stabilizer, 0.3 parts of compound emulsifier, 15 to 25 parts of water-soluble dietary fiber, 1.97 parts of compound electrolytes, 0.03 to 0.6 parts of preservatives, and 0.05 to 0.2 parts of sour agent;
- the octacosanol is octacosanol with a purity of ⁇ 98% extracted from fresh sugarcane filter mud;
- the flavonoids are bamboo leaf flavonoids with a purity of ⁇ 95%;
- the detritiated water has a deuterium content of 50 to 100 ppm.
- the compound emulsifier is two or more of Tween 60, Tween 80, molecularly distilled monoglyceride, sucrose fatty acid ester, glyceryl monostearate, Span 60, and Span 80. A mixture of more than one species.
- the stabilizer is one or a mixture of two or more of gum arabic, fish gelatin, xanthan gum, pectin, sodium carboxymethyl cellulose, cyclodextrin and konjac gum.
- the compound electrolyte is a mixture of 0.65 parts of sodium citrate + 0.6 parts of calcium lactate + 0.37 parts of potassium chloride + 0.35 parts of magnesium lactate.
- the water-soluble dietary fiber is one or two of modified polydextrose, partially hydrolyzed guar gum (PHGG), wheat starch resistant dextrin, corn starch resistant dextrin, and fructooligosaccharides. mixture.
- modified polydextrose partially hydrolyzed guar gum (PHGG)
- PHGG partially hydrolyzed guar gum
- wheat starch resistant dextrin wheat starch resistant dextrin
- corn starch resistant dextrin corn starch resistant dextrin
- fructooligosaccharides mixture.
- the sour agent is one or a mixture of two of citric acid, malic acid, lactic acid and bird's nest acid.
- the preservative is one or a mixture of two of hydroxybenzoates, potassium sorbate, and nisin.
- the high-energy beverage made by synergistically refining the combination of ultra-high purity octacosanol-flavonoid composite deuterated water and its preparation method includes the following steps:
- the ultra-high-purity octacosanol-flavonoid compound deuterated water combination is a high-energy beverage that is synergistically refined. According to actual needs, by adjusting the changes in components, it is suitable for use in health care, beauty, weight loss, New generation sports drinks, astronauts, divers and military military high-energy drinks and other fields.
- the high-energy drink made by synergistically refining the ultra-high-purity octacosanol-flavonoid complex deuterated water combination:
- magic water also called high-energy drink
- the original sports drink was a drink made by adding corresponding ingredients to the drink to replenish the water, sugar, salt, protein and vitamins that the human body loses during high-intensity exercise. Obviously, this is a passive supplement formulation concept;
- the present invention uses ultra-high purity octacosanol-flavonoid compound deuterated water combination to supplement some special nutrients and coordinate with refined high-energy drinks to regulate these organs in a state of extreme fatigue in a targeted manner:
- the present invention adopts the company’s [a supercritical-microwave-assisted ultrafine homogenate negative pressure cavitation high pressure combination one-step preparation method to strengthen the extraction of total flavonoids from bamboo leaves (Patent application number: 202210302314.1)] and the purity is ⁇ 95 % of bamboo leaf flavonoids, the analysis results of the main nutrients show that it contains flavonoids, active polysaccharides, phenolic acid compounds, anthraquinone compounds, manganese, zinc, selenium and other trace elements.
- Flavonoids have obvious physiological activities such as anti-ulcer, antispasmodic, antibacterial, anti-inflammatory, hypolipidemic, and analgesic effects; active polysaccharides are sugar chains bonded by glycosylated bonds, which are beneficial to the human body's esophagus, bladder, kidneys, lungs, It has curative effects on liver and uterine cancer, and can promote wound healing, lower blood pressure, detoxify, and relieve fatigue.
- the main mechanism is to enhance the body's liquid immunity and increase the activity of white blood cells and phagocytes; phenolic acid compounds can sterilize and make the body smell fragrant. It can refresh the brain, whiten the skin, clear away heat, relieve fire, nourish yin and nourish the skin. It can refresh the mind and reduce fatigue.
- Anthraquinone compounds have hemostatic, antibacterial, purgative and diuretic effects. Trace elements are one of the six indispensable nutrients for the human body. It has various health-care effects such as clearing fire and improving eyesight, moistening the lungs and relieving cough, laxative and detoxification, soothing alcohol and soothing the nerves, promoting cell metabolism, improving blood circulation, and enhancing human immunity. It can also treat bronchitis, hypertension, hyperlipidemia, diabetes, etc. Diseases are cured well;
- the dosage group of bamboo leaf flavonoids with a purity of 50% in the conventional market and the dosage group of bamboo leaf flavonoids with a purity of ⁇ 95% are used in the present invention.
