WO2020016785A1 - Electrodos de placas - Google Patents
Electrodos de placas Download PDFInfo
- Publication number
- WO2020016785A1 WO2020016785A1 PCT/IB2019/056079 IB2019056079W WO2020016785A1 WO 2020016785 A1 WO2020016785 A1 WO 2020016785A1 IB 2019056079 W IB2019056079 W IB 2019056079W WO 2020016785 A1 WO2020016785 A1 WO 2020016785A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- conductive plate
- tissue
- electrode
- conductive
- substance
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0472—Structure-related aspects
- A61N1/0492—Patch electrodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
- A61N1/0432—Anode and cathode
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
- A61N1/0432—Anode and cathode
- A61N1/0436—Material of the electrode
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
- A61N1/0444—Membrane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
- A61N1/0448—Drug reservoir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0452—Specially adapted for transcutaneous muscle stimulation [TMS]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0456—Specially adapted for transcutaneous electrical nerve stimulation [TENS]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36014—External stimulators, e.g. with patch electrodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36014—External stimulators, e.g. with patch electrodes
- A61N1/36025—External stimulators, e.g. with patch electrodes for treating a mental or cerebral condition
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/40—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
Definitions
- the present disclosure relates to electrodes, particularly with plate electrodes and optionally with plate electrodes that are concentric rings, are superimposed on each other or that one of the plates surrounds the other plate, for sending electrical impulses to tissues
- the art discloses electrodes of electrical stimulation of tissues, such as those disclosed by the scientific article PMC3606894 Epilepsy Behav. 2013 Apr; 27 (1): 154-158 and by patents EP2493374 Bl and US6135953 A.
- the scientific article PMC3606894 Epilepsy Behav. 2013 Apr; 27 (1): 154-158 teaches a three-pole concentric ring electrode as a non-invasive alternative to stimulate the brain, carrying electrical signals through the skull.
- the article electrode It works with two concentric rings, which according to the tests, allows focusing the stimulation signal under the skull without altering brain activity, specifically in the formation of memory.
- EP2493374 Bl teaches a concentric ring electrode, with construction parameters that obey specific ranges that relate the diameter of a central ring-shaped plate and concentric ring-shaped plates.
- the electrode has a central node surrounded by at least two concentric rings to allow the stimulus signal to be focused on the tissues.
- Electrodes taught in US6135953 A have conductive plates and are arranged in different ways, in particular, in one of the embodiments of the invention a first electrode with an interstitium in between is taught, where another second smaller electrode fits.
- the first electrode is used as a dispersive plate, which functions as a return electrode of the electric currents that circulate through the body of a patient during an electrical surgery, this causes the electric current focused on the second electrode with the surface of Smaller contact, can be dispersed on the relatively larger surface of the dispersive plate, reducing the power per square centimeter.
- the present disclosure relates to electrodes of electrical tissue stimulation.
- electrodes comprising: a first conductive plate; a second conductive plate that surrounds the first conductive plate; where the first conductive plate and the second conductive plate are separated from each other.
- a method for inducing an electrical current in a tissue comprises the following steps: A) locating the electrical tissue stimulation electrode, which includes: a first conductive plate ; and a second conductive plate that surrounds the first conductive plate; wherein the first conductive plate and the second conductive plate are separated from each other, in contact with the tissue; B) apply an activation signal to the first electrode conductive plate, to generate an electric field that induces a current in the tissue; and C) apply an electrical potential to the second electrode conductive plate, to obtain an electrical potential differential with respect to the first conductive plate; wherein the electrical potential of the second conductive plate forces the current induced by the first conductive plate to penetrate the surface of the tissue in contact with the conductive plates and prevents the induced current from flowing through the surface of said tissue.
- a method for delivering an ionically charged substance is disclosed by means of the electrode taught herein, which comprises the following steps: prior to step A) of the above method, a substance is disposed on the tissue, and in step B) the electrode is located on the disposed substance, where the electric field of step B) has sufficient strength and duration to cause the tissue cell walls to become temporarily permeable, to allow the substance to pass through them without damage tissue cells.
- FIG. 1 illustrates a mode of disclosure and a detailed sectional view of it.
- FIG. 2 illustrates a diagram of an embodiment of the disclosure, with a substance in contact with the first conductive plate.
- FIG. 3 illustrates a diagram of one embodiment of the disclosure, comprising a layer of electrical conductive material and a sponge layer
- FIG. 4a teaches an electrode configuration in which both conductive plates are made of a combination of conductive material and sponge.
- FIG. 4b teaches an electrode configuration in which the first conductive plate is made entirely of conductive material, while the second conductive plate is made of sponge.
- FIG. 4c teaches an electrode configuration in which the two conductive plates are made entirely of sponge.
- FIG. 4d teaches an electrode configuration in which the first conductive plate is made entirely of sponge, while the second conductive plate is made of conductive material.
