WO2018047345A1 - Installation de traitement de comprimés - Google Patents

Installation de traitement de comprimés Download PDF

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Publication number
WO2018047345A1
WO2018047345A1 PCT/JP2016/076816 JP2016076816W WO2018047345A1 WO 2018047345 A1 WO2018047345 A1 WO 2018047345A1 JP 2016076816 W JP2016076816 W JP 2016076816W WO 2018047345 A1 WO2018047345 A1 WO 2018047345A1
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WIPO (PCT)
Prior art keywords
tablet
container
processing
tablet container
unit
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Application number
PCT/JP2016/076816
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English (en)
Japanese (ja)
Inventor
真嗣 井戸
小林　剛
和寿 湯浅
Original Assignee
日揮株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 日揮株式会社 filed Critical 日揮株式会社
Priority to CN201680087030.8A priority Critical patent/CN109414372B/zh
Priority to PCT/JP2016/076816 priority patent/WO2018047345A1/fr
Priority to JP2018509934A priority patent/JP6435436B2/ja
Publication of WO2018047345A1 publication Critical patent/WO2018047345A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/06—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of pills, lozenges or dragees

Definitions

  • the present invention relates to a technique for handling a tablet container in order to insert a tablet into a processing apparatus that executes tablet inspection / printing and to discharge a tablet from the processing apparatus.
  • a pharmaceutical factory where tablets are manufactured, the factory building is divided into a plurality of processing chambers, and in each processing chamber, tableting molding of drug powder, coating processing on the molded tablets, etc. are performed.
  • a tablet processing facility in which various processing devices are arranged (hereinafter, sometimes referred to as “processing facility” for simplicity) is provided (for example, Patent Document 1).
  • processing facility for simplicity
  • Patent Document 1 in order to efficiently carry tablets between processing devices, for example, a tablet to be processed is accommodated in a large tablet container having an internal capacity of 1000 liters to transport tablets in the pharmaceutical factory. May be implemented.
  • a small tablet container of 200 liters or less may be used.
  • the number of operations for transporting the pill container, loading the pill into the processing apparatus, and dispensing the pill after processing into the pill container will increase, increasing the burden on the operator. End up.
  • a tablet insertion section is provided on the upper side of the processing apparatus, and a tablet dispensing section is a processing apparatus.
  • Patent Document 2 for an inspection apparatus
  • Patent Document 3 for a printing apparatus.
  • a processing chamber for input operation is provided on the upper floor of a processing chamber (processing area 6) in which a processing apparatus is disposed, and a space between these processing chambers is provided by an input path.
  • a technique is described in which tablets are connected and connected.
  • a dedicated conveying device (conveying member 64) provided in the processing chamber in which the processing device is arranged is used for the operation of dispensing the tablet from the processing device to the tablet container.
  • JP 2011-178559 A Paragraphs 0022, 0028, FIGS. JP 2008-143653 A: paragraph 0003, FIG. JP 2013-52686 A: Paragraph 0016, FIG.
  • the present invention has been made under such a background, and an object thereof is to provide a tablet processing facility having a simple configuration.
  • the tablet processing facility of the present invention is a tablet processing facility for processing tablets, A processing chamber provided with a loading / unloading unit for loading / unloading a tablet container containing a tablet to be processed; One manipulator device provided in the processing chamber and comprising a gripping part for gripping a tablet container and an articulated arm that changes the orientation and position of the gripping part; A processing apparatus that is provided in the processing chamber and includes at least one of tablet inspection and tablet printing, and an input unit into which tablets before processing are input and a dispensing unit at which processed tablets are discharged.
  • a tablet container that is carried into the processing chamber and contains a pre-processed tablet is gripped by the gripping unit and conveyed to the input unit, and the tablet in the tablet container is transferred to the processing device via the input unit.
  • the tablet processing facility may have the following characteristics.
  • the control unit outputs a control signal for changing the orientation of the gripping unit so that the angle at which the tablet container is tilted is larger at the time of completion of filling than at the start of filling of the tablet during the charging step.
  • the tablet dispensed from the dispensing unit is collected into the tablet container through an opening formed on the upper surface side of the tablet container, and the control unit In the period of the can-collecting step, after starting the can-collecting in a state where the tablet container is tilted, a control signal for changing the orientation of the grip portion so that the opening portion faces the upper surface is output.
