WO2018015242A1 - Dispositif d'administration de médicament pour la détection d'une fin de dose - Google Patents

Dispositif d'administration de médicament pour la détection d'une fin de dose Download PDF

Info

Publication number
WO2018015242A1
WO2018015242A1 PCT/EP2017/067523 EP2017067523W WO2018015242A1 WO 2018015242 A1 WO2018015242 A1 WO 2018015242A1 EP 2017067523 W EP2017067523 W EP 2017067523W WO 2018015242 A1 WO2018015242 A1 WO 2018015242A1
Authority
WO
WIPO (PCT)
Prior art keywords
cartridge
dose
drug
indicator member
delivery device
Prior art date
Application number
PCT/EP2017/067523
Other languages
English (en)
Inventor
André LARSEN
Original Assignee
Novo Nordisk A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk A/S filed Critical Novo Nordisk A/S
Publication of WO2018015242A1 publication Critical patent/WO2018015242A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31566—Means improving security or handling thereof
    • A61M5/3157—Means providing feedback signals when administration is completed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31566—Means improving security or handling thereof
    • A61M5/31568—Means keeping track of the total dose administered, e.g. since the cartridge was inserted
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3125—Details specific display means, e.g. to indicate dose setting
    • A61M2005/3126—Specific display means related to dosing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3317—Electromagnetic, inductive or dielectric measuring means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3379—Masses, volumes, levels of fluids in reservoirs, flow rates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/50—General characteristics of the apparatus with microprocessors or computers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically

