WO2014171433A1 - 崩壊可能なカプセル及びその製造方法並びに崩壊可能なカプセルを含む喫煙器具 - Google Patents
崩壊可能なカプセル及びその製造方法並びに崩壊可能なカプセルを含む喫煙器具 Download PDFInfo
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- WO2014171433A1 WO2014171433A1 PCT/JP2014/060663 JP2014060663W WO2014171433A1 WO 2014171433 A1 WO2014171433 A1 WO 2014171433A1 JP 2014060663 W JP2014060663 W JP 2014060663W WO 2014171433 A1 WO2014171433 A1 WO 2014171433A1
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- capsule
- film
- weight
- collapsible
- capsule according
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Images
Classifications
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- A—HUMAN NECESSITIES
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- A24D—CIGARS; CIGARETTES; TOBACCO SMOKE FILTERS; MOUTHPIECES FOR CIGARS OR CIGARETTES; MANUFACTURE OF TOBACCO SMOKE FILTERS OR MOUTHPIECES
- A24D3/00—Tobacco smoke filters, e.g. filter-tips, filtering inserts; Filters specially adapted for simulated smoking devices; Mouthpieces for cigars or cigarettes
- A24D3/06—Use of materials for tobacco smoke filters
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- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24D—CIGARS; CIGARETTES; TOBACCO SMOKE FILTERS; MOUTHPIECES FOR CIGARS OR CIGARETTES; MANUFACTURE OF TOBACCO SMOKE FILTERS OR MOUTHPIECES
- A24D1/00—Cigars; Cigarettes
- A24D1/002—Cigars; Cigarettes with additives, e.g. for flavouring
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/30—Encapsulation of particles, e.g. foodstuff additives
- A23P10/35—Encapsulation of particles, e.g. foodstuff additives with oils, lipids, monoglycerides or diglycerides
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24D—CIGARS; CIGARETTES; TOBACCO SMOKE FILTERS; MOUTHPIECES FOR CIGARS OR CIGARETTES; MANUFACTURE OF TOBACCO SMOKE FILTERS OR MOUTHPIECES
- A24D3/00—Tobacco smoke filters, e.g. filter-tips, filtering inserts; Filters specially adapted for simulated smoking devices; Mouthpieces for cigars or cigarettes
- A24D3/06—Use of materials for tobacco smoke filters
- A24D3/061—Use of materials for tobacco smoke filters containing additives entrapped within capsules, sponge-like material or the like, for further release upon smoking
Definitions
- the present invention relates to a collapsible capsule.
- Patent Document 1 Conventionally, capsules have been widely used in the fields of medicines, cosmetics, health foods, etc.
- Patent Document 1 the application has been expanded, and not only a technique for increasing the strength of the capsule film to make it difficult to break, but also a technique for making it easy to break, has been demanded.
- Examples of the use of the technology to make it easy to break include embedding a capsule containing a fragrance in a cigarette filter to break the capsule when smoking and enjoy the scent, and enjoy the sound and feel when the capsule breaks Etc.
- Patent Document 2 discloses that in a soft capsule having a seam, the joint surface of the seam is inclined or a fringe is provided using a special mold to thicken only the joint part. Patent Document 2 discloses that in a soft capsule with a seam for bathing agent, it is possible to prevent the adhesion portion of the film from being locally thinned.
- flavor contained in a capsule has many volatile things, and the storage stability of the contents is required before using. Further, when used in a smoking device, the capsule may not be broken even if the smoker softens during smoking due to moisture during smoking and the smoker applies pressure with a finger.
- carrageenan As a gelling agent for capsule film.
- carrageenan has a high thickening effect and has a high gelation rate, so that it contains a large amount of carrageenan, which hinders encapsulation. That is, when the content of carrageenan is high, because of high viscosity and fast gelation, the capsules have poor moldability, such as poor sphericity and ease of solidification at the tip of the injection nozzle, and preferred capsules could not be produced. .
- Patent Document 3 starch, dextrin, non-gelling polysaccharide, etc. are blended with carrageenan as a base or filler for increasing the solid content concentration of the film, and low viscosity is obtained. It is disclosed to reduce the gelation rate.
- carrageenan which is considered to be less hygroscopic than gelatin, is used, the effects of humidity can be reduced by adding starch, dextrin, non-gelling polysaccharides, etc. In some cases, additional values such as ease of cracking with fingers after drying and sound and touch when cracking cannot be obtained stably over time.
- Patent Documents 4 to 11 disclose that a capsule is embedded in a cigarette filter, but the manufacturability of the capsule, storage stability, ease of cracking with fingers after drying, Added value such as touch is not considered.
- the present invention has no adhesion between capsules, no change in capsule contents over time, excellent heat resistance and moisture resistance, can be easily broken when pressure is applied with a finger, has a good feeling of cracking, content
- the object is to provide a capsule that can be released and can be disintegrated.
- a disintegratable capsule (sometimes referred to as capsule A).
- 150 ⁇ (X) ⁇ 630 (1) (In the above formula, (X) represents the breaking strength (g) / the outer diameter (mm) of the capsule). 0.15 ⁇ (Y) ⁇ 0.53 (2)
- (Y) represents a distance / outer diameter ratio, and the distance is a distance deformed to reach the maximum load when the capsule is broken by pressing the capsule at 22 ° C. and 80% RH.
- the film-forming base comprises agar and carrageenan.
- the capsule film may be alginic acid or a salt thereof, fur celeran, curdlan, gati gum, gum arabic, pullulan, welan gum, xanthan gum, gellan gum, tragacanth gum, pectin, glucomannan, guar gum, tara gum, tamarind seed gum, locust bean gum
- the disintegratable material according to any one of [1] to [14], further comprising a film forming agent that is at least one selected from the group consisting of psyllium seed gum, amase seed gum and diyutan gum capsule.
- the collapsible capsule according to any one of [15] to [22], which is a part.
- the capsule film is a plasticizer (for example, at least one selected from polyhydric alcohols, monosaccharides, disaccharides, oligosaccharides, sugar alcohols, polyvinyl alcohol, triacetin, starch derivatives, starches, and cellulose derivatives).
- a plasticizer for example, at least one selected from polyhydric alcohols, monosaccharides, disaccharides, oligosaccharides, sugar alcohols, polyvinyl alcohol, triacetin, starch derivatives, starches, and cellulose derivatives.
- the present invention is a capsule having a content and a capsule film, which contains an oily component as the content, and a film-forming base (particularly, a film-forming base containing agar and carrageenan) as the capsule film. And a film-forming agent (particularly a film-forming agent containing at least guar gum) is also included.
- a collapsible capsule may satisfy the formula (1) and / or the formula (2) defined in the capsule A.
- the same components as described above can be used as the film-forming base and the film-forming agent.
- a capsule containing a film-forming base containing agar and carrageenan and a film-forming agent containing guar gum (underivatized guar gum or a derivative thereof) is used as a capsule film. included.
- the types and ratios of the film-forming base and the film-forming agent can be selected from the same types and ranges as those of the capsule A.
- the guar gum may contain a guar gum enzyme degradation product.
- the film forming agent may contain guar gum and alginic acid or a salt thereof.
- the ratio of the film forming base and the film forming agent may be 60% by weight or more.
- the ratio of the film forming agent may be 0.1 to 5 parts by weight with respect to 1 part by weight of the film-forming base.
- Capsules with a weight percentage of 0.3 to 3 parts by weight with respect to 1 part by weight of the film-forming base are included.
- the capsule film was further selected from plasticizers (for example, polyhydric alcohol, monosaccharide, disaccharide, oligosaccharide, sugar alcohol, polyvinyl alcohol, triacetin, starch derivative, starch, and cellulose derivative). At least one plasticizer).
- the plasticizer may include at least one selected from glycerin, starch, starch derivatives, and cellulose derivatives.
- the proportion of the plasticizer may be 3 to 40 parts by weight with respect to 100 parts by weight of the film-forming base.
- the capsule B may also be a capsule for a smoking device, like the capsule A. Therefore, the present invention also includes a smoking device including the capsule B.
- the collapsible capsule of the present invention improves the adhesion between capsules, has excellent heat resistance and moisture resistance, does not change over time, and can be easily broken when pressure is applied with a finger.
- the feeling of cracking is good and the contents can be released.
- the capsules obtained have a uniform cracking feeling, heat resistance and moisture resistance, and are excellent in that there are few variations. Further, by making the collapsible capsule of the present invention transparent or translucent, coloring according to the image of the product is also possible.
- FIG. 1 shows a schematic diagram of a collapsible capsule of the present invention.
- FIG. 2 shows a suitably substantially concentric aligned composite nozzle device for use in the present invention.
- FIG. 3 is a photograph of the capsule after the heat resistance test.
- FIG. 4 is a photograph of the capsule after the heat resistance test.
- the collapsible capsule of the present invention is a capsule 3 having a content 1 and a capsule film 2, which contains an oily component as the content of the capsule and has at least a film-forming group as the capsule film.
- This capsule may satisfy the following formula (1) and the following formula (2).
- 150 ⁇ (X) ⁇ 630 (1) (In the above formula, (X) represents the breaking strength (g) / the outer diameter (mm) of the capsule). 0.15 ⁇ (Y) ⁇ 0.53 (2)
- (Y) represents a distance / outer diameter ratio, and the distance is a distance deformed to reach the maximum load when the capsule is broken by pressing the capsule at 22 ° C. and 80% RH.
- Mm Mm
- the collapsible capsules of the present invention can be used for smoking devices, preferably cigarettes, cigars or pipes.
- the collapsible capsule of the present invention can break the film by applying pressure with a finger during use after being encapsulated in a smoking device.
- the film is broken, the fragrance and the like of the contents are released, and the scent can be enjoyed.
- the shape of the collapsible capsule of the present invention is not particularly limited, and may be, for example, a spherical shape or a football shape, but a spherical shape is preferable, and a true spherical shape is more preferable.
- the ratio of the minor axis / major axis of the collapsible capsule of the present invention is not particularly limited, but is preferably 0.90 to 1.00, preferably 0.95 to 1.00. Is more preferable. By using the above ratio, it has an appropriate breaking strength, is excellent in storage stability, is easily broken, and can be stored in a filter of a smoking instrument when used for a filter of a smoking instrument.
- the formula (1) is as follows. 150 ⁇ (X) ⁇ 630 (1)
- (X) represents the breaking strength (g) / the outer diameter (mm) of the capsule).
- the breaking strength (g) was measured with a rheometer CR-500DX (measuring instrument, manufactured by Sun Kagaku Co., Ltd.) at 22 ° C. and 60% RH, and Rheo Data analyzer for Win (physical data analysis software).
- the outer diameter (mm) of the capsule means the major axis when the planar shape (cross section) of the capsule is circular, and the planar shape (cross section) of the capsule is circular. If not, it means the maximum diameter.
- the value represented by (X) is usually more than 150 and less than 630 (for example, 180 or more and 600 or less, preferably 190 or more and 580 or less), for example, more than 200 and less than 560,
- it is excellent in moisture resistance, and when applied with an appropriate force by hand, it can be easily broken and has a good feeling of cracking, and preferably 220 ⁇ (X) ⁇ 530, more preferably 230 ⁇ ( X) ⁇ 480.
- the breaking strength of the collapsible capsule of the present invention can be selected according to the outer diameter and the like, and is not particularly limited.
- the breaking strength is 100 to 5000 g (for example, 150 to 4000 g), preferably 200.0 to 3000.0 g. Although it depends on the outer diameter of the capsule, it is more preferably 250.0 to 2800.0 g, still more preferably 700.0 to 2000.0 g.
- the fracture strength is adjusted to obtain the effect of the present invention. can do.
- the capsule tends to break, and if it exceeds 5000 g, although it depends on the outer diameter of the capsule, it becomes difficult to crush the capsule with a finger, which is not preferable.
- Fracture strength was measured with a rheometer CR-500DX (measuring instrument, manufactured by Sun Scientific Co., Ltd.) at 22 ° C. and 60% RH, and Rheo Data analyzer for Win, physical property data automatic analysis software, Co., Ltd. This is the value analyzed by Sun Science.
- the distance is a value measured with a rheometer CR-500DX manufactured by Sun Kagaku Co., Ltd.
- the distance / outer diameter ratio is adjusted within the scope of the present invention by adjusting the content of the film-forming base and the hydrophilic polymer film-forming agent and / or adjusting in the manufacturing process such as the cooling process and the drying process. it can.
- the distance (mm) / outer diameter (mm) ratio (Y) at 22 ° C. and 80% RH is usually 0.15 to 0.53 (for example, 0.18 to 0.5). ), For example, about 0.20 or more and 0.48 or less, preferably 0.22 to 0.47, more preferably 0.25 to 0.46, and still more preferably 0.30 to 0.00. 45 and 0.34 or more (for example, 0.35 to 0.53, preferably 0.36 to 0.5, more preferably 0.37 to 0.48).