  • a plurality of tablet containers are carried into the processing chamber, and from the start of tablet loading into the tablet processing device in the tablet container in the loading step, until the loading is completed.
  • the charging time required is shorter than the time required to complete the collection after the collection of the tablets into the tablet container in the collection step, and the control unit includes the plurality of the collection units.
  • the gripping portion is released from the gripping portion in a state of being placed at a preset can collecting execution position, A control signal is output so as to execute an input step for another tablet container among the plurality of tablet containers in parallel with the can collecting step for the one tablet container.
  • a control signal is output so as to select another tablet container to be used in (1) from the tablet containers arranged at the standby position before the loading step. Furthermore, a plurality of tablet containers carried into the processing chamber are arranged at the standby position at a position associated with the order of execution of the charging step and the can-collecting step.
  • the manipulator device is configured to be pivotable about a pivot axis, and the gripping unit of the manipulator device can reach the transport destination of the tablet container including the carry-in / out unit, the input unit and the dispensing unit of the processing device. Must be located within the appropriate turning radius.
  • the tablet container has an internal volume in the range of 10 to 200 liters.
  • the present invention is provided in a processing chamber in which a processing device for inspecting and printing tablets is disposed, and using a single manipulator device having a multi-joint arm, charging of the tablet from the tablet container to the processing device, the processing device Since the tablet is dispensed from the tablet container to the tablet container, the tablet container can be handled with a tablet processing facility having a simple configuration.
  • FIG. 1 shows an outline of a tablet manufacturing process carried out in a pharmaceutical factory.
  • tablets are formed by tableting a raw material powder (tablet process: treatment P1), and the formed tablets are coated with a film or a sugar coating (coating process: treatment P2).
  • coating process treatment P2
  • the tablets after inspection / printing are packaged to obtain products ( Packaging process: Process P4).
  • the pharmaceutical factory in this example may produce any kind of tablets such as uncoated tablets and coated tablets, and special tablets such as orally dispersing tablets (OD (Oral Dispersing) tablets). It may be what performs.
  • OD Oral Dispersing
  • a coating process is abbreviate
  • the pharmaceutical factory divides the interior of the factory building (not shown) into a plurality of processing chambers, and arranges various processing apparatuses for performing the processing P1 to P4 in each processing chamber, thereby individually processing each processing P1 to P4.
  • a processing facility (tablet processing facility) is formed.
  • the tablets molded by the tableting process are conveyed between the processing facilities using a stacker crane or a conveyor (not shown) while being accommodated in a tablet container.
  • tablets are transported using a pail can-shaped tablet container 2 that can open and close the lid on the upper surface side.
  • the tablet container 2 has an internal volume of 10 to 200 liters, preferably 40 to 100 liters.
  • the tablet container 2 has a shorter drop distance from the tablet inlet than conventional large-sized tablet containers with an internal capacity of 1000 liters, so that the tablet container 2 is dispensed to the tablet container 2 and the like. The occurrence of cracks in can be suppressed.
  • a transport operation for a larger number of tablet containers 2, from the tablet container 2 to the processing device. And a dispensing operation from the processing device to the tablet container 2 occur. Therefore, the processing facility according to the present embodiment is configured to automatically execute operations related to the transport of the tablet container 2, the loading of the tablet, and the can collection using the manipulator device 6.
  • the processing equipment of this example is intended for processing equipment for performing an inspection / printing process among a plurality of types of processing equipment provided according to the manufacturing process described above.
  • This processing facility may include a processing apparatus (inspection / printing apparatus) capable of performing both inspection and printing, and may perform these processes collectively.
  • a processing apparatus inspection apparatus, printing apparatus
  • a processing apparatus that individually performs inspection and printing may be provided in different processing chambers, and may be configured as a plurality of processing facilities that perform these processes separately.
  • the processing facility of this example is provided with a single manipulator device 6 at a substantially central portion of the processing chamber 11, and a transport tray 21 for transporting the tablet container 2 around the manipulator device 6. At least one of inspection and printing is performed on the tray mounting table 31 on which the tablet is placed, the standby shelf 4 that waits for the tablet containers 2 lowered from the transport tray 21, and the tablets taken out from the tablet containers 2
  • the processing apparatus 5 to be performed, a work space 33 in which a lid is attached to the tablet container 2 containing the processed tablets, and a weighing device 32 in which the tablet container 2 containing the tablets is weighed are arranged. It has a structure.