- the bamboo leaf flavonoids are melted with 1% gum arabic to prepare a corresponding dosage suspension, which is administered orally every day. once. Observe 5d. They were randomly divided into 2 groups according to body weight and weighed once a week. After 2 weeks, blood was collected from the eyeballs of rats without fasting to measure serum HDL-C;
- the present invention uses the method described in our company’s [A preparation method for extracting octacosanol using an ultrasonic-microwave-assisted composite solvent secondary recrystallization and distillation synergistic refining combination (patent application number: 202210303916.9)] from fresh sugarcane filter mud.
- Octacosanol with a purity of ⁇ 98% is extracted from it. It is a functional substance with anti-fatigue physiological activity. It has various physiological effects such as anti-fatigue, enhancing endurance and physical strength, improving myocardial function, and lowering blood lipids. It is a A very good natural health functional factor:
- 3It can increase blood sugar and serum testosterone levels in bodies due to exercise fatigue and prevent myocardial damage
- Reduces excess calcium and fat content in blood is a promoter of calcitonin formation, and can be used to prevent and treat hypercalcemia, osteoporosis, high cholesterol and high lipoprotein blood type diseases;
- rats were randomly divided into 3 groups: the tail suspension group (hereinafter referred to as group A), the tail suspension plus octacosanol with a purity of 80% in the conventional market (hereinafter referred to as group B), and the tail suspension plus the octacosanol used in the present invention.
- group A the tail suspension group
- group B the tail suspension plus octacosanol with a purity of 80% in the conventional market
- group B the tail suspension plus the octacosanol used in the present invention.
- the octacosanol group with a purity of ⁇ 98% (hereinafter referred to as group C); 8 rats in each group, the supply amount is 25 mg/kg body weight per rat per day, the experimental period is 14 days; on the end of the experiment, the rats are fasted for 12 hours Afterwards, blood and tissue samples were collected; heart blood was collected by cardiac puncture, trunk blood was collected after decapitation, the thymus and spleen were removed and weighed, and the left hind limb femur was separated and removed; the weight of immune organs and the fluidity of red blood cell membranes were observed. and biomechanical properties of femur, etc.:
- the weight of the thymus and spleen of rats in group B was significantly lower than that of rats in group A, but the weight of the thymus of rats in group C was 0.37g, which was significantly higher than that of rats in group B, 0.24g;
- the thymus and spleen are important immune organs of the body, which suggests that the purity used in the present invention is ⁇ 98%.
- the octacosanol has a certain protective effect on the decline of immune function caused by suspension simulated weightlessness;
- the fluidity of the red blood cell membrane is usually expressed by the P value of the fluorescence polarization degree of the red blood cell membrane.
- the larger the P value the smaller the hydrocarbon chain activity, the smaller the membrane fluidity, and the greater the blood microviscosity; conversely, the greater the membrane fluidity.
- the larger the blood the smaller the microviscosity of the blood.
- the average P values of the red blood cell membranes of rats in groups B and C were 0.28 and 0.32 respectively, which were significantly higher than 0.26 in rats in group A.
- the viscosity of the blood of rats in group C was greater than that in group B. There is a downward trend compared with rats;
- Table 2 shows the biomechanical measurement values of the femur obtained through the three-point bending test. After 14 days of tail hanging, the maximum load and elastic limit load of the femur of rats in group C were significantly higher than those in groups A and B. The results show that the octacosanol used in the present invention with a purity of ⁇ 98% can significantly resist the decline in the biomechanical properties of the femur of suspended rats;
- Table 3 shows the biomechanical performance data of the femur calculated from the biomechanical and geometric parameters of the femur. The results show that the octacosanol group with a purity of ⁇ 98% used in the present invention can significantly improve the biomechanics of the suspended rat femur. performance;
- the experiments show that the octacosanol used in the present invention with a purity of ⁇ 98% has the following functions on tail-suspended rats: 1 significantly increase the weight of the thymus; 2 improve the fluidity of the red blood cell membrane of simulated weightless rats; 3 significantly improve Femoral biomechanical properties; the octacosanol used in the present invention with a purity of ⁇ 98% can effectively combat certain adverse effects of tail-suspended rats; during the entire experimental process, no side effects of octacosanol were observed; It shows that a series of physiological and biochemical changes that occur in the body of astronauts under the condition of weightlessness can be used to improve exercise endurance by taking health drinks or foods added with octacosanol with a purity of ⁇ 98% used in the present invention. , reduce blood lipids, improve blood viscosity, improve hypoxic endurance and prevent osteoporosis, and may become a health drink or food ingredient for astronauts.
- the deuterated water used in the present invention has a deuterium content of 25 to 100 ppm, and is used in disease prevention and drinking water.
- the deuterium content is 1/7000 of hydrogen.
- the deuterium content in natural water is generally 145-150ppm
- the deuterium content in seawater is 155ppm
- the deuterium content in glacier water is about 138-140ppm.