- the above-mentioned range is preferable because the resulting capsule is excellent in heat resistance and moisture resistance, and can be easily broken and enjoyed when a moderate force is applied by hand.
- the distance at 22 ° C. and 80% RH is usually 0.5 to 1.9 mm (for example, less than 0.70 to 1.70 mm) for a capsule having an outer diameter of about 3.5 mm, and more preferably 0. .77 to 1.65 mm, more preferably 0.88 to 1.60 mm, and 1.17 mm or more (for example, 1.18 to 1.9 mm, preferably 1.2 to 1.7 mm, more preferably 1.21 to 1.65 mm).
- the film thickness of the collapsible capsule of the present invention is not particularly limited, but is usually 5 to 120 ⁇ m, and is preferably 10 to 100 ⁇ m, more preferably 20 to 90 ⁇ m, from the viewpoint that the obtained effect of the present invention is particularly excellent. And particularly preferably 20 to 60 ⁇ m.
- the film thickness of the capsule film is a value measured using a digital microscope (trade name; VHX-900, using a calibration scale of 10 ⁇ m) manufactured by Keyence Corporation.
- the coating rate of the collapsible capsule of the present invention is not particularly limited, but is excellent in heat resistance and moisture resistance, and can be more easily broken when a moderate force is applied by hand, from the point of good crack feeling Usually, it is 5.0% or more and 18.0% or less, preferably 5.5% or more and 15.0% or less, and more preferably 5.5% or more and 12.0% or less.
- the coating rate represents the weight ratio of the coating to the whole capsule.
- the moisture content of the capsule film of the present invention is not particularly limited, it is usually 10.0% or more and 19.0% or less, and preferably 11.0% or more and 18. It is 0% or less, and more preferably 12.0 to 16.0%. Since all capsules can be easily broken with the same force and the disintegrating quality becomes uniform, the average value of the moisture content of the capsules is particularly preferably within the above range.
- the water content of the present invention is a value measured by the method described in the Japanese Pharmacopoeia. Specifically, the dry weight after treatment at 110 ° C. for 120 minutes from the state of 22 ° C. and 60% RH is calculated and calculated. It is the value.
- the outer diameter ( ⁇ m) / film thickness ( ⁇ m) ratio of the collapsible capsule of the present invention is not particularly limited, but is usually 50.0 to 300.0, preferably 80.0 to 250.0, More preferably, it is 100.5 to 200.0. Since any capsule can be easily broken with the same force and the disintegrating quality becomes uniform, it is preferable that the average value of the capsule outer diameter / film thickness ratio is within the above range.
- the water activity value of the capsule film of the capsule of the present invention is usually 0.400 or more and 0.650 or less, preferably 0.410 or more and 0.630 or less, from the point that the effect of the present invention to be obtained is particularly excellent, More preferably, it is 0.420 or more and 0.620 or less.
- the water activity value (Aw) of the present invention means the ratio of free water measured immediately after production with a water activity measurement system manufactured by Rotronic at 22 ° C. and 60% RH (relative humidity).
- Examples of the water activity measurement system manufactured by Rotronic include Aw series (for example, Aw-Lab, Aw-Palm, Aw-Quick, etc.).
- the outer diameter of the capsule of the present invention is not particularly limited, and is usually 1.0 to 15.0 mm, preferably 1.5 to 10.0 mm, and more preferably 2.0 to 5.0 mm.
- the outer diameter means the long diameter when the capsule has a circular planar shape (cross section), and means the maximum diameter when the capsule has a planar shape (cross section) that is not circular.
- the size of the capsule can be adjusted by changing the number of rotations of the pump at the time of manufacture (changing the liquid feeding amount).
- the capsule of the present invention is not particularly limited, but a seamless capsule is preferable because force is easily transmitted when it is divided with a finger.
- a film-forming base is used.
- the film-forming base used for the capsule film of the present invention is not particularly limited, and examples thereof include agar, carrageenan, gelatin and the like. These can use a commercial item. These may be used individually by 1 type, and 2 or more types may be mixed and used for them. For example, a combination of agar and carrageenan, a combination of gelatin and carrageenan, and the like may be used, but the combination of agar and gelatin is preferably excluded.
- As the film-forming base it is preferable to combine at least agar and carrageenan.
- a capsule having excellent properties as described above can be obtained efficiently.
- a film forming agent in particular, at least guar gum
- the content of these film-forming bases in the capsule film is not particularly limited as long as the effects of the present invention are not hindered, but is usually 10 to 80% by weight, for example, 15% by weight or more and less than 65% by weight, preferably 20 to 60% by weight.
- the content of the base in the capsule film is less than 10% by weight (for example, less than 15% by weight) or more than 80% by weight (for example, 65% by weight or more), the feeling of cracking of the capsule is impaired, which is not preferable.
- the agar is not particularly limited, and examples thereof include powder agar, solid agar, and flake agar, and powder agar is preferable.
- the raw material for the agar used in the present invention is not particularly limited, and examples thereof include red algae. Examples of red algae include Amakusa and Ogonori, and Amakusa is preferred. Commercially available agar can be used.
- the agar is not particularly limited, but the obtained capsule has excellent heat resistance and moisture resistance, and can be easily broken when applied with an appropriate force by hand, has a good feeling of cracking, and enjoys the feel. Therefore, a high-strength material is preferable, specifically, a jelly strength of 600 g / cm 2 or more is preferable, a 650 g / cm 2 or more is more preferable, and a 700 g / cm 2 or more is more preferable. .
- the jelly strength is a value measured by the Nissho water method. Specifically, a gel prepared by preparing a 1.5% solution of agar, left at 20 ° C. for 15 hours, and solidified was 20 per 1 cm 2 of the surface.
- the maximum weight (number of grams) that can withstand the second is taken as the jelly strength.
- the jelly strength means a value at 1.5% concentration. These may be used individually by 1 type, and 2 or more types may be mixed and used for them.
- the content in these capsule films is not particularly limited, but is usually 60% by weight or less, preferably 55% by weight or less. When the content of the agar exceeds 60% by weight, the capsule becomes hard and the breaking strength is improved, but it is difficult to crush or the feeling of cracking is impaired, which is not preferable.
- the carrageenan is not particularly limited, and examples thereof include ⁇ (kappa) carrageenan, ⁇ (iota) carrageenan, ⁇ (lambda) carrageenan, ⁇ (mu) carrageenan, ⁇ (new) carrageenan, ⁇ carrageenan, and ⁇ (zeta) carrageenan. Or pi carrageenan etc. are mentioned. These may be used individually by 1 type, and 2 or more types may be mixed and used for them.
- the content in these capsule films is not particularly limited as long as the effects of the present invention are not hindered.
- the present invention it is excellent in gelation ability at the time of manufacture, and the resulting capsule is excellent in heat resistance and moisture resistance, and when it is applied with an appropriate force by hand, it can be more easily broken, and the feeling of cracking is good.
- ⁇ (kappa) carrageenan and ⁇ (iota) carrageenan are preferable.
- Carrageenan is produced by extraction from all algae of the red algae such as Sugioriaceae, Mirinaceae and Ibarariaceae using known means and methods. A commercially available carrageenan can be used.
- Examples of commercially available products include Genuvisco (Iota type, Sanki Co., Ltd.), Genugel (Kappa type, Sanki Co., Ltd.), Sachiagel ME4 (SATIAGEL ME4, Kappa type, Cargill Japan Co., Ltd.), etc. Suitable examples include Sachiagel ME4 (SATIAGEL ME4, Kappa type, Cargill Japan Co., Ltd.).
- Genuvisco Iota type, Sanki Co., Ltd.
- Genugel Kappa type, Sanki Co., Ltd.
- Sachiagel ME4 SATIAGEL ME4, Kappa type, Cargill Japan Co., Ltd.
- Suitable examples include Sachiagel ME4 (SATIAGEL ME4, Kappa type, Cargill Japan Co., Ltd.).
- the capsule of the present invention is transparent or translucent and is colored according to the image of the product, it is preferable to use kappa carrageenan.
- the viscosity of the carrageenan is not particularly limited, but the resulting capsule has excellent storage stability, disintegration, and the like, and can be easily broken when applied with an appropriate force by hand, has a good feeling of cracking, and feel. Is preferably 5 mPa ⁇ s or more.
- the upper limit of the viscosity is not particularly limited, but is preferably 500 mPa ⁇ s or less.
- the viscosity is a value measured by a method described in the 8th edition of the Food Additives Standard, and can be measured using, for example, a B-type viscometer (manufacturer name: BROOK FIELD, MODEL: LVDVE115).
- the carrageenan is not particularly limited, but preferably has a pH of 7.5 to 15.0, more preferably a pH of 7.8 to 13.0, from the viewpoint of excellent storage stability and disintegration of the resulting capsule. .
- the carrageenan is not particularly limited, but preferably has less impurities, so that the total amount of 2-propanol and methanol measured by the method described in the 8th edition of the Food Additives is 0.50% or less. Is preferred.
- the content of the carrageenan in the capsule film is not particularly limited, but is usually 1.0% by weight or more and less than 50.0% by weight, preferably 3.0% by weight or more and 45.0%. % By weight or less. This is because when the content of carrageenan is too large, the viscosity of the capsule coating liquid increases and the capsule of the present invention cannot be produced.
- the gelatin is not particularly limited, and examples thereof include pork gelatin, beef gelatin, and fish gelatin. These can use a commercial item. These may be used individually by 1 type, and 2 or more types may be mixed and used for them.
- Non-mammal capsules can be made by not using mammal-derived gelatin when the purpose is not to use mammals (eg, cows, pigs, etc.) due to religious restrictions, allergies, etc. it can.
- the gelatin is not particularly limited, and gelatin derivatives such as succinylated gelatin, gelatin hydrolyzate, hydrolyzed gelatin, and cross-linked gelatin may be used.
- the gelatin is not particularly limited, but the resulting capsule has excellent heat resistance and moisture resistance, and can be easily broken when applied with an appropriate force by hand, has a good feeling of cracking, and enjoys the feel. Therefore, a material having a high strength is preferable. For example, a material having a bloom strength (bloom number) of 190 or more is preferable, a material having 220 or more is more preferable, and a material having 250 or more is more preferable. Bloom strength is defined by the mass required for a 12.7 mm diameter cylindrical piston to be pushed into a 4 mm gel. Commercial products (for example, products of Rousselot) can be used for these. These may be used individually by 1 type, and 2 or more types may be mixed and used for them.
- the content in these capsule films is not particularly limited, but is usually less than 65% by weight and preferably 60% by weight or less. When the gelatin content is 65% by weight or more, the capsule becomes hard and the breaking strength is improved, but it is difficult to be crushed.
- the film-forming base used for the capsule film of the present invention is not particularly limited, but the obtained capsule is excellent in heat resistance and moisture resistance, and can be easily broken when an appropriate force is applied by hand. Since the cracking feeling is good and the touch can be enjoyed, among the above-mentioned materials, an embodiment including a base having high strength (high jelly strength, high bloom strength) is preferable.
- the capsule film of the present invention may further contain a hydrophilic polymer film-forming agent, if necessary.
- the hydrophilic polymer film-forming agent used in the capsule film of the present invention is not particularly limited, but examples thereof include seaweed-derived polysaccharides such as alginic acid or a salt thereof, farseleran and curdlan; and resin-derived polysaccharides such as gati gum and gum arabic.
- Saccharides polysaccharides derived from microorganisms such as pullulan, welan gum, xanthan gum and gellan gum; polysaccharides derived from plants such as tragacanth gum, pectin and glucomannan; derived from seeds such as guar gum, tara gum, tamarind seed gum, locust bean gum, psyllium seed gum and amaseed gum
- polysaccharides include fermented polysaccharides such as diyutan gum and the like, and xanthan gum, locust bean gum, guar gum, alginic acid, or a salt thereof from the viewpoint of excellent capsule formability, storage stability, heat resistance, disintegration, and the like. preferable.
- These capsules are excellent in heat resistance and moisture resistance, and can be easily broken when a moderate force is applied by hand. preferable. These may be used alone or in combination of two or more.
- the values represented by (X) and (Y), the coating rate and moisture content, the water activity value, etc. are the adjustment and / or cooling step of the content of the film-forming base and the hydrophilic polymer film-forming agent. It can be adjusted within the scope of the present invention by adjustment in a manufacturing process such as a drying process. Furthermore, if necessary, a plasticizer described later may be optionally added to adjust the values represented by (X) and (Y).
- the contents of the film-forming base and the hydrophilic polymer film-forming agent are not particularly limited as long as the effects of the present invention are not hindered.