- FIG. 4e teaches an electrode configuration in which the first conductive plate is made entirely of conductive material, while the second conductive plate is formed by a conductive layer and a sponge layer.
- FIG. 4f teaches an electrode configuration in which the first conductive plate is made of a combination of conductive material and sponge and the second conductive plate is made of conductive material.
- FIG. 5 illustrates a diagram of an embodiment of the disclosure, with a sponge in the gap between the conductive plates.
- FIG. 6A illustrates an example of an embodiment of the disclosure in which the first conductive plate comprises two conductive plates.
- FIG. 6B illustrates an example of an embodiment of the disclosure in which the first conductive plate comprises three conductive plates.
- FIG. 7A illustrates an example of an embodiment of the disclosure in which the first conductive plate and the second conductive plate are superimposed on each other in an isometric view.
- FIG. 7B illustrates an example of an embodiment of the disclosure in which the first conductive plate and the second conductive plate are superimposed on each other in a frontal view perpendicular to the plane where the conductive plates are inscribed.
- FIG. 7C illustrates an example of one embodiment of the disclosure in which the first conductive plate and the second conductive plate are superimposed on each other and separated by a dielectric, in a left side view.
- FIG. 7D illustrates an example of an embodiment of the disclosure in which the first conductive plate and the second conductive plate are superimposed on each other and in contact, in a left side view.
- FIG. 8 illustrates a flow chart of a method for inducing in an tissue, an electric current with an electrode of electrical tissue stimulation.
- FIG. 9 illustrates a flow chart of a method for administering to a tissue, a substance with an electrical tissue stimulation electrode.
- the present disclosure refers to electrodes and methods for electrically stimulating organic tissues, as well as methods for inducing electrical currents by means of electrodes in organic tissues and to methods for administering substances to organic tissues, by means of electrodes.
- the organic tissue or tissue refers to biological tissues of living beings formed by one or more cells of a single class or by several types of cells, which form an organ or organism.
- the tissue can be healthy tissue, such as epithelial tissue, connective tissue, muscle tissue, nerve tissue, among others.
- the tissue can also be a tissue with a total or partial biochemical imbalance, said biochemical imbalance in turn can correspond to benign neoplastic tissue, malignant neoplastic tissue or any cell outside homeostasis.
- the tissue may correspond to cells in vivo or prior to implantation of said cells in an in vivo environment.
- the tissue may refer to cells in an ex vivo environment, for example cells in vitro.
- the tissue can come from animals, which include, without limitation: mammals, bird species (including chickens, turkeys, geese and ducks, among others), fish, crustacean species (shrimp, lobsters, crayfish, among others) and reptiles (such as crocodiles and alligators, among others).
- animals include, without limitation: mammals, bird species (including chickens, turkeys, geese and ducks, among others), fish, crustacean species (shrimp, lobsters, crayfish, among others) and reptiles (such as crocodiles and alligators, among others).
- mammal refers to any species classified as a mammal, including humans, non-human primates, such as cynomolgus monkey, chimpanzees, baboons and gorillas; domestic and farm animals including equine species, bovine species, pig species, goat species, canine species, feline species, sheep species, rabbits, llamas; ungulates, such as cattle, sheep, pigs, horses, goats; canine, feline, murine, rabbit; and rodents such as guinea pigs, hamsters and rats; among others.
- non-human primates such as cynomolgus monkey, chimpanzees, baboons and gorillas
- domestic and farm animals including equine species, bovine species, pig species, goat species, canine species, feline species, sheep species, rabbits, llamas
- ungulates such as cattle, sheep, pigs, horses, goats
- the electrodes of the disclosure is illustrated, and a sectional view with a detail thereof, wherein the electrode comprises: a first conductive plate (1); and a second conductive plate (2) surrounding the first conductive plate (1); where the first conductive plate (1) and the second conductive plate (2) are separated from each other by an interstitium (3).
- the interstitium (3) is occupied by a gas (3a), which is selected from the group consisting of air, industrial gases such as carbon dioxide acetylene (C2H2), carbon dioxide (CO2), carbon monoxide ( CO), chlorine (Cfi), hydrogen (H 2 ) hydrogen chloride (HC1), methane (CH4), nitrous oxide (N 2 0), propane (C33 ⁇ 4), sulfur dioxide (SO2) and air gases, such as argon (Ar), nitrogen (N 2 ), oxygen (O2).
- the electrode has conductive plates (1) and (2) electrically isolated from each other, allowing the creation of an electrical potential barrier to force the entry of an induced current into the tissue; The electric potential barrier will be described later.
- the conductive plates (1) and (2) are electrically connected to each other.
- the electrode of this disclosure can be made of a combination of materials, in which one part of the electrode is composed of sponge and the other part is composed of solid conductive metals (la and 2a).
