WO2016141774A1 - Uses of jilin ginseng oligopeptide in preparing food product or healthcare food product for improving and enhancing sexual function - Google Patents
Uses of jilin ginseng oligopeptide in preparing food product or healthcare food product for improving and enhancing sexual function Download PDFInfo
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- the invention relates to a new use of Jilin ginseng oligopeptide, in particular to the use of Jilin ginseng oligopeptide in foods and health foods for improving and enhancing sexual function.
- a bioactive peptide refers to a peptide compound that is beneficial or physiologically active to the living activities of a living organism.
- Peptides are intermediate in amino acid and protein in molecular structure, but they have functions that cannot be replaced by amino acids and proteins.
- Oligopeptides also known as active small molecule peptides, generally consist of 10 or fewer amino acids. Studies have found that oligopeptides are more effective than single amino acid absorption and can directly participate in protein synthesis, thus improving the body's protein utilization. In the case of obstacles in the amino acid transport system, the ingestion of oligopeptides can achieve good absorption.
- bioactive peptides have a wide range of biological activities, such as immune regulation, cholesterol lowering, blood pressure lowering, antithrombotic, anti-cancer, anti-viral, anti-oxidation and scavenging free radicals, and promote growth.
- bioactive peptides have emerged with their high efficiency and safety, and gradually show their important role in clinical nutrition and broad application prospects.
- Ginseng is a valuable Chinese herbal medicine.
- the medicinal use of ginseng has been more than 4,000 years old.
- the ginseng of our country is the dry root and rhizome of the ginseng of the Araliaceae plant, which is mainly produced in Jilin province.
- the Ministry of Health of China approved ginseng as a new resource food.
- Ginseng has the effects of replenishing vitality, quenching thirst, and calming the nerves.
- Studies on ginseng extract ginsenosides also found that ginsenoside Rb 1 significantly improved sexual function in mice.
- the effect of oligopeptides as an important component of ginseng on sexual function has not been reported.
- the ginseng oligopeptide can be directly absorbed in the human body without digesting, thereby avoiding the waste of the active substance and greatly improving its biological activity, and can be used as a novel formula for improving the food function of the food or health food.
- the object of the present invention is to provide a low-viscosity, easy-to-absorb and fast-absorbing Jilin ginseng oligopeptide in the preparation of an improved and enhanced functional food or health food, and a method for improving and enhancing sexual function through diet. New approach.
- the food described therein is a powder, a liquid beverage, a milk powder, and a dairy or bakery product.
- the health food described therein is a powder, a tablet, a soft/hard capsule or an oral solution.
- Jilin Ginseng Oligopeptide has a function of enhancing sexual function, and has found its use in preparing foods or health foods which improve and enhance sexual functions.
- Animal experiments have found that Jilin ginseng oligopeptides can effectively improve the sexual function of male mice.
- Sample Jilin ginseng oligopeptide, produced by Jilin Peptide Bioengineering Co., Ltd., light yellow solid powder, the main component is a small molecule oligopeptide with molecular weight less than 1000, the content is 97.4%.
- mice Male mice were randomly divided into 7 groups according to their body weight, 24 in each group.
- a blank control group whey protein group (0.50g/kg ⁇ bw) and 5 Jilin ginseng oligopeptide dose groups (0.125g/kg ⁇ bw 0.25g/kg ⁇ bw, 0.50g/kg ⁇ bw, 1.00g) were established. /kg ⁇ bw, 2.00g/kg ⁇ bw, respectively, expressed in Jilin ginseng oligopeptides one, two, three, four, five groups).
- Each group of animals was subdivided into 2 subgroups, 12 in each group.
- mice were given distilled water, and the other groups were given the corresponding concentrations of whey protein and aqueous solution of Jilin ginseng oligopeptide. Each group of mice was given normal feed, free to eat and drink. The rats were intragastrically administered once a day, and each experiment was carried out after 30 days of continuous gavage.
- mice in the first subgroup of each group were taken, and the body weight of the mice was weighed 30 min after the last administration.
- the blood was taken from the eyeball, and the blood samples of the mice were placed in a refrigerator at 4 ° C for about 3 hours, centrifuged at 2000 r / min for 15 min to separate serum, and serum NO and testosterone levels were measured.