- a capsule film solution is prepared, and the capsule film of the present invention is obtained.
- the blending ratio of the film-forming base and the hydrophilic polymer film-forming agent in the capsule film of the present invention is not particularly limited, but the obtained capsule is excellent in heat resistance and moisture resistance, and an appropriate force is applied by hand.
- the film-forming agent of the hydrophilic polymer with respect to the film-forming base is usually added to 1 part by weight of the film-forming base.
- it is usually about 0.1 to 5 parts by weight, and is preferably about 0.25 to 5 parts by weight (for example, 0.3 to 3 parts by weight), more preferably 0.5 to 3 parts by weight from the viewpoint of more excellent effects.
- Part, particularly about 0.5 to 2 parts by weight (for example, 0.6 to 1.5 parts by weight) is more preferable.
- it is preferable that the content of each film-forming base does not exceed the above range.
- a capsule using alginic acid or a salt thereof for the capsule film is preferable from the viewpoint of excellent storage stability and disintegration of the obtained capsule.
- alginate metal salt is mentioned suitably.
- the alginate is not particularly limited, and examples thereof include alkali metal salts such as sodium salt and potassium salt, alkaline earth metal salts such as calcium and magnesium salts, metal salts such as iron and tin, and sodium alginate and alginic acid. Potassium is particularly preferred and sodium alginate is most preferred.
- the metal salt of alginic acid preferably has a low viscosity, for example, 500 mPa ⁇ s or less is preferable, and 400 mPa ⁇ s or less is more preferable.
- the viscosity is a value measured by the method described in the 8th edition of the food additive official standard, and can be measured using, for example, a B-type viscometer (manufacturer name: BROOK FIELD, MODEL: LVDVE115).
- the disintegratable capsule of the present invention is transparent or translucent, it is preferable to use sodium alginate as the alginate. This facilitates capsule coloring. These may be used individually by 1 type, and 2 or more types may be mixed and used for them.
- Alginic acid or a salt thereof can be obtained by extracting alginic acid from brown algae by a known means or method. Moreover, these can use a commercial item. As a commercial item, a sun argin (Sanki Co., Ltd.) etc. are mentioned, for example.
- the content of alginic acid or a salt thereof in the capsule film is not particularly limited, and is usually 1.0% by weight or more and less than 50.0% by weight, preferably 3.0%. % By weight or more and 45.0% by weight or less, more preferably 5% by weight or more and 40% by weight or less, and particularly preferably 10% by weight or more and 35% by weight or less.
- the ratio of alginic acid or a salt thereof in the film forming agent is, for example, 5% by weight or more (for example, 8 to 100% by weight), preferably 10% by weight or more (for example, 15% To 90% by weight), more preferably 20% by weight or more (for example, 23 to 80% by weight), particularly 25% by weight or more (for example, 28 to 70% by weight).
- the guar gum may be used when carrageenan is used as a film-forming base. Guar gum is produced by pulverizing or extracting from legume guar seeds using known means and methods.
- a guar gum derivative may be used instead of or in addition to guar gum, and the derivative is not particularly limited, and examples thereof include hydroxypropyl guar gum, cationized guar gum, and guar gum decomposition products.
- the guar gum degradation product is not particularly limited as long as it has the effects of the present invention, and examples include guar gum enzyme degradation products.
- guar gums include guar gums (underivatized guar gums), guar gum degradation products and the like, and particularly guar gum enzyme degradation products are preferred. These may be used individually by 1 type, and 2 or more types may be mixed and used for them. These can use a commercial item.
- Fibertron Densitomo Pharma Co., Ltd.
- Gua Fiber Meiji Food Materials Co., Ltd.
- Sun Fiber Teaiyo Chemical Co., Ltd.
- DuFiber Teaisho Pharmaceutical Co., Ltd.
- Neovisco G Sansho Co., Ltd.
- Meipro HPG Series Sanki Co., Ltd.
- Jaguar C Series Sanki Co., Ltd.
- Meipro Gum Sanki Co., Ltd.
- Serpar FG Series Somar Corp.
- RG100 MRC polysaccharides
- the proportion of guar gum in the capsule film is, for example, 1 to 50% by weight, preferably 3 to 45% by weight, more preferably 5 to 40% by weight, especially 10 to 35% by weight (eg 15 to 15%). 30% by weight).
- the proportion of guar gum in the film forming agent is, for example, 5% by weight or more (for example, 8 to 100% by weight), preferably 10% by weight or more (for example, 15 to 90% by weight), More preferably, it may be 20% by weight or more (for example, 25 to 80% by weight), particularly 30% by weight or more (for example, 35 to 75% by weight).
- the capsule film of the present invention is not particularly limited, but may contain a colorant.
- the colorant is not particularly limited, and known dyes and pigments can be used. These contents are not particularly limited as long as the effects of the present invention are not hindered. These can use a commercial item.
- the capsule film of the present invention is not particularly limited and may contain a sweetener.
- the sweetener is not particularly limited, and examples thereof include sucralose, acesulfame, aspartame, saccharin, trehalose, sorbitol, sucrose and the like. These may be used individually by 1 type, and 2 or more types may be mixed and used for them. These contents are not particularly limited as long as the effects of the present invention are not hindered. These can use a commercial item.
- the capsule film of the present invention is not particularly limited, and may further include a plasticizer for adjusting the breaking strength, the distance, the film rate, the moisture content, the water activity value, etc., if necessary. Further, by using a plasticizer, it is easy to efficiently obtain capsules with relatively small variations (that is, SD values are small).
- the plasticizer is not particularly limited, and examples thereof include polyhydric alcohols such as glycerin, polyethylene glycol, propylene glycol, and polypropylene glycol; monosaccharides such as glucose, fructose, glucose, and galactose; sucrose, maltose, trehalose, and coupling sugar.
- polyhydric alcohols such as glycerin, polyethylene glycol, propylene glycol, and polypropylene glycol
- monosaccharides such as glucose, fructose, glucose, and galactose
- sucrose, maltose, trehalose and coupling sugar.
- Oligosaccharides such as malto-oligosaccharides; sugar alcohols such as sorbitol, maltitol, lactitol, palatinit, xylitol, mannitol, galactitol; polyvinyl alcohol; triacetin; polydextrose, dextrin, maltodextrin, indigestible dextrin , Starch derivatives such as cyclodextrin ( ⁇ , ⁇ , or ⁇ ); starch; hydroxymethylcellulose (HPMC), hydroxypropylcellulose (HPC), methyl Cellulose (MC), and cellulose derivatives such as carboxymethyl cellulose (CMC). These may be used individually by 1 type, and 2 or more types may be mixed and used for them.
- sugar alcohols such as sorbitol, maltitol, lactitol, palatinit, xylitol, mannitol, galactitol
- polyvinyl alcohol triacetin
- DE starch degradation degree
- glycerin starch, starch derivatives, cellulose derivatives and the like may be suitably used.
- a polyhydric alcohol such as glycerin
- another plasticizer or a plasticizer other than the polyhydric alcohol, such as at least one selected from starch, starch derivatives, and cellulose derivatives.
- the content of the plasticizer in the capsule film is not particularly limited, but the capsule obtained is excellent in heat resistance and moisture resistance, and can be easily cracked and enjoyed feeling when an appropriate force is applied by hand.
- the film forming base is preferably less than 15% by weight, more preferably 13% by weight or less, except when the film-forming base is used alone (agar alone, carrageenan alone or gelatin alone).
- the content of the plasticizer in the capsule film is, for example, about 40% by weight, preferably about 35% by weight.
- the upper limit can be made 30% by weight or less.
- glycerin when gelatin is used alone as the film-forming base, glycerin is preferably 10% by weight or less, more preferably 5% by weight or less, and even more preferably substantially free of glycerin because of compatibility with gelatin. .
- substantially does not contain glycerin means that glycerin is not blended or blended in such an amount that the influence of glycerin cannot be felt.
- the proportion of the plasticizer can be selected from a range of about 70 parts by weight or less (for example, 1 to 65 parts by weight) with respect to 100 parts by weight of the film-forming base, for example, 50 parts by weight or less (for example, 1 .5 to 47 parts by weight), preferably 45 parts by weight or less (for example, 2 to 42 parts by weight), more preferably 40 parts by weight or less (for example, 3 to 40 parts by weight), particularly 35 parts by weight or less (for example, 4 parts by weight). (About 35 parts by weight).
- the proportion of the plasticizer can be selected from a range of about 50 parts by weight or less (for example, 0.5 to 45 parts by weight) with respect to 100 parts by weight of the total amount of the film forming base and the film forming agent. 40 parts by weight or less (eg 1 to 35 parts by weight), preferably 30 parts by weight or less (eg 1.5 to 28 parts by weight), more preferably 25 parts by weight or less (eg 2 to 23 parts by weight), especially It may be about 20 parts by weight or less (eg, 3 to 20 parts by weight).
- the capsule of the present invention is configured as a capsule 3 having a content 1 and a capsule film 2, but is not particularly limited as long as it essentially has the above-described configuration. Further, in order to maintain the humidity of the capsule and make it easy to break.
- the coating layer may be formed by coating with various coating agents such as zein. Although it does not specifically limit as a coating agent, The well-known coating agent generally used, for example, cellulose derivatives (For example, hydroxypropyl methylcellulose, methylcellulose, ethylcellulose), starch, starch derivatives (for example, dextrin etc.), methacrylic acid copolymer, shellac Water-soluble shellac, silicone oil, carnauba wax, zein and the like. These may be used individually by 1 type, and may be used in combination of 2 or more types as needed. Examples of commercially available products include Opadry and Eudragit.
- the thickness of the coating layer is not particularly limited as long as it does not interfere with the effects of the present invention.
- a coating method a method in which a coating agent dissolved or dispersed in a volatile solvent or the like is sprayed or applied to a capsule after drying to volatilize the volatile solvent (topping method), the coating agent is used as a volatile solvent, or the like.
- examples include a method of immersing the capsule after drying in a solution dissolved or dispersed in it to volatilize the volatile solvent (dip method), a method of pre-dispersing and suspending the capsule film solution (kneading method), etc. There is no particular limitation on the method.
- the content of the capsule of the present invention is not particularly limited as long as it mainly contains an oil component, but may be composed of only an oil component. It does not specifically limit as an oil-based component of the content of a capsule, For example, a fragrance
- the pharmacologically active ingredient and the surfactant are not essential and may not be included, but may be included as long as the effects of the present invention are not hindered.
- the pharmacologically active component and the surfactant are not particularly limited as long as the effects of the present invention are not hindered, and known ones can be used. These may be used individually by 1 type, and 2 or more types may be mixed and used for them. These contents are not particularly limited as long as the effects of the present invention are not hindered. These can use a commercial item.
- Examples of the pharmacologically active ingredient include, but are not limited to, for example, glycyrrhizic acid and derivatives thereof and salts thereof (for example, dipotassium glycyrrhizinate, monoammonium glycyrrhizinate), seaprose, semi-alkaline proteinase, serrapeptase, tranexamic acid, proctase, And anti-inflammatory agents such as pronase and bromelain.
- glycyrrhizic acid and derivatives thereof and salts thereof for example, dipotassium glycyrrhizinate, monoammonium glycyrrhizinate
- seaprose semi-alkaline proteinase
- serrapeptase tranexamic acid
- proctase proctase
- anti-inflammatory agents such as pronase and bromelain.
- the fragrance used in the present invention is not particularly limited as long as it is an oily component, and either natural fragrance or synthetic fragrance may be used.
- the synthetic fragrance used in the present invention is not particularly limited as long as it has been conventionally used for the purpose of imparting fragrance and flavor.
- “Synthetic fragrance soy chemistry and product knowledge” Mi Indo, Chemical Industry) Nikkansha
- esters esters, alcohols, aldehydes, ketones, phenols, ethers, lactones, hydrocarbons, nitrogen-containing compounds, sulfur-containing compounds, acids and the like. These may be used alone or in combination of two or more.