- deuterated water is water that uses modern technology to reduce deuterium to 10-130ppm;
- Deuterium has an accumulative effect in the body and is difficult to metabolize on its own. It can cause many adverse effects on the human body's DNA, heredity, metabolism and enzyme system;
- deuterated water can be adapted to be used as an auxiliary product for other tumors such as prostate cancer, breast cancer, lung cancer, and pancreatic cancer;
- deuterated water may provide new prevention strategies for depression
- drinking deuterated water is also an option that can help achieve results.
- deuterated water to make non-alcoholic beverages, such as drinking water, mineralized water, magnetized water, soft drinks and functional drinks, can improve human health and quality of life.
- non-alcoholic beverages such as drinking water, mineralized water, magnetized water, soft drinks and functional drinks.
- deuterated water products At present, the United States, Russia, Hungary, Ukraine, Japan, Germany, France, etc. have deuterated water products on the market. Low-deuterium water has been used in various metabolic diseases and cancers;
- Deuterated water is not only used in scientific research. Deuterated water can activate immune cells, improve the body's basal metabolic level, resist cell mutation and delay Functions such as aging are more beneficial to the survival, development and reproduction of living organisms, and are of great significance to human health.
- This invention uses water-soluble dietary fiber, an alternative and innovative solution for reducing sugar and replacing sugar.
- This invention uses water-soluble dietary fiber technology to replace sugar.
- the water-soluble dietary fiber used in the present invention is not only a high-quality water-soluble dietary fiber, but also a unique low-calorie filler; sugar is replaced with dietary fiber to reduce carbohydrate content and calories, and the plant-based one-to-one applied Sugar substitute; not only is it a good source of natural fiber, but it does not use any masking agents and has no aftertaste, giving it the same flavor as regular sugar;
- Water absorption and expansion can increase the volume of feces, promote intestinal peristalsis, and have a good preventive effect on constipation, hemorrhoids, colon cancer and other diseases;
- Resistant dextrin is recognized by the US FDA as a GRAS substance and has no intake limit.
- resistant dextrin is widely used as a nutritional fortifier and has been recognized as a government-specified health food material by the Japanese Ministry of Health, Labor and Welfare.
- the Ministry of Health [2012] Letter No. 516 plans to announce that resistant dextrin is a common food and can be added to various foods in unlimited amounts;
- modified polydextrose is considered an important source of dietary fiber. Research shows that when young women drink a bottle of beverage containing 7-10g of modified polydextrose every day for 5 consecutive days, their feces will become significantly softer and constipation will be effectively relieved;
- modified polydextrose is regarded as an important water-soluble dietary fiber
- Fructooligosaccharides are fermented by bacteria in the large intestine to generate L-lactic acid, which can dissolve calcium, magnesium, iron and other minerals and promote the body's absorption of minerals. It inhibits the growth of harmful bacteria and regulates the balance in the intestine; it can promote the absorption and utilization of trace elements iron and calcium to prevent osteoporosis; it can reduce liver toxins and generate anti-cancer organic acids in the intestine, which has significant anti-cancer effects.
- fructooligosaccharide promotes calcium absorption by 70.8%. Therefore, fructooligosaccharides can promote growth and development and prevent osteoporosis; at the same time, it can also promote the natural formation of vitamins B1, B2, B3, B6, B12 and folic acid, thereby improving the body's metabolism, immunity and disease resistance. Prevent and improve skin diseases caused by toxins in the body, prevent facial sores, dark spots, freckles, acne, and age spots, make the skin bright and slow down aging.
- Bifidobacterium absorbs fructooligosaccharides, it rapidly proliferates, inhibits the action of spoilage bacteria such as Escherichia coli, Salmonella and Clostridium, reduces the production of toxic metabolites (such as indole, nitrosamine), and rapidly metabolizes the toxicity oligosaccharides are excreted from the body, reduce the burden on the liver, protect the liver, and prevent various chronic diseases, cancers, etc.; fructo-oligosaccharides are rarely decomposed by gastric acid and enzymes in the digestive tract, and are extremely difficult to be absorbed by the human body;
- the caloric value of fructo-oligosaccharide is less than 1.5Kcal/g, while the caloric value of sucrose is 4.6Kcal/g. Therefore, after ingesting fructo-oligosaccharide, it will not cause obesity and is an ideal low-calorie functional sweetener. .
- Fructooligosaccharides cannot be used by Streptococcus mutans to generate insoluble glucan and provide a place for oral microbial deposition, acid production and corrosion (tartar), thus preventing dental caries.