- the first conductive plate (1) and the second conductive plate (2) are made of conductive materials that are selected, without being limited, from the group formed, among others, by zinc, magnesium, tin, aluminum, silver, platinum, copper , gold, aluminum, lead iron, mercury, nicrom, nickel, chromium, carbon, indium, gallium, graphite and combinations thereof.
- the first conductive plate (1) can be an array of electrodes as shown in FIG: 6A and FIG. 6B.
- the plates of the plate electrode can be circular and concentric shaped like those in FIG. 1 to FIG. 5, or interiors as shown in FIG. 6B and FIG. 6B, or be superimposed on each other like those taught by the figures from FIG. 7A to FIG. 7D.
- the conductive plates (1) and (2) of the electrode are drying each other, that is to say they are cut from each other.
- the conductive plates (1) and (2) that are secant of each other can also be electrically insulated despite being drying, in this way both conductive plates (1) and (2) at the time of being used to stimulate a tissue, they can be in contact with the tissue using a method with an independent activation signal for each conductive plate (1 and 2), improving the efficiency of tissue stimulation compared to the modality illustrated in FIG. FIG. 7A to FIG. 7D.
- the conductive plates (1) and (2) can have different geometric shapes as will be described later.
- the dimensions of the electrode can be between 0.001 cm and 1 meter, without being limited to this range, as it varies depending on the dimensions of the tissue to be stimulated.
- the electrode dimensions are between 0.001 cm and 40 cm.
- the conductive plates (1) and (2) when the conductive plates (1) and (2) are superimposed on each other, they can be electrically isolated from each other by means of a dielectric (9) as shown in FIG. 7B and FIG. 7C. Also, the conductive plates (1) and (2) can be electrically connected in the area where the conductive plates make contact.
- FIG. 7B an embodiment of the electrode is illustrated in a front view perpendicular to the plane where the conductive plates (1) and (2) are inscribed.
- the conductive plates (1) and (2) are circular and superimposed on each other but separated by a dielectric (9).
- FIG. 7C the embodiment of the electrode illustrated in FIG. 7B.
- FIG. 7C is illustrated in a left side view of a variation embodiment of the electrode illustrated in FIG. 7B in which the conductive plates (1) and (2) are in electrical contact with each other.
- Fas different electrode shapes, dimensions and configurations allow to stimulate tissue efficiently without stimulating tissue regions that for practical reasons should not be stimulated, such as high sensitivity, or healthy tissue regions that do not need stimulation. Fas different forms of the electrode together with the method disclosed below allow to control the currents that are induced in the tissue.
- the electrode comprises sponges, which may or may not be electrical conductors, where the first conductive plate (1) and / or the second conductive plate (2), are made of sponge.
- the sponge to function as a driver a conductive liquid or gel (6) with which the sponge is moistened and allows electric conduction, for example, a liquid with a diluted electrolyte.
- the electrode made of sponge is moistened with conductive liquids or gels (6), so that the liquid or gel with which the electrode is moistened contributes to establishing the electrical contact between the electrode and the tissue to be stimulated.
- the sponge can also store a substance that is administered to a tissue, this procedure will be detailed later.
- the first conductive plate (1) may be made of sponge, while the second conductive plate (2) is made of a conductive material.
- the ring-shaped conductive plate (2) is made of sponge, such as natural or synthetic sponge. It is also possible that both the first conductive plate (1) and the second conductive plate (2) are made of sponge.
- the electrode body comprises a layer of dielectric material (9), on which the first conductive plate (1) and the second conductive plate (2) are arranged, so that they remain fixed in position.
- the layer of dielectric material (9) serves as a support on which the electrode is constructed, and is made of dielectrics selected, among others, from the group consisting of glass, ceramics, rubber, mica, wax, paper, dry wood, porcelain, baque lita, and combinations thereof.
- Said coating of dielectric material (9) also prevents the conductive plate (1 and 2) from coating from rusting. Additionally, said coating of dielectric material (9) also allows electrically decoupling the electrode from the tissue to be stimulated. Electrically decoupling the electrode from the tissue to be stimulated is useful for protecting the tissue from electric shocks that could damage it.
- electrically decoupling corresponds to disconnecting two electrical circuits.
- the conductive plates (1) and (2) are covered by a protective material that prevents the conductive plates (1) and (2) from degrading or oxidizing upon contact with air or oxidizing gases .
- the conductive plates (1) and (2) have a shape that is selected, among others, from the group consisting of two-dimensional shapes such as rectangles, circles, ovals, parallelograms, rhombuses, etc., or three-dimensional shapes such as spheres, cylinders, polyhedra , prisms, toroids of revolution, etc., or combinations thereof.
- the conductive plates (1) and (2) can have the same or different shapes between them.
- the conductive plates (1) and (2) of the electrode are electrically insulated concentric rings, and operates with the same methods mentioned, where around the second conductive plate (2), there is at least one additional conductive plate surrounding the second conductive plate (2), concentrically, that is, forming more than one ring around the first conductive plate (1).
- the concentric rings are electrically connected to each other.
