WO2015133358A1 - 練歯磨組成物 - Google Patents
練歯磨組成物 Download PDFInfo
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- WO2015133358A1 WO2015133358A1 PCT/JP2015/055591 JP2015055591W WO2015133358A1 WO 2015133358 A1 WO2015133358 A1 WO 2015133358A1 JP 2015055591 W JP2015055591 W JP 2015055591W WO 2015133358 A1 WO2015133358 A1 WO 2015133358A1
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- toothpaste composition
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/463—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfuric acid derivatives, e.g. sodium lauryl sulfate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Definitions
- the present invention relates to a toothpaste composition that suppresses foam dripping from the mouth when brushing teeth, has an excellent creamy feel, and has a high flavor.
- the feeling of foam in the oral cavity is one of the textures that can give a feeling of cleaning.
- saliva is constantly secreted in the oral cavity, and especially if you brush your teeth for a long time, the dentifrice composition is diluted with saliva. As a result, there was a problem that bubbles dropped from the mouth, the creamy feeling of the bubbles was not felt, and the satisfaction of brushing the teeth was lowered.
- the surfactant generally used as a foaming agent has a problem that it develops the bitterness peculiar to it or reduces the expression of a fragrance to be blended for masking unpleasant taste. For this reason, in a dentifrice composition, it was difficult to improve foam performance, maintaining favorable flavor standing.
- Patent Document 1 Japanese Translation of PCT International Publication No. 2011-105647.
- Patent Document 1 does not mention bubble dripping from the mouth.
- polyethylene glycol is generally used as a humectant or thickener in the oral field, but there are few examples of blending highly polymerized polyethylene glycol having an average molecular weight of 50,000, particularly 100,000 or more, into the preparation.
- Patent Document 2 JP 2006-506359 A
- Patent Document 3 JP-A-2013-112613
- Patent Document 4 International Publication No. 10/073975
- the present invention has been made in view of the above circumstances, and an object of the present invention is to provide a toothpaste composition that suppresses foam dripping from the mouth when brushing teeth, is excellent in foam creaminess, and has a high flavor.
- the present inventor has obtained (A) highly polymerized polyethylene glycol, (B) alkyl sulfate, (C) amphoteric surfactant, and (D) nonionic surfactant. Containing (C) component / (D) component in a mass ratio of 0.05 to 5, foam dripping from the mouth during tooth brushing is suppressed, foam creamy feeling is excellent, and flavor is high It has been found that a toothpaste composition can be obtained.
- the toothpaste composition of the present invention is less likely to drip from the mouth when brushing teeth, gives a foam that can be held appropriately in the mouth, improves the creamy feeling of the foam, has a high flavor of the blended fragrance, and feels good to use Is excellent, and can provide sufficient toothpaste and satisfaction with use.
- the present invention provides the following toothpaste composition and a method for improving bubble sag in the toothpaste composition.
- A Highly polymerized polyethylene glycol, (B) alkyl sulfate, (C) amphoteric surfactant and (D) nonionic surfactant are contained, and (C) component / (D) component has a mass ratio of 0.
- the highly polymerized polyethylene glycol as component (A) has a viscosity of 10 mPa ⁇ s or more at 25 ° C. measured at 25 ° C. measured with a Brookfield viscometer and 2 W / V at 25 ° C. measured with the viscometer.
- the (C) component betaine amphoteric surfactant is fatty acid amidopropyl betaine and / or 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolium betaine in [1], [2] or [3] The toothpaste composition as described.
- the highly polymerized polyethylene glycol as component (A) has a viscosity of 10 mPa ⁇ s or more at 25 ° C. measured at 25 ° C. measured with a Brookfield viscometer and 2 W / V at 25 ° C. measured with the viscometer.
- Component (A) is 0.05 to 0.5% by mass
- Component (B) is 1 to 3.5% by mass
- Component (C) is 0.05 to 1% by mass
- Component (D) is 0.1 to A method for improving dripping by combining the components (A) and (B) in the toothpaste composition according to [8] or [9] containing 3% by mass.
- the present invention it is possible to provide a toothpaste composition in which foam dripping from the mouth during brushing is suppressed, the creamy feeling of the foam is excellent, and the flavor is high.
- This toothpaste composition can provide sufficient toothpaste feeling and satisfaction with use.
- the toothpaste composition of the present invention comprises (A) highly polymerized polyethylene glycol, (B) alkyl sulfate, (C) amphoteric surfactant, (D) nonionic surfactant, and (C) component / ( D) The ratio of the component is within a specific range.