  • a loading / unloading port 111 configured to be freely opened and closed by an opening / closing door (not shown) is provided on one side of the processing chamber 11. Via the loading / unloading port 111, the conveyance tray 21 on which the plurality of tablet containers 2 are placed is carried in / out between a conveyance path (not shown) and the processing chamber 11. The tablet container 2 on the transport tray 21 contains tablets to be processed.
  • a standby area 12 is arranged next to the processing chamber 11.
  • a passage 112 that can be opened and closed by an opening / closing door 112 a is provided between the processing chamber 11 and the standby area 12, and an operator waiting in the standby area 12 enters the processing chamber 11 through the passage 112. can do.
  • the processing chamber 11 and the standby area 12 may be partitioned into separate spaces by walls. Further, the standby area 12 may be partitioned from the processing chamber 11 by partitioning the common space with a safety fence or the like.
  • the installation of the opening / closing door 112a in the passage 112 is not an essential requirement, and the installation of the opening / closing door 112a may be omitted according to necessity.
  • the manipulator device 6 is configured so as to be able to extend and fold, and a gripping part 63 that grips the tablet container 2, and to support the gripping part 63 rotatably around a rotation axis extending in the extending direction of the arm. And a revolving part 61 for revolving the articulated arm 62 around a revolving axis extending in the vertical direction.
  • the grip part 63 is configured as an end effector capable of gripping the tablet container 2 from the side surface side, for example.
  • the gripping part 63 can switch between a gripping state for lifting and transporting the tablet container 2 and maintaining it in a predetermined posture and an open state for opening the tablet container 2 from the gripping state.
  • the degree of freedom of operation (the number of rotation axes) of the manipulator device 6 that combines the articulated arm 62, the gripping unit 63, and the turning unit 61 is not limited to a specific number. Further, the manipulator device 6 may be provided with an interlock function for stopping the operation when an operator enters the processing chamber 11 through the passage 112.
  • the transport destination of the tablet container 2 including the tray mounting table 31 and the processing device 5 (the input unit 51 and the dispensing unit 52 described later) is the tip of the articulated arm 62 of the manipulator device 6.
  • the gripping portion 63 provided in is disposed within a reachable turning radius.
  • the loading / unloading port 111 and the tray mounting table 31 provided on the side surface of the processing chamber 11 constitute a loading / unloading unit of the processing facility.
  • a total of ten tablet containers 2 are placed on the transport tray 21 by stacking two stages including, for example, five tablet containers 2.
  • the standby shelf 4 is divided into two upper and lower stages of an upper shelf part 41 and a lower shelf part 42, and five tablet containers 2 can be arranged on each shelf part 41, 42.
  • the tablet containers 2 on the transport tray 21 are transported one by one to a predetermined placement position in the standby shelf 4 by the manipulator device 6.
  • Each tablet container 2 conveyed to the standby shelf 4 is in a state in which the lid is removed by the operator, the unprocessed tablets are loaded into the processing apparatus 5, and the processed tablets can be collected. .
  • an operation for putting the tablet in the tablet container 2 into the processing device 5 at each placement position of the tablet container 2 in the shelf portions 41 and 42 (input) The execution order for carrying out the operation (can collection step) of collecting the tablets (step) and the processed tablets into the empty tablet container 2 is set in association with each other.
  • the tablet containers 2 are transported from the standby shelf 4 to the processing device 5 in ascending order of numbers assigned to the mounting positions (1 ⁇ 2 ⁇ ... ⁇ 10), and the charging step is performed.
  • the empty tablet container 2 is returned to the original placement position (standby conveyance step).
  • the standby shelf 4 corresponds to a standby position for waiting for an empty tablet container 2.
  • the tablet containers 2 are transported from the standby shelf 4 to the processing device 5 in ascending order of the numbers. This operation is performed.
  • the processing device 5 is configured as an inspection / printing device, an inspection device, or a printing device, and executes at least one of inspection and printing on the tablet loaded from the tablet container 2.
  • the processing apparatus 5 is not particularly limited in its internal configuration as long as it can perform predetermined inspection and printing on each tablet loaded from the tablet container 2.
