CN106880784A - It is a kind of with fatigue-relieving, the Chinese medicine composition of anti-aging and its application - Google Patents
It is a kind of with fatigue-relieving, the Chinese medicine composition of anti-aging and its application Download PDFInfo
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/062—Ascomycota
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/16—Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
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Abstract
The invention discloses a kind of with fatigue-relieving, the Chinese medicine composition of anti-aging and its application, Chinese medicine composition is mixed by the raw material of following percentage by weight：5~15% red yeast rice, 5~15% Notogineng Extract, 30~50% Rhizoma Chuanxiong extract, 30~50% ginkgo biloba p.e；Chinese medicine composition with fatigue-relieving, anti-aging can be used for preparing has prevention and fatigue-relieving and the medicine or health food of aging.By Chinese medicine composition and the assistant agent of surplus that percentage by weight is 65~90%, addition or the prevention being made without dietary supplement natto, protein, mineral matter, vitamin etc. and fatigue-relieving and the Chinese medicine preparation of aging, have functions that fatigue-relieving, anti-aging.The present invention not only " dissolving stasis ", more " can give birth to new " based on " promoting blood circulation and removing blood stasis ", supplemented by " qi-restoratives ", can effectively alleviate physical fatigue, while the effect of there is anti-aging, and non-evident effect.
Description
Technical field
The present invention relates to a kind of with fatigue-relieving, the Chinese medicine composition of anti-aging and its application.
Background technology
Modern medicine proves that the free radical that has its source in of aging increases and cell ageing, so as to cause human internal environment to dislike
Change, organ dysfunction fails.And interior environmental degradation, free radical increases, and cell ageing is due to fatigue (human body energy is unbalance)
The result of formation.
British scientist research finds, overworked that human body cell can be caused to cross presenility, so as to make one easy senilism.From
The people's cell aging rate average specific of thing physical work is not the contemporary 7 years soon of physical work.It is assessment cell ageing degree,
Researcher is measured the length of cell telomere.Telomere is DNA (DNA) base of protection dyeing body end position
Unit, the length of telomere dominates whether cell enters aging in cell.Cell often divides a telomere will become shorter, therefore
Telomere is shorter, and frequency dividing cell is more, and cell is also more aging.Research discovery, is engaged in the cell telomere ratio of physical labourer
With average short 140 DNA bases pair of the cell telomere of age nonmanual workers, because cell telomere can lose 20 every year on average
Individual base-pair, this shows that the cell of physical labourer is old about 7 years.
Fatigue is that the function that body is crossed use (transfiniting) and caused is reduced and the uncomfortable state of body occurs, is mainly shown as tired
Labor is sleepy, may occur in which the simultaneous phenomenons such as dizzy, forgetful, sleep quality decline.The generation of fatigue is produced with energy substance consumption, metabolism
The factor relations such as thing accumulation, homeostasis sexual maladjustment, free radical influence are close.
Chinese traditional treatment aging and fatigue are of the invention based on " promoting blood circulation and removing blood stasis ", supplemented by " qi-restoratives " based on " qi-restoratives ", with
Simple " qi-restoratives " method compares, with more significant effect.Blood stasis if do not removed, simply supplement simply, not only effect on driving birds is not good, and
And can cause more to mend more stagnant, more mend the disadvantage of more void.Chinese medicine composition of the invention not only " dissolving stasis ", more can " raw new ", " raw new "
Aspect includes " the new blood of life, the new thing of life, raw Xin Mai, the old life of change are new " four aspects, can effectively alleviate physical fatigue, while having
The effect of anti-aging, and non-evident effect.
The content of the invention
The technical problems to be solved by the invention are directed to the deficiencies in the prior art, and provide a kind of with alleviation
Fatigue, the Chinese medicine composition of anti-aging and its application, in anti-aging, antifatigue generation and development, promote fatigue recovery
Everyway has remarkable result.
To achieve these goals, the present invention is adopted the following technical scheme that：
A kind of Chinese medicine composition with fatigue-relieving, anti-aging, is mixed by the raw material of following percentage by weight：
5~15% red yeast rice, 5~15% Notogineng Extract, 30~50% Rhizoma Chuanxiong extract, 30~50% ginkgo leaf are extracted
Thing；Above-mentioned each raw material mixing can be prepared by described Chinese medicine composition.