- the first conductive plate (1) can be an electrode for commercial use, which is arranged in the center of a layer of insulating material (9) that is used as a base, while the second conductive plate (2) is arranged so that it surrounds the first conductive plate (1), without touching each other.
- a dielectric material (9) is provided between the first conductive plate (1) and the second conductive plate (2).
- the dielectric material (9) allows a higher voltage to be reached between the conductive plates (1) and (2), so that tissue that is at a greater depth can be stimulated, such as the tissue of a kidney that is found at a certain depth under the skin tissue that covers the abdominal area of an animal.
- FIG. 6A illustrates an example of one embodiment of the disclosure in which the first conductive plate (1) comprises two conductive plates (1A and 1B).
- FIG. 6B illustrates an example of one embodiment of the disclosure in which the first conductive plate (1) comprises three conductive plates (1A, 1B and 1C).
- a substance (6) is used, which is, for example, a gel or hydrogel for the contact of the first conductive plate (1) or the second conductive plate (2), or both, with the fabric, maintaining the electrical insulation between the two.
- An electrical potential barrier can also be applied through the second conductive plate (2), and the electrical signals are induced with the first conductive plate
- the electric potential barrier corresponds to a region of the tissue with an electric field intensity formed by the electric potential applied by the second conductive plate (2), which opposes the passage of electrically charged particles, in a direction that depends on the sign of the electric charge
- a conductive gel or hydrogel (6) is used to make contact between the electrode and the tissue, this hydrogel reduces the resistance on the surface of the tissue.
- the gap (3) can be left free for the air to serve as a dielectric (9) or to use a commercially available dielectric (9) to keep the plates separated from each other.
- the gap (3) can be filled with dielectrics of the group consisting of paper and polyvinylchloride (PolyVinyl Chloride by its acronym in English PVC), amber, bakelite, pyrex glass 7740, nylon, silicone, polyethylene, polystyrene, porcelain, rubber, neoprene , tef ón, titanium oxide or combinations of these, among others.
- FIG. 5 a diagram of an embodiment of the disclosure with a sponge (3b) in the gap (3) between the conductive plates (1) and
- the sponge (3b) serves as a dielectric (9) between the conductive plates (1) and (2), optionally serves as a support for the same plates of the same electrode.
- One of The advantages of the sponge (3b) is that it can be used to absorb a substance that is subsequently administered to a tissue using a method of the present disclosure.
- the sponge (3b) is moistened with a liquid desiccant from which an adsorbed substance is extracted using electric fields commanded by an activation signal and an electrical potential supplied to the electrode of the disclosure, as will be described below, and the substance extracted from the liquid desiccant is then administered to the tissue.
- the substance administered to the tissue serves to increase the electrical conduction towards the tissue.
- the conductive plates (1) and (2) are made of sponge, which is moistened with a gel or a conductive liquid (6), which can be a saline solution.
- the disclosed electrode can be operated with iontophoresis methods.
- this paper presents a method of stimulation that makes use of the concentric electrodes with which an improved method of electrical tissue stimulation is achieved.
- the first conductive plate (1) and the second conductive plate (2) can be connected to devices that generate an activation signal, such as a magnetic function generator as described in the application no. NC2017 / 000264, filed on November 17, 2017.
- the first conductive plate (1) is connected, according to its application, to a device that is selected from the group consisting of a signal generator, a measuring device, a tissue stimulation device, electric massage devices, for example an analog-digital circuit of a data acquisition card or a controller, among others.
- both the first conductive plate (1) and the second conductive plate (2) are electrically connected to a signal generating apparatus or directly to a computing unit, said plates can be isolated or electrically connected to each other , if the application requires it.
- both the first conductive plate (1) and the second conductive plate (2) placed on the same layer of insulating material (9) separated by an air gap (3a), also have a sponge layer (lb) of the first conductive plate (1) and a sponge layer (2b) of the second conductive plate (2).
- FIG. 4a to FIG. 4 f different configurations of conductive plates (1) and (2) and electrode sponges of the present disclosure are illustrated.
- both conductive plates (1) and (2) are made of a combination of conductive material (la and 2a) and sponge (lb and 2b).
- FIG. 4b an electrode configuration is taught in which the first conductive plate (1) is made entirely of conductive material (4b), while the second conductive plate (2) is made of sponge (2b).
- FIG. 4c an electrode configuration is shown in which the two conductive plates (1) and (2) are made entirely of sponge (lb and 2b).
- an electrode configuration is taught in which the first conductive plate (1) is made entirely of sponge (lb), while the second conductive plate (2) is made of conductive material (2a).
- an electrode configuration is taught in which the first conductive plate (1) is made entirely of conductive material (la), while the second conductive plate (2) is formed by a conductive layer (2a) and a layer of sponge (2b).
- the first conductive plate (1) is made of a combination of conductive material (la) and sponge (lb) and the second conductive plate (2) is made of conductive material (2a) .