- the highly polymerized polyethylene glycol of component (A) is a polymer compound having a structure in which ethylene glycol is polymerized, and is a 5 W / V (mass / volume (volume))% aqueous solution at 25 ° C. measured with a Brookfield viscometer. It is preferable that the viscosity is 10 mPa ⁇ s or more and the viscosity of the 2 W / V% aqueous solution at 25 ° C. measured by the viscometer is 800 mPa ⁇ s or less.
- the highly polymerized polyethylene glycol preferably has the following viscosity physical properties (1) or (2).
- Viscosity of 5 W / V% aqueous solution at 25 ° C. is 10 to 20,000 mPa ⁇ s
- the viscosity of the 2 W / V% aqueous solution at 25 ° C. is 800 mPa ⁇ s or less.
- more preferable highly polymerized polyethylene glycol is 5 W at 25 ° C.
- the viscosity of the / V% aqueous solution is 10 to 18,000 mPa ⁇ s, particularly 30 to 10,000 mPa ⁇ s, especially 55 to 2,000 mPa ⁇ s.
- the present invention by using highly polymerized polyethylene glycol having a viscosity within the above specific range as the component (A), it is possible to sufficiently contribute to the improvement of foam dripping from the mouth and to further improve the creamy feeling of the foam. If the viscosity of the 5 W / V% aqueous solution is less than 10 mPa ⁇ s, it may not sufficiently contribute to the improvement of foam dripping from the mouth, and the effect of improving the creamy feeling of the foam may be inferior. When it exceeds 800 mPa ⁇ s, not only the flavor is deteriorated, but also the stability of the toothpaste composition may be lowered.
- component (A) As the highly polymerized polyethylene glycol of component (A), the following commercially available products can be used.
- ⁇ POLYOX WSR N-10 Manufactured by Dow Chemical Co., Ltd., viscosity of 5 W / V% aqueous solution: 12 to 50 mPa ⁇ s, measuring device: Brookfield RVT, rotor No. 1, rotation speed 50 rpm, measuring temperature 25 ° C., measuring time 0.5 minutes
- ⁇ POLYOX WSR N-80 Manufactured by Dow Chemical Co., Ltd., viscosity of 5 W / V% aqueous solution: 55 to 115 mPa ⁇ s, measuring equipment: Brookfield RVT, rotor No.
- the blending amount of the highly polymerized polyethylene glycol is preferably 0.05 to 0.5% (mass%, the same applies hereinafter) of the whole composition, more preferably 0.1 to 0.3%.
- the blending amount is 0.05% or more, the dripping from the mouth can be sufficiently improved, and the creamy feeling of the foam can be sufficiently improved.
- a content of 0.5% or less is suitable for suppressing deterioration in flavor.
- alkyl sulfate is mix
- sodium alkyl sulfate such as sodium lauryl sulfate and sodium myristyl sulfate can be used, and sodium lauryl sulfate is particularly preferred from the standpoint of flavor.
- sodium lauryl sulfate manufactured by Toho Chemical Industry Co., Ltd .
- sodium lauryl sulfate sodium myristyl sulfate
- Nikko Chemicals Co., Ltd .; NIKKOL SMS and the like can be used.
- the amount of alkyl sulfate is preferably 1 to 3.5%, more preferably 1.5 to 2.5% of the total composition. If the blending amount is 1% or more, the creamy feeling of the foam can be improved. 3.5% or less is suitable for suppressing deterioration in flavor. Furthermore, in order to prevent the foaming property of the toothpaste composition from increasing too much and dripping the foam from the mouth, and to prevent the feeling of use such as irritation in the oral cavity from becoming worse, It is preferably not too much, and is preferably 3.5% or less.
- a betaine amphoteric surfactant can be suitably blended.
- the betaine amphoteric surfactant include fatty acid amidopropyl betaine, 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolium betaine, and the number of carbon atoms of the hydrocarbon group of the betaine amphoteric surfactant is 8-18 are preferred.
- Particularly preferred is fatty acid amidopropyl betaine having 8 to 18 carbon atoms in the fatty acid, and among these, coconut oil fatty acid amidopropyl betaine is more preferred from the standpoint of flavor.
- Amphoteric surfactant can use a commercial item, and specifically, the following are mentioned.