In above-mentioned technical proposal, described Chinese medicine composition is preferably mixed by the raw material of following percentage by weight：
10% red yeast rice, 10% Notogineng Extract, 40% Rhizoma Chuanxiong extract, 40% ginkgo biloba p.e.
The present invention also provides a kind of above-mentioned Chinese medicine composition with fatigue-relieving, anti-aging and is preparing with prevention
With the application in terms of fatigue-relieving and the medicine or health food of aging.
The present invention also provides a kind of Chinese medicine preparation prevented with fatigue-relieving and aging, containing described tired with alleviating
The Chinese medicine composition of labor, anti-aging；
Described prevention and fatigue-relieving and the Chinese medicine preparation of aging, by the Chinese traditional medicine composition that percentage by weight is 65~90%
The assistant agent of thing and surplus is made；
Described assistant agent be in dietary supplement, filler or disintegrant any one, two kinds and the above to be to appoint
The mixture that meaning ratio is mixed；
Described dietary supplement be any one or two kinds in mineral matter, vitamin, natto, protein powder with
The mixture that arbitrary proportion is mixed；Wherein：Mineral matter is any one in selenium, zinc, calcium, magnesium, potassium, iron, chromium, manganese, two
The mixture planted and mixed with arbitrary proportion above, vitamin is beta carotene, vitamin B1, vitamin B6, vitamin
In C, vitamin D, vitamin E any one, the mixture that is mixed with arbitrary proportion of two kinds and the above, protein powder is
In soybean protein isolate, lactalbumin, pea protein, collagen any one, two kinds and the above mix with arbitrary proportion
Mixture；
Described filler is to meet《Chinese Pharmacopoeia》The common medicinal supplementary material that pharmaceutic adjuvant standard specifies, such as starch；
Described disintegrant is to meet《Chinese Pharmacopoeia》The common medicinal supplementary material that pharmaceutic adjuvant standard specifies, such as microcrystalline cellulose
Element or magnesium stearate.
The present invention also provides a kind of preparation method for preventing the Chinese medicine preparation with fatigue-relieving and aging, including following step
Suddenly：
(1) obtained after being well mixed the red yeast rice of the ratio, Notogineng Extract, Rhizoma Chuanxiong extract, ginkgo biloba p.e
Chinese medicine composition with fatigue-relieving, anti-aging；
(2) assistant agent of the ratio is ground to and assistant agent powder is obtained after 80-100 mesh；
(3) assistant agent that the Chinese medicine composition and step (2) that by under lucifuge state by ratio the step of (1) obtains are obtained
Powder obtains the Chinese medicine preparation of prevention and fatigue-relieving and aging using equal increments method after well mixed；
In above-mentioned technical proposal, the Chinese medicine preparation that will further can be obtained conventionally is processed into capsule, piece
Agent or granule.
In the present invention, described prevention and fatigue-relieving and the Chinese medicine preparation of aging, instructions of taking is：Orally, one day 2
It is secondary, each 800mg.
The compatibility that Chinese medicine composition of the invention passes through above-mentioned several bulk drugs, is got a haircut by various effect bases and waves effect,
And cooperative effect is produced between multiple efficacies, useful effect in body, in anti-aging, antifatigue generation and development, rush
The everyway for entering fatigue recovery has remarkable result.
The anti-aging of Chinese medicine preparation of the present invention, antifatigue generation and development, promote fatigue recovery effect can by with
Lower zoopery is proved：
The experiment of zoopery I --- anti-aging
1. experiment material
1.1 test specimens and reagent
Chinese medicine capsules prepared by the embodiment of the present invention 1；D- galactolipins (Shanghai reagent factory), are matched somebody with somebody with sterile saline
Into 5% concentration；Hepatocuprein (SOD) and glutathione peroxidase (GSH-Px) detection kit are to build up in Nanjing
Bioengineering Research Institute's product.
1.2 experimental animals and packet
SPF grades of female KM kind healthy mice 50, body weight is 18~22g, is randomly divided into 5 groups.Experimental animal is by Changsha
City Kaifu District Dong Chuan Animal Sciences service department provides, experimental animal credit number SCXK (Hunan) 2009-0012.Feed is by growing
Shashi Kaifu District Dong Chuan Animal Sciences service department provides.Divide cage to decontrol to raise, 22~24 DEG C of room temperature, relative humidity 52%~
56%, free water, feed are weighed weekly 1 time.