- the present invention has discovered and verified through experimental research: The influence of various factors on the stability of a high-energy beverage collaboratively refined with an ultra-high-purity octacosanol-flavonoid compound deuterium-free water combination:
- emulsifier type and dosage plays an important role in the formation of a stable emulsion system; a suitable emulsifier can significantly reduce the surface tension between the two phases, change the interface state of the system, and help stabilize the uniform dispersion of droplets. ;
- the oil-soluble emulsifier Span 80 was selected as an example to conduct experiments to examine the stabilizing effect of its dosage on beverages;
- Tween 80 was selected as an example to conduct experiments to examine the stabilizing effect of its dosage on beverages;
- This experiment selected three commonly used hydrophilic colloids: xanthan gum, sodium carboxymethyl cellulose (CMC), and gum arabic as stabilizers to conduct a single-factor test on body stability. Under the same conditions, the beverage was observed to change from static to static. When a large amount of precipitation occurs, the type of stabilizer required for the final test will be determined based on the stabilizing effect;
- xanthan gum sodium carboxymethyl cellulose (CMC), and gum arabic have better effects when used alone in beverages.
- CMC carboxymethyl cellulose
- xanthan gum has the best effect, which is in line with its own growth rate. Characteristics of the strongest thickening effect;
- Xanthan gum serves as a thickener, emulsifier, and stabilizer. Due to its pseudoplasticity, xanthan gum can increase the richness of the drink and stabilize the suspension of each component. It is thickened but not sticky, and has good fragrance release; As an emulsification aid in beverages, gum arabic has good water solubility and emulsification as a food adhesive. During the embedding process, it can increase the efficiency of the embedding, enhance the taste, prevent precipitation and maintain the flavor of the capsule; carboxyl Sodium methylcellulose (CMC) has multiple functions such as thickening, suspension, emulsification, and stabilization. It has good water retention, dispersion, and thixotropy, and can control the size and growth of ice crystals during transportation and storage. Used as a protective agent for beverages; therefore, the combination of the above three can prevent beverages from agglomerating;
- 1.8x104r/min is selected as the optimal emulsification speed; the emulsification time is too short, the emulsification process is not sufficient, and the floating phenomenon of the drink is serious; when the emulsification process is basically completed, extending the stirring time will have minimal improvement in stability. , has little value in actual production, so the emulsification time is 25 minutes;
- Homogenization is a common physical method to prevent precipitation and stratification of beverages.
- the choice of homogenization temperature and pressure directly affects the homogenization effect.
- the pressure is 30-35Mpa and the temperature is 60-70°C to homogenize the beverage.
- the test shows that when the pressure is 30-35Mpa and the temperature is 60-70°C, there is no stratification of the product when homogenized twice. , floating and settling phenomena. It can also be seen from the experiment that the greater the pressure, the higher the temperature, the more times of homogenization, and the finer the particles, but the temperature and pressure are too high. Too many times of homogenization will consume too much production cost.
- the pressure is 30-35Mpa
- the temperature is 60-70°C
- the homogenization is performed twice.
- the first homogenization is 3 to 4 minutes with an interval of 25 minutes;
- the second homogenization is 1 to 2 minutes.
- the diameter is 3 ⁇ m. ⁇ 5 ⁇ m oil-in-water droplets. It can produce drinks with good quality, good texture and stable structure;
- high shear emulsification time > water-soluble emulsifier dosage > oil-soluble emulsifier dosage > stabilizer dosage;
- UHT 105-121°C, 6-10 seconds
- the purity of flavonoids and octacosanol must reach at least 90% to achieve the effects of effectively lowering lipids and preventing cardiovascular and other diseases.
- the purity used in the present invention is ⁇ 95% bamboo leaf flavonoids and octacosanol with a purity of ⁇ 98% can be used in beverages not only for anti-fatigue and improving human body function, but also for further development in fields such as disease prevention;
- the present invention proposes a synergistic combination of ultra-high-purity octacosanol-flavonoid complex deuterium-free water, which can be reasonably and effectively strengthened and improved by cross-comparison and integration based on the characteristics of each extract. It regulates complementary and synergistic effects, which is beneficial to absorption and circulation in the body; it introduces ultra-high purity extracts into beverages, changing the concept of passive supplementation and creating the concept of actively conditioning beverages.
- the present invention solves the problem of poor water solubility of octacosanol and flavonoids. It will not cause any flavor and sensory problems in the beverage and has good uniformity;
- the materials selected are made from halal certified raw materials, without religious distinction; sugar-free, pigment-free, green, pure and healthy, which also provides quality and safety guarantee for halal high-energy drinks;
- Figure 1 shows the purity test report of bamboo leaf flavonoids extracted from this product.
- Figure 2 shows the results of the purity test report of bamboo leaf flavonoids extracted from this product.
- Figure 3 is the purity test report of octacosanol extracted from fresh sugarcane filter mud by this product.
- Figure 4 shows the purity test report results of this product extracting octacosanol from fresh sugarcane filter mud.