- ⁇ Palm oil fatty acid amidopropyl betaine EVONIC, TEGO BETAIN CK OK
- 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolium betaine manufactured by Lion Corporation; Enacol C-40H
- the blending amount of the amphoteric surfactant is preferably 0.05 to 1% of the total composition in terms of pure content in terms of foamy creamy feeling, dripping from the mouth, and good taste. Preferably it is 0.1 to 1%, more preferably 0.1 to 0.5%.
- the blending amount is 0.05% or more, the creamy feeling of the foam is improved, and the dripping from the mouth can be further suppressed. It is suitable for suppressing that the foaming property of a toothpaste composition increases too much and foam dripping from a mouth worsens that it is 1% or less. Furthermore, it is also preferable for preventing the bitterness peculiar to amphoteric surfactants from occurring.
- the nonionic surfactant is particularly preferably polyoxyethylene hydrogenated castor oil, more preferably polyoxyethylene hydrogenated castor oil having an average added mole number of ethylene oxide of 20 to 40, particularly 20.
- polyoxyethylene hydrogenated castor oil polyoxyethylene (40) hydrogenated castor oil (manufactured by Nippon Emulsion Co., Ltd .: EMALEX HC-40, average number of moles of ethylene oxide added 40), polyoxyethylene (20) hydrogenated castor oil (Nippon Emulsion Co., Ltd .: EMALEX HC-20, average added mole number of ethylene oxide 20).
- the amount of the nonionic surfactant is preferably 0.1 to 3%, more preferably 0, based on the creamy feeling of the foam, the dripping from the mouth, and the flavor. .2 to 1.5%.
- the blending amount is 0.1% or more, the creamy feeling of the foam is improved, and the dripping from the mouth can be further suppressed. 3% or less is suitable for suppressing deterioration in flavor.
- the blending ratio of (C) amphoteric surfactant and (D) nonionic surfactant is such that (C) / (D) is 0.05 to 5, preferably 0.1 to 5, more preferably 0.1 to 3, and still more preferably 0.5 to 1.5.
- (C) / (D) is 0.05 to 5, preferably 0.1 to 5, more preferably 0.1 to 3, and still more preferably 0.5 to 1.5.
- the total content of the surfactant including the components (B), (C) and (D) is 1.15 to 7.5%, particularly 1.5 to 5.2% of the whole composition.
- the range of 2 to 4% is preferable. If it is within this range, the dripping of the foam can be further suppressed, and the creamy feeling of the foam is also more excellent. Moreover, flavor standing improves more.
- the total content is not too much to suppress the foaming property of the toothpaste composition from being excessively increased and to prevent the dripping of the foam from becoming worse and to prevent the flavor from becoming worse. Furthermore, it is also preferable for suppressing the bitterness derived from the surfactant.
- surfactants other than the components (B), (C), and (D) may be blended as necessary within a range not impeding the effects of the present invention.
- anionic surfactants other than alkyl sulfates for example, N-acyl sarcosine salts such as N-lauroyl sarcosine sodium and N-myristoyl sarcosine sodium, N-acyl glutamate, N-methyl-N-acyl Examples include sodium taurine, sodium N-methyl-N-acylalanine, sodium ⁇ -olefin sulfonate, and the like.
- the toothpaste composition of the present invention preferably further contains (E) a fragrance.
- a fragrance a natural fragrance added as a general fragrance for a dentifrice, a fragrance obtained by processing a natural fragrance, a single fragrance, a blended fragrance, and the like are known fragrance materials used in dentifrice compositions.
- One species can be used alone, or two or more species can be used in combination.
- the flavor of the blended fragrance can be sufficiently exhibited.
- Preferable fragrances include mint-based fragrances, spice-based fragrances, and fruit-based fragrances. When these are used, particularly good flavor standing is obtained.
- the blending amount of the fragrance of the component (E) is preferably 0.5 to 2.5%, more preferably 0.8 to 1.8% of the whole composition from the viewpoint of good flavor. As the amount is increased, the flavor is improved, and when 0.5% or more is blended, a good flavor can be imparted. A content of 2.5% or less is suitable for suppressing deterioration in flavor. When there are too many compounding quantities, it may become impossible to maintain favorable flavor standing.
- abrasive, a thickener, a binder, and a sweetener, a colorant, a preservative, a medicinal component, etc. can be blended if necessary.
- a compounding quantity may be a normal quantity in the range which does not prevent the effect of this invention.
- silica-based abrasives such as silica gel, precipitated silica, aluminosilicate, zirconosilicate, dicalcium phosphate dihydrate and anhydrous, tertiary calcium phosphate, tetracalcium phosphate, calcium pyrophosphate, etc.