1.3 instruments and producer
Low temperature ultracentrifuge (German Bekaa Man)；Assay balance (plum Teller-support benefit Instrument Ltd.)；
722 visible spectrophotometers (the analytical instrument factory of Shanghai the 3rd)；Electric drying oven with forced convection (the Shanghai good fortune limited public affairs of agate experimental facilities
Department)；Electro-heating standing-temperature cultivator (Shanghai Fuma Experiment Equipment Co., Ltd.).
1.4 dosage choices
Experiment sets 0.20g/kgBW, 0.40g/kgBW, 1.20g/kgBW and (is respectively equivalent to human body recommended dose
5th, 10,30 times) basic, normal, high three dosage groups, negative control group and model groups.During experiment, weigh respectively 2.00g, 4.00g,
12.00g samples add distilled water to 200ml, corresponding dosage are made into by test solution, for each dosage group gavage.Control group and model group are given
Give isometric physiological saline.Experimental animal presses the capacity gavage per 10g body weight 0.2mL, once a day, continuously at least 30 days.It is real
Animal freely ingests drinking-water during testing.
2. experimental technique
2.1 administrations
The daily gavage of sample sets gives the solution of 0.20g/kgBW, 0.40g/kgBW, 1.20g/kgBW；Model group
Give isometric physiological saline, gastric infusion, once a day, and nape part hypodermic injection simultaneously 5% D- galactolipins 0.5mL；It is empty
White group gives the sterile saline of same volume, and successive administration 6 weeks records weekly 1 body weight, and observes the growth of animal at any time
Situation.
The preparation of 2.2 serum and the measure of biochemical indicator
After D- galactolipins and by reagent 6 weeks, mouse is extractd eyeball and takes blood, is won eyeball of mouse and is taken blood about 1ml, be put into from
Scheming, with 3000rmin-1Centrifugation 15min, isolates serum.The measure of SOD, using xanthine oxidase, according to paddy light
The explanation of sweet peptide peroxidase conjugation kit determines the activity of GSH-Px in serum, and specific steps follow strictly kit specification and enter
OK.
2.3 data processing experimental datas are usedRepresent, compare between group and difference is judged using t inspections.
3 experimental results
Influence of 3.1 samples to mice serum SOD contents
Influence of the table 1-1 samples to mice serum SOD contents
Note：* compare with model group, P<0.05；* compares with model group, P<0.01；#Compare with blank group, P<0.05.
As seen from the above table, model group SOD in serum is significantly lower than blank control group (P<0.05), sample low dose group can increase
SOD in serum content, compares that there was a significant difference (P ＜ 0.05) with control group, and middle and high dosage group compares with control group, can be substantially
Increase SOD in serum content, there is highly significant sex differernce (P ＜ 0.01).
Influence of 3.2 samples to mice serum GSH-Px contents
Influence of the table 1-2 samples to mice serum GSH-Px contents
Note：* compare with model group, P<0.05；* compares with model group, P<0.01；#Compare with blank group, P<0.05.
As seen from the above table, model group GSH-Px in serum is significantly lower than blank control group (P<0.05), sample low dose group energy
Increase GSH-Px in serum content, compare that there was a significant difference (P ＜ 0.05) with control group, middle and high dosage group compares with control group,
GSH-Px in serum content can substantially be increased, there is highly significant sex differernce (P ＜ 0.01).
4. result brief summary
Model group SOD in serum and GSH-Px activity are significantly lower than blank control group, after giving sample, can make D- galactolipins
Mice serum SOD and the GSH-Px activity of caused aging are significantly gone up, and point out sample to strengthen activities of antioxidant enzymes in Mice Body,
Be conducive to removing free radical, with anti-aging effects.
Zoopery II --- the experiment of Chinese medicine composition fatigue-relieving effect
1. experiment material
1.1 test specimens
Chinese medicine capsules prepared by the embodiment of the present invention three.
1.2 experimental animals and packet
SPF grades of male Kunming kind healthy mice 160, body weight is 18~22g.Divide cage to decontrol to raise, 22~24 DEG C of room temperature,
Relative humidity 52%~56%.