Definitions

  • the present invention generally relates to a drug delivery device adapted to expel a drug of dose from a drug cartridge. More specifically, the invention relates to the issue of informing a user of an end-of-dose condition.
  • Drug delivery devices in the form of injection devices for subcutaneous administration of fluid drugs have greatly improved the lives of patients who must self-administer drugs and biological agents.
  • Drug injection devices may take many forms, from simple disposable devices to highly sophisticated electronically controlled motorized instruments with numerous functions. Regardless of their form, they have proven to be great aids in assisting patients to self- administer injectable drugs and biological agents. They also greatly assist care givers in administering injectable medicines to those incapable of performing self-injections.
  • injection devices have proven to provide an accurate, convenient, and often discrete, way to administer drugs and biological agents, such as insulin.
  • injection devices use a pre-filled cartridge containing the medication of interest, e.g. 1.5 or 3.0 ml of insulin or growth hormone.
  • the cartridge is typically in the form of a generally cylindrical transparent ampoule with a needle pierceable septum at one end and an opposed piston designed to be moved by the dosing mechanism of the injection device.
  • the injection devices are generally of two types: “Durable” devices and "disposable” devices.
  • a durable device is designed to allow a user to replace one cartridge with another cartridge, typically a new cartridge in place of an empty cartridge.
  • a disposable device is provided with an integrated cartridge which cannot be replaced by the user; when the cartridge is empty the entire device is discarded.
  • the drive means delivering the force to move the cartridge piston forwards during expelling of a dose of drug.
  • injection devices have been manually actuated by the user pushing an extendable button during expelling, however, alternatively the driving force may be provided by a spring being pre-strained or strained dur- ing dose setting and subsequently released, this allowing for "automatic" dispensing of drug.
  • the internal parts of the device apply pressure to a fluid drug in a container to overcome flow resistance in the device, i.e. mostly the attached injection needle, and the tissue/skin of the recipient.
  • injection systems using a cartridge comprising an elastic rubber piston is characterised in that the piston will be more or less deformed when the piston driver, e.g. typically a piston rod, is advanced, this typically providing the largest contribution to elastic deformation build-up during out-dosing.
  • the piston driver e.g. typically a piston rod
  • the properties should be detected in a simple and effective way, the arrangement being sensitive, cost-effective and reliable.
  • a method of providing an end-of-dose notification to a user comprising the steps of providing a drug delivery device comprising a cartridge containing a drug to be expelled and a user-settable dose expelling mechanism, setting a dose to be expelled, expelling the set dose from the cartridge, monitor- ing volume change in the cartridge during expelling, and notify the user when volume change has reached a pre-determined value, e.g. stopped, this indicating an end-of-dose state.
  • the definition "monitoring volume change in the cartridge during expelling” includes the period after the dose expelling mechanism has stopped moving (or is close to having stopped) and covers the situations in which volume change is monitored (i) both before and after the dose expelling mechanism has stopped moving (or is close to having stopped), and (ii) only after the dose expelling mechanism has stopped moving (or is close to having stopped). In this way a simple and reliable method is provided allowing a user to be informed when a "true" end-of-dose state has been reached.
  • the volume change may be calculated using a capacitive sensor arrangement, wherein the capacitive sensor arrangement may comprise at least one transmitter member arranged on the outer surface of the cartridge.
  • the dose expelling mechanism comprises an indicator member rotating during expelling of a dose
  • the method comprising the further step of detecting rotational movement of the indicator member, wherein the monitoring of volume change in the cartridge starts when rotational movement of the indicator member has been detected, i.e. detection starts during rotation.
  • the method comprises the further step of determining when rotational movement of the indicator member has stopped or reached a predetermined value, wherein the monitoring of volume change in the cartridge starts when it has been determined that rotational movement of the indicator member has stopped or reached a pre-determined value.
  • Rotational movement of the indicator member may be detected using a capacitive sensor arrangement.
  • An expected end-of-delivery time may be calculated based on at least the expelled dose size, the expelled dose size being calculated based on a determined amount of rotation of the indicator member, wherein the expected end-of-delivery time is displayed to the user.
  • the displayed end-of-delivery time is displayed as a count-down value.
  • a drug delivery device comprising a drug-filled cartridge or means for receiving a drug-filled cartridge, the cartridge comprising an axially displaceable piston and a distal outlet portion.
  • the drug delivery device comprises a drug expelling mechanism comprising dose setting means allowing a user to set the size of a dose of drug to be expelled, and a piston rod adapted to move the piston of a cartridge in a distal direction to thereby expel drug from the cartridge.
  • the drug delivery device further comprises electronic circuitry comprises sensor means adapted to monitoring volume change in a cartridge during expelling, and means for notifying the user when volume change has stopped, this indicating an end-of-dose state.
  • the sensor means may comprise a capacitive sensor arrangement adapted to detect a variable volume parameter, and a comprised cartridge may comprise at least one capacitive transmitter member arranged on the outer surface of the cartridge.
  • the drug expelling mechanism comprises an indicator member rotating during expelling of a dose