- Agents calcium carbonate, aluminum hydroxide, alumina, zeolite, hydroxyapatite, synthetic resin abrasives, and the like.
- the blending amount of these abrasives is usually 2 to 50%, particularly 10 to 30% of the whole composition.
- the thickener examples include sugar alcohols such as sorbit and xylit, and polyhydric alcohols such as glycerin and propylene glycol.
- polyethylene glycol having an average molecular weight of 190 to 2,000 is compatible with the component (A) which is a polymer, so that it can swell and disperse in the aqueous phase. It can be preferably used.
- the blending amount of these thickeners is usually preferably 5 to 50%, particularly preferably 20 to 45% of the whole composition.
- an organic or inorganic binder can be blended.
- sodium carboxymethylcellulose, methylcellulose, hydroxymethylcellulose, cellulose derivatives such as cationized cellulose, alginic acid derivatives such as sodium alginate, propylene glycol alginate, gums such as xanthan gum, karaya gum, gum arabic, sodium polyacrylate examples thereof include organic binders such as polyvinyl alcohol, carboxyvinyl polymer, polyvinyl pyrrolidone, and carrageenan, and inorganic binders such as gelling silica, gelling aluminum silica, bee gum, and laponite.
- the amount of the binder is usually 0.1 to 10%, particularly preferably 0.5 to 5%.
- sweetening agent examples include saccharin sodium, stevioside, stevia extract and the like.
- colorant examples include Red No. 2, No. 3, 225, No. 226, Yellow No. 4, No. 5, Blue No. 1, No. 2, Mica titanium, titanium oxide and the like.
- preservative examples include paraoxybenzoic acid esters such as methylparaben and ethylparaben, benzoic acid such as sodium benzoate, and salts thereof.
- known ingredients that are usually blended such as bactericides, anti-inflammatory agents, enzymes, fluorides, copper compounds, vitamins, plant extracts, anticalculus agents, antiplaque agents, etc. of the present invention are used.
- An effective amount can be blended within a range that does not interfere with the effect.
- nonionic fungicides such as isopropylmethylphenol
- cationic fungicides such as cetylpyridinium chloride, chlorhexidine hydrochloride, benzalkonium chloride, benzethonium chloride, tranexamic acid, epsilon aminocaproic acid, allantoin, glycyrrhetic acid, glycyrrhizin
- Anti-inflammatory agents such as dipotassium acid, enzymes such as dextranase, mutanase, amylase and protease, fluorides such as sodium fluoride and sodium monofluorophosphate, water-soluble phosphate compounds, copper compounds such as copper gluconate, potassium nitrate Inorganic salts such as aluminum lactate, zinc chloride, zinc citrate and strontium chloride, vitamins such as ascorbic acid and tocopherol acetate, plant extracts and the like.
- Dentifrice compositions having the compositions shown in Tables 1 to 3 were prepared by conventional methods and evaluated by the following methods. The results are shown in the table.
- Evaluation criteria A Average point 3.5 points or more and 4.0 points or less ⁇ : Average point 3.0 points or more and less than 3.5 points ⁇ : Average point 2.0 points or more and less than 3.0 points ⁇ : Average point 1. 0 points or more and less than 2.0 points
- Evaluation criteria A Average point 3.5 points or more and 4.0 points or less ⁇ : Average point 3.0 points or more and less than 3.5 points ⁇ : Average point 2.0 points or more and less than 3.0 points ⁇ : Average point 1. 0 points or more and less than 2.0 points
- Evaluation criteria A Average point 3.5 points or more and 4.0 points or less ⁇ : Average point 3.0 points or more and less than 3.5 points ⁇ : Average point 2.0 points or more and less than 3.0 points ⁇ : Average point 1. 0 points or more and less than 2.0 points
- the viscosity of the highly polymerized polyethylene glycol is the viscosity at 25 ° C. measured with a Brookfield viscometer (Brookfield RVT or RVF), as described above. Moreover, the viscosity of 5 W / V% of polyethylene glycol 4000 measured by the same method was less than 10 mPa ⁇ s. ⁇ Highly polymerized polyethylene glycol; POLYOX WSR N-80 (Viscosity of 5 W / V% aqueous solution manufactured by Dow Chemical Company: 85 mPa ⁇ s (rotor No.