- esters are not particularly limited, for example, propyl formate, butyl formate, amyl formate, octyl formate, linalyl formate, citronellyl formate, geranyl formate, neryl formate, terpinyl formate, ethyl acetate, isopropyl acetate, isoamyl acetate, acetic acid Hexyl, cis-3-hexenyl acetate, trans-2-hexenyl acetate, octyl acetate, nonyl acetate, decyl acetate, dodecyl acetate, dimethylundecadienyl acetate, styryl acetate, osmenyl acetate, mircenyl acetate, dihydromyrcenyl acetate, acetic acid Linalyl, citronellyl acetate, geranyl acetate, neryl
- the alcohols are not particularly limited, and examples thereof include 3-heptanol, 1-nonanol, 1-undecanol, 2-undecanol, 1-dodecanol, prenol, 10-undecen-1-ol, dihydrolinalool, tetrahydromegol, Myrcenol, dihydromyrsenol, tetrahydromyrcenol, osmenol, terpineol, hortrienol, 3-tyanol, benzyl alcohol, ⁇ -phenylethyl alcohol, ⁇ -phenylethyl alcohol, 3-methyl-1-pentanol, 1- Heptanol, 2-heptanol, 3-octanol, 1-nonanol, 2-nonanol, 2,6-dimethylheptanol, 1-decanol, trans-2-hexenol, cis-4-hexenol, methyltrimethyl Lopenteny
- aldehydes are not particularly limited. For example, acetaldehyde, n-hexanal, n-heptanal, n-octanal, n-nonanal, 2-methyloctanal, 3,5,5-trimethylhexanal, decanal, undecanal 2-methyldecanal, dodecanal, tridecanal, tetradecanal, trans-2-hexenal, trans-4-decenal, cis-4-decenal, trans-2-decenal, 10-undecenal, trans-2-undecenal, Trans-2-dodecenal, 3-dodecenal, trans-2-tridecenal, 2,4-hexadienal, 2,4-decadeienal, 2,4-dodecadienal, 5,9-dimethyl-4,8-decadienal, citral, Dimethyl Tanganal, ⁇ -methylene citronellal, citronellyloxyacetal
- the ketones are not particularly limited, and examples thereof include 2-pentanone, 3-hexanone, 2-heptanone, 3-heptanone, 4-heptanone, 2-octanone, 3-octanone, 2-nonanone, 2-undecanone, methylheptenone.
- the phenols are not particularly limited, and examples thereof include thymol, carvacrol, ⁇ -naphthol isobutyl ether, anethole, ⁇ -naphthol methyl ether, ⁇ -naphthol ethyl ether, cresol, veratrol, hydroquinone dimethyl ether, 2,6-dimethoxy.
- Phenol, 4-ethyl guaiacol, eugenol, isoeugenol, ethylisoeugenol, tert-butylhydroquinone dimethyl ether and the like can be mentioned.
- the ethers are not particularly limited, and examples thereof include decyl vinyl ether, ⁇ -terpinyl methyl ether, isopropexene, 2,2-dimethyl-5- (1-methyl-1-propenyl) -tetrahydrofuran, rose furan, 1,4-cineole, nerol oxide, 2,2,6-trimethyl-6-vinyltetrahydropyran, methyl hexyl ether, oxime epoxide, limonene oxide, rubofix, caryophyllene oxide, linalool oxide, 5-isopropenyl-2-methyl -2-Vinyltetrahydrofuran, nerol oxide, rose oxide and the like.
- the lactones are not particularly limited, and examples thereof include ⁇ -undecalactone, ⁇ -dodecalactone, ⁇ -hexalactone, ⁇ -nonalactone, ⁇ -decalactone, ⁇ -dodecalactone, jasunmilactone, and methyl ⁇ -decalactone. 7-decenolactone, jasmolactone, propylidenephthalide, ⁇ -hexalactone, ⁇ -2-decenolactone, ⁇ -dodecalactone, dihydrocoumarin, coumarin and the like.
- the hydrocarbons are not particularly limited, and examples thereof include osymene, limonene, ⁇ -ferrandrene, terpinene, 3-carene, bisabolen, valencene, alloocimene, myrcene, farnesene, ⁇ -pinene, ⁇ -pinene, camphene, terpinolene. , P-cymene, cedrene, ⁇ -caryophyllene, kadinene and the like.
- the nitrogen-containing compound or sulfur-containing compound is not particularly limited.
- the acids are not particularly limited, and for example, acetic acid, propionic acid, butyric acid, valeric acid, hexanoic acid, octanoic acid, decanoic acid, dodecanoic acid, 2-decenoic acid, geranic acid, 2-methylbutyric acid, 2-ethyl Butyric acid, phenylacetic acid, cinnamic acid, isobutyric acid, isovaleric acid, 3-methylvaleric acid, 2-hexenoic acid, 2-methyl-2-pentenoic acid, 2-methylheptanoic acid, myristic acid, stearic acid, lactic acid, Examples include pyruvic acid and cyclohexanecarboxylic acid.
- the natural fragrance is not particularly limited, and for example, orange, neroli, mandarin, petit glen, bergamot, tangerine, mandarin orange, cinnamon, daidai, hassaku, iyokan, lemon, lime, grapefruit, yuzu, sudachi, kabosu, sweetie, Oils such as raspberries are listed.
- fragrances although not particularly limited, for example, Citronella, Elemi, Oliveranum, Marjoram, Angelica Root, Star Anise, Basil, Hay, Caramas, Caraway, Cardamom, Pepper, Cascarilla, Ginger, Sage, Clary Sage , Clove, coriander, eucalyptus, fennel, pimento, juniper, phenegreak, laurel, mace, cedar, senkyu, almond, anise, artemisia, alfalfa, apricot, amblet, rush, strawberry, fig, ylang ylang, winter green, ume, Elder, Enju, Oak moss, Allspice, Oris, Currant, Cassie, Chamomile, Galanga, Karin, Gambia, Guava, gooseberry, Camphor, Gardenia, Kubeba, Mine, Cranberry, Cola, Salamander, Sandalak, Sandalwood, Sandal Red, Perilla,
- the lipophilic solvent used for the contents of the capsule of the present invention is not particularly limited, and those commonly used in the food, pharmaceutical or cosmetic industry can be used.
- triglycerides especially medium chain triglycerides (eg, caprylic and capric triglycerides), vegetable oils (eg, olive oil, sunflower oil, corn oil, peanut oil, grape seed oil, wheat germ oil, rapeseed oil, jojoba oil, safflower Oil), mineral oil, silicone oil or a mixture of these and triglycerides, fatty acids (eg, eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), etc.), fatty acid esters (eg, isopropyl myristate), sucrose fatty acid esters (SAIB) ), Liquid paraffin, squalane and the like. These may be used individually by 1 type, and 2 or more types may be mixed and used for them. These contents are not particularly limited as long
- the method for producing the disintegratable capsule of the present invention is not particularly limited and can be appropriately selected from known production methods. For example, it is described in Japanese Patent No. 5047285 or Japanese Patent Publication No. 10-506841. Can be used. Specific examples include a dropping method (seamless capsule method) using a double or multiple (triple or more) nozzle. By this method, the capsule contents can be filled into a capsule film, molded and dried.
- the adjustment of the breaking strength, distance, water activity value of the capsule film, moisture content of the capsule film, etc. is performed by appropriately controlling the drying conditions (for example, drying temperature, relative humidity during drying, drying time, etc.) after capsule formation. Alternatively, the moisture content of the capsule film may be reduced.
- a rotary die cannot be used because the uniformity of the film thickness is inferior seamlessly if the film becomes too thick.
- the dripping method uses, for example, a composite nozzle device that is appropriately arranged in a substantially concentric manner as shown in FIG.
- the composite nozzle device includes, for example, the following parts, an inner nozzle 4 that receives and distributes the capsule contents supplied from the A to the inner nozzle 4, and an outer side that receives and distributes the capsule coating liquid supplied from the B to the outlet nozzle 5.
- the inner nozzle 4 and the outer nozzle 5 are arranged substantially concentrically.
- the capsule contents and the capsule coating liquid are simultaneously discharged from the inner nozzle 4 and the outer nozzle 5 into the oil liquid or gas at a constant speed by a pump or gravity, and the carrier flow 6 flows coaxially and flows downstream. Formed inside and cut by a physical force such as vibration, the discharged liquid is cut at regular intervals, and the cut portion is made spherical by the interface or surface tension between the oil liquid or gas and the capsule film liquid, The layer is gelled by cooling to produce a wet capsule.
- the capsule film material 2 surrounds the extruded capsule contents 1 to form a capsule 3.
- the contents of the capsule of the present invention do not include a step of including gas.
- the interface or surface tension is not particularly limited, but is preferably 15 to 50 mN / m at the interface between the capsule coating liquid and the content liquid, for example.
- Sigma702 manufactured by KSV INSTRUMENTS (FINLAND) is used for measurement of the interface or surface tension.
- the adjustment of the temperature condition in the vicinity of the multiple nozzles is appropriately controlled during capsule production.
- controlling the temperature of the capsule contents to a set value ⁇ 2 ° C. (more preferably ⁇ 1 ° C.) within a range of 5 to 25 ° C. (more preferably 12 to 22 ° C.);
- the temperature of the capsule film solution should be controlled to a set value ⁇ 2 ° C. (more preferably ⁇ 1 ° C.) in the range of 50 to 99 ° C. (more preferably 60 to 95 ° C.).
- the temperature of the lipophilic solvent is set within a range of 1 to 25 ° C. (more preferably 5 to 20 ° C.). It is preferable that the temperature be controlled to ° C (more preferably ⁇ 0.5 ° C). Furthermore, in addition to the above conditions, (4) the difference between the temperature of the capsule contents and the temperature of the capsule coating solution is more preferably 25 ° C. or higher and 94 ° C. or lower (more preferably 38 ° C. or higher and 85 ° C. or lower). When the lipophilic solvent is added to the oil component of the capsule content, the difference between the temperature of the capsule film solution and the temperature of the lipophilic solvent is 35 ° C.
- the film layer is gelled by cooling, it is cooled by cooling oil.
- the cooling temperature with the cooling oil is, for example, about 5 to 20 ° C.
- the above temperature conditions (1) to (5) can be appropriately selected or combined by those skilled in the art depending on the degree of quality required for the seamless capsule.
- the above temperature control can be easily performed by those skilled in the art by combining, for example, PID control and feedback control, but is not limited to these control methods.
- the capsule film solution can be prepared by dissolving the film forming agent in a solvent.
- the solvent is not particularly limited as long as the effect of the present invention is not hindered, and examples thereof include water and alcohols such as ethanol, and water is preferable.
- Heat treatment is preferable when the film-forming agent is dissolved in a solvent.
- the heating temperature is not particularly limited, but is about 60 to 100 ° C, and more preferably about 70 to 95 ° C.
- the viscosity of the capsule film solution (mixed solution) at 90 ° C. is not particularly limited, but 70 is obtained from the point that the combination of the constitution of the present invention is obtained and effects such as capsule disintegration (film uniformity) are obtained.
- the viscosity is a value measured using a B-type viscometer (manufacturer name: BROOK FIELD, MODEL: LVDVE115). When the viscosity of the capsule film solution exceeds 500 mPa ⁇ s, the capsule of the present invention cannot be obtained.
- the cooling temperature is not particularly limited, but is usually 20 ° C. or lower, preferably 10 ° C. or lower.
- the cooling time is not particularly limited, but is usually about 10 minutes to 30 hours.
- a dry capsule After producing a wet capsule by the above-described method, it is dried to obtain a dry capsule.
- This drying is generally performed using, for example, a “rotary drum dryer” with a ventilator,
- a fluid type may be used in which the capsules are dried while flowing and dried.
- the drying temperature is not particularly limited, but may be about 20 to 50 ° C.
- the present invention includes embodiments in which the above configurations are combined in various ways within the technical scope of the present invention as long as the effects of the present invention are exhibited.
- the outer diameter of the capsule was measured using a digital caliper (trade name: Quick Mini 25, model number: PK-0510SU, measurement range: 0 to 25 mm) manufactured by Mitutoyo Corporation at room temperature ( 22 to 23 ° C.) and 45 to 53% RH.
- the breaking strength of the capsule after drying is a value measured with a rheometer CR-500DX manufactured by Sun Science Co., Ltd. at room temperature (22-23 ° C.) and 60% RH.
- the water activity value of the capsule film is a value measured at 22 ° C. and 60% RH using a water activity measurement system (Palm Aw1 type) manufactured by Rotronic.
- the moisture content of the capsule film is a value calculated by measuring a dry weight after treatment at 110 ° C. for 120 minutes from a dry weight state of 22 ° C. and 60% RH to 110 ° C. for 120 minutes.
- the thickness of the capsule film is a value measured using a digital microscope (trade name; VHX-900, 10 ⁇ m calibration scale) manufactured by Keyence Corporation.
- the distance at 22 ° C. and 80% RH is a value measured by a rheometer CR-500DX manufactured by Sun Scientific Co., Ltd.
- Powdered agar is commercially available from red algae seaweed (jelly strength: 750 ⁇ 100 g / cm 2 (Ina Food Industry Co., Ltd.) and jelly strength: 1000 ⁇ 100 g / cm 2 (Ina Food Industry Co., Ltd.) )) Were mixed and used.
- the jelly strength represents a 1.5% concentration.