  • the processing apparatus 5 provided in the processing facility of the present example has a tablet before processing on the upper side of the processing apparatus 5 (for example, the position on the top surface side of the top plate of the processing apparatus 5). Is provided. Further, on the lower side of the tablet container 2 (for example, the position on the lower side of the side wall surface of the tablet container 2), a dispensing part 52 for dispensing the processed tablet is provided.
  • a dispensing part 52 for dispensing the processed tablet is provided on the lower side of the tablet container 2 (for example, the position on the lower side of the side wall surface of the tablet container 2).
  • FIGS. 7 to 9 showing the inside of the processing chamber 11 viewed from the side, the orientation of the processing apparatus 5 is changed from that of FIG. 2 which is a plan view.
  • the input unit 51 of this example is a chute-like member provided on the top surface of the top plate of the processing apparatus 5, and the manipulator is connected to the top plate from the connection position. It is provided so as to extend obliquely upward in the direction in which the device 6 is arranged.
  • the tablet is guided by the loading unit 51 so as to flow down to a hopper (not shown) provided in the processing device 5. Is done.
  • the hopper has a receiving capacity larger than the internal capacity of the tablet container 2.
  • the upper surface of the bowl-shaped charging part 51 is covered with a lid-shaped dust collecting part 511, and the dust generated when the tablet is charged is exhausted to the outside through the suction pipe 511a.
  • a guide portion 512 for preventing the tablets from scattering from the opening of the tablet container 2 to the outside is provided at the tip of the dust collecting portion 511.
  • the guide part 512 of this example is formed in a semi-conical shape (a shape obtained by dividing the funnel into two in the vertical direction).
  • the guide part 512 is arranged so that the opening on the distal end side of the cone faces the opening of the tablet container 2, and guides the tablets discharged from the opening of the tablet container 2 toward the input part 51.
  • the illustration of the dust collecting portion 511 is omitted in the drawings other than FIG.
  • the tablets put into the hopper in the processing apparatus 5 are, for example, discharged from the hopper, and then conveyed downward using a belt conveyor or a conveyance drum that aligns and conveys the tablets individually.
  • the tablets being transported are subjected to external inspection using the dispensing unit 52 after at least one of inspection of cracks, scratches, dirt, etc. using an inspection camera or the like and printing on the tablet surface using printing means is performed.
  • a belt conveyor, a conveyance drum, an inspection camera, a printing means, etc. are not shown).
  • the payout portion 52 of the present example is a chute-like member provided at a position on the lower side of the side wall surface of the processing apparatus 5. It is provided so as to extend obliquely downward from the connection position with the wall surface toward the side of the processing device 5.
  • the tablet dispensed from the processing device 5 is transferred to the tablet container 2 by the dispensing unit 52. It is guided in and collected in the tablet container 2.
  • the lower region of the dispensing unit 52 is configured to be rotatable around a rotation shaft 524 extending in the lateral direction, and can change the dispensing direction of the tablet following the change in the direction of the tablet container 2 that receives the tablet. .
  • the lid-shaped dispensing part 52 is provided with a lid-shaped dust collecting part 521 that covers the opening of the tablet container 2.
  • the dust collecting part 521 is connected to the suction pipe 521a, and the dust generated when the tablet is dispensed is discharged to the outside through the suction pipe 521a.
  • a lower region of the dispensing part 52 that is rotatable around the rotation shaft 524 extends through the dust collecting part 521 and extends toward the tablet container 2 disposed to face the lower surface of the dust collecting part 521.
  • the dust collecting part 521 is movable together with the lower region of the dispensing part 52 and can change the direction of covering the opening of the tablet container 2 following the change of the direction of the tablet container 2.
  • the illustration of the dust collecting portion 521 is omitted in the drawings other than FIG.
  • the dispensing unit 52 is filled with the shutter 522 for switching between the tablet dispensing state and the stopped state, and the tablet dispensed to the tablet container 2 overflows from the insertion unit 51.
  • a full sensor 523 for preventing this is also provided.
  • the tablet container 2 dispensed from the dispensing unit 52 is collected in a state where the grasping by the grasping unit 63 is released, the tablet container 2 is placed.
  • a collection base 501 is provided. The collection base 501 corresponds to the can collection position of the present embodiment.