- An ultra-high-purity octacosanol-flavonoid composite deuterated water combination synergistically refined high-energy drink and its preparation method including the following components: 0.05 to 0.1 parts of octacosanol, 0.12 to 0.2 parts of flavonoids, and deuterated water. 900 to 1000 parts of water, 0.1 to 0.3 parts of stabilizer, 0.3 parts of compound emulsifier, 15 to 25 parts of water-soluble dietary fiber, 1.97 parts of compound electrolytes, 0.03 to 0.6 parts of preservatives, and 0.05 to 0.2 parts of sour agent;
- the octacosanol is octacosanol with a purity of ⁇ 98% extracted from fresh sugarcane filter mud;
- the flavonoids are bamboo leaf flavonoids with a purity of ⁇ 95%;
- the deuterated water has a deuterium content of 25 to 100 ppm.
- Its preparation method includes the following steps:
- An ultra-high-purity octacosanol-flavonoid composite deuterated water combination synergistically refined high-energy drink and its preparation method including the following components: 0.05 to 0.1 parts of octacosanol, 0.12 to 0.2 parts of flavonoids, and deuterated water. 900 to 1000 parts of water, 0.1 to 0.3 parts of stabilizer, 0.3 parts of compound emulsifier, 15 to 25 parts of water-soluble dietary fiber, 1.97 parts of compound electrolytes, 0.03 to 0.6 parts of preservatives, and 0.05 to 0.2 parts of sour agent;
- the octacosanol is octacosanol with a purity of ⁇ 98% extracted from fresh sugarcane filter mud;
- the flavonoids are bamboo leaf flavonoids with a purity of ⁇ 95%;
- the deuterated water has a deuterium content of 25 to 100 ppm.
- Its preparation method includes the following steps:
- An ultra-high-purity octacosanol-flavonoid composite deuterated water combination synergistically refined high-energy drink and its preparation method including the following components: 0.05 to 0.1 parts of octacosanol, 0.12 to 0.2 parts of flavonoids, and deuterated water. 900 to 1000 parts of water, 0.1 to 0.3 parts of stabilizer, 0.3 parts of compound emulsifier, 15 to 25 parts of water-soluble dietary fiber, 1.97 parts of compound electrolytes, 0.03 to 0.6 parts of preservatives, and 0.05 to 0.2 parts of sour agent;
- the octacosanol is octacosanol with a purity of ⁇ 98% extracted from fresh sugarcane filter mud;
- the flavonoids are bamboo leaf flavonoids with a purity of ⁇ 95%;
- the deuterated water has a deuterium content of 25 to 100 ppm.
- Its preparation method includes the following steps:
- An ultra-high-purity octacosanol-flavonoid composite deuterated water combination synergistically refined high-energy drink and its preparation method including the following components: 0.05 to 0.1 parts of octacosanol, 0.12 to 0.2 parts of flavonoids, and deuterated water. 900 to 1000 parts of water, 0.1 to 0.3 parts of stabilizer, 0.3 parts of compound emulsifier, 15 to 25 parts of water-soluble dietary fiber, 1.97 parts of compound electrolytes, 0.03 to 0.6 parts of preservatives, and 0.05 to 0.2 parts of sour agent;
- the octacosanol is octacosanol with a purity of ⁇ 98% extracted from fresh sugarcane filter mud;
- the flavonoids are bamboo leaf flavonoids with a purity of ⁇ 20%;
- the deuterated water has a deuterium content of 25 to 100 ppm.
- Its preparation method includes the following steps:
- An ultra-high-purity octacosanol-flavonoid composite deuterated water combination synergistically refined high-energy drink and its preparation method including the following components: 0.05 to 0.1 parts of octacosanol, 0.12 to 0.2 parts of flavonoids, and deuterated water. 900 to 1000 parts of water, 0.1 to 0.3 parts of stabilizer, 0.3 parts of compound emulsifier, 15 to 25 parts of water-soluble dietary fiber, 1.97 parts of compound electrolytes, 0.03 to 0.6 parts of preservatives, and 0.05 to 0.2 parts of sour agent;
- the octacosanol is octacosanol with a purity of ⁇ 80% extracted from fresh sugar cane filter mud;
- the flavonoids are bamboo leaf flavonoids with a purity of ⁇ 95%;
- the deuterated water has a deuterium content of 25 to 100 ppm.
- Its preparation method includes the following steps:
- Example 1 In order to observe the effect of high-energy drinks on the concentration of serum high-density lipoprotein cholesterol in rats, a comparative experiment was carried out between Example 1 and Control Example 1-1, and the serum high-density lipoprotein cholesterol (HDL-C) level index of rats was measured. , giving specific data reference for the effect of high-energy drinks on increasing density lipoprotein cholesterol (HDL-C):
- Rats were selected, provided with basic feed, and had free access to water and food; the room temperature in the breeding room was 23 ⁇ 5°C, the relative humidity was 40% to 70%, and the lighting changed naturally. After the animals were observed and adapted for 5 days, 80 animals were selected for experiments and randomly divided into 4 groups. Three of the groups were fed mixed high-fat animal model feed: 20% sucrose, 15% lard, 1.2% cholesterol, 0.2% sodium cholate, 6.6% casein, 0.5% calcium hydrogen phosphate, 0.3% stone powder, and the drinking water of two of the three groups of mice was replaced with the high-energy drink prepared in Example 1 and Comparative Example 1-1. of high-energy drinks. Weigh once a week, record food intake and calculate food utilization. The trial lasts for 30 days.