- POLYOX WSR N-10 Manufactured by Dow Chemical Co., Ltd., viscosity of 5 W / V% aqueous solution: 35 mPa ⁇ s (rotor No. 1, rotation speed 50 rpm, measurement time 0.5 minutes)
- POLYOX WSR N-750 (Dow Chemical Co., Viscosity of 5 W / V% aqueous solution: 1,100 mPa ⁇ s (Rotor No.
- Table 4 below shows formulation examples. All of these toothpaste compositions were difficult to drip, excellent in creamy feeling, and good in flavor.
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Abstract
Description
このため、歯磨剤組成物において、香味立ちを良好に維持しつつ泡性能を向上することは難しかった。
〔1〕
(A)高重合ポリエチレングリコール、(B)アルキル硫酸塩、(C)両性界面活性剤及び(D)ノニオン性界面活性剤を含有し、(C)成分/(D)成分が質量比として0.05~5であることを特徴とする練歯磨組成物。
〔2〕
(A)成分の高重合ポリエチレングリコールが、ブルックフィールド型粘度計で測定した25℃における5W/V%水溶液の粘度が10mPa・s以上であり、かつ前記粘度計で測定した25℃における2W/V%水溶液の粘度が800mPa・s以下のものである〔1〕に記載の練歯磨組成物。
〔3〕
(C)成分が、ベタイン系両性界面活性剤である〔1〕又は〔2〕に記載の練歯磨組成物。
〔4〕
(C)成分のベタイン系両性界面活性剤が、脂肪酸アミドプロピルベタイン及び/又は2-アルキル-N-カルボキシメチル-N-ヒドロキシエチルイミダゾリウムベタインである〔1〕、〔2〕又は〔3〕に記載の練歯磨組成物。
〔5〕
(D)成分が、エチレンオキサイドの平均付加モル数20~40のポリオキシエチレン硬化ヒマシ油である〔1〕~〔4〕のいずれかに記載の練歯磨組成物。
〔6〕
(A)成分を0.05~0.5質量%、(B)成分を1~3.5質量%、(C)成分を0.05~1質量%、(D)成分を0.1~3質量%含有する〔1〕~〔5〕のいずれかに記載の練歯磨組成物。
〔7〕
更に、(E)香料を0.5~2.5質量%含有する〔1〕~〔6〕のいずれかに記載の練歯磨組成物。
〔8〕
(A)高重合ポリエチレングリコール及び(B)アルキル硫酸塩を配合した練歯磨組成物に、(C)両性界面活性剤及び(D)ノニオン性界面活性剤を、(C)成分/(D)成分が質量比として0.05~5の範囲で配合することを特徴とする、前記練歯磨組成物における(A)、(B)成分の併用による泡垂れの改善方法。
〔9〕
(A)成分の高重合ポリエチレングリコールが、ブルックフィールド型粘度計で測定した25℃における5W/V%水溶液の粘度が10mPa・s以上であり、かつ前記粘度計で測定した25℃における2W/V%水溶液の粘度が800mPa・s以下のものである〔8〕に記載の練歯磨組成物における(A)、(B)成分の併用による泡垂れの改善方法。
〔10〕
(A)成分を0.05~0.5質量%、(B)成分を1~3.5質量%、(C)成分を0.05~1質量%、(D)成分を0.1~3質量%配合した〔8〕又は〔9〕に記載の練歯磨組成物における(A)、(B)成分の併用による泡垂れの改善方法。
〔11〕
更に、(E)香料を0.5~2.5質量%配合した〔8〕、〔9〕又は〔10〕に記載の練歯磨組成物における(A)、(B)成分の併用による泡垂れの改善方法。
5W/V%水溶液の粘度が20,000mPa・sを超える場合は、粘度測定が不能となるため、2W/V%水溶液における粘度を採用する。即ち、本発明において、高重合ポリエチレングリコールは、下記(1)又は(2)の粘度物性を有することが好ましい。
(1)25℃における5W/V%水溶液の粘度が10~20,000mPa・s
(2)(1)で粘度が20,000mPa・sを超える場合は、25℃における2W/V%水溶液の粘度が800mPa・s以下
本発明において、より好ましい高重合ポリエチレングリコールは、25℃における5W/V%水溶液の粘度が10~18,000mPa・s、特に30~10,000mPa・s、とりわけ55~2,000mPa・sのものである。