  • the work space 33 is a mounting table on which the tablet container 2 after the collection of tablets is placed. In the work space 33, the operator attaches a lid to the tablet container 2 in which tablets are collected.
  • the work space 33 corresponds to a retreat position in which the tablet container 2 after collecting the cans is retracted from the collecting table 501 that is the can collecting execution position.
  • the weighing device 32 measures the weight of the tablet container 2 after collecting the tablets in order to confirm that each tablet container 2 is filled with a predetermined amount of tablets.
  • the operation devices such as the manipulator device 6 and the processing device 5 provided in the processing chamber 11 are each connected to a computer device for operation control.
  • the computer device that controls the operation of the manipulator device 6 corresponds to the control unit 7 of this example.
  • the manipulator device 6 Based on the control signal output from the control unit 7, the manipulator device 6 selects the tablet container 2 to be transported, transports the tablet container 2 between predetermined positions, and holds the tablet container 2 by the gripping unit 63. Make changes. *
  • the operation of the processing apparatus according to the present embodiment (handling of the tablet container 2) will be described with reference to FIGS.
  • the transport tray 21 on which the plurality of tablet containers 2 are placed is loaded into the processing chamber 11 and placed on the tray mounting table 31.
  • the manipulator device 6 grips each tablet container 2 on the transport tray 21 by the gripping portion 63 and transports the tablet containers 2 from the transport tray 21 to the standby shelf 4 one by one (process P31 in FIG. 6). , FIG. 7).
  • the operator enters the processing chamber 11 and removes the lid of each tablet container 2 (process P32 in FIG. 6).
  • the frame line is shown with the broken line.
  • the manipulator device 6 moves to the standby shelf 4 in ascending order of the numbers (see FIG. 4) set in association with the placement positions of the tablet containers 2 on the placement shelf 4.
  • the placed tablet container 2 is gripped by the gripping unit 63, and the tablet container 2 is transported from the standby shelf 4 to the input unit 51. Thereafter, the tablet container 2 is tilted while one end of the upper surface of the tablet container 2 is brought into contact with the input part 51, and an opening on the tablet container 2 side and an opening formed on the upper end part side of the input part 51 are formed. It is made to oppose (FIG. 4).
  • the tablets stored in the tablet container 2 flow out toward the loading unit 51, and the tablet loading operation to the processing device 5 is performed (loading step, process P33 in FIG. 6, FIG. 8). .
  • the manipulator device 6 in the initial stage of the charging step, is in a state in which the inclination of the tablet container 2 is reduced (for example, the surface provided with the opening of the tablet container 2 faces upward).
  • the tablet container 2 is gripped in a state in which the formation surface of the opening is inclined by 90 degrees.
  • the tablet storage level the height of the upper surface of the tablet reservoir
  • the inclination of the tablet container 2 is reduced, and the amount of tablet input per unit time is relatively small.
  • the tablet storage level in the hopper increases, and even when the amount of tablet input per unit time is increased, tablet breakage is unlikely to occur. Therefore, when a preset time has elapsed, as shown by a broken line in FIG. 4, the tablet container 2 is gripped in a state where the inclination is further increased (for example, the surface where the opening is formed is inclined more than 90 degrees), and the tablet All the tablets in the container 2 are loaded toward the processing device 5. As a result, it is possible to complete the loading of the tablet into the processing device 5 in a shorter time than when the tablet is continuously loaded while the inclination of the tablet container 2 is small.
  • control unit 7 changes the orientation of the gripping unit 63 so that the angle at which the tablet container 2 is tilted is greater when the tablet is completed than when the tablet is started. It can be said that the control signal is output to the manipulator device 6.
  • a comparison is made with a case where a tablet is put into the processing apparatus 5 using a large tablet container (hereinafter also referred to as “large container”) having an internal capacity of 1000 liters.
  • a processing chamber for input operation hereinafter also referred to as “input chamber”.
  • input chamber a processing chamber for input operation
  • throwing-in part 51 were connected, and the tablet was injected
  • the tablet drop distance from the large container disposed on the upper floor of the processing chamber 11 to the hopper in the processing apparatus 5 becomes long, and the tablet is easily broken.
  • the tablet is loaded into the processing device 5 using the tablet container 2 having a size that can be gripped by the gripping portion 63 (for example, the internal capacity is in the range of 10 to 200 liters) with respect to the above-mentioned problems.