- Carrageenan is composed of ⁇ carrageenan (trade name: SATIAGEL ME4; Cargill Japan Co., Ltd.), total amount of 2-propanol and methanol: 0.10% or less, pH: 8.0 to 11.0, viscosity (food additive The general test method (rotary viscometer method) described in the official official document): 5.0 mPa ⁇ s or more) was used.
- dextrin starch degradation product (maltodextrin)
- maltodextrin Maltodextrin (Matsutani Chemical Industry Co., Ltd.) having DE (starch degradation degree) of 10 or more was used.
- Purified guar gum A was FG-50 (trade name, Somaru Corporation).
- the purified guar gum B used was RG100 (trade name, MRC Polysaccharide Co., Ltd.)
- the guar gum enzymatic degradation product used Sunfiber (Taiyo Kagaku Co., Ltd.) Sodium alginate and calcium alginate Used a commercial product having a viscosity of 300 mPa ⁇ s or less, and a commercial product with a bloom strength of 270 (trade name: 270FG, Rousselot Co., Ltd.). (Commercial name: BCN250SC, Nitta Gelatin Co., Ltd.) was used.
- the sizes (outer diameters) of the capsules of the following examples and comparative examples were adjusted by changing the number of rotations of the pump at the time of manufacture (changing the liquid feeding amount). Moreover, about the capsule of the following Examples and Comparative Examples, the touch which crushed the capsule was evaluated by applying a pressure with a finger.
- capsules of the following examples and comparative examples were evaluated according to the following evaluation criteria.
- ⁇ Easy to crush and comfortably break when pressure is applied with a finger
- ⁇ Feels a little hard when pressure is applied with a finger, but is easy to crush
- ⁇ Crushes when pressure is applied with a finger, but equivalent force Can not be crushed if you do not apply
- ⁇ If you do not crush even if you apply pressure with your fingers or if you do not apply enough force to hurt your fingers when you apply pressure with your fingers
- the capsule capsule liquid is put into a seamless capsule manufacturing apparatus (trade name: Spherex (registered trademark), manufactured by Freund Sangyo Co., Ltd.).
- the temperature was controlled to a set value ⁇ 2 ° C. at 20 ° C.
- the temperature of the capsule coating solution was controlled to a set value ⁇ 2 ° C. at 70 ° C., and cooled with cooling oil (about 10 ° C.) to produce capsules.
- the capsule was dried (25 ° C., humidity 50% RH or less) to obtain a seamless capsule.
- the properties of the obtained capsules were measured. The results are shown in Table 18 below.
- the obtained capsule was translucent and had a strong bluish purple or a strong purple bluish color.
- I grabbed the obtained capsule and applied force with my finger I could easily crack it and crack it and enjoy the sound and feel that the capsule would break. I also enjoyed the sweet scent of vanilla.
- Example 2 In addition to the capsule of Example 1, zein (trade name: Kobayashi Zein DP, Kobayashi Fragrance Co., Ltd.) 10% diluted solution, so as to be 2% by weight with respect to the total weight of the capsule by a known method, Coating was performed. The properties of the obtained capsules were measured. The results are shown in Table 18 below.
- the obtained capsule was translucent and had a strong bluish purple or a strong purple bluish color.
- I grabbed the obtained capsule and applied force with my finger I could easily crack it and crack it and enjoy the sound and feel that the capsule would break. I also enjoyed the sweet scent of vanilla.
- Example 3 A mixed solution prepared so that the obtained capsule has the formulation shown in Table 2 below was dissolved at 95 ° C. (viscosity of mixed solution: 151 mPa ⁇ s), defoamed, and allowed to stand to prepare a capsule film solution. did.
- the capsule film solution and orange oil as the capsule contents are put into a seamless capsule manufacturing apparatus (trade name: Spherex (registered trademark), manufactured by Freund Sangyo Co., Ltd.), and the temperature of the capsule contents is set near the multiple nozzles.
- a capsule was produced by controlling to a set value ⁇ 2 ° C. at 18 ° C., controlling the temperature of the capsule coating liquid to a set value ⁇ 2 ° C. at 73 ° C., and cooling with cooling oil (about 10 ° C.). Subsequently, the capsule was dried in the same manner as in Example 1, and the drying time was adjusted to obtain a seamless capsule. The properties of the obtained capsules were measured. The results are shown in Table 18 below.
- the obtained capsule was translucent and bright red. When I grabbed the obtained capsule and applied force with my finger, I could easily crack it and crack it and enjoy the sound and feel that the capsule would break. I also enjoyed the orange scent.
- Example 4 A mixed solution prepared so that the obtained capsule has the formulation shown in Table 3 below was dissolved at 95 ° C. (viscosity of mixed solution: 175 mPa ⁇ s), defoamed, and allowed to stand to prepare a capsule film solution. did.
- the capsule film solution and 1-menthol 30% MCT solution as the capsule contents are put into a seamless capsule manufacturing apparatus (trade name: Spherex (registered trademark), manufactured by Freund Sangyo Co., Ltd.).
- the temperature of the contents was controlled to a set value ⁇ 2 ° C. at 22 ° C.
- the temperature of the capsule coating solution was controlled to a set value ⁇ 2 ° C. at 80 ° C.
- cooling oil about 10 ° C.
- the obtained capsule was translucent and bright yellow. When I grabbed the obtained capsule and applied force with my finger, I could easily crack it and crack it and enjoy the sound and feel that the capsule would break. I also enjoyed the refreshing scent of menthol.
- Example 5 A mixed solution prepared so that the obtained capsule has the formulation shown in Table 4 below was dissolved at 95 ° C. (viscosity of the mixed solution: 119 mPa ⁇ s), defoamed, and allowed to stand to prepare a capsule film solution. did.
- the capsule film liquid and rose oil as the capsule contents are put into a seamless capsule manufacturing apparatus (trade name: Spherex (registered trademark), manufactured by Freund Sangyo Co., Ltd.), and the temperature of the capsule contents is set near the multiple nozzles.
- the capsule was controlled at 16 ° C. to a set value ⁇ 2 ° C.
- the capsule film temperature was controlled at 78 ° C. to the set value ⁇ 2 ° C.
- cooled with cooling oil about 10 ° C.
- the obtained capsule was translucent and bright red. When I grabbed the obtained capsule, it felt somewhat hard, but when I applied force with my fingers, I could easily crack it and crack it, and enjoyed the sound and feel of the capsule breaking. Also enjoyed the scent of rose.
- Example 6 Dissolve the mixture prepared so that the resulting capsules have the formulation shown in Table 5 below at 95 ° C. (viscosity of the mixture: 210 mPa ⁇ s), deaerate, and then leave to stand to produce a capsule film solution. did.
- the capsule film liquid and cinnamon oil as the capsule contents are put into a seamless capsule manufacturing apparatus (trade name: Spherex (registered trademark), manufactured by Freund Sangyo Co., Ltd.), and the temperature of the capsule contents is set near the multiple nozzles.
- the capsule was prepared by controlling the temperature of the capsule coating solution at 20 ° C. to a set value of ⁇ 2 ° C. at 70 ° C. and cooling with cooling oil (about 10 ° C.). Subsequently, the capsule was dried in the same manner as in Example 1, and the drying time was adjusted to obtain a seamless capsule. The properties of the obtained capsules were measured. The results are shown in Table 18 below.
- the obtained capsule was translucent and bright red. When I grabbed the obtained capsule and applied force with my finger, I could easily crack it and crack it and enjoy the sound and feel that the capsule would break. Also enjoyed the scent of cinnamon.
- Example 7 A mixed solution prepared so that the obtained capsule has the formulation shown in Table 6 below was dissolved at 95 ° C. (viscosity of the mixed solution: 330 mPa ⁇ s), defoamed, and allowed to stand to prepare a capsule film solution. did.
- a capsule was produced in the same manner as in Example 1 except that raspberry oil was used as the capsule film solution and the capsule contents. The properties of the obtained capsules were measured. The results are shown in Table 18 below.
- the obtained capsule was translucent and bright green. When I grabbed the obtained capsule and applied force with my finger, I could easily crack it and crack it and enjoy the sound and feel that the capsule would break. I also enjoyed the scent of raspberries.
- Example 8 A mixed liquid prepared so that the obtained capsule has the formulation shown in Table 7 below was dissolved at 95 ° C. (viscosity of the mixed liquid: 200 mPa ⁇ s), defoamed, and allowed to stand to prepare a capsule film solution. did.
- a capsule was produced in the same manner as in Example 1 except that peppermint oil was used as the capsule film solution and the capsule contents. The properties of the obtained capsules were measured. The results are shown in Table 18 below.
- the obtained capsule was translucent and bright yellow. When I grabbed the obtained capsule and applied force with my finger, I could easily crack it and crack it and enjoy the sound and feel that the capsule would break. I also enjoyed the smell of peppermint.
- Example 9 Dissolve the mixture prepared so that the resulting capsule has the formulation shown in Table 8 below at 95 ° C. (viscosity of the mixture: 95 mPa ⁇ s), deaerate, and then leave to stand to prepare a capsule film solution. did.
- a capsule was produced in the same manner as in Example 1 except that coffee oil was used as the capsule film solution and the capsule contents. The properties of the obtained capsules were measured. The results are shown in Table 18 below.
- the obtained capsule was translucent and bright red. When I grabbed the obtained capsule and applied force with my finger, I could easily crack it and crack it and enjoy the sound and feel that the capsule would break. Also enjoyed the aroma of coffee.
- Example 10 The capsule of Example 1 was further coated with a 0.5% solution of Eudragit (trade name: Eudragit EPO, Rohm) so as to be 2% by weight based on the total weight of the capsule by a known method. went. The properties of the obtained capsules were measured. The results are shown in Table 18 below.
- Eudragit trade name: Eudragit EPO, Rohm
- Example 11 Dissolve the mixture prepared so that the obtained capsule has the formulation shown in Table 9 below at 95 ° C. (viscosity of the mixture: 132 mPa ⁇ s), deaerate, and then leave to stand to prepare a capsule film solution. did.
- a capsule was produced in the same manner as in Example 1 except that lemon oil was used as the capsule film solution and the capsule contents. The properties of the obtained capsules were measured. The results are shown in Table 18 below.
- the obtained capsule was translucent and bright green. When I grabbed the obtained capsule and applied force with my finger, I could easily crack it and crack it and enjoy the sound and feel that the capsule would break. I also enjoyed the lemon scent.
- Example 12 A mixed solution prepared so that the obtained capsule has the formulation shown in Table 10 below was dissolved at 95 ° C. (viscosity of mixed solution: 192 mPa ⁇ s), defoamed, and allowed to stand to prepare a capsule film solution. did.
- a capsule was produced in the same manner as in Example 1 except that jasmine oil was used as the capsule film solution and the capsule contents. The properties of the obtained capsules were measured. The results are shown in Table 18 below.
- the obtained capsule was translucent and bright green. When I grabbed the obtained capsule and applied force with my finger, I could easily crack it and crack it and enjoy the sound and feel that the capsule would break. I also enjoyed the scent of jasmine.
- Example 13 A mixed liquid prepared so that the obtained capsule has the formulation shown in Table 11 below was dissolved at 95 ° C. (viscosity of mixed liquid: 173 mPa ⁇ s), defoamed, and allowed to stand to prepare a capsule film solution. did.
- a capsule was produced in the same manner as in Example 1 except that bergamot oil was used as the capsule film solution and the capsule contents. The properties of the obtained capsules were measured. The results are shown in Table 18 below.
- the obtained capsule was translucent. When I grabbed the obtained capsule and applied force with my finger, I could easily crack it and crack it and enjoy the sound and feel that the capsule would break. Also enjoyed the scent of bergamot.
- Example 14 A mixed solution prepared so that the resulting capsules have the formulation shown in Table 12 below was dissolved at 95 ° C. (viscosity of the mixed solution: 131 mPa ⁇ s), defoamed, and allowed to stand to prepare a capsule film solution. did.
- a capsule was produced in the same manner as in Example 1 except that chamomile oil was used as the capsule film solution and the capsule contents. The properties of the obtained capsules were measured. The results are shown in Table 18 below.
- the obtained capsule was translucent and bright blue. When I grabbed the obtained capsule and applied force with my finger, I could easily crack it and crack it and enjoy the sound and feel that the capsule would break. Also enjoyed the scent of chamomile.
- Example 15 Dissolve the mixture prepared so that the resulting capsule has the formulation shown in Table 13 below at 95 ° C. (viscosity of the mixture: 275 mPa ⁇ s), deaerate, and then leave to stand to produce a capsule film solution. did.
- a capsule was produced in the same manner as in Example 1 except that rosemary oil was used as the capsule film solution and the capsule contents. The properties of the obtained capsules were measured. The results are shown in Table 18 below.