- the modalities illustrated in FIG. 6A, FIG. 6B, FIG. 7A, FIG. 7B, FIG. 7C, FIG. 7D they can also have the configurations of conductive plates (1) and (2) and sponges illustrated in the figures of FIG. 1 to FIG. 5.
- the sponge (lb and 2b) is moistened with a conductive substance (6) that allows electric conduction through the sponge (lb and lb), and also reduces the electrical resistance on the tissue surface.
- a conductive substance (6) that allows electric conduction through the sponge (lb and lb), and also reduces the electrical resistance on the tissue surface.
- the conductive material (la and 2a) In addition to the conductive material (la and 2a).
- the sponge (lb and 2b) can be moistened with an ionically charged substance to be administered by a technique, such as iontophoresis.
- a technique such as iontophoresis. Due to the shape of the electrode described herein, its function is not limited to the acquisition or administration of electrical signals, for example, a method of administering medication to a tissue can be employed, by means of the iontophoresis technique.
- a substance can be made to cross the tissue surface, by electrophoresis, electroosmosis processes, increasing the permeability of the tissue surface with an electric field or combination thereof.
- the substance can be any medication.
- the disclosed electrode together with the method of substance administration disclosed herein, are used to administer substances to a tissue
- these substances can be strong electrolytes that when dissolved in water produce loose ions, creating a solution ionically charged which conducts electricity.
- the substances dissolved in water are selected, among others, from the group consisting of salt, nitric acid, hydrochloric acid, sodium hydroxide, copper sulfate solution, sodium chloride, molten gold, molten aluminum and combinations thereof.
- a signal is applied to the first conductive plate (1) in which it generates an electric field strength, in a range between 2V / cm and 5V / cm, and frequencies between 0.1 Hz and 50 MHz, preferably between 0.1 Hz and 500 kHz.
- the electric field strength must exceed the ionic charge of the substance.
- said sponges are replaced by a reservoir with a permeable membrane.
- Said reservoir serves to house gels or solid desiccants that have previously adsorbed an ionically charged substance.
- the method to administer a substance it is possible to extract or regenerate the liquid that has been adsorbed by the solid desiccant to be administered to the tissue using electric fields.
- the activation signal used to activate the conductive plates (1) and (2) the release of the ionically charged substance from the desiccant is dosed into the tissue.
- FIG. 8 a flow chart of a method for inducing an electrical current to a tissue is illustrated, with an electrical tissue stimulation electrode, where method (100) comprises the following steps: (101) A) locating the stimulation electrode electrical tissue that includes: a first conductive plate (1); and a second conductive plate (2) surrounding the first conductive plate (1); wherein the first conductive plate (1) and the second conductive plate (2) are separated from each other, on the tissue and with the conductive plates (1) and (2) in contact with the tissue; (102) B) apply an activation signal to the first conductive plate (1) of the electrode to generate an electric field that induces a current in the tissue; and (103) C) apply an electrical potential to the second conductive plate (2) of the electrode to obtain an electrical potential differential with respect to the first conductive plate, where the electrical potential of the second conductive plate (2) forces the current induced by the first conductive plate (1) to penetrate the surface of the tissue in contact with the conductive plates (1) and (2) and prevents the induced current from flowing through the surface of said tissue.
- the way in which the electrode is constructed allows
- step B) and in step C) applying an activation signal and applying an electrical potential corresponds to providing a voltage to a terminal Electric power supply of the conductive plate (1 and / or 2), this voltage can be fixed or variable in time.
- each conductive plate (1 and 2) are not electrically connected or electrically isolated, several activation signals can be used for each conductive plate (1 and 2), which allows it to function as an electrical potential barrier .
- the activation signals that are applied to the electrode in their conductive plates (1) and (2) may be outdated or have different frequencies.
- an electrode like the one disclosed in which an activation signal with a frequency of 2000 Hz and a voltage of 20 V is applied to the first conductive plate (1), while in the second conductive plate (2) applies an electric potential with a frequency of 2020 Hz and a voltage of 24 V.
- the electrical potential applied on the second conductive plate (2) is positive when the activation signal is positive, and negative when the activation signal is negative.
- the activation signal is selected from the group consisting of alternating current signal or direct current signal, pulsed signal, pulse train altered or not altered, square signal with useful cycle variation, signal triangular wave, sawtooth wave signal, amplitude modulated signal (AM by Amplitude Modulation), frequency modulated signal (FM by Frequency Modulation), phase modulated signal (PM by acronym for Phase Modulation), pulse position modulated (PPM) or combinations of these.
- the electrode and the method to induce an electric comment with an electrode of electrical stimulation of tissues in a tissue allow to administer a medication below the surface of a tissue.
- a current flow up to a maximum of 1 mA (milliampere) / cm 2 (square centimeter) is used.
- the administration of current does not exceed a duration of 3 minutes, because it can cause burns and local irritation.