- the serum testosterone content was determined by Xi'an Nuclear Instrument Factory ⁇ radioimmunoassay counter XH-6080, and the reagent was reagent from Beijing North Biotechnology Research Institute.
- the NO content in the serum was carried out according to the instructions of the nitric oxide detection kit, and the kit was purchased from the Biyuntian Biotechnology Research Institute.
- the animals were sacrificed, and the testes, epididymis, seminal vesicles and prostate were accurately weighed on an electronic balance, and the organ index (organ weight/body weight ⁇ 100) was calculated.
- mice in the second subgroup of each group were taken and administered 60 minutes after the last administration.
- Female mice were given continuous administration of diethylstilbestrol 3 days before the experiment, and administered subcutaneously at a dose of 1 mg/kg per day to enter the estrus period.
- a single male mouse was placed in a 30 cm x 15 cm x 15 cm mating box for 5 min, and then 2 female mice were placed. Record the time from the cage to the first mating (ie mating latency) and the number of matings within 20 min. The observation time was from 20:00 to 23:00, and the mating test was carried out under low light and quiet conditions.
- ** indicates p ⁇ 0.01 compared to the whey protein group.
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Abstract
Uses of Jilin ginseng oligopeptide in preparing a food product or healthcare food product for improving and enhancing sexual function.
Description
本发明涉及吉林人参低聚肽的一种新用途，具体来说是吉林人参低聚肽在改善和增强性功能的食品或保健食品中的用途。The invention relates to a new use of Jilin ginseng oligopeptide, in particular to the use of Jilin ginseng oligopeptide in foods and health foods for improving and enhancing sexual function.
随着社会和经济的不断发展，人类对生活质量的要求越来越高，现代社会的快节奏引起男性的身心疲劳、劳累过度、烟酒过量等诱因使得男性性功能障碍的发病率不断升高。据估计，全球范围内患不同程度性功能障碍的男子至少有数亿人。我国上海对1582名40岁以上的城市男性进行调查，发现***功能障碍发病率高达73.1％。性功能障碍直接影响男性的自尊心和心理健康，损害夫妻感情及家庭稳定，且与其它的涉及男性健康的疾病如心血管疾病、糖尿病、肝肾疾病、***疾病以及精神方面的疾病等密切相关，因此寻找安全而有效的天然化学物来增强性功能和改善性功能障碍显得尤为迫切。With the continuous development of society and economy, human beings have higher and higher requirements for the quality of life. The rapid rhythm of modern society causes men's physical and mental fatigue, overwork, excessive alcohol and tobacco, etc., causing the incidence of male sexual dysfunction to rise. . It is estimated that there are at least hundreds of millions of men with varying degrees of sexual dysfunction worldwide. A survey of 1,582 urban men over the age of 40 in Shanghai, China, found that the incidence of erectile dysfunction was as high as 73.1%. Sexual dysfunction directly affects men's self-esteem and mental health, damages marital relationship and family stability, and is closely related to other diseases involving men's health such as cardiovascular disease, diabetes, liver and kidney disease, prostate disease and mental illness. Therefore, it is particularly urgent to find safe and effective natural chemicals to enhance sexual function and improve sexual dysfunction.
生物活性肽是指对生物机体的生命活动有益或具有生理作用的肽类化合物。肽在分子结构上处于氨基酸和蛋白质的中间位置，但它具有氨基酸和蛋白质所不能替代的功能。低聚肽，又称为活性小分子肽，一般由10个或10个以下氨基酸组成。研究发现低聚肽比单个氨基酸的吸收更有效，且能直接参与蛋白质的合成，因此提高了机体对蛋白质的利用率。在氨基酸运输***出现障碍的情况下，摄入低聚肽却能获得良好的吸收效果。另外，生物活性肽类具有广泛的生物活性，如免疫调节、降胆固醇、降血压、抗血栓、抗癌、抗病毒、抗氧化和清除自由基作用、促进生长等。目前生物活性肽以其高效、安全的特点异军突起，逐渐显示出其在临床营养中的重要作用和广泛的应用前景。A bioactive peptide refers to a peptide compound that is beneficial or physiologically active to the living activities of a living organism. Peptides are intermediate in amino acid and protein in molecular structure, but they have functions that cannot be replaced by amino acids and proteins. Oligopeptides, also known as active small molecule peptides, generally consist of 10 or fewer amino acids. Studies have found that oligopeptides are more effective than single amino acid absorption and can directly participate in protein synthesis, thus improving the body's protein utilization. In the case of obstacles in the amino acid transport system, the ingestion of oligopeptides can achieve good absorption. In addition, bioactive peptides have a wide range of biological activities, such as immune regulation, cholesterol lowering, blood pressure lowering, antithrombotic, anti-cancer, anti-viral, anti-oxidation and scavenging free radicals, and promote growth. At present, bioactive peptides have emerged with their high efficiency and safety, and gradually show their important role in clinical nutrition and broad application prospects.