- the bamboo leaf flavonoids used in the present invention have a purity of ⁇ 95%, the serum HDL-C concentration of the test rats can be significantly increased.
- the bamboo leaf flavonoids with a purity of 20% are used, the serum HDL-C concentration is not significantly increased ( Table 10).
- Example 1 In order to observe the effects of different purity extracts of high-energy drinks on improving the swimming time and anti-fatigue effects of mice, a comparative experiment was carried out between Example 1 and Control Examples 1-2. 30 rats were taken and randomly divided into Example 1 Prepare beverages (hereinafter referred to as beverage group A), prepare beverages in Comparative Examples 1-2 (hereinafter referred to as beverage group B), deionized water blank control group (hereinafter referred to as group C), 10 mice in each group, and administer intragastric administration to mice , 10ml each, the dosage is equivalent to 3g/kg, administered continuously for 15 days and 30min after the last dose:
- mice were placed on the upper end of a vertically suspended smooth glass rod, so that their muscles were in a state of static tension. The mice were recorded from climbing the rod until their muscles were fatigued and unable to hold the glass rod and fell to the ground. Time, repeat 3 times, terminate the test after the third fall, and the cumulative time of 3 times is used as the pole climbing time (s);
- mice Each group continued to be administered intragastrically for 5 days. 30 minutes after the last administration, 8% of the body weight was weighted with a lead wire at the base of its tail. The mice were placed in a swimming box at room temperature, and the time from the beginning of swimming to the death of the mice was recorded. swimming time (min);
- Deionized water blank control group experiment Mice were given deionized water by gavage, 10 ml each, at a dose equivalent to 3g/kg, for 5 consecutive days, and then performed weight-bearing swimming 30 minutes after the last administration, in room temperature water. Put 8% of the body weight on the tail with a lead skin, swim until exhaustion, sink into the water and stay up for 10 seconds, record the time;
- mice in each group were administered intragastrically for 5 days. 30 minutes after the last administration, they were put into normal temperature water for 60 minutes and then taken out. Blood was taken from the supraorbital venous plexus and serum urea nitrogen was measured using a kit method. Then the animals were killed immediately, the liver was removed, rinsed with 0.9% NaCl solution, dried with filter paper, and the liver glycogen content was measured by the anthrone method;
- mice After mice were gavaged for 15 days and swam under weight, the blood lactate in group A was significantly lower than that in group B, indicating that this effect may be related to the purity of the test substance;
- liver glycogen content of group A was significantly higher than that of group B, indicating that the octacosanol used in the present invention with a purity of ⁇ 98% can improve the glycogen accumulation capacity in animals;
- the serum urea nitrogen level was measured after swimming in mice administered intragastric administration for 20 days.
- the level of serum urea nitrogen in group A was significantly lower than that in group B.
- the difference was extremely significant, indicating that the octacosanol used in the present invention with a purity of ⁇ 98% can significantly reduce the serum urea nitrogen level.
- Urea nitrogen improves the body's endurance and adaptability to exercise load;
- beverage group A uses octacosanol with a purity of ⁇ 98%, it has a significant anti-fatigue effect, indicating that the high-energy beverage of the present invention has an anti-fatigue health care effect;
- beverage group B uses It is low-purity octacosanol, and its anti-fatigue effect is significantly lower than that of beverage group A.