- the obtained capsule was translucent and bright blue. When I grabbed the obtained capsule and applied force with my finger, I could easily crack it and crack it and enjoy the sound and feel that the capsule would break. I also enjoyed the scent of rosemary.
- Example 16 A mixed solution prepared so that the obtained capsule has the formulation shown in Table 14 below was dissolved at 95 ° C. (viscosity of mixed solution: 168 mPa ⁇ s), defoamed, and allowed to stand to prepare a capsule film solution. did.
- a capsule was produced in the same manner as in Example 1 except that cranberry oil was used as the capsule film solution and the capsule contents. The properties of the obtained capsules were measured. The results are shown in Table 18 below.
- the obtained capsule was translucent and bright red. When I grabbed the obtained capsule and applied force with my finger, I could easily crack it and crack it and enjoy the sound and feel that the capsule would break. I also enjoyed the cranberry scent.
- Example 17 A mixed solution prepared so that the obtained capsule has the formulation shown in Table 15 below was dissolved at 95 ° C. (viscosity of the mixed solution: 130 mPa ⁇ s), defoamed, and allowed to stand to prepare a capsule film solution. did.
- a capsule was produced in the same manner as in Example 1 except that ginger oil was used as the capsule film solution and the capsule contents. The properties of the obtained capsules were measured. The results are shown in Table 18 below.
- the obtained capsule was translucent and bright red. When I grabbed the obtained capsule and applied force with my finger, I could easily crack it and crack it and enjoy the sound and feel that the capsule would break. I also enjoyed the scent of ginger.
- Example 18 A mixed solution prepared so that the obtained capsule has the formulation shown in Table 16 below was dissolved at 95 ° C. (viscosity of the mixed solution: 150 mPa ⁇ s), defoamed, and allowed to stand to prepare a capsule film solution. did.
- a capsule was produced in the same manner as in Example 1 except that cardamom oil was used as the capsule film solution and the capsule contents. The properties of the obtained capsules were measured. The results are shown in Table 18 below.
- the obtained capsule was translucent and bright red. When I grabbed the obtained capsule and applied force with my finger, I could easily crack it and crack it and enjoy the sound and feel that the capsule would break. I also enjoyed the scent of cardamom.
- Example 19 A mixed solution prepared so that the obtained capsule has the formulation shown in Table 17 below was dissolved at 95 ° C. (viscosity of the mixed solution: 180 mPa ⁇ s), defoamed, and allowed to stand to prepare a capsule film solution. did.
- a capsule was produced in the same manner as in Example 1 except that spearmint oil was used as the capsule film solution and the capsule contents. The properties of the obtained capsules were measured. The results are shown in Table 18 below.
- the obtained capsule was translucent and bright red. When I grabbed the obtained capsule and applied force with my finger, I could easily crack it and crack it and enjoy the sound and feel that the capsule would break. I also enjoyed the spearmint scent.
- a capsule coating solution is prepared using a mixed solution prepared so that the resulting capsule has the formulation shown in Table 19 below, and a capsule is produced in the same manner as in Example 1 except that the obtained capsule coating solution is used. did. The properties of the obtained capsules were measured. The results are shown in Table 20 below.
- the capsules obtained in Comparative Examples 1 and 2 ruptured when pressure was applied with a finger, but none of them was easily crushed and enjoyed the sound and feel of the capsule breaking.
- the capsule obtained in Comparative Example 3 did not burst when pressure was applied with a finger.
- the capsule of the example the capsule was not softened or dissolved, and it was confirmed that the capsule of the present invention was excellent in heat resistance.
- the photographs of the capsules after the heat resistance test of the capsules of Examples 7, 8 and 13 and the capsule of Comparative Example 13 are shown in FIG.
- the capsules of Examples 7, 8 and 13 are represented in order from the left, and the right end represents the capsule of Comparative Example 1.
- FIG. 4 when the sample bottle was turned upside down, the capsule of Comparative Example 1 was softened and adhered to the container.
- Capsule coating solution was prepared using a mixed solution prepared so that the obtained capsule or coating had the formulation shown in Table 21 below, and capsules were obtained in the same manner as in Example 1 except that the obtained capsule coating solution was used. Alternatively, a film was produced, and the characteristics of the obtained capsule or film were measured.
- Example 20 capsules were produced in the same manner as in Example 1, and the same characteristics as in Example 1 were measured.
- Example 20, 21, and 22 comparative example 4 a film was obtained as follows and warm water resistance (heat resistance and moisture resistance) was evaluated about the obtained film.
- the film was prepared by preparing a 5% by weight aqueous solution, heating to 95 ° C., putting 10 g of the aqueous solution in a petri dish with a diameter of 90 mm, and drying in an environment of 22 ° C. and 60% RH until the water content was 12.5% by weight. It was produced by doing.
- coat was cut into 2 cm x 2 cm, and it immersed in the hot water of 70 degreeC and 75 degreeC, and the presence or absence of melt
- in the composition of Example 20 and Example 22 since it did not melt
- Example 22 shows that a combination of agar, carrageenan, and a film-forming agent can be used to obtain a capsule having relatively excellent characteristics.
- agar, carrageenan, and guar gum This indicates that the SD (standard deviation) value can be further reduced.
- This SD value is an index of the uniformity of capsule quality, and the smaller the value, the more uniform.
- the difference in SD at 22 ° C. and 80% RH is 0.1, but considering that the distance value is about several (mm), the SD of 0.1 It can be said that the difference in values is large.
- the capsule of Example 20 and the capsule of Example 21 were each crushed with fingers, the capsule of Example 20 cracked with a good crack feeling without any trouble.
- Example 20 and Example 21 had a significant difference in crack feeling. .
- Example 22 and the comparative example 4 are the results of having removed the sodium alginate which comprises the composition of Example 20, a little change in the solubility with respect to warm water also by addition of sodium alginate (slightly melt
- Examples 23 to 27 Powder agar, guar gum enzyme degradation product, sodium alginate, kappa carrageenan, glycerin, starch degradation product (maltodextrin), blue No. 1, and water are mixed so that the resulting capsule has the blending ratio shown in Table 1 below. It melt
- the capsule capsule solution was introduced into a seamless capsule manufacturing apparatus (trade name: Spherex (registered trademark), manufactured by Freund Sangyo Co., Ltd.).
- the temperature is controlled to a set value ⁇ 2 ° C. at 20 ° C.
- the capsule film temperature is controlled to a set value ⁇ 2 ° C. at 70 ° C., cooled with cooling oil (about 10 ° C.), and various outer diameters (1.0 mm) , 2.0 mm, 3.5 mm, 6 mm, 10 mm).