人参为名贵中药材，有关人参的药用已经有四千多年的历史。目前世界上的人参主要有四种：即我国的“吉林人参”、朝鲜的“高丽参”、日本的“东洋参”和加拿大、美国的“西洋参”。我国的人参为五加科植物人参的干燥根及根茎，主要产于吉林省。2012年9月4日，中国***批准人参成为新资源食品，人参的应用将由单一的中药材及保健产品拓展到食品、饮料等领域，范围大幅扩大，这为我国的人参产业发展提供了新的契机。人参具有大补元气、生津止渴、安神等功效。研究发现，人参可加速性成熟过程,对于性机能及性器官发育均有良好促进作用,对应激所致性行为低下亦有较好改善作用。对人参提取物人参皂甙的研究也发现，人参皂苷Rb1可显著改善小鼠性功能。而其中的低聚肽类作为人参中重要的成分对性功能的影响目前未见报道。人参低聚肽在人体不需消化可直接吸收，因而可避免活性物质的
浪费，大大提高其生物活性，可作为一种新型的具有改善和增强性功能作用的食品或保健食品的配方。Ginseng is a valuable Chinese herbal medicine. The medicinal use of ginseng has been more than 4,000 years old. At present, there are four main types of ginseng in the world: China's "Jilin Ginseng", North Korea's "Gao Lishen", Japan's "American ginseng" and Canada, the United States'"Americanginseng". The ginseng of our country is the dry root and rhizome of the ginseng of the Araliaceae plant, which is mainly produced in Jilin Province. On September 4, 2012, the Ministry of Health of China approved ginseng as a new resource food. The application of ginseng will be expanded from a single Chinese herbal medicine and health care products to food, beverage and other fields, and the scope will be greatly expanded, which provides a new development for China's ginseng industry. Opportunity. Ginseng has the effects of replenishing vitality, quenching thirst, and calming the nerves. The study found that ginseng can accelerate the process of sexual maturation, promote the sexual function and sexual organ development, and improve the sexual behavior caused by stress. Studies on ginseng extract ginsenosides also found that ginsenoside Rb 1 significantly improved sexual function in mice. The effect of oligopeptides as an important component of ginseng on sexual function has not been reported. The ginseng oligopeptide can be directly absorbed in the human body without digesting, thereby avoiding the waste of the active substance and greatly improving its biological activity, and can be used as a novel formula for improving the food function of the food or health food.
发明内容Summary of the invention
本发明的目的在于提供一种低粘度、易吸收且吸收快的吉林人参低聚肽在制备改善和增强性功能食品或保健食品中的用途，为通过饮食方式来改善和增强性功能提供一种新途径。The object of the present invention is to provide a low-viscosity, easy-to-absorb and fast-absorbing Jilin ginseng oligopeptide in the preparation of an improved and enhanced functional food or health food, and a method for improving and enhancing sexual function through diet. New approach.
其中所述的食品为粉剂、液体饮料、奶粉及奶制品或烘焙制品。The food described therein is a powder, a liquid beverage, a milk powder, and a dairy or bakery product.
其中所述的保健食品为粉剂、片剂、软/硬胶囊或口服液。The health food described therein is a powder, a tablet, a soft/hard capsule or an oral solution.
本发明发现了现有物质—吉林人参低聚肽具有增强性功能的功能，发现了其在制备改善和增强性功能的食品或保健食品中的用途。动物实验发现吉林人参低聚肽能够有效的提高雄性小鼠的性功能。The present inventors have found that the existing substance, Jilin Ginseng Oligopeptide, has a function of enhancing sexual function, and has found its use in preparing foods or health foods which improve and enhance sexual functions. Animal experiments have found that Jilin ginseng oligopeptides can effectively improve the sexual function of male mice.