Mouse is divided into I group (Loaned swimming test), II group (serum urea), III group of (blood lactase acid measure), IV group of (glycogen
Original is determined), totally 4 groups, every group 40.Every group is randomly divided into control group, basic, normal, high dosage group, every group of 10 mouse.
1.3 instruments and reagent
Weigh balance, electronic balance, centrifuge, cell crushing instrument, water bath, oscillator, OLYMPUSAU400 of animal is complete
Automatic biochemistry analyzer, SBA401C bio-sensings analyzer, 7222 spectrophotometers, swimming trunk (size about 53cm × 40cm ×
35cm), sheet lead, timer, hemoglobin pipet, sample injector, pipette, test tube.
Serum urea testing cassete, is provided by Shanghai Foxing Changzheng medical science Co., Ltd；Hepatic glycogen testing cassete, by Nanjing
Bioengineering Research Institute's offer is provided.
1.4 dosage choices
Animal subject is divided into three dosage levels：High dose be 1.20g/kgBW, middle dosage be 0.40g/kgBW, low dose
It is 0.20g/kgBW to measure, and is respectively equivalent to 30 times, 10 times, 5 times that human body recommends consumption.High, medium and low dose of test liquid configuration
When, separately sampled product content 12.00g, 4.00g, 2.00g add distilled water to 200ml, animal subject gavage are given respectively, often
It once, control group gives isometric distilled water, and gavage volume is 0.2mL/10gBW, continuous 30 days.
2. experimental technique
2.1 Loaned swimming tests
After last gavage 30min, swimming trunk went swimming, the depth of water about 30cm, 25 DEG C ± 1.0 DEG C of water temperature, rat-tail root are placed in
The sheet lead of the body weight of load 5%.Record mouse is since the time swimming to death as walking weight load (s).Swimming time
It is measurement data, if dosage group swimming time is considerably longer than control group swimming time, and difference has conspicuousness (P ＜ 0.05),
Can determine that tested material plays the role of to extend the mice burden swimming time.
2.2 serum ureas are determined
After last gavage 30min, the not swimming with a load attached to the body 90min in the water that temperature is 30 DEG C pulls out eyeball and adopts after rest 60min
Blood.2000 revs/min of centrifugation 15min after standing 3h in 4 DEG C, take serum automatic clinical chemistry analyzer and determine serum urea.Gained
Data are measurement data, if dosage group serum urea content is significantly lower than control group, and difference has conspicuousness (P ＜ 0.05),
Can determine that tested material is reduced the effect that tired mouse urea is produced.
2.3 hepatic glycogen are determined：Anthrone method
After last gavage 30min, animal is put to death, take after liver is rinsed through physiological saline and blotted with filter paper, take liver
100mg, remaining operations carry out hepatic glycogen measure by testing cassete specification.The data obtained is measurement data, if dosage group hepatic glycogen
Content is apparently higher than control group, and difference has conspicuousness (P ＜ 0.05), can determine that tested material has promotion mouse liver glycogen reserves
Effect.
2.4 blood lactase acids are determined
After last gavage 30min, angular vein clump takes the μ l of blood 20, the then not swimming with a load attached to the body in the water that temperature is 30 DEG C
Stop after 10min, ibid taken a blood sample 20 μ l respectively at 0min after motion and 20min, determine blood lactase acid, calculate below blood lactase acid curve
Product.
Blood lactase acid TG-AUC=1/2 × (the blood lactase acid value of 0min after the preceding blood lactase acid value+swimming of swimming) × 10+1/2
× blood lactase acid the value of 20min (after swimming after the blood lactase acid value+swimming of 0min) × 20
The data obtained is measurement data, if dosage group blood lactase acid TG-AUC is significantly lower than control group, and difference has
Conspicuousness (P ＜ 0.05), can determine that tested material plays the role of to reduce mouse blood lactase acid TG-AUC.
2.5 result judgements
Loaned swimming test result is positive, and in blood lactase acid, serum urea, three biochemical indicators of hepatic glycogen any two refer to
Mark is positive, you can judge that tested material has the effect for alleviating physical fatigue.
3. result and analysis
Influence of 3.1 samples to rat body weight：
Influence (I group) of the table 3-1 samples to rat body weight
Influence (II group) of the table 3-2 samples to rat body weight
Influence (III group) of the table 3-3 samples to rat body weight
Influence (IV group) of the table 3-4 samples to rat body weight
As seen from the above table, each dosage group mouse experiment just, in, the latter stage body weight difference that compares that there are no significant with control group group
(*P ＞ 0.05).