- a point for the application of medications does not exceed the current density of 0.5 mA / cm 2 , commonly working up to 0.4 mA / cm 2 .
- the signal applied to treat excessive sweating lasts between 20 to 40 minutes, daily and reduces the frequency of use (once a week) and normally takes 8 to 12 times until the reduction in sweating expected is achieved.
- the specific current for this type of treatment varies between 15 mA and 20 mA of direct current.
- the substance used is an ionically charged substance, its charge is positive or negative.
- the activation signal used to administer said substance is of the same electrical nature, that is, for an ionically negative substance an activation signal with a negative net charge is used and if the substance is ionically positive, then the signal is positive net charge.
- a method is configured to deliver an ionically charged substance with the electrical stimulation electrode, which comprises the following steps: before step A), a substance is disposed on the tissue and in step B) the electrode is located on the disposed substance, where the electric field of step B) has sufficient strength and duration to cause the tissue cell walls become temporarily permeable to allow the substance to pass through them without damaging tissue cells.
- the device is located on the surface of the tissue to apply a substance (6), which may be or not ionically charged, with the first conductive plate (1) a positive or negative electric field is generated, contrary to the charge of the substance (6), an electrical potential barrier is generated on the tissue with the second conductive plate (2) charging it with an electrical signal of inverse polarity to the signal on the first conductive plate (1).
- a substance (6) which may be or not ionically charged
- the activation signal applied in step B) has a frequency between 0.1 Hz and 50 MHz and a voltage variation between IV and 24 V.
- the activation signal applied in step B) has a frequency between 0.1 Hz and 500 kHz and a voltage variation between 1 V and 24 V.
- the electrode works at a voltage greater than 24 V according to the application in which it is used, this to maintain an electric field that manages to stimulate the interior of the tissue without damaging it.
- the electric field of step B) has an intensity between 2V / cm and 5V / cm. In these ranges of electric field strength it is possible to stimulate the tissue with the electrode in contact with the tissue, without damaging it.
- the electrode in this configuration is an electrode coated with a dielectric material.
- the substance is injected into the tissue.
- more than one electrode is located on different parts of a body.
- a flow chart of a method for administering a substance with an electrical tissue stimulation electrode in a tissue comprises the following steps: (121) a) arranging the substance on the tissue; (122) b) locate the electrical tissue stimulation electrode that includes: a first conductive plate; and a second conductive plate that surrounds the first conductive plate; and where the first conductive plate and the second conductive plate are separated from each other, on the surface of the tissue with the conductive plates in contact with the tissue; (123) c) apply an activation signal to the first electrode conductive plate to generate an electric field that induces a current in the tissue; and (124) d) apply an electrical potential to the second electrode conductive plate to obtain an electrical potential differential with respect to the first conductive plate; where the electric field of the passage (123) c) has sufficient strength and duration to cause the cell walls of the tissue to become temporarily permeable to allow the substance to enter them without damaging the tissue cells.
- the activation signal applied in step (123) c) has a frequency between 0.1 Hz and 50 MHz and a voltage variation between IV and 24 V.
- the activation signal applied in step (123) c) has a frequency between 0.1 Hz and 500 kHz and a voltage variation between 1 V and 24 V.
- the electric field of step (123) c) has an intensity between 2V / cm and 5V / cm. In these ranges of electric field strength it is possible to stimulate the tissue with the electrode in contact with the tissue, without damaging it.
- the electrode in this configuration is an electrode coated with a dielectric material.
- the substance is ionically charged, and where the electric field is equal to or greater than the charge of the substance.
- the substance is injected into the tissue.
- the activation signal to stimulate the tissue in contact with the first conductive plate (1) is in a range of voltages that allow generating an electric field intensity between 2V / cm and 5V / cm, and a range of frequencies between 0.1 Hz and 50 MHz, optionally, the frequency range is between 0.1 Hz and 500 kHz.