下面结合具体实施例对本发明做进一步说明，这些实例应被理解为仅是举例说明，而非以任何方式限制本发明的范围。The invention is further illustrated by the following examples, which are to be considered as illustrative and not restrictive.
实施例1、对雄性小鼠性功能影响的实验研究Example 1. Experimental study on the effects of sexual function in male mice
一、材料和方法I. Materials and methods
样品：吉林人参低聚肽，由吉林肽谷生物工程有限责任公司生产，淡黄色固体粉末，主要成分为分子量小于1000的小分子低聚肽，含量为97.4％。Sample: Jilin ginseng oligopeptide, produced by Jilin Peptide Bioengineering Co., Ltd., light yellow solid powder, the main component is a small molecule oligopeptide with molecular weight less than 1000, the content is 97.4%.
实验动物：健康清洁级成年ICR雄性小鼠168只，体重18～22g，成年ICR雌性小鼠48只，体重14～19g，由北京大学医学部实验动物中心提供。实验动物分笼饲养，每笼6只，自由饮食、饮水。动物饲养实验室符合国标清洁级，温度范围25℃±1℃，相对湿度50％～60％，室内照明控制在12h/12h光暗周期节律。Experimental animals: 168 healthy and clean adult ICR male mice, weighing 18-22 g, 48 adult ICR female mice, weighing 14-19 g, provided by Experimental Animal Center of Peking University Medical School. The experimental animals were kept in cages, 6 per cage, free to eat and drink. The animal feeding laboratory meets the national standard clean level, the temperature range is 25 °C ± 1 °C, the relative humidity is 50% ~ 60%, and the indoor lighting is controlled at 12h/12h light and dark cycle rhythm.
二、实验方法Second, the experimental method
剂量及分组：将雄性小鼠按体重随机分为7组，每组24只。设立空白对照组、乳清蛋白组(0.50g/kg·bw)及5个吉林人参低聚肽剂量组(0.125g/kg·bw 0.25g/kg·bw、0.50g/kg·bw、1.00g/kg·bw、2.00g/kg·bw，分别用吉林人参低聚肽一、二、三、四、五组来表示)。各组动物再分为2个亚组，每组12只。空白对照组小鼠灌胃蒸馏水，其余各组灌胃相应浓度的乳清蛋白及吉林人参低聚肽的水溶液。各组小鼠均给以普通饲料，自由进食和饮水。每天灌胃1次，连续灌胃30d后进行各项实验。Dosage and grouping: Male mice were randomly divided into 7 groups according to their body weight, 24 in each group. A blank control group, whey protein group (0.50g/kg·bw) and 5 Jilin ginseng oligopeptide dose groups (0.125g/kg·bw 0.25g/kg·bw, 0.50g/kg·bw, 1.00g) were established. /kg·bw, 2.00g/kg·bw, respectively, expressed in Jilin ginseng oligopeptides one, two, three, four, five groups). Each group of animals was subdivided into 2 subgroups, 12 in each group. The blank control mice were given distilled water, and the other groups were given the corresponding concentrations of whey protein and aqueous solution of Jilin ginseng oligopeptide. Each group of mice was given normal feed, free to eat and drink. The rats were intragastrically administered once a day, and each experiment was carried out after 30 days of continuous gavage.