上記5W/V%水溶液の粘度が10mPa・sに満たないと、口からの泡垂れ改善に十分に寄与せず、泡のクリーミー感向上効果が劣る場合があり、上記2W/V%水溶液の粘度が800mPa・sを超えると、香味立ちが悪くなるだけでなく、練歯磨組成物の安定性が低下する場合がある。
・POLYOX WSR N-10
(ダウ・ケミカル社製、5W/V%水溶液の粘度:12~50mPa・s、測定機器:ブルックフィールド RVT、ローターNo.1、回転数50rpm、測定温度25℃、測定時間0.5分)
・POLYOX WSR N-80
(ダウ・ケミカル社製、5W/V%水溶液の粘度:55~115mPa・s、測定機器:ブルックフィールド RVT、ローターNo.1、回転数50rpm、測定温度25℃、測定時間0.5分)
・POLYOX WSR N-750
(ダウ・ケミカル社製、5W/V%水溶液の粘度:1,000~1,200mPa・s、測定機器:ブルックフィールド RVF、ローターNo.2、回転数10rpm、測定温度25℃、測定時間1分)
・POLYOX WSR-205
(ダウ・ケミカル社製、5W/V%水溶液の粘度:4,500~8,800mPa・s、測定機器:ブルックフィールド RVF、ローターNo.2、回転数2rpm、測定温度25℃、測定時間5分)
・POLYOX WSR-1105
(ダウ・ケミカル社製、5W/V%水溶液の粘度:8,800~17,600mPa・s、測定機器:ブルックフィールド RVF、ローターNo.2、回転数2rpm、測定温度25℃、測定時間5分)
・POLYOX WSR N-12K
(ダウ・ケミカル社製、2W/V%水溶液の粘度:400~800mPa・s、測定機器:ブルックフィールド RVF、ローターNo.1、回転数10rpm、測定温度25℃、測定時間1分)
(B)アルキル硫酸塩としては、ラウリル硫酸ナトリウム、ミリスチル硫酸ナトリウム等のアルキル硫酸ナトリウムを用いることができるが、特にラウリル硫酸ナトリウムが香味立ちの点からより好ましい。具体的には、ラウリル硫酸ナトリウム(東邦化学工業(株)製;ラウリル硫酸ナトリウム)、ミリスチル硫酸ナトリウム(日光ケミカルズ(株)製;NIKKOL SMS)等を使用できる。
ベタイン系両性界面活性剤としては、脂肪酸アミドプロピルベタイン、2-アルキル-N-カルボキシメチル-N-ヒドロキシエチルイミダゾリウムベタイン等が挙げられ、前記ベタイン系両性界面活性剤の炭化水素基の炭素数は8~18が好ましい。特に好ましくは、脂肪酸の炭素数が8~18である脂肪酸アミドプロピルベタインであり、その中でもヤシ油脂肪酸アミドプロピルベタインが、香味立ちの点からより好ましい。
・ヤシ油脂肪酸アミドプロピルベタイン(EVONIC社製;TEGO BETAIN CK OK)
・2-アルキル-N-カルボキシメチル-N-ヒドロキシエチルイミダゾリウムベタイン(ライオン(株)製;エナジコール C-40H)
ポリオキシエチレン硬化ヒマシ油としては、ポリオキシエチレン(40)硬化ヒマシ油(日本エマルション(株)製:EMALEX HC-40、エチレンオキサイドの平均付加モル数40)、ポリオキシエチレン(20)硬化ヒマシ油(日本エマルション(株)製:EMALEX HC-20、エチレンオキサイドの平均付加モル数20)等が挙げられる。
この場合、(C)両性界面活性剤と(D)ノニオン性界面活性剤との配合比率は、(C)/(D)が質量比として0.05~5であり、好ましくは0.1~5、より好ましくは0.1~3、さらに好ましくは0.5~1.5である。上記範囲内であると、口からの泡垂れのなさ、泡のクリーミー感、香味立ちが優れる。0.05未満であると、香味立ちが悪くなる。5を超えると、練歯磨組成物の発泡性が増し過ぎてしまい、泡のクリーミー感を損ねると同時に、口からの泡垂れがひどくなる。
防腐剤としては、メチルパラベン、エチルパラベン等のパラオキシ安息香酸エステル、安息香酸ナトリウム等の安息香酸又はその塩などが挙げられる。
具体的には、イソプロピルメチルフェノール等の非イオン性殺菌剤、塩化セチルピリジニウム、塩酸クロルヘキシジン、塩化ベンザルコニウム、塩化ベンゼトニウム等のカチオン性殺菌剤、トラネキサム酸、イプシロンアミノカプロン酸、アラントイン、グリチルレチン酸、グリチルリチン酸ジカリウム等の抗炎症剤、デキストラナーゼ、ムタナーゼ、アミラーゼ、プロテアーゼ等の酵素、フッ化ナトリウム、モノフルオロリン酸ナトリウム等のフッ化物、水溶性リン酸化合物、グルコン酸銅等の銅化合物、硝酸カリウム、乳酸アルミニウム、塩化亜鉛、クエン酸亜鉛、塩化ストロンチウムなどの無機塩類、アスコルビン酸、酢酸トコフェロール等のビタミン類、植物抽出物などが挙げられる。