- a method for preparing bamboo leaf flavonoid extract through column purification 200910223926.6 shows that the purity of bamboo leaf flavonoids is 20.78%;
- a production method for extracting bamboo leaf flavonoids from bamboo leaves 200610053134.5 shows that the purity of bamboo leaf flavonoids is ⁇ 24%;
- a method for separating and purifying flavonoids and lactones from bamboo leaves based on microwave-assisted technology CN201510481490 shows that the purity of bamboo leaf flavonoids is ⁇ 29%;
- a preparation method of bamboo leaf flavonoids extract 200910223927.0 shows that the purity of bamboo leaf flavonoids is 42%;
- a method for extracting flavonoids from bamboo leaves 201110003352.9 shows that the purity of bamboo leaf flavonoids is 30 ⁇ 50%;
- a method for extracting bamboo leaf flavonoids 201110406495.4 shows that the purity of bamboo leaf flavonoids is 30 ⁇ 50%;
- the production process for extracting bamboo leaf flavonoid series products from bamboo leaves 200610053436.2 shows that the purity of bamboo leaf flavonoids is 60%;
- bamboo leaf flavonoids extract 200810195064.6 shows that the purity of bamboo leaf flavonoids is 40%-65%;
- Zhu Hongli et al. extracted the crude bamboo leaf extract with chloroform, and then passed the chloroform layer sample through X-5 macroporous resin. After elution with a high-concentration alcohol solution, the primary purified sample was passed through a polyamide column. The total flavonoid content in the purified sample can reach 78.97%;
- the article shows that the flavonoid content of the obtained bamboo leaves reaches more than 40%
- the bamboo leaf flavonoids described in Reference Document 2 are only a conceptual summary, and are actually just a crude extract with low extraction rate and many impurities (such as phenols, Saponics, whiplash, alkaloids, polysaccharides, protein, crude fat, chlorophyll, anthraquinone compounds, mushroom lactosides, inorganic salts, moisture, minerals, ash, heavy metals, arsenic and manganese, zinc , selenium and other trace elements, more than 20 mineral elements, 82 aromatic compounds, 16 amino acids, 53 volatile components, 10 alcohols, 17 aldehydes, etc.), the so-called bamboo leaf flavonoids are only the components of these substances Some of the contents are, at best, just a trade name.
- Zhang Xiangnian et al. melted the insect wax, poured it into ether, and used the reduction method to catalyze it with LiAIH4. After reduction at 70-80°C for 2.5 hours, a high-carbon fatty alcohol mixture was obtained. After purification by molecular distillation, a mixture containing 16.7% octacosanol was obtained. Small quantity of product.
- Wang Xingguo et al. used crude bran wax as raw material, refined it, and used ultrasonic hydrolysis of rice bran wax, extraction of fatty alcohols, and molecular distillation technology to separate octacosanol and triacontanol to prepare products with a purity greater than 80%.
- Xiamen University Chemical Plant uses Sichuan and other beeswax as raw materials, and uses the residue from the production of triacontanol to extract octacosanol.
- the purity is 12.8% and 18%.
- Xiamen University also uses insecticide wax as raw material to produce octacosanol.
- the outstanding disadvantage is that the cost is high, and the content of octacosanol has not made a big breakthrough.
- Wheat germ beverage and its preparation method - 201010615889.6 The octacosanol described in claim 4 is first extracted from the wheat germ using a supercritical CO2 extraction method to obtain white flake crystals of octacosanol, of which 28 Alkanol content is 42.1 ⁇ 43.5%;
- the 24-34 carbon higher alkanols contained in Cuban Policosanol account for more than 90% of the weight of the extract, of which the octacosanol content is 60%-70%.
- octacosanol In Japan, most octacosanol is extracted from rice bran oil and rice germ oil. The content of octacosanol is generally 10% ⁇ 15%, which is a mixture of C22 ⁇ C36 fatty alcohols. Most of the octacosanol produced by octacosanol is made from rice bran oil and rice germ oil. The octacosanol content in octacosanol products is usually 12%.
- octacosanol purified by most international and domestic manufacturers is generally about 12%, which is a mixture of C22 ⁇ C36 fatty alcohols. Even Japanese octacosanol products only contain about 15%.
- the early products of octacosanol were mainly wheat germ oil concentrates; currently, except for Japan’s progress in using rice bran to produce octacosanol, there is no large-scale production technology of octacosanol from rice bran abroad. No advantage.
- the current main raw materials for extracting octacosanol are rice bran wax, wormwood, wheat germ oil, and sugar cane wax, because it is insoluble in water and soluble in organic solvents, and the structure of the existing substance is relatively complex, currently such substances are If the raw material is saponified and extracted with an organic solvent (n-hexane, acetone, etc.), a white or light yellow powdery body will be obtained.
- This powdery crystal is a natural high-grade alkanol mixture (containing 24-34 carbon atoms). Higher alkanols), the current product technology only contains less than 50% octadecane.
- the conventional extraction purity of octacosanol can only reach 15-35%.
- the bamboo leaf flavonoids described in Reference Document 2 are only a conceptual summary, and are actually just a crude extract with low extraction rate and many impurities (such as phenols, Saponics, whiplash, alkaloids, polysaccharides, protein, crude fat, chlorophyll, anthraquinone compounds, mushroom lactosides, inorganic salts, moisture, minerals, ash, heavy metals, arsenic and manganese, zinc , selenium and other trace elements, more than 20 mineral elements, 82 aromatic compounds, 16 amino acids, 53 volatile components, 10 alcohols, 17 aldehydes, etc.), the so-called bamboo leaf flavonoids are only the components of these substances Some of the contents are, at best, just a trade name.