1)血清中NO和睾酮检测及性器官称重
1) Detection of NO and testosterone in serum and weighing of sexual organs
取各组第1亚组12只小鼠，末次给样30min后称量小鼠体重。眼球取血，将小鼠血样置4℃冰箱约3h，2000r/min离心15min分离血清，分别检测血清中NO和睾酮含量。血清睾酮含量采用西安核仪器厂γ放射免疫计数器XH-6080测定，试剂为北京北方生物技术研究所试剂。血清中NO含量按一氧化氮检测试剂盒说明书进行，试剂盒购自碧云天生物技术研究所。采完血后处死动物，分别取睾丸、附睾、精囊和***于电子天平上精确称重，计算脏器指数(脏器重量/体重×100)。Twelve mice in the first subgroup of each group were taken, and the body weight of the mice was weighed 30 min after the last administration. The blood was taken from the eyeball, and the blood samples of the mice were placed in a refrigerator at 4 ° C for about 3 hours, centrifuged at 2000 r / min for 15 min to separate serum, and serum NO and testosterone levels were measured. The serum testosterone content was determined by Xi'an Nuclear Instrument Factory γ radioimmunoassay counter XH-6080, and the reagent was reagent from Beijing North Biotechnology Research Institute. The NO content in the serum was carried out according to the instructions of the nitric oxide detection kit, and the kit was purchased from the Biyuntian Biotechnology Research Institute. After the blood was collected, the animals were sacrificed, and the testes, epididymis, seminal vesicles and prostate were accurately weighed on an electronic balance, and the organ index (organ weight/body weight × 100) was calculated.
2)雄性小鼠交配实验方法2) Male mouse mating experiment method
取各组第2亚组12只小鼠，末次给药60min后进行。雌性小鼠于实验前3d连续给予乙烯雌酚，每天按1mg/kg皮下注射给药，使之进入动情期。小鼠交配试验开始时现将单只雄性小鼠放入30cm×15cm×15cm的交配箱中适应5min，然后放入2只雌性小鼠。记录合笼至第一次交配的时间(即交配潜伏期)及20min内交配的次数。观察时间为20:00～23:00，交配试验在弱光、安静条件下进行。Twelve mice in the second subgroup of each group were taken and administered 60 minutes after the last administration. Female mice were given continuous administration of diethylstilbestrol 3 days before the experiment, and administered subcutaneously at a dose of 1 mg/kg per day to enter the estrus period. At the beginning of the mouse mating test, a single male mouse was placed in a 30 cm x 15 cm x 15 cm mating box for 5 min, and then 2 female mice were placed. Record the time from the cage to the first mating (ie mating latency) and the number of matings within 20 min. The observation time was from 20:00 to 23:00, and the mating test was carried out under low light and quiet conditions.
统计方法：所有实验数据均以
表示。采用SPSS13.0软件进行单因素方差分析，p<0.05有统计学意义。Statistical method: all experimental data are Said. One-way analysis of variance was performed using SPSS13.0 software, p<0.05 was statistically significant.
三、实验结果Third, the experimental results
1)吉林人参低聚肽对雄性小鼠性器官脏器指数的影响1) Effects of Jilin ginseng oligopeptide on organ organ index in male mice
如表1所示，见表1，各组小鼠睾丸的脏器指数相比较均无显著性差异(p﹥0.05)，与乳清蛋白组相比，吉林人参低聚肽剂量组小鼠的附性器官(精囊+***)指数显著升高(p﹤0.05)。As shown in Table 1, as shown in Table 1, there was no significant difference in the organ index of the testes of each group (p>0.05). Compared with the whey protein group, the Jilin ginseng oligopeptide dosage group of mice The index of the sex organs (sperm sac + prostate) was significantly increased (p < 0.05).
表1 吉林人参低聚肽对小鼠性器官脏器指数的影响(
n＝12)Table 1 Effect of Jilin Ginseng Oligopeptide on Sex Organ Index in Mice n=12)
注：*表示与乳清蛋白组相比p﹤0.05。
Note: * indicates p<0.05 compared to the whey protein group.
2)吉林人参低聚肽对小鼠血清NO和睾酮含量的影响2) Effects of Jilin ginseng oligopeptide on serum NO and testosterone levels in mice
如表2所示，空白对照组与乳清蛋白组小鼠血清NO和睾酮含量均无显著性差异(p﹥0.05)；与乳清蛋白组相比，吉林人参低聚肽各剂量组小鼠血清NO和睾酮含量均有所增高，其中吉林人参低聚肽二、三、四剂量组小鼠血清NO浓度增高最为显著(p﹤0.01)，吉林人参低聚肽一、二、三剂量组小鼠血清睾酮浓度增高最为显著(p﹤0.01)。As shown in Table 2, there was no significant difference in serum NO and testosterone levels between the blank control group and the whey protein group (p>0.05). Compared with the whey protein group, the Jilin ginseng oligopeptide was administered to each dose group. Serum NO and testosterone levels were increased. The serum NO concentration of the ginseng oligopeptides in the second, third and fourth dose groups was the most significant (p<0.01), and the Jilin ginseng oligopeptides in the first, second and third dose groups were small. The increase in serum testosterone concentration was most significant (p<0.01).