表1~3に示す組成の歯磨組成物(練歯磨剤)を常法により調製し、下記方法で評価した。結果を表に併記する。
10人のパネラーが、ラミネートチューブに充填した歯磨組成物を市販品歯ブラシ上に1cm押出し、3分間歯のブラッシングを行い、歯磨き中の口からの泡垂れについて、「泡垂れしない」、「ごくわずかに泡垂れするが問題ない」、「やや泡垂れする」、「泡垂れする」の4段階で回答を得た。この回答のうち、「泡垂れしない」を4点、「ごくわずかに泡垂れするが問題ない」を3点、「やや泡垂れする」を2点、「泡垂れする」を1点として、判定した。
10名の平均点から、以下の基準で◎及び○の評価が確保されるものを、歯磨き中に口から泡が垂れにくいと感じられる歯磨組成物であると判断した。
評価基準
◎:平均点3.5点以上4.0点以下
○:平均点3.0点以上3.5点未満
△:平均点2.0点以上3.0点未満
×:平均点1.0点以上2.0点未満
10人のパネラーが、ラミネートチューブに充填した歯磨組成物を市販品の歯ブラシ上に1cm押出し、3分間歯のブラッシングを行い、歯磨き中の泡のクリーミー感について、対照((A)高重合ポリエチレングリコール、(C)両性界面活性剤、(D)ノニオン性界面活性剤を含まない以外は実施例1と同様の組成の歯磨組成物)と比較し、「向上する」、「やや向上する」、「ごくわずかに向上する」、「向上しない」の4段階で回答を得た。この回答のうち、「向上する」を4点、「やや向上する」を3点、「ごくわずかに向上する」を2点、「向上しない」を1点として、判定した。
10名の平均点から、以下の基準で◎及び○の評価が確保されるものを、歯磨き中の泡のクリーミー感が向上していると感じられる歯磨組成物であると判断した。
評価基準
◎:平均点3.5点以上4.0点以下
○:平均点3.0点以上3.5点未満
△:平均点2.0点以上3.0点未満
×:平均点1.0点以上2.0点未満
10人のパネラーが、ラミネートチューブに充填した歯磨組成物を市販品歯ブラシ上に1cm押出し、3分間歯のブラッシングを行い、歯磨き中の香味立ちについて、「非常に良い」、「良い」、「やや悪い」、「悪い」の4段階で回答を得た。この回答のうち、「非常に良い」を4点、「良い」を3点、「やや悪い」を2点、「悪い」を1点として、判定した。
10名の平均点から、以下の基準で◎及び○の評価が確保されるものを、歯磨き中の香味立ちが良好な歯磨組成物であると判断した。
評価基準
◎:平均点3.5点以上4.0点以下
○:平均点3.0点以上3.5点未満
△:平均点2.0点以上3.0点未満
×:平均点1.0点以上2.0点未満
・高重合ポリエチレングリコール;
POLYOX WSR N-80
(ダウ・ケミカル社製、5W/V%水溶液の粘度:85mPa・s(ロー
ターNo.1、回転数50rpm、測定時間0.5分))
POLYOX WSR N-10
(ダウ・ケミカル社製、5W/V%水溶液の粘度:35mPa・s(ロー
ターNo.1、回転数50rpm、測定時間0.5分))
POLYOX WSR N-750
(ダウ・ケミカル社製、5W/V%水溶液の粘度:1,100mPa・s
(ローターNo.2、回転数10rpm、測定時間1分))
POLYOX WSR N-12K
(ダウ・ケミカル社製、2W/V%水溶液の粘度:420mPa・s(ロ
ーターNo.1、回転数10rpm、測定時間1分))
・ポリエチレングリコール4000(比較成分)
(三洋化成工業社製、医薬部外品原料規格2006記載の平均分子量2,
600~3,800)
・ラウリル硫酸ナトリウム
(東邦化学工業社製)
・ミリスチル硫酸ナトリウム
(日光ケミカルズ社製)
・ヤシ油脂肪酸アミドプロピルベタイン
(TEGO BETAIN CK OK、EVONIC社製)
・2-アルキル-N-カルボキシメチル-N-ヒドロキシエチルイミダゾリ
ウムベタイン
(エナジコール C-40H、ライオン社製)
・ポリオキシエチレン(40)硬化ヒマシ油
(エチレンオキサイド平均付加モル数40、EMALEX HC-40、
日本エマルション社製)
・ポリオキシエチレン(20)硬化ヒマシ油
(エチレンオキサイド平均付加モル数20、EMALEX HC-20、
日本エマルション社製)
なお、香料A-1~A-3、B-1、B-2、Cの組成の詳細は、後述の表5~11に示す通りである。