  • the electronic circuitry comprises sensor means adapted to detect rotational movement of the indicator member.
  • the electronic circuitry is adapted to calculate an expected end-of-delivery time based on at least the expelled dose size, wherein the expelled dose size being calculated based on a determined amount of rotation of the indicator member.
  • the electronic circuitry may comprise a display, wherein the expected end-of-delivery time is displayed to the user on the display.
  • the means for notifying the user when volume change has stopped or reached a pre-determined value may also be provided by the display.
  • the drug expelling mechanism comprises an indicator member rotating during expelling of a dose
  • the electronic circuitry comprises sensor means adapted to detect rotational movement of the indicator member.
  • the monitoring of volume change in the cartridge starts when rotational movement of the indicator member has been detected.
  • the monitoring of volume change in the cartridge starts when it has been determined that rotational movement of the indicator member has stopped or reached a pre-determined value.
  • the drug delivery device may comprise a cartridge holder portion adapted to accommodate a cartridge, the cartridge holder portion comprising the electronic circuitry.
  • the drug delivery device comprises a flexible sheet on which is formed or mounted the electronic circuitry, comprising the sensor means, a display, a processor, and an energy source.
  • the sensor means, display, processor, and energy source may be in the form of printed electronics.
  • drug is meant to encompass any flowable medicine formulation capable of being passed through a delivery means such as a cannula or hollow needle in a controlled manner, such as a liquid, solution, gel or fine suspension, and containing one or more drug agents.
  • Representative drugs include pharmaceuticals such as peptides (e.g. insulins, insulin containing drugs, GLP-1 containing drugs as well as derivates thereof), proteins, and hormones, biologically derived or active agents, hormonal and gene based agents, nutritional formulas and other substances in both solid (dispensed) or liquid form.
  • peptides e.g. insulins, insulin containing drugs, GLP-1 containing drugs as well as derivates thereof
  • proteins e.g. insulins, insulin containing drugs, GLP-1 containing drugs as well as derivates thereof
  • hormones e.g. insulins, insulin containing drugs, GLP-1 containing drugs as well as derivates thereof
  • hormones e.g. insulins, insulin containing drugs, GLP-1 containing drugs as well as
  • figs. 1 A and 1 B show a generic drug delivery device with and without a cap mounted
  • fig. 2 shows a drug cartridge comprising capacitive transmitters
  • fig. 3 shows in a sectional view a piston rod distal portion
  • figs. 4A and 4B show a drug delivery device with an electronic label.
  • distal end in the appended figures is meant to refer to the end of the injection device which usually is adapted to carry an injection needle as depicted e.g. in fig. 1 B whereas the term “proximal end” is meant to refer to the opposite end pointing away from the injection needle end.
  • the component is a unitary component, however, the same member or element may alternatively comprise a number of subcomponents just as two or more of the described components could be provided as unitary components, e.g. manufactured as a single injection moulded part.
  • a prefilled drug delivery such a device providing the basis for the exemplary embodiments of the present invention.
  • the pen-formed drug delivery assembly 100 shown in figs. 1A and 1 B may represent a "generic" drug delivery device
  • the actually shown device is a FlexTouch® prefilled drug delivery pen as manufactured and sold by Novo Nordisk A S, Bagsvaerd, Denmark.
  • FlexTouch® prefilled drug delivery pen as manufactured and sold by Novo Nordisk A S, Bagsvaerd, Denmark.
  • WO 2014/161952 which is hereby incorporated by reference.
  • the pen assembly 100 comprises a cap part 1 10 and a main drug delivery device (or part) 105 having a proximal body or drive assembly portion with a housing 101 in which a drug expelling mechanism is arranged or integrated, and a distal cartridge holder 120 in which a drug-filled transparent cartridge 130 with a distal drug outlet in the form of a needle- penetrable septum 131 is arranged and retained in place by a non-removable cartridge holder attached to the proximal portion, the cartridge holder having openings allowing a portion of the cartridge to be inspected as well as distal coupling means 125 allowing a needle assembly to be releasably mounted.
  • the cartridge holder 120 comprises proximal coupling means 121 adapted to engage corresponding coupling means arranged on the cap interior surface.
  • the cap may be designed to engage coupling means arranged on the main device distal portion.
  • the cartridge is provided with a piston driven by a piston rod forming part of the expelling mechanism and may for example contain an insulin, GLP-1 or growth hormone formulation.
  • a proximal-most rotatable dose setting member 180 serves to manually set a desired dose of drug shown in display window 102 and which can then be expelled when the button 190 is actuated.
  • the expelling mechanism may comprise a spring as in the shown embodiment which is strained during dose setting and then released to drive the piston rod when the release button is actuated.
  • the expelling mechanism may be fully manual in which case the dose member and the actuation button moves proximally during dose setting corresponding to the set dose size, and then is moved distally by the user to expel the set dose, e.g. as in a FlexPen® manufactured and sold by Novo Nordisk A/S.
  • figs. 1A and 1 B show a drug delivery device of the pre-filled type, i.e.
  • the drug delivery device may be designed to allow a loaded cartridge to be replaced, e.g. in the form of a "rear-loaded” drug delivery device in which the cartridge holder is adapted to be removed from the device main portion, or alternatively in the form of a "front-loaded” device in which a cartridge is inserted through a distal opening in the cartridge holder which is non-removable attached to the main part of the device.
  • fig. 2 discloses a modified traditional drug cartridge 200 comprising a cylindrical main portion 201 and a neck portion 202.