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Radiology & Medical Imaging (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Biophysics (AREA)
- Child & Adolescent Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Social Psychology (AREA)
- Developmental Disabilities (AREA)
- Pharmacology & Pharmacy (AREA)
- Dermatology (AREA)
- Medical Informatics (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Electrotherapy Devices (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
Description
Claims
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201980058995.8A CN112672784A (zh) | 2018-07-16 | 2019-07-16 | 板状电极 |
SG11202100424WA SG11202100424WA (en) | 2018-07-16 | 2019-07-16 | Plate electrodes |
EP19837532.1A EP3824944A4 (en) | 2018-07-16 | 2019-07-16 | PLATE ELECTRODES |
KR1020217004168A KR20210032994A (ko) | 2018-07-16 | 2019-07-16 | 플레이트 전극들 |
CA3106445A CA3106445A1 (en) | 2018-07-16 | 2019-07-16 | Plate electrodes |
MX2021000455A MX2021000455A (es) | 2018-07-16 | 2019-07-16 | Electrodos de placas. |
JP2021500877A JP2021529627A (ja) | 2018-07-16 | 2019-07-16 | 平板電極 |
US17/259,976 US20210268275A1 (en) | 2018-07-16 | 2019-07-16 | Plate electrodes |
AU2019304232A AU2019304232A1 (en) | 2018-07-16 | 2019-07-16 | Plate electrodes |
IL280185A IL280185A (en) | 2018-07-16 | 2021-01-14 | electrode surface |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CONC2018/0007478A CO2018007478A1 (es) | 2018-07-16 | 2018-07-16 | Electrodo de anillos concéntricos |
CONC2018/0007478 | 2018-07-16 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2020016785A1 true WO2020016785A1 (es) | 2020-01-23 |
WO2020016785A4 WO2020016785A4 (es) | 2020-03-19 |
Family
ID=69148225
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IB2019/056079 WO2020016785A1 (es) | 2018-07-16 | 2019-07-16 | Electrodos de placas |
Country Status (12)
Country | Link |
---|---|
US (1) | US20210268275A1 (es) |
EP (1) | EP3824944A4 (es) |
JP (1) | JP2021529627A (es) |
KR (1) | KR20210032994A (es) |
CN (1) | CN112672784A (es) |
AU (1) | AU2019304232A1 (es) |
CA (1) | CA3106445A1 (es) |
CO (1) | CO2018007478A1 (es) |
IL (1) | IL280185A (es) |
MX (1) | MX2021000455A (es) |
SG (1) | SG11202100424WA (es) |
WO (1) | WO2020016785A1 (es) |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6135953A (en) | 1996-01-25 | 2000-10-24 | 3M Innovative Properties Company | Multi-functional biomedical electrodes |
US20040088036A1 (en) * | 2001-03-20 | 2004-05-06 | Gilbert Bruce R. | Device for surface stimulation of acupuncture points |
WO2016038545A1 (en) * | 2014-09-10 | 2016-03-17 | Ecole Polytechnique Federale De Lausanne (Epfl) | Non-invasive drawable electrode for neuromuscular electrical stimulation and biological signal sensing |
EP2493374B1 (en) | 2009-10-28 | 2016-12-14 | The Board of Governors for Higher Education, State of Rhode Island and Providence Plantations | Biomedical electrode |
WO2017000264A1 (zh) | 2015-06-30 | 2017-01-05 | 华为技术有限公司 | 一种投影*** |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2001286569A (ja) * | 2000-04-05 | 2001-10-16 | Polytronics Ltd | 経皮投薬装置 |
JP2003169853A (ja) * | 2001-12-07 | 2003-06-17 | Biocell Technology Kk | イオントフォレシス素子 |
US9827437B2 (en) * | 2006-01-17 | 2017-11-28 | Endymed Medical Ltd | Skin treatment devices and methods |
CN106955415B (zh) * | 2011-03-24 | 2019-06-18 | 因卡伯实验室有限责任公司 | 用于治疗剂的两阶段经皮离子电渗递送的***及方法 |
-
2018
- 2018-07-16 CO CONC2018/0007478A patent/CO2018007478A1/es unknown
-
2019
- 2019-07-16 KR KR1020217004168A patent/KR20210032994A/ko not_active Application Discontinuation
- 2019-07-16 AU AU2019304232A patent/AU2019304232A1/en active Pending
- 2019-07-16 CN CN201980058995.8A patent/CN112672784A/zh active Pending
- 2019-07-16 CA CA3106445A patent/CA3106445A1/en active Pending
- 2019-07-16 JP JP2021500877A patent/JP2021529627A/ja active Pending
- 2019-07-16 EP EP19837532.1A patent/EP3824944A4/en active Pending
- 2019-07-16 SG SG11202100424WA patent/SG11202100424WA/en unknown
- 2019-07-16 WO PCT/IB2019/056079 patent/WO2020016785A1/es unknown
- 2019-07-16 US US17/259,976 patent/US20210268275A1/en active Pending
- 2019-07-16 MX MX2021000455A patent/MX2021000455A/es unknown
-
2021
- 2021-01-14 IL IL280185A patent/IL280185A/en unknown
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6135953A (en) | 1996-01-25 | 2000-10-24 | 3M Innovative Properties Company | Multi-functional biomedical electrodes |
US20040088036A1 (en) * | 2001-03-20 | 2004-05-06 | Gilbert Bruce R. | Device for surface stimulation of acupuncture points |