- the capsule was dried (25 ° C., humidity 50% RH or less) to obtain a seamless capsule.
- the properties of the obtained capsules were measured. The results are shown in Table 25 below.
- the obtained capsule was translucent and blue. When I grabbed the obtained capsule and applied force with my finger, I could easily crack it and crack it and enjoy the sound and feel that the capsule would break. I also enjoyed the sweet scent of rose.
- Examples 28 to 32 Each of the capsules of Examples 23 to 27 was further coated with a 10% starch diluted solution on the outer capsule layer by a known method so as to be 2% by weight based on the total weight of the capsule. The properties of the obtained capsules were measured. The results are shown in Table 25 below.
- the obtained capsule was translucent and blue. When I grabbed the obtained capsule and applied force with my finger, I could easily crack it and crack it and enjoy the sound and feel that the capsule would break. I also enjoyed the sweet scent of rose.
- the collapsible capsule of the present invention has no adhesion between capsules, excellent heat resistance and moisture resistance, no change in capsule contents over time, can be easily broken when pressure is applied with a finger, cracking It has a good feeling, can release the contents, and can suppress discoloration. For example, it can be included in a smoking device.
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Abstract
Description
しかしながら、ゼラチンを皮膜に採用した場合は勿論、ゼラチンより吸湿性が低いとされているカラギーナンを採用した場合であっても、デンプンや、デキストリン、非ゲル化多糖類等を配合すると、湿度の影響を受けやすくなり、乾燥後における手指での割れやすさ、割れる際の音や感触等の付加価値を、経時的に安定して得ることはできない場合がある。
[1]内容物とカプセル皮膜を有するカプセルであって、内容物として油性成分を含み、カプセル皮膜として、少なくとも造膜性基剤を含み、下記式(1)及び下記式(2)を満足することを特徴とする崩壊可能なカプセル(カプセルAということがある)。
150<(X)<630 (1)
(上記式中、(X)は、破壊強度(g)/カプセルの外径(mm)を表す。)
0.15≦(Y)≦0.53 (2)
(上記式中、(Y)は、ディスタンス/外径比を表し、前記ディスタンスは、22℃80%RHにおいてカプセルにプレスをかけてカプセルを破壊したときの、最大荷重に達するまでに変形した距離(mm)を表す。)
[2]カプセルの膜厚が、5~120μmであることを特徴とする前記[1]記載の崩壊可能なカプセル。
[3]カプセルの皮膜率が、5.0%以上18.0%以下であることを特徴とする前記[1]又は[2]に記載の崩壊可能なカプセル。
[4]カプセル皮膜の含水率が、10.0~19.0%であることを特徴とする前記[1]~[3]のいずれか1項に記載の崩壊可能なカプセル。
[5]カプセルの破壊強度が、150~4000gであることを特徴とする前記[1]~[4]のいずれか1項に記載の崩壊可能なカプセル。
[6]式(2)が、0.18≦(Y)≦0.5であることを特徴とする前記[1]~[5]のいずれか1項に記載の崩壊可能なカプセル。
[7]カプセル皮膜の水分活性値が、0.400以上0.650以下であることを特徴とする前記[1]~[6]のいずれか1項に記載の崩壊可能なカプセル。
[8]崩壊可能なカプセルが、シームレスカプセルであることを特徴とする前記[1]~[7]のいずれか1項に記載の崩壊可能なカプセル。
[9]カプセルの外径が、1.0~15.0mmであることを特徴とする前記[1]~[8]のいずれか1項に記載の崩壊可能なカプセル。
[10]前記造膜性基剤が、寒天、カラギーナン及びゼラチンからなる群から選ばれる1種以上であることを特徴とする前記[1]~[9]のいずれか1項に記載の崩壊可能なカプセル。
[11]前記造膜性基剤が、少なくとも、ゼリー強度が600g/cm2以上の寒天、又はブルーム強度が190以上のゼラチンを含むことを特徴とする前記[1]~[10]のいずれか1項に記載の崩壊可能なカプセル。
[12]カラギーナンが、カッパカラギーナン又はイオタカラギーナンであることを特徴とする前記[10]又は[11]に記載の崩壊可能なカプセル。
[13]前記造膜性基剤が、寒天及びカラギーナンを含む前記[1]~[12]のいずれか1項に記載の崩壊可能なカプセル。
[14]前記造膜性基剤が、寒天とカラギーナンとを、前者/後者(重量比)=90/10~30/70の割合で含む前記[1]~[13]のいずれか1項に記載に崩壊可能なカプセル。
[15]さらに、カプセル皮膜が、アルギン酸又はその塩、ファーセレラン、カードラン、ガティガム、アラビアガム、プルラン、ウェランガム、キサンタンガム、ジェランガム、トラガントガム、ペクチン、グルコマンナン、グアーガム、タラガム、タマリンドシードガム、ローカストビーンガム、サイリウムシードガム、アマシードガム及びダイユータンガムからなる群から選ばれる1種以上である皮膜形成剤を含むことを特徴とする前記[1]~[14]のいずれか1項に記載の崩壊可能なカプセル。
[16]前記皮膜形成剤が、グアーガム(誘導体化されていないグアーガム又はその誘導体)を含む前記[15]記載の崩壊可能なカプセル。
[17]グアーガムが、グアーガム酵素分解物を含む前記[16]記載の崩壊可能なカプセル。
[18]前記皮膜形成剤が、グアーガム及びアルギン酸又はその塩を含むことを特徴とする前記[15]~[17]のいずれか1項に記載の崩壊可能なカプセル。
[19]アルギン酸塩が、アルギン酸ナトリウムであることを特徴とする前記[18]記載の崩壊可能なカプセル。
[20]アルギン酸又はその塩とグアーガムとの割合が、前者/後者(重量比)=70/30~10/90である前記[18]又は[19]に記載の崩壊可能なカプセル。
[21]カプセル皮膜において、造膜性基剤及び皮膜形成剤の割合が60重量%以上である前記[15]~[20]のいずれか1項に記載の崩壊可能なカプセル。
[22]皮膜形成剤の割合が、造膜性基剤1重量部に対して0.1~5重量部である前記[15]~[21]のいずれか1項に記載の崩壊可能なカプセル。
[23]カプセル皮膜が、寒天及びカラギーナンを含む造膜性基剤と、グアーガムを含む皮膜形成剤とを含み、寒天とカラギーナンとの割合が前者/後者(重量比)=85/15~35/65であり、カプセル皮膜において、造膜性基剤及び皮膜形成剤の割合が70重量%以上であり、皮膜形成剤の割合が造膜性基剤1重量部に対して0.3~3重量部である前記[15]~[22]のいずれか1項に記載の崩壊可能なカプセル。
[24]さらに、カプセル皮膜が、可塑剤(例えば、多価アルコール、単糖類、2糖類、オリゴ糖、糖アルコール、ポリビニルアルコール、トリアセチン、デンプン誘導体、デンプン、及びセルロース誘導体から選択された少なくとも1種の可塑剤)を含む前記[1]~[23]のいずれか1項に記載の崩壊可能なカプセル。
[25]可塑剤が、グリセリン、デンプン、デンプン誘導体、及びセルロース誘導体から選択された少なくとも1種を含む前記[24]記載の崩壊可能なカプセル。
[26]可塑剤が、多価アルコールと、多価アルコール以外の可塑剤とを含む前記[24]又は[25]記載の崩壊可能なカプセル。
[27]可塑剤が、グリセリンと、デンプン、デンプン誘導体及びセルロース誘導体から選択された少なくとも1種とを、前者/後者(重量比)=90/10~10/90の割合で含む前記[24]~[26]のいずれか1項に記載の崩壊可能なカプセル。
[28]可塑剤の割合が、造膜性基剤100重量部に対して3~40重量部である前記[26]又は[27]に記載の崩壊可能なカプセル。
[29]喫煙器具用であることを特徴とする前記[1]~[28]のいずれか1項に記載の崩壊可能なカプセル。
[30]前記[1]~[28]のいずれか1項に記載の崩壊可能なカプセルを含む喫煙器具。
[31]90℃におけるカプセル皮膜液の粘度が、70~500mPa・s以上であることを特徴とする前記[1]~[28]のいずれか1項に記載の崩壊可能なカプセルの製造方法。
なお、カプセルBもまた、カプセルAと同様に、喫煙器具用のカプセルであってもよい。そのため、本発明には、カプセルBを含む喫煙器具も含まれる。
150<(X)<630 (1)
(上記式中、(X)は、破壊強度(g)/カプセルの外径(mm)を表す。)
0.15≦(Y)≦0.53 (2)
(上記式中、(Y)は、ディスタンス/外径比を表し、前記ディスタンスは、22℃80%RHにおいてカプセルにプレスをかけてカプセルを破壊したときの、最大荷重に達するまでに変形した距離(mm)を表す。)
150<(X)<630 (1)
(上記式中、(X)は、破壊強度(g)/カプセルの外径(mm)を表す。)
前記破壊強度(g)は、22℃60%RHにおいて、レオメーターCR-500DX(測定機器、(株)サン科学製)で測定し、レオデーターアナライザー(Rheo Data analyzer for Win、物性データ自動解析ソフト、(株)サン科学製)で分析した値であり、カプセルの外径(mm)は、カプセルの平面形状(断面)が円形の場合は長径を意味し、カプセルの平面形状(断面)が円形でない場合は最大径を意味する。
後記する造膜性基剤及び親水性高分子の皮膜形成剤の含有量の調整及び/又は冷却工程、乾燥工程等の製造工程での調整により、本発明の効果が得られる前記破壊強度に調整することができる。100gを下回ると、カプセルが割れやすく、5000gを超えると、カプセルの外径にもよるが、指でカプセルを潰すことが困難になり、好ましくない。破壊強度は、22℃60%RHにおいて、レオメーターCR-500DX(測定機器、(株)サン科学製)で測定し、レオデーターアナライザー(Rheo Data analyzer for Win、物性データ自動解析ソフト、(株)サン科学製)で分析した値である。
また、寒天とカラギーナンとを組み合わせる場合、寒天とカラギーナンとの割合は、例えば、前者/後者(重量比)=95/5~5/95(例えば、93/7~10/90)、好ましくは90/15~15/85(例えば、88/12~20/80)、さらに好ましくは85/15~25/75(例えば、83/17~30/70)程度であってもよく、通常90/10~30/70(例えば、88/12~30/70、好ましくは85/15~35/65、さらに好ましくは83/17~40/60)であってもよい。
これらは、1種単独で使用してもよく、2種以上を混合して用いてもよい。これらは、市販品を使用することができる。市販品としては、ファイバロン(大日本住友製薬(株))、グアファイバー(明治フードマテリアル(株))、サンファイバー(太陽化学(株))ドゥファイバー(大正製薬(株))、ネオビスコG(三晶(株))、メイプロHPGシリーズ(三晶(株))、ジャガーCシリーズ(三晶(株))、メイプロガム(三晶(株))、セルパールFGシリーズ(ソマール(株))、RG100(MRCポリサッカライド(株))等が挙げられる。
(1)カプセル内容物の温度を、5~25℃(より好ましくは12~22℃)の範囲で設定値±2℃(より好ましくは±1℃)に制御すること、
(2)カプセル皮膜液の温度を、50~99℃(より好ましくは60~95℃)の範囲で設定値±2℃(より好ましくは±1℃)に制御すること。
また、カプセルの内容物の油性成分に、親油性溶媒を加えて用いる場合、(3)親油性溶媒の温度を、1~25℃(より好ましくは5~20℃)の範囲で設定値±1℃(より好ましくは±0.5℃)に制御することが好ましい。
さらに、上記条件に加えて、(4)カプセル内容物の温度とカプセル皮膜液の温度の差が、25℃以上94℃以下(より好ましくは38℃以上85℃以下)であることがより好ましい。
また、カプセルの内容物の油性成分に、親油性溶媒を加えて用いる場合、(5)カプセル皮膜液の温度と親油性溶媒の温度の差が、35℃以上94℃以下(より好ましくは49℃以上85℃以下)であることがより好ましい。
さらに、ノズルを通過した後、膜層を冷却によってゲル化させる際、冷却オイルによって冷却する。冷却オイルでの冷却温度は、例えば、5~20℃程度である。
◎:指で圧力をかけた際に、潰しやすく、心地よく割れる
○:指で圧力をかけた際に、やや硬さを感じるが、潰しやすい
△:指で圧力をかけた際に潰れるが相当力をいれないと潰れない
×:指で圧力をかけても潰れない又は指で圧力をかけた際に指が痛くなるほど力をいれないと潰れない
κカラギーナン、粉末寒天、グアーガム、アルギン酸ナトリウム、グリセリン、青色一号、及び水を、得られるカプセルが下記表1の配合割合となるように混合して、95℃で溶解し(混合液の粘度:124mPa・s)、脱泡した後、静置して、カプセル皮膜液を作製した。
実施例1のカプセルに、さらに、ツェイン(商品名:小林ツェインDP、小林香料株式会社)10%希釈溶液で、公知の方法によりカプセルの総重量に対して、2%重量分となるように、コーティングを行った。得られたカプセルの特性を測定した。結果を下記表18に示す。
得られるカプセルが下記表2の処方となるように調製した混合液を、95℃で溶解し(混合液の粘度:151mPa・s)、脱泡した後、静置して、カプセル皮膜液を作製した。
得られるカプセルが下記表3の処方となるように調製した混合液を、95℃で溶解し(混合液の粘度:175mPa・s)、脱泡した後、静置して、カプセル皮膜液を作製した。
得られるカプセルが下記表4の処方となるように調製した混合液を、95℃で溶解し(混合液の粘度:119mPa・s)、脱泡した後、静置して、カプセル皮膜液を作製した。
得られるカプセルが下記表5の処方となるように調製した混合液を、95℃で溶解し(混合液の粘度:210mPa・s)、脱泡した後、静置して、カプセル皮膜液を作製した。
得られるカプセルが下記表6の処方となるように調製した混合液を、95℃で溶解し(混合液の粘度:330mPa・s)、脱泡した後、静置して、カプセル皮膜液を作製した。
得られるカプセルが下記表7の処方となるように調製した混合液を、95℃で溶解し(混合液の粘度:200mPa・s)、脱泡した後、静置して、カプセル皮膜液を作製した。
得られるカプセルが下記表8の処方となるように調製した混合液を、95℃で溶解し(混合液の粘度:95mPa・s)、脱泡した後、静置して、カプセル皮膜液を作製した。
実施例1のカプセルに、さらに、オイドラギット(商品名:オイドラギット EPO、ローム社)0.5%溶液で、公知の方法によりカプセルの総重量に対して、2%重量分となるように、コーティングを行った。得られたカプセルの特性を測定した。結果を下記表18に示す。
得られるカプセルが下記表9の処方となるように調製した混合液を、95℃で溶解し(混合液の粘度:132mPa・s)、脱泡した後、静置して、カプセル皮膜液を作製した。
得られるカプセルが下記表10の処方となるように調製した混合液を、95℃で溶解し(混合液の粘度:192mPa・s)、脱泡した後、静置して、カプセル皮膜液を作製した。
得られるカプセルが下記表11の処方となるように調製した混合液を、95℃で溶解し(混合液の粘度:173mPa・s)、脱泡した後、静置して、カプセル皮膜液を作製した。
得られるカプセルが下記表12の処方となるように調製した混合液を、95℃で溶解し(混合液の粘度:131mPa・s)、脱泡した後、静置して、カプセル皮膜液を作製した。
得られるカプセルが下記表13の処方となるように調製した混合液を、95℃で溶解し(混合液の粘度:275mPa・s)、脱泡した後、静置して、カプセル皮膜液を作製した。