Influence of 3.2 samples to the mice burden swimming time
Influence of the table 3-5 samples to the mice burden swimming time
Note：Compare with control group, * P<0.05, * * P<0.01
As seen from the above table, low dose group compares with distilled water control group, can increase the time of mice burden swimming, has significantly
Sex differernce (*P ＜ 0.05), middle and high dosage group compares with distilled water control group, can substantially increase the time of mice burden swimming,
Have highly significant sex differernce (**P ＜ 0.01).
Influence of 3.3 samples to mice serum urea
Influence of the table 3-6 samples to mice serum urea
Note：Compare with control group, * P<0.05, * * P<0.01
As seen from the above table, in, low dose group compare with distilled water control group, mice serum urea level can be reduced, have
Significant difference (*P ＜ 0.05), high dose group compares with distilled water control group, can substantially reduce mice serum urea level, has
Highly significant sex differernce (**P ＜ 0.01).
Influence of 3.4 samples to mouse blood lactase acid change after motion
Influence of the table 3-7 samples to mouse blood lactase acid change after motion
Note：Compare with control group, * P<0.05, * * P<0.01
As seen from the above table, low dose group compares with distilled water control group, the reduction of blood lactase acid TG-AUC, has conspicuousness poor
Different (*P ＜ 0.05), middle and high dosage group compares with distilled water control group, and the reduction of blood lactase acid TG-AUC is obvious, has height aobvious
Work sex differernce (**P ＜ 0.01).
Influence of 3.5 samples to mouse liver glycogen reserves after motion
Influence of the table 3-8 samples to mouse liver glycogen reserves after motion
Note：Compare with control group, * P<0.05, * * P<0.01
As seen from the above table, low dose group compares with distilled water control group, can increase mouse liver glycogen reserves, has conspicuousness poor
Different (*P ＜ 0.05), middle and high dosage group compares with distilled water control group, can substantially increase mouse liver glycogen reserves, has height aobvious
Work sex differernce (**P ＜ 0.01).
4. brief summary
After inventive samples give mouse various dose 30 days through gavage, at the same carry out mice burden swimming, serum urea,
4 Indexs measures such as hepatic glycogen content and blood lactase acid TG-AUC, as a result show that inventive samples can extend mouse swimming with a load attached to the body
Swimming time, the serum urea for reducing tired mouse is produced, and increases the storage level of mouse hepatic glycogen, and blood lactase acid is clear after accelerated motion
Except speed.It is considered that Chinese medicine composition of the invention has the effect for alleviating physical fatigue.
In a word, be may certify that by above-mentioned various experiments, Chinese medicine composition energy anti-aging of the invention, reduction lactic acid,
Serum urea level, effectively alleviates the discomfort such as limbs fatigue, sleepy, DOMS, apocleisis of generation after moving and feels.
Specific embodiment
The specific embodiment to technical solution of the present invention is described in detail below, but the present invention is not limited in following description
Hold：
Chinese medicine material in the present invention is existing commercially available prod, and such as red yeast rice is purchased from the standing grain bioengineering of Zhejiang three to be had
Limit company, remaining raw material is purchased from Shaanxi Sen Fu Bioisystech Co., Ltd.
Embodiment 1：
It is a kind of to prevent and fatigue-relieving and the Chinese medicine preparation of aging, it is prepared from by following methods：
(1) Chinese medical extract of following weight is weighed：Red yeast rice 40g, Notogineng Extract 40g, ginkgo biloba p.e 150g, river
Rhizome of chuanxiong extract 150g；Each raw material is well mixed and obtains final product the Chinese medicine composition with fatigue-relieving, anti-aging, treated after bacterium inspection
With；
(2) natto powder 18g, magnesium stearate 2g are ground to be well mixed after 80-100 mesh respectively and obtain assistant agent powder, bacterium
It is stand-by after inspection；
(3) assistant agent obtained with fatigue-relieving, the Chinese medicine composition of anti-aging, step (2) for obtaining step (1)
Powder obtains the Chinese medicine preparation of prevention and fatigue-relieving and aging using equal increments method after well mixed；
The Chinese medicine preparation fully-automatic capsule machine that will be obtained is filled into capsule, and every capsule 's content is 400mg, is obtained altogether
1000；By capsule whole grain, polishing, inspection, packaging, the human body recommended amounts of the capsule are everyone (adult) daily 2 times, every time
2.