  • the main portion is provided with a pair of transmitters 210, 21 1 formed from conductive material on the outer surface, the transmitters taking up approximately 25% of the cylindrical surface in the shown embodiment.
  • the circumferential width of each of the transmitters vary along the length of the cartridge, the first transmitter 210 having a circumferential width which diminishes towards the distal end of the cartridge, and the second transmitter 21 1 having a circumferential width which increases towards the distal end of the cartridge.
  • the combined circumferential width for the two transmitters is constant along the length of the transmitters.
  • the portion of the drug delivery device surrounding the cartridge comprises electronic sensor circuitry adapted to interact with the cartridge transmitters.
  • Two alternating electrical fields shifted in phase are applied on each of the two transmitters on the outer surface of the cartridge. This induces an alternating electrical field in the drug with a phase depending on the size of each of the areas of the two transmitters covered by the drug.
  • a capacitive receiver 220 arranged on the opposite side of the cartridge pick up the electrical field and by measuring the phase-shift, the remaining drug volume in the cartridge can be determined.
  • the continued expelling of drug after the piston rod stops rotating can be detected and an end-of-dose notification can be communicated to the user, e.g. by means of a display.
  • the end-of-dose detection is based on de- termination of volume change as a function of time, and not on determination of absolute volume values, the method is not sensitive to normal variations in e.g. cartridge dimensions and thus robust.
  • the drug delivery device cartridge holder portion comprises a flexible sheet on which is formed or mounted electronic circuitry comprising sensor means adapted to provide the above-described functionality, e.g. electric field generators, capacitive receiver plates, a processor, a display and an energy source, the flexible sheet being mounted at least in part to the exterior and/or inte- rior surface of the cartridge holder housing.
  • the processor Based on input from the capacitive receiver the processor is adapted to control the display to indicate that end-of-dose event has been detected.
  • one or more or all of the sensor means, display, processor, and energy source may be in the form of printed electronics, see e.g. WO 2015/071354 which is hereby incorporated by reference.
  • the energy source may be incorporated in the device cap, this allowing e.g. a conventional button type "battery” cell to be utilized.
  • the "label electronics” may comprise a capacitor adapted to store energy provided by the battery, the label and the cap comprising corresponding galvanic contacts allowing charging of the capacitor during the time when the cap is mounted on the cartridge holder.
  • the contacts may be utilized to detect removal of the cap, this providing that the electronics are powered on.
  • the cap may be provided with a replaceable or rechargeable battery allowing the cap to be used as a durable component in combination with disposable pen devices.
  • the drug delivery device expelling mechanism is provided with output means allowing rotational movement of an expelling mechanism component to be detected during drug expelling.
  • Many known drug expelling mechanisms including the above-mentioned FlexTouch® pre- filled drug delivery pen, comprise components which rotate during drug expelling corresponding to the expelled dose, e.g. a piston driver and the piston rod as in the FlexTouch® pen, see the above-mentioned WO 2014/161952.
  • the piston rod also moves axially just as it has a relatively small diameter and is arranged at a distance from the outer pen housing, the piston rod may not be considered the best component to provide a detectable rotational output.
  • the piston driver in the FlexTouch® has a larger diameter and does not move axially during drug expelling, however, the driver is positioned in the device main part at a distance from the cartridge holder portion.
  • the pen device 300 shown in fig. 3 is provided with an indicator disc 310 which engages the piston rod 330 and rotates therewith yet allows the piston rod to move axially relative to the indicator disc, this allowing the indicator disc to be arranged axially stationary relative to the housing and cartridge holder.
  • the indicator disc comprises a circumferential edge portion 31 1 on which a number of conductive sensor areas 312 are provided, e.g. by printing.
  • the electronic circuitry arranged in the cartridge holder portion 320 comprises additional ca- pacitive sensor means 321 allowing rotation of the indicator disc to be detected as the disc conductive areas pass the sensor means.
  • the system may be adapted to merely sense motion which may be used to initiate volume sensing, e.g. starting when rotation is initially detected or when rotation stops.
  • the electronic circuitry may be adapted to detect and count the number of passing disc sensor areas to thus determine the amount of expelled drug, i.e. the dose size.
  • a determined dose size may be used to provide different information to the user. For example, for a pre-filled device the initial drug volume is known and it would thus be possible after each expelled dose to calculate and display the amount of remaining drug.
  • the detected dose amounts could be stored in a dose log and subsequently transmitted to an external device, e.g. via an antenna incorporated in the flexible label.
  • a timer e.g. a simple relative timer
  • a time-dose log could be created, the relative time being "translated" to real time when the log is transmitted to an external device with a build-in real time clock.
  • Fig. 4A shows a drug delivery device 400 in which a flexible electronic label 440 is mounted on the cartridge holder portion 420, the label comprising electronic circuitry provided with ca- pacitive sensing means for sensing both the current cartridge drug volume and rotation of the above-described indicator disc, as well as a display adapted to display both a detected ex- pelled dose size 441 , a calculated count-down value 442 and an indicator 443 (see fig. 4B) for a detected end-of-dose state.
  • the electronic label is manufactured using, at least in part, printed electronics.
  • the display window 402 should correctly show "0" instead of "12" as the expelling mechanism in the shown states has returned the scale drum the zero position.