表2 吉林人参低聚肽对小鼠血清NO和睾酮含量的影响(
n＝12)Table 2 Effect of Jilin Ginseng Oligopeptide on Serum NO and Testosterone Content in Mice ( n=12)
注：**表示与乳清蛋白组相比p﹤0.01。Note: ** indicates p<0.01 compared to the whey protein group.
3)吉林人参低聚肽对小鼠交配潜伏期及20min内交配次数的影响3) Effect of Jilin ginseng oligopeptide on mating latency and mating frequency in 20min
如表3所示，空白对照组与乳清蛋白组小鼠交配潜伏期及20min内交配次数均无显著性差异(p﹥0.05)；与乳清蛋白组相比，吉林人参低聚肽各剂量组小鼠交配潜伏期均缩短，其中以二、三剂量组最为显著(p﹤0.05)，吉林人参低聚肽二、三、四剂量组小鼠20min内交配次数显著增多(p﹤0.01)。As shown in Table 3, there was no significant difference in the mating latency between the blank control group and the whey protein group and the number of mating within 20 min (p>0.05). Compared with the whey protein group, the Jilin ginseng oligopeptide was dosed. The mating latency of mice was shortened, especially in the second and third dose groups (p<0.05). The number of mating in the ginseng oligopeptide 2, 3, and 4 dose groups increased significantly within 20 min (p<0.01).
表3 吉林人参低聚肽对小鼠交配潜伏期及20min内交配次数的影响(
n＝12)Table 3 Effect of Jilin Ginseng Oligopeptide on Mating Latent Period and Mating Times in 20min ( n=12)
注：*表示与乳清蛋白组相比p﹤0.05；**表示与乳清蛋白组相比p﹤0.01。
Note: * indicates p<0.05 compared to the whey protein group; ** indicates p<0.01 compared to the whey protein group.
四、实验结论Fourth, the conclusion of the experiment
本研究通过设立空白对照组和乳清蛋白组作为对照组，探讨吉林人参低聚肽对雄性小鼠性功能的影响。结果表明，吉林人参低聚肽可以显著增加雄性小鼠附性器官指数，提高血清中的NO和睾酮浓度，缩短小鼠交配潜伏期并增加交配次数，从而有效的增强小鼠性功能，具备作为一种新型增强性功能制剂的潜力，其适宜浓度范围为每天0.125～1g/kg·bw。
In this study, the effects of Jilin ginseng oligopeptides on sexual function in male mice were investigated by establishing a blank control group and a whey protein group as a control group. The results showed that Jilin ginseng oligopeptide could significantly increase the sex organ index of male mice, increase the concentration of NO and testosterone in serum, shorten the mating latency of mice and increase the number of mating, thus effectively enhancing the sexual function of mice. The potential of the novel enhanced functional preparations is suitably in the range of 0.125 to 1 g/kg·bw per day.
Claims (3)
- 吉林人参低聚肽在制备改善和增强性功能的食品或保健食品中的用途。The use of Jilin ginseng oligopeptides in the preparation of foods or health foods for improving and enhancing sexual function.
- 根据权利要求1所述的吉林人参低聚肽在制备改善和增强性功能的食品或保健食品中的用途，其特征在于：所述改善和增强性功能的食品为粉剂、液体饮料、奶粉及奶制品和烘焙制品。The use of the Jilin ginseng oligopeptide according to claim 1 for the preparation of a food or health food for improving and enhancing sexual function, characterized in that the food for improving and enhancing sexual function is powder, liquid beverage, milk powder and milk Products and baked goods.
- 根据权利要求1所述的吉林人参低聚肽在制备改善和增强性功能的食品或保健食品中的用途，其特征在于：所述改善和增强性功能的保健食品为粉剂、片剂、软/硬胶囊和口服液。 The use of the Jilin ginseng oligopeptide according to claim 1 for the preparation of a food or health food for improving and enhancing sexual function, characterized in that the health food for improving and enhancing sexual function is powder, tablet, soft/ Hard capsules and oral liquids.
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