Embodiment 2：
It is a kind of to prevent and fatigue-relieving and the Chinese medicine preparation of aging, it is prepared from by following methods：
(1) Chinese medical extract of following weight is weighed：Red yeast rice 40g, Notogineng Extract 40g, ginkgo biloba p.e 140g, river
Rhizome of chuanxiong extract 140g；Each raw material is well mixed and obtains final product the Chinese medicine composition with fatigue-relieving, anti-aging, treated after bacterium inspection
With；
(2) by starch 28g, magnesium stearate 2g, Se-enriched yeast 9.8g, vitamin B10.08g, vitamin B60.12g grinds respectively
It is milled to be well mixed after 80-100 mesh and obtains assistant agent powder, it is stand-by after bacterium inspection
(3) assistant agent obtained with fatigue-relieving, the Chinese medicine composition of anti-aging, step (2) for obtaining step (1)
Powder obtains the Chinese medicine preparation of prevention and fatigue-relieving and aging using equal increments method after well mixed；
The Chinese medicine preparation fully-automatic capsule machine that will be obtained is filled into capsule, and every capsule 's content is 400mg, is obtained altogether
1000；By capsule whole grain, polishing, inspection, packaging, the human body recommended amounts of the capsule are everyone (adult) daily 2 times, every time
2.
Embodiment 3：
It is a kind of to prevent and fatigue-relieving and the Chinese medicine preparation of aging, it is prepared from by following methods：
(1) Chinese medical extract of following weight is weighed：Red yeast rice 32g, Notogineng Extract 32g, ginkgo biloba p.e 160g, river
Rhizome of chuanxiong extract 160g；Each raw material is well mixed and obtains final product the Chinese medicine composition with fatigue-relieving, anti-aging, treated after bacterium inspection
With；
(2) microcrystalline cellulose 216g is ground to 80-100 mesh and obtains assistant agent powder, it is stand-by after bacterium inspection；
(3) assistant agent obtained with fatigue-relieving, the Chinese medicine composition of anti-aging, step (2) for obtaining step (1)
Powder obtains the Chinese medicine preparation of prevention and fatigue-relieving and aging using equal increments method after well mixed；
The Chinese medicine preparation that will be obtained is dried with 60%~80% alcohol granulation, is pressed into 0.6g/ pieces Chinese medicinal tablet 1000
Piece；The human body recommended amounts of the tablet are everyone (adult) daily 2 times, and 2 tablets once.
Embodiment 4：
It is a kind of to prevent and fatigue-relieving and the Chinese medicine preparation of aging, it is prepared from by following methods：
(1) Chinese medical extract of following weight is weighed：Red yeast rice 35g, Notogineng Extract 35g, ginkgo biloba p.e 160g, river
Rhizome of chuanxiong extract 160g；Each raw material is well mixed and obtains final product the Chinese medicine composition with fatigue-relieving, anti-aging, treated after bacterium inspection
With；
(2) vitamin E powder 16g, microcrystalline cellulose 194g are ground to be well mixed after 80-100 mesh respectively and obtain assistant agent
Powder, it is stand-by after bacterium inspection；
(3) assistant agent obtained with fatigue-relieving, the Chinese medicine composition of anti-aging, step (2) for obtaining step (1)
Powder obtains the Chinese medicine preparation of prevention and fatigue-relieving and aging using equal increments method after well mixed；
The Chinese medicine preparation that will be obtained is dried with 60%~80% alcohol granulation, is pressed into 0.6g/ pieces Chinese medicinal tablet 1000
Piece；The human body recommended amounts of the tablet are everyone (adult) daily 2 times, and 2 tablets once.
Examples detailed above is technology design and technical characterstic to illustrate the invention, can not limit of the invention with this
Protection domain.Equivalent transformation or modification that all essence of the invention is done, should all cover in protection scope of the present invention
Within.