  • the tablet container 2 itself is “small”, and the charging step can be performed in the processing chamber 11 without providing the charging chamber on the upper floor of the processing chamber 11. As a result, compared to the case of using a large container, it is possible to shorten the tablet drop distance in the charging step, and to effectively prevent the tablet from cracking.
  • the posture of the small tablet container 2 can be easily changed by the manipulator device 6, the change in the posture of the tablet container 2 shown by the solid line and the broken line in FIG. Easy to apply method.
  • the processing facility of the present example using the small tablet container 2 there is no need to provide an input chamber on the upper floor of the processing chamber 11, so the height of the processing chamber 11 (the height of the factory building of the preparation factory is ) There is also an effect that it is possible to make it compact.
  • the manipulator device 6 waits on the standby shelf 4 that is the standby position along the order of the numbers (see FIG. 4) set in association with the mounting positions of the tablet containers 2 on the mounting shelf 4.
  • the empty tablet container 2 is gripped by the gripping part 63, and the tablet container 2 is transported from the standby shelf 4 toward the dispensing part 52.
  • the dust collecting unit 521 stands by in a state where the opening is directed obliquely downward.
  • the manipulator device 6 tilts the grasped tablet container 2 so that the opening of the tablet container 2 faces obliquely upward, and the tablet container 2 is positioned at a position where the opening on the tablet container 2 side and the opening on the dust collecting portion 521 side face each other. Place.
  • the lower region of the dispensing unit 52 penetrating the dust collecting unit 521 is inserted into the tablet container 2, and the tablet dispensed from the processing device 5 can be collected in the tablet container 2. .
  • the shutter 522 is opened, the tablet dispensed from the processing device 5 flows on the dispensing unit 52, and the tablet collecting operation for the tablet container 2 is carried out (can collecting step, process 35 in FIG. 6, FIG. 8).
  • the manipulator device 6 holds the tablet container 2 in an inclined state.
  • the tablets dispensed from the lower end of the dispensing unit 52 Can flow down in the tablet container 2 and form a tablet reservoir on the lower side of the tablet container 2.
  • the manipulator device 6 changes the posture of the tablet container 2 so that the formation surface of the opening faces upward. That is, during the tablet can collection step, the control unit 7 changes the direction of the gripping unit 63 so that the opening of the tablet container 2 faces the upper surface after starting the can collection with the tablet container 2 tilted. It can be said that the control signal to be output is output to the manipulator device 6.
  • the manipulator device 6 places the tablet container 2 on the collection base 501 that is the collection position, and releases the gripping of the tablet container 2 by the grasping portion 63.
  • the can collecting step can be performed even if the tablet container 2 is not grasped by the grasping portion 63, and the conveyance of the other tablet containers 2 is performed in parallel during the can collecting step. Is possible.
  • the opening of the large container is used to dispense the tablet.
  • the payout portion 52 is positioned higher than the height of the lower end portion.
  • a transport device that re-transports the tablet dispensed from the dispensing unit 52 to the height position of the opening of the large container is required (FIG. 3 of Patent Document 1).
  • the large container has a long drop distance from the opening to the lower side of the container, and the tablet is liable to break even when the can is collected.
  • the lower region of the dispensing unit 52 is defined as the tablet container 2. It is possible to provide the payout portion 52 at a height position where it can be directly inserted therein. As a result, it is not only necessary to install a transport device for re-transporting the tablets dispensed from the processing device 5, but the falling distance from the lower end of the dispensing portion 52 to the lower side in the tablet container 2 is shortened. Generation of cracks can be effectively suppressed.
  • the processing equipment of this example using the small tablet container 2 whose posture can be changed by the manipulator device 6 further causes the tablet to break by the change in the posture of the tablet container 2 described using the solid line and the broken line in FIG. It is easy to apply a restraining can method.
  • the manipulator device 6 is placed on the can table 501 when a predetermined amount of processed tablets are collected into the empty tablet container 2 by the can collecting step described with reference to FIGS.
  • the tablet container 2 after completion of the can collecting step is grasped by the grasping portion 63 and conveyed to the work space 33 (retraction step, process P36 in FIG. 6).