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  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

L'invention concerne un procédé pour fournir une notification de fin de dose à un utilisateur, comprenant les étapes consistant à (i) la fourniture d'un dispositif d'administration de médicament comprenant une cartouche contenant un médicament à expulser, et un mécanisme d'expulsion de dose réglable par l'utilisateur, (ii) à régler une dose à expulser, (iii) à expulser la dose définie de la cartouche, (iv) à surveiller le changement de volume dans la cartouche pendant l'expulsion, et (v) à avertir l'utilisateur lorsque le changement de volume s'est arrêté, ce qui indique un état de fin de dose. Dans un autre aspect, l'invention concerne un dispositif d'administration de médicament correspondant.
PCT/EP2017/067523 2016-07-21 2017-07-12 Dispositif d'administration de médicament pour la détection d'une fin de dose WO2018015242A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16180559 2016-07-21
EP16180559.3 2016-07-21

Publications (1)

Publication Number Publication Date
WO2018015242A1 true WO2018015242A1 (fr) 2018-01-25

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PCT/EP2017/067523 WO2018015242A1 (fr) 2016-07-21 2017-07-12 Dispositif d'administration de médicament pour la détection d'une fin de dose

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109011117A (zh) * 2018-08-27 2018-12-18 中山市普利斯微创介入医械有限公司 一种一次性使用给药管
CN114746138A (zh) * 2019-09-25 2022-07-12 杨森制药公司 测量与药物施用相关联的参数和结合参数测量的药物施用装置
WO2023078848A1 (fr) * 2021-11-03 2023-05-11 Sanofi Dispositif d'alimentation électrique pour une unité électronique d'un dispositif d'administration de médicament

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007107558A2 (fr) * 2006-03-20 2007-09-27 Novo Nordisk A/S Détermination du contenu d'une cartouche à l'aide de moyens capacitifs
WO2012140097A2 (fr) * 2011-04-11 2012-10-18 Novo Nordisk A/S Dispositif d'injection incorporant une surveillance de dose
WO2014161952A1 (fr) 2013-04-05 2014-10-09 Novo Nordisk A/S Dispositif d'enregistrement de dose destiné à un dispositif d'administration de médicament
WO2015071354A1 (fr) 2013-11-13 2015-05-21 Novo Nordisk A/S Dispositif d'administration de médicament avec fonction indicatrice de temps

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007107558A2 (fr) * 2006-03-20 2007-09-27 Novo Nordisk A/S Détermination du contenu d'une cartouche à l'aide de moyens capacitifs
WO2012140097A2 (fr) * 2011-04-11 2012-10-18 Novo Nordisk A/S Dispositif d'injection incorporant une surveillance de dose
WO2014161952A1 (fr) 2013-04-05 2014-10-09 Novo Nordisk A/S Dispositif d'enregistrement de dose destiné à un dispositif d'administration de médicament
WO2015071354A1 (fr) 2013-11-13 2015-05-21 Novo Nordisk A/S Dispositif d'administration de médicament avec fonction indicatrice de temps

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109011117A (zh) * 2018-08-27 2018-12-18 中山市普利斯微创介入医械有限公司 一种一次性使用给药管
CN109011117B (zh) * 2018-08-27 2023-11-21 中山市普利斯微创介入医械有限公司 一种一次性使用给药管
CN114746138A (zh) * 2019-09-25 2022-07-12 杨森制药公司 测量与药物施用相关联的参数和结合参数测量的药物施用装置
WO2023078848A1 (fr) * 2021-11-03 2023-05-11 Sanofi Dispositif d'alimentation électrique pour une unité électronique d'un dispositif d'administration de médicament

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