Claims (11)
- (A)高重合ポリエチレングリコール、(B)アルキル硫酸塩、(C)両性界面活性剤及び(D)ノニオン性界面活性剤を含有し、(C)成分/(D)成分が質量比として0.05~5であることを特徴とする練歯磨組成物。
- (A)成分の高重合ポリエチレングリコールが、ブルックフィールド型粘度計で測定した25℃における5W/V%水溶液の粘度が10mPa・s以上であり、かつ前記粘度計で測定した25℃における2W/V%水溶液の粘度が800mPa・s以下のものである請求項1記載の練歯磨組成物。
- (C)成分が、ベタイン系両性界面活性剤である請求項1又は2記載の練歯磨組成物。
- (C)成分のベタイン系両性界面活性剤が、脂肪酸アミドプロピルベタイン及び/又は2-アルキル-N-カルボキシメチル-N-ヒドロキシエチルイミダゾリウムベタインである請求項1、2又は3記載の練歯磨組成物。
- (D)成分が、エチレンオキサイドの平均付加モル数20~40のポリオキシエチレン硬化ヒマシ油である請求項1~4のいずれか1項記載の練歯磨組成物。
- (A)成分を0.05~0.5質量%、(B)成分を1~3.5質量%、(C)成分を0.05~1質量%、(D)成分を0.1~3質量%含有する請求項1~5のいずれか1項記載の練歯磨組成物。
- 更に、(E)香料を0.5~2.5質量%含有する請求項1~6のいずれか1項記載の練歯磨組成物。
- (A)高重合ポリエチレングリコール及び(B)アルキル硫酸塩を配合した練歯磨組成物に、(C)両性界面活性剤及び(D)ノニオン性界面活性剤を、(C)成分/(D)成分が質量比として0.05~5の範囲で配合することを特徴とする、前記練歯磨組成物における(A)、(B)成分の併用による泡垂れの改善方法。
- (A)成分の高重合ポリエチレングリコールが、ブルックフィールド型粘度計で測定した25℃における5W/V%水溶液の粘度が10mPa・s以上であり、かつ前記粘度計で測定した25℃における2W/V%水溶液の粘度が800mPa・s以下のものである請求項8記載の練歯磨組成物における(A)、(B)成分の併用による泡垂れの改善方法。
- (A)成分を0.05~0.5質量%、(B)成分を1~3.5質量%、(C)成分を0.05~1質量%、(D)成分を0.1~3質量%配合した請求項8又は9記載の練歯磨組成物における(A)、(B)成分の併用による泡垂れの改善方法。
- 更に、(E)香料を0.5~2.5質量%配合した請求項8、9又は10記載の練歯磨組成物における(A)、(B)成分の併用による泡垂れの改善方法。
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JP2011105647A (ja) | 2009-11-18 | 2011-06-02 | Lion Corp | 歯磨組成物 |
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US5820854A (en) * | 1997-03-27 | 1998-10-13 | The Procter & Gamble Company | Oral compositions containing polyoxyethylene |
US5833956A (en) * | 1997-04-02 | 1998-11-10 | Colgate-Palmolive Company | Oral composition containing an anionic, a nonionic and an amphoteric surfactant system |
JP2009084277A (ja) * | 2007-09-14 | 2009-04-23 | Sunstar Inc | 歯磨組成物 |
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JP7331182B2 (ja) | 2017-10-12 | 2023-08-22 | サンスター株式会社 | シリカ含有口腔用組成物 |
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CN106029053B (zh) | 2019-10-22 |
KR102306478B1 (ko) | 2021-09-29 |
KR20160120275A (ko) | 2016-10-17 |
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