  • the operation of the manipulator device 6 in the charging step and the canning step described above will be described in more detail with reference to the time chart of FIG.
  • the horizontal axis of the time chart in FIG. 10 indicates the elapsed time.
  • the vertical axis indicates the amount of tablets accommodated in the hopper in the processing apparatus 5 into which the unprocessed tablets are charged, or in the tablet container 2 in which the processed tablets are collected.
  • the vertical axis of FIG. 10 shows the value in “can conversion” obtained by dividing the amount of tablets contained in each of the hopper and the tablet container 2 by the amount of tablets that can be accommodated in the tablet container 2.
  • the change in the amount of tablets accommodated in the hopper is indicated by a solid line
  • the change in the amount of tablets accommodated in the tablet container 2 is indicated by an alternate long and short dash line.
  • a band-shaped label with a downward-sloping hatch is also shown for the period in which the gripping part 63 of the manipulator device 6 grips the tablet container 2 that is performing the loading step. is there.
  • a band-like label with a left-down hatching is also shown for the period in which the gripping part 63 is gripping the tablet container 2 that is executing the can collecting step.
  • the processing device 5 provided in the processing facility of this example starts charging the tablet in the tablet container 2 into the processing device 5 in the charging step until the charging is completed.
  • the charging time A required for the collection is shorter than the collection time B required to complete the collection after the collection of the tablets into the tablet container 2 is started in the collection step.
  • the tablet container 2 is placed on the collection base 501 as described above (broken line in FIG. 5, FIG. 8), and the grip portion 63. Releases the gripping of the tablet container 2 by. As a result, during the period in which the can step for one tablet container 2 is being performed, the charging step for the other tablet containers 2 can be performed in parallel with the can step.
  • the loading step is performed on the “other tablet container 2” with the smallest number assigned to the placement position. Then, when the charging step for the other tablet containers 2 is completed, a standby transport step for transporting the empty tablet containers 2 to the standby shelf 4 is performed.
  • a can collecting step is performed for the “next one tablet container 2” having the smallest number assigned to the placement position. To do.
  • Implementation of the charging step and the can collection step based on the time chart planned in advance is actually provided with a sensor for measuring the level of the tablet pool in the hopper of the processing device 5 or the tablet container 2 to be collected. Based on the result, the tablet container 2 that is being charged with the tablet may be tilted in real time, or the opening of the shutter 522 configured to be able to adjust the amount of the tablet dispensed from the processing device 5 may be operated in real time. Also, based on the results of preliminary experiments conducted in advance, the inclination of the tablet container 2 and the opening of the shutter 522 are previously determined so that the amount of tablets collected in the hopper or tablet container 2 changes along the time chart. It may be set and the gripping unit 63 and the shutter 522 may be operated based on this setting.
  • the processing facility has the following effects. Using a single manipulator device 6 provided in the processing chamber 11 in which the processing device 5 for inspecting and printing tablets is arranged and having a multi-joint arm 62, the tablets are put into the processing device 5 from the tablet container 2. Then, the dispensing of the tablet from the processing device 5 to the tablet container 2 is executed. As a result, the tablet container 2 can be handled with a processing facility having a simple configuration without using a separately provided charging device and dispensing device.
  • the processing facility can be operated efficiently.
  • the case where the tablet loading step is performed in parallel has been described.
  • performing these steps in parallel is not an essential requirement.
  • the processing device 5 in which the can collection time B shown in FIG. 10 is as short as the input time A after the can collection step for one tablet container 2 is completed, These steps may be performed alternately as the dosing steps are performed.
  • the order in which the charging step and the can collecting step are performed on the plurality of tablet containers 2 is also executed based on the order of execution set in association with the placement position of each tablet container 2 in the standby shelf 4. It is not limited. For example, even if each tablet container 2 is attached with a bar code or RF (Radio Frequency) tag including information indicating the execution order in advance and each step is executed based on the result of reading the information regarding the execution order. Good.
  • RF Radio Frequency
  • the standby shelf 4 on which the tablet containers 2 before the loading step is placed, the standby position on which the empty tablet containers 2 after the loading step are placed, and the tablet containers 2 after the can collecting step are placed.