得られるカプセルが下記表14の処方となるように調製した混合液を、95℃で溶解し(混合液の粘度:168mPa・s)、脱泡した後、静置して、カプセル皮膜液を作製した。
得られるカプセルが下記表15の処方となるように調製した混合液を、95℃で溶解し(混合液の粘度:130mPa・s)、脱泡した後、静置して、カプセル皮膜液を作製した。
得られるカプセルが下記表16の処方となるように調製した混合液を、95℃で溶解し(混合液の粘度:150mPa・s)、脱泡した後、静置して、カプセル皮膜液を作製した。
得られるカプセルが下記表17の処方となるように調製した混合液を、95℃で溶解し(混合液の粘度:180mPa・s)、脱泡した後、静置して、カプセル皮膜液を作製した。
得られるカプセルが下記表19の処方となるように調製した混合液を用いて、カプセル皮膜液を作製し、得られたカプセル皮膜液を用いる以外は、実施例1と同様にして、カプセルを製造した。得られたカプセルの特性を測定した。結果を下記表20に示す。
前記実施例及び比較例の各サンプルのカプセルを、80℃の恒温槽に60分間放置し、カプセルの軟化、溶解を目視で確認した。
前記実施例及び比較例の各サンプルのカプセルを、25℃85%RHの環境下に120分間放置し、内容物の流出、カプセルの変形、変色、カプセル同士の付着を目視で確認した。
得られるカプセル又は皮膜が下記表21の処方となるように調製した混合液を用いて、カプセル皮膜液を作製し、得られたカプセル皮膜液を用いる以外は、実施例1と同様にして、カプセル又は皮膜を製造し、得られたカプセル又は皮膜の特性を測定した。
皮膜は、5重量%水溶液を作製し、95℃に加熱した後、直径90mmのシャーレに水溶液を10g入れ、22℃60%RHの環境下で、水分量が12.5重量%となるまで乾燥することにより、作製した。そして、得られた皮膜を、2cm×2cmにカットして70℃及び75℃の温水に浸し、溶解の有無を確認した。また、実施例20及び実施例22の組成では、後述のように、75℃の温水にも溶解しなかったため、さらに、80℃の温水に浸し、溶解の有無を確認した。
なお、実施例20と実施例21とでは、22℃80%RHにおけるSDの差は0.1であるが、ディスタンスの値が数(mm)程度であることを考慮すると、0.1のSD値の差は大きなものといえる。実際、実施例20のカプセルと実施例21のカプセルとを、それぞれ指で潰してみたところ、実施例20のカプセルは何ら支障なく良好な割れ感で割れたが、実施例21のカプセルでは、実施例20に比べると、かなり指で圧力をかけないと割れないカプセルや、逆に割れ易過ぎるカプセルが混在しており、実施例20と実施例21とでは、割れ感に有意な差があった。
なお、実施例22及び比較例4は、実施例20の組成を構成するアルギン酸ナトリウムを除いた結果であるが、アルギン酸ナトリウムの添加によっても、温水に対する溶解性にやや変化(80℃でやや溶解)が見られたが、グアーガムの添加の有無による変化に比べると小さいものであった。これらの結果から、グアーガムが特異的に耐熱性及び耐湿性の向上に寄与していることがわかる。
粉末寒天、グアーガム酵素分解物、アルギン酸ナトリウム、κカラギーナン、グリセリン、澱粉分解物(マルトデキストリン)、青色一号、及び水を、得られるカプセルが下記表1の配合割合となるように混合して、95℃で溶解し(混合液の粘度:148mPa・s)、脱泡した後、静置して、カプセル皮膜液を作製した。
実施例23~27のカプセルのそれぞれに、さらに、澱粉10%希釈溶液で、公知の方法によりカプセルの総重量に対して、2%重量分となるように、カプセル外層にコーティングを行った。得られたカプセルの特性を測定した。結果を下記表25に示す。
2 カプセル皮膜
3 崩壊可能なカプセル
4 内側ノズル
5 外側ノズル
6 担体流
A カプセル内容物材料の投入口
B カプセル皮膜材料の投入口
Claims (46)
- 内容物とカプセル皮膜を有するカプセルであって、内容物として油性成分を含み、カプセル皮膜として、少なくとも造膜性基剤を含み、下記式(1)及び下記式(2)を満足することを特徴とする崩壊可能なカプセル。
150<(X)<630 (1)
(上記式中、(X)は、破壊強度(g)/カプセルの外径(mm)を表す。)
0.15≦(Y)≦0.53 (2)
(上記式中、(Y)は、ディスタンス/外径比を表し、前記ディスタンスは、22℃80%RHにおいてカプセルにプレスをかけてカプセルを破壊したときの、最大荷重に達するまでに変形した距離(mm)を表す。) - カプセルの膜厚が、5~120μmであることを特徴とする請求項1記載の崩壊可能なカプセル。
- カプセルの皮膜率が、5.0%以上18.0%以下であることを特徴とする請求項1又は2に記載の崩壊可能なカプセル。
- カプセル皮膜の含水率が、10.0~19.0%であることを特徴とする請求項1~3のいずれか1項に記載の崩壊可能なカプセル。
- カプセルの破壊強度が、150~4000gであることを特徴とする請求項1~4のいずれか1項に記載の崩壊可能なカプセル。
- 式(2)が、0.18≦(Y)≦0.5であることを特徴とする請求項1~5のいずれか1項に記載の崩壊可能なカプセル。
- カプセル皮膜の水分活性値が、0.400以上0.650以下であることを特徴とする請求項1~6のいずれか1項に記載の崩壊可能なカプセル。
- 崩壊可能なカプセルが、シームレスカプセルであることを特徴とする請求項1~7のいずれか1項に記載の崩壊可能なカプセル。
- カプセルの外径が、1.0~15.0mmであることを特徴とする請求項1~8のいずれか1項に記載の崩壊可能なカプセル。
- 前記造膜性基剤が、寒天、カラギーナン及びゼラチンからなる群から選ばれる1種以上であることを特徴とする請求項1~9のいずれか1項に記載の崩壊可能なカプセル。
- 前記造膜性基剤が、少なくとも、ゼリー強度が600g/cm2以上の寒天、又はブルーム強度が190以上のゼラチンを含むことを特徴とする請求項1~10のいずれか1項に記載の崩壊可能なカプセル。
- カラギーナンが、カッパカラギーナン又はイオタカラギーナンであることを特徴とする請求項10又は11に記載の崩壊可能なカプセル。
- 前記造膜性基剤が、寒天及びカラギーナンを含む請求項1~12のいずれか1項に記載の崩壊可能なカプセル。
- 前記造膜性基剤が、寒天とカラギーナンとを、前者/後者(重量比)=90/10~30/70の割合で含む請求項1~13のいずれか1項に記載に崩壊可能なカプセル。
- さらに、カプセル皮膜が、アルギン酸又はその塩、ファーセレラン、カードラン、ガティガム、アラビアガム、プルラン、ウェランガム、キサンタンガム、ジェランガム、トラガントガム、ペクチン、グルコマンナン、グアーガム、タラガム、タマリンドシードガム、ローカストビーンガム、サイリウムシードガム、アマシードガム及びダイユータンガムからなる群から選ばれる1種以上である皮膜形成剤を含むことを特徴とする請求項1~14のいずれか1項に記載の崩壊可能なカプセル。
- 前記皮膜形成剤が、グアーガムを含む請求項15記載の崩壊可能なカプセル。
- グアーガムが、グアーガム酵素分解物を含む請求項16記載の崩壊可能なカプセル。
- 前記皮膜形成剤が、グアーガム及びアルギン酸又はその塩を含むことを特徴とする請求項15~17のいずれか1項に記載の崩壊可能なカプセル。
- アルギン酸塩が、アルギン酸ナトリウムであることを特徴とする請求項18記載の崩壊可能なカプセル。
- アルギン酸又はその塩とグアーガムとの割合が、前者/後者(重量比)=70/30~10/90である請求項18又は19に記載の崩壊可能なカプセル。
- カプセル皮膜において、造膜性基剤及び皮膜形成剤の割合が60重量%以上である請求項15~20のいずれか1項に記載の崩壊可能なカプセル。
- 皮膜形成剤の割合が、造膜性基剤1重量部に対して0.1~5重量部である請求項15~21のいずれか1項に記載の崩壊可能なカプセル。
- カプセル皮膜が、寒天及びカラギーナンを含む造膜性基剤と、グアーガムを含む皮膜形成剤とを含み、寒天とカラギーナンとの割合が前者/後者(重量比)=85/15~25/75であり、カプセル皮膜において、造膜性基剤及び皮膜形成剤の割合が70重量%以上であり、皮膜形成剤の割合が造膜性基剤1重量部に対して0.3~3重量部である請求項15~22のいずれか1項に記載の崩壊可能なカプセル。
- さらに、カプセル皮膜が、多価アルコール、単糖類、2糖類、オリゴ糖、糖アルコール、ポリビニルアルコール、トリアセチン、デンプン誘導体、デンプン、及びセルロース誘導体から選択された少なくとも1種の可塑剤を含む請求項1~23のいずれか1項に記載の崩壊可能なカプセル。
- 可塑剤が、グリセリン、デンプン、デンプン誘導体、及びセルロース誘導体から選択された少なくとも1種を含む請求項24記載の崩壊可能なカプセル。
- 可塑剤が、多価アルコールと、多価アルコール以外の可塑剤とを含む請求項24又は25記載の崩壊可能なカプセル。
- 可塑剤が、グリセリンと、デンプン、デンプン誘導体及びセルロース誘導体から選択された少なくとも1種とを、前者/後者(重量比)=90/10~10/90の割合で含む請求項24~26のいずれか1項に記載の崩壊可能なカプセル。
- 可塑剤の割合が、造膜性基剤100重量部に対して3~40重量部である請求項24~27のいずれか1項に記載の崩壊可能なカプセル。
- 喫煙器具用であることを特徴とする請求項1~28のいずれか1項に記載の崩壊可能なカプセル。
- 請求項1~28のいずれか1項に記載の崩壊可能なカプセルを含む喫煙器具。
- 90℃におけるカプセル皮膜液の粘度が、70~500mPa・s以上であることを特徴とする請求項1~28のいずれか1項に記載された崩壊可能なカプセルの製造方法。
- 内容物とカプセル皮膜を有するカプセルであって、内容物として油性成分を含み、カプセル皮膜として、寒天及びカラギーナンを含む造膜性基剤と、グアーガムを含む皮膜形成剤とを含む崩壊可能なカプセル。
- 前記造膜性基剤が、寒天とカラギーナンとを、前者/後者(重量比)=90/10~30/70の割合で含む請求項32に記載に崩壊可能なカプセル。
- グアーガムが、グアーガム酵素分解物を含む請求項32又は33に記載の崩壊可能なカプセル。
- 前記皮膜形成剤が、グアーガム及びアルギン酸又はその塩を含む請求項32~34のいずれか1項に記載の崩壊可能なカプセル。
- アルギン酸又はその塩とグアーガムとの割合が、前者/後者(重量比)=70/30~10/90である請求項35記載の崩壊可能なカプセル。
- カプセル皮膜において、造膜性基剤及び皮膜形成剤の割合が60重量%以上である請求項32~36のいずれか1項に記載の崩壊可能なカプセル。
- 皮膜形成剤の割合が、造膜性基剤1重量部に対して0.1~5重量部である請求項32~37のいずれか1項に記載の崩壊可能なカプセル。
- 寒天とカラギーナンとの割合が前者/後者(重量比)=85/15~30/70であり、カプセル皮膜において、造膜性基剤及び皮膜形成剤の割合が70重量%以上であり、皮膜形成剤の割合が造膜性基剤1重量部に対して0.3~3重量部である請求項32~38のいずれか1項に記載の崩壊可能なカプセル。
- さらに、カプセル皮膜が、多価アルコール、単糖類、2糖類、オリゴ糖、糖アルコール、ポリビニルアルコール、トリアセチン、デンプン誘導体、デンプン、及びセルロース誘導体から選択された少なくとも1種の可塑剤を含む請求項32~39のいずれか1項に記載の崩壊可能なカプセル。
- 可塑剤が、グリセリン、デンプン、デンプン誘導体、及びセルロース誘導体から選択された少なくとも1種を含む請求項40記載の崩壊可能なカプセル。
- 可塑剤が、多価アルコールと、多価アルコール以外の可塑剤とを含む請求項40又は41記載の崩壊可能なカプセル。
- 可塑剤が、グリセリンと、デンプン、デンプン誘導体及びセルロース誘導体から選択された少なくとも1種とを、前者/後者(重量比)=90/10~10/90の割合で含む請求項40~42のいずれか1項に記載の崩壊可能なカプセル。
- 可塑剤の割合が、造膜性基剤100重量部に対して3~40重量部である請求項40~43のいずれか1項に記載の崩壊可能なカプセル。
- 喫煙器具用であることを特徴とする請求項32~44のいずれか1項に記載の崩壊可能なカプセル。
- 請求項32~44のいずれか1項に記載の崩壊可能なカプセルを含む喫煙器具。
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EP14784928.5A EP2997837A4 (en) | 2013-04-15 | 2014-04-15 | Disintegrable capsule, manufacturing method for same, and smoking equipment containing said disintegrable capsule |
US14/651,849 US10015984B2 (en) | 2013-04-15 | 2014-04-15 | Disintegrable capsule, manufacturing method for same, and smoking device containing said disintegrable capsule |
RU2015114527A RU2668327C2 (ru) | 2013-04-15 | 2014-04-15 | Разрушающаяся капсула, способ ее изготовления и устройство для курения, содержащее разрушающуюся капсулу |
CN201480002754.9A CN104812256B (zh) | 2013-04-15 | 2014-04-15 | 可崩解胶囊及其制造方法以及包含可崩解胶囊的吸烟器具 |
UAA201511187A UA122116C2 (uk) | 2013-04-15 | 2014-04-15 | Капсула, що руйнується, застосування капсули, що руйнується, для вивільнення масляного інгредієнта у пристрої для куріння та пристрій для куріння, який містить капсулу, що руйнується |
JP2015512476A JPWO2014171433A1 (ja) | 2013-04-15 | 2014-04-15 | 崩壊可能なカプセル及びその製造方法並びに崩壊可能なカプセルを含む喫煙器具 |
KR1020157010134A KR102186313B1 (ko) | 2013-04-15 | 2014-04-15 | 붕괴 가능한 캡슐 및 그 제조 방법 및 붕괴 가능한 캡슐을 포함하는 흡연 기구 |
PH12015502378A PH12015502378A1 (en) | 2013-04-15 | 2015-10-13 | Disintegrable capsule, manufacturing method for same, and smoking equipment containing said disintegrable capsule |
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JP7064466B2 (ja) | 2022-05-10 |
CN104812256B (zh) | 2018-12-11 |
RU2015114527A (ru) | 2017-05-18 |
JP7254848B2 (ja) | 2023-04-10 |
WO2014170947A1 (ja) | 2014-10-23 |
RU2015114527A3 (ja) | 2018-03-12 |
JPWO2014170947A1 (ja) | 2017-02-16 |
JP2021097702A (ja) | 2021-07-01 |
RU2668327C2 (ru) | 2018-09-28 |
PH12015502378B1 (en) | 2016-02-22 |
US10015984B2 (en) | 2018-07-10 |
EP2997837A1 (en) | 2016-03-23 |
JPWO2014171433A1 (ja) | 2017-02-23 |
KR102186313B1 (ko) | 2020-12-03 |
JP2023082087A (ja) | 2023-06-13 |
UA122116C2 (uk) | 2020-09-25 |
US20160021927A1 (en) | 2016-01-28 |
AP2015008369A0 (en) | 2015-04-30 |
CN104812256A (zh) | 2015-07-29 |
KR20150140624A (ko) | 2015-12-16 |
JP5581446B1 (ja) | 2014-08-27 |
JP2019170383A (ja) | 2019-10-10 |
PH12015502378A1 (en) | 2016-02-22 |
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