Claims (9)
1. a kind of Chinese medicine composition with fatigue-relieving, anti-aging, it is characterised in that：By the raw material of following percentage by weight
Mix：5~15% red yeast rice, 5~15% Notogineng Extract, 30~50% Rhizoma Chuanxiong extract, 30~50% silver
Apricot leaf extract.
2. Chinese medicine composition according to claim 1, it is characterised in that：By the raw material mixing of following percentage by weight
Into：10% red yeast rice, 10% Notogineng Extract, 40% Rhizoma Chuanxiong extract, 40% ginkgo biloba p.e.
3. the Chinese medicine composition with fatigue-relieving, anti-aging described in a kind of any one of claim 1-2 has in preparation
Application in terms of preventing with fatigue-relieving and the medicine or health food of aging.
It is 4. a kind of to prevent and fatigue-relieving and the Chinese medicine preparation of aging, it is characterised in that：As described in claim 1 with alleviation
Fatigue, the Chinese medicine composition of anti-aging are made.
5. Chinese medicine preparation according to claim 4, it is characterised in that：By the Chinese traditional medicine composition that percentage by weight is 65~90%
The assistant agent of thing and surplus is made.
6. Chinese medicine preparation according to claim 5, it is characterised in that：Described assistant agent is dietary supplement, filling
In agent or disintegrant any one, the mixture that is mixed with arbitrary proportion of two kinds and the above.
7. Chinese medicine preparation according to claim 6, it is characterised in that：Described dietary supplement is mineral matter, dimension
Any one in raw element, natto, plant protein powder or two kinds of mixtures mixed with arbitrary proportion；Wherein：Mineral
The mixture that matter is mixed for any one in selenium, zinc, calcium, magnesium, potassium, iron, chromium, manganese, two kinds and the above with arbitrary proportion,
Vitamin is beta carotene, vitamin B1, vitamin B6, vitamin C, vitamin D, in vitamin E any one, two kinds and
The mixture for being mixed with arbitrary proportion above；Protein powder is soybean protein isolate, lactalbumin, pea protein, collagen
In albumen any one, the mixture that is mixed with arbitrary proportion of two kinds and the above；Described filler, disintegrant are
Meet《Chinese Pharmacopoeia》The common medicinal supplementary material that pharmaceutic adjuvant standard specifies.
8. the preparation method of the Chinese medicine preparation described in a kind of claim 4, it is characterised in that：Comprise the following steps：
(1) had after being well mixed the red yeast rice of the ratio, Notogineng Extract, Rhizoma Chuanxiong extract, ginkgo biloba p.e
The Chinese medicine composition of fatigue-relieving, anti-aging；
(2) assistant agent of the ratio is ground to and assistant agent powder is obtained after 80-100 mesh；
(3) the assistant agent powder that the Chinese medicine composition and step (2) that by under lucifuge state by ratio the step of (1) obtains are obtained
The Chinese medicine preparation of prevention and fatigue-relieving and aging is obtained after well mixed using equal increments method.
9. preparation method according to claim 8, it is characterised in that：Described prevention and fatigue-relieving and the Chinese medicine of aging
Preparation is processed into capsule, tablet or granule further according to conventional method.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107853703A (en) * | 2017-11-13 | 2018-03-30 | 广禾堂草本生物科技（上海）有限公司 | A kind of preparation method for being used to alleviate the preparation of physical fatigue |
| CN107912773A (en) * | 2017-11-13 | 2018-04-17 | 广禾堂草本生物科技（上海）有限公司 | A kind of preparation for being used to alleviate physical fatigue |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102178734A (en) * | 2011-04-26 | 2011-09-14 | 庞会心 | Chinese medicinal composition for preventing and treating cardiovascular and cerebrovascular diseases and resisting fatigue |
-
2017
- 2017-03-23 CN CN201710177171.5A patent/CN106880784A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102178734A (en) * | 2011-04-26 | 2011-09-14 | 庞会心 | Chinese medicinal composition for preventing and treating cardiovascular and cerebrovascular diseases and resisting fatigue |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107853703A (en) * | 2017-11-13 | 2018-03-30 | 广禾堂草本生物科技（上海）有限公司 | A kind of preparation method for being used to alleviate the preparation of physical fatigue |
| CN107912773A (en) * | 2017-11-13 | 2018-04-17 | 广禾堂草本生物科技（上海）有限公司 | A kind of preparation for being used to alleviate physical fatigue |
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