- bamboo leaf flavonoids and octacosanol of different purity have different effects in different fields. Because the higher the purity of bamboo leaf flavonoids and octacosanol, the stronger their activity and greater polarity. If you want to effectively lower lipids, prevent cardiovascular and other diseases, improve hypoxic endurance and prevent osteoporosis, For performance and other effects, the purity must reach at least 90%. Therefore, purity determines the physiological activity of a drug;
- the octacosanol used in the present invention is extracted from fresh sugar cane filter mud with a purity of ⁇ 98%; the flavonoids used are bamboo leaf flavonoids with a purity of ⁇ 95%. According to the characteristics of each extract, crossover and integration are carried out, and ultra-high purity extracts are introduced into beverages, which changes the concept of passive supplementation and creates the concept of actively conditioning beverages, which reasonably and effectively greatly strengthens and improves the complementary and synergistic effects of beverages on body regulation.
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Abstract
La présente invention concerne une boisson hautement énergétique préparée par combinaison et raffinage synergique d'un composé octacosanol-flavonoïde de très grande pureté et d'eau deutérée, et son procédé de préparation, comprenant les composants suivants : l'octacosanol, les flavonoïdes, l'eau deutérée, un stabilisant, un émulsifiant composé, une fibre alimentaire soluble dans l'eau, des électrolytes composés, un conservateur et un acidulant; l'octacosanol est un octacosanol avec une pureté ≥ 98 % extrait de la boue de filtre de canne à sucre fraîche, les flavonoïdes sont des flavonoïdes de feuille de bambou ayant une pureté ≥ 95 %, et la teneur en deutérium de l'eau deutérée est de 25 à 100 ppm.
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CN202210486849.9A CN114916631A (zh) | 2022-05-06 | 2022-05-06 | 一种超高纯度二十八烷醇-黄酮复合去氘水组合协同精制的高能饮料及其制备方法 |
CN202210486849.9 | 2022-05-06 |
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CN114916631A (zh) * | 2022-05-06 | 2022-08-19 | 广州绿徽新材料研究院有限公司 | 一种超高纯度二十八烷醇-黄酮复合去氘水组合协同精制的高能饮料及其制备方法 |
CN117981830A (zh) * | 2024-02-02 | 2024-05-07 | 广州绿徽新材料研究院有限公司 | 一种多组合协同精制的饮料 |
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CN101797344A (zh) * | 2010-04-16 | 2010-08-11 | 南京中医药大学 | 一种淡竹叶精制总黄酮的制备方法 |
CN105237339A (zh) * | 2015-09-11 | 2016-01-13 | 广西大新县雷平永鑫糖业有限公司 | 以糖厂混合汁浮渣为原料提取二十八烷醇的方法 |
CN109077203A (zh) * | 2018-08-18 | 2018-12-25 | 安徽国科生物科技有限公司 | 一种低氘水富微功能饮料及其制备方法 |
CN110313525A (zh) * | 2018-03-28 | 2019-10-11 | 北京海生泰合医药科技有限公司 | 一种酸性乳清蛋白饮料的生产工艺 |
CN114916631A (zh) * | 2022-05-06 | 2022-08-19 | 广州绿徽新材料研究院有限公司 | 一种超高纯度二十八烷醇-黄酮复合去氘水组合协同精制的高能饮料及其制备方法 |
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CN109090394A (zh) * | 2018-08-13 | 2018-12-28 | 安徽国科生物科技有限公司 | 一种预防和治疗四高的低氘水饮料的制备方法 |
CN109965167B (zh) * | 2019-04-15 | 2022-02-15 | 江南大学 | 一种二十八烷醇运动饮料及其制备方法 |
CN112316124A (zh) * | 2020-12-04 | 2021-02-05 | 浙江蓝美生物技术有限公司 | 一种可保护与改善心脏健康的蓝莓粉复方固体制剂及其制备方法和应用 |
CN112868956A (zh) * | 2021-01-27 | 2021-06-01 | 中央民族大学 | 一种多功能运动饮料及其制备方法 |
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Patent Citations (5)
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CN101797344A (zh) * | 2010-04-16 | 2010-08-11 | 南京中医药大学 | 一种淡竹叶精制总黄酮的制备方法 |
CN105237339A (zh) * | 2015-09-11 | 2016-01-13 | 广西大新县雷平永鑫糖业有限公司 | 以糖厂混合汁浮渣为原料提取二十八烷醇的方法 |
CN110313525A (zh) * | 2018-03-28 | 2019-10-11 | 北京海生泰合医药科技有限公司 | 一种酸性乳清蛋白饮料的生产工艺 |
CN109077203A (zh) * | 2018-08-18 | 2018-12-25 | 安徽国科生物科技有限公司 | 一种低氘水富微功能饮料及其制备方法 |
CN114916631A (zh) * | 2022-05-06 | 2022-08-19 | 广州绿徽新材料研究院有限公司 | 一种超高纯度二十八烷醇-黄酮复合去氘水组合协同精制的高能饮料及其制备方法 |
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