EP2493374B1 (en) | 2009-10-28 | 2016-12-14 | The Board of Governors for Higher Education, State of Rhode Island and Providence Plantations | Biomedical electrode |
WO2016038545A1 (en) * | 2014-09-10 | 2016-03-17 | Ecole Polytechnique Federale De Lausanne (Epfl) | Non-invasive drawable electrode for neuromuscular electrical stimulation and biological signal sensing |
WO2017000264A1 (zh) | 2015-06-30 | 2017-01-05 | 华为技术有限公司 | 一种投影*** |
Non-Patent Citations (4)
Title |
---|
BORTOLETTO, M. ET AL.: "Reduced Current Spread by Concentric Electrodes in Transcranial Electrical Stimulation (tES", BRAIN STIMULATION, vol. 9, no. 4, 9 March 2016 (2016-03-09), pages 525 - 528, XP029612286, DOI: 10.1016/j.brs.2016.03.001 * |
EPILEPSY BEHAV, vol. 27, no. 1, April 2013 (2013-04-01), pages 154 - 158 |
MAKEYEV, O. ET AL.: "Improving the accuracy of Laplacian estimation with novel multipolar concentric ring electrodes", MEASUREMENT, vol. 80, 19 November 2015 (2015-11-19), pages 44 - 52, XP029358641, DOI: 10.1016/j.measurement.2015.11.017 * |
See also references of EP3824944A4 |
Also Published As
Publication number | Publication date |
---|---|
US20210268275A1 (en) | 2021-09-02 |
MX2021000455A (es) | 2021-03-25 |
KR20210032994A (ko) | 2021-03-25 |
CO2018007478A1 (es) | 2020-01-17 |
EP3824944A1 (en) | 2021-05-26 |
CA3106445A1 (en) | 2020-01-23 |
IL280185A (en) | 2021-03-01 |
CN112672784A (zh) | 2021-04-16 |
AU2019304232A1 (en) | 2021-02-04 |
EP3824944A4 (en) | 2022-04-20 |
SG11202100424WA (en) | 2021-02-25 |
WO2020016785A4 (es) | 2020-03-19 |
JP2021529627A (ja) | 2021-11-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US20210186600A1 (en) | Electroporation with cooling to treat tissue | |
KR940000071B1 (ko) | 피부투과식 약물 도포구 | |
ES2260957T3 (es) | Metodo y aparato para una combinacion de electroporacion y iontoforesis, para la administracion de medicamentos y genes. | |
US20040138712A1 (en) | Combination stimulating and exothermic heating device and method of use thereof | |
WO1996016693A1 (en) | Iontophoresis method and apparatus | |
CA2622777A1 (en) | Iontophoresis device to deliver multiple active agents to biological interfaces | |
JPH03133464A (ja) | イオントフォレーゼに用いる電極用装置 | |
BRPI0616487A2 (pt) | aparato e método de iontoforese para liberação sistêmica de agentes ativos | |
Ewing et al. | SaBer DBS: a fully programmable, rechargeable, bilateral, charge-balanced preclinical microstimulator for long-term neural stimulation | |
BRPI0616788A2 (pt) | sistemas, dispositivos e métodos de transferência de fármaco de modo transdérmico, e métodos que empregam agonista opióide e/ou antagonista opóide | |
JP2022512003A (ja) | 非熱エネルギーの適用による皮膚腺の治療 | |
US20070081944A1 (en) | Iontophoresis apparatus and method for the diagnosis of tuberculosis | |
EP3268080A1 (en) | Iontophoretic device, arrangement and method | |
WO2020016785A1 (es) | Electrodos de placas | |
Tizatl et al. | 3D model and simulation of electroporation application on healthy and tumoral breast tissue | |
SU825095A1 (ru) | Устройство для полостного электрофореза | |
ES2884924T3 (es) | Dispositivo de electrodo y electrodo de aguja para uso en el suministro de pulsos eléctricos a un tejido deseado de un mamífero | |
JP2000342697A (ja) | イオントフォレーシス用の電極構造体及び電流密度測定装置 | |
KR20090009330U (ko) | 갈바니이온영동도입기능을 갖는 화장품용기 | |
Gazelius | Iontophoresis-theory | |
RU2495684C1 (ru) | Устройство для коррекции функционального состояния организма человека | |
KR100526750B1 (ko) | 삼각형의 자극점을 가지는 물리 치료기 또는 지압구 | |
WO2022099391A1 (pt) | Aparelho de iontoforese com vibração mecânica e comunicação sem fio | |
Gonzalez et al. | Electroporation of the skin | |
Singh et al. | Facilitated transdermal delivery by iontophoresis |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 19837532 Country of ref document: EP Kind code of ref document: A1 |
|
ENP | Entry into the national phase |
Ref document number: 2021500877 Country of ref document: JP Kind code of ref document: A |
|
ENP | Entry into the national phase |
Ref document number: 3106445 Country of ref document: CA |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
ENP | Entry into the national phase |
Ref document number: 2019304232 Country of ref document: AU Date of ref document: 20190716 Kind code of ref document: A |
|
ENP | Entry into the national phase |
Ref document number: 20217004168 Country of ref document: KR Kind code of ref document: A |
|
ENP | Entry into the national phase |
Ref document number: 2019837532 Country of ref document: EP Effective date: 20210216 |