  • a configuration may be adopted in which the retracted position to be placed is set as a separate position and the implementation status of each step is grasped according to the position where the tablet container 2 is placed. In this case, since the next step to be performed on the tablet container 2 placed at each position is uniquely determined, a plurality of tablet containers 2 placed at each position are individually identified. Even if the selection is made randomly, the charging step and the can-collecting step can be executed in the correct order for each tablet container 2.
  • the manipulator device 6 can be transported, and the size of the tablet container 2 does not interfere with the ceiling surface or the side wall surface of the processing chamber 11 in the operation of feeding the tablet, collecting the cans, or transporting the tablet container 2.
  • the size is such that cracking due to the drop of the tablet from the opening to the lower side of the tablet container 2 is unlikely to occur, the case of handling the tablet container 2 having an internal capacity exceeding 200 liters is denied. It is not a thing.
  • the operation performed by the operator in the processing chamber 11 is not limited to the removal and attachment of the lid of the tablet container 2.
  • other operations such as fastening these tablet containers 2 on the tray mounting table 31 with a fastening band may be performed.
  • the technology for transporting the tablet container 2 by providing one manipulator device 6 in the processing equipment including the processing device 5 that performs at least one of tablet inspection and printing has been described.
  • the processing provided with the processing device for performing other processing such as tableting process, coating process, packaging process, etc., described with reference to FIG.
  • the tablet transport operation using the tablet container 2 occurs in the chamber 11 (tablet processing facility)
  • the tablet container 2 using the manipulator device 6 may be transported.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Specific Conveyance Elements (AREA)
  • Basic Packing Technique (AREA)

Abstract

Le problème décrit par la présente invention est de fournir une installation de traitement de comprimés présentant une configuration simple. La solution selon l'invention porte sur une installation de traitement de comprimés dans laquelle les comprimés sont transformés, un dispositif manipulateur unique (6) étant disposé à l'intérieur d'une chambre de traitement (11) et un dispositif de traitement (5) inspectant et/ou imprimant un comprimé, ledit dispositif manipulateur comprenant une pièce de préhension (63) qui saisit un récipient de comprimés (2) et un bras articulé (62). Une unité de commande (7) délivre, au dispositif manipulateur (6), un signal de commande pour mettre en œuvre : une étape d'introduction pour le transport, vers une section d'introduction (51), d'un récipient de comprimés (2) qui accueille un comprimé non transformé, en saisissant le récipient de comprimés (2) à l'aide de la pièce de préhension (63), et en introduisant le comprimé à l'intérieur du récipient de comprimés (2) dans le dispositif de traitement (5); et une étape d'étanchéification destiné à transporter, vers une section de distribution (52), le récipient de comprimés (2) après que le comprimé ait été introduit, et à étanchéifier le récipient de comprimés (2) contenant le comprimé transformé par l'intermédiaire de la pièce de distribution (52).
PCT/JP2016/076816 2016-09-12 2016-09-12 Installation de traitement de comprimés WO2018047345A1 (fr)

Priority Applications (3)

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CN201680087030.8A CN109414372B (zh) 2016-09-12 2016-09-12 药片处理设备
PCT/JP2016/076816 WO2018047345A1 (fr) 2016-09-12 2016-09-12 Installation de traitement de comprimés
JP2018509934A JP6435436B2 (ja) 2016-09-12 2016-09-12 錠剤処理設備

Applications Claiming Priority (1)

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PCT/JP2016/076816 WO2018047345A1 (fr) 2016-09-12 2016-09-12 Installation de traitement de comprimés

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WO2014013973A1 (fr) * 2012-07-19 2014-01-23 大塚製薬株式会社 Machine à imprimer et comprimé associé
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JP2009504199A (ja) * 2005-05-16 2009-02-05 インテリジェント ホスピタル システムズ リミテッド 自動薬局混合システム（ａｐａｓ）
WO2014013973A1 (fr) * 2012-07-19 2014-01-23 大塚製薬株式会社 Machine à imprimer et comprimé associé
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JP2020189370A (ja) * 2019-05-22 2020-11-26 株式会社日本設計工業 容器のロボットハンドリングシステム
JP7252543B2 (ja) 2019-05-22 2023-04-05 株式会社日本設計工業 容器のロボットハンドリングシステム

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JPWO2018047345A1 (ja) 2018-11-15
CN109414372A (zh) 2019-03-01
JP6435436B2 (ja) 2018-12-05

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