JPH10506841A - シームレスカプセルの製造方法 - Google Patents
シームレスカプセルの製造方法Info
- Publication number
- JPH10506841A JPH10506841A JP8512566A JP51256696A JPH10506841A JP H10506841 A JPH10506841 A JP H10506841A JP 8512566 A JP8512566 A JP 8512566A JP 51256696 A JP51256696 A JP 51256696A JP H10506841 A JPH10506841 A JP H10506841A
- Authority
- JP
- Japan
- Prior art keywords
- nozzle
- shell material
- shell
- seamless capsule
- capsule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
- B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
- B01J2/06—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a liquid medium
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
- B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
- B01J2/04—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a gaseous medium
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2984—Microcapsule with fluid core [includes liposome]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2984—Microcapsule with fluid core [includes liposome]
- Y10T428/2985—Solid-walled microcapsule from synthetic polymer
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Medicinal Preparation (AREA)
- Building Environments (AREA)
- Apparatus For Making Beverages (AREA)
- General Preparation And Processing Of Foods (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.少なくとも外側ノズル及び内側ノズルを有する同心円的に整列した複合ノ ズル装置を準備する工程と、 シェル材料を前記外側ノズルに、充填材料を前記内側ノズルに供給する工程と 、 前記外側ノズルを通って前記シェル材料を、前記内側ノズルを通って前記充填 材料を同時に押し出す工程とを有し、前記ノズルを通る前記シェル材料の流量フ ラックスは、前記内側ノズルを通る前記充填材料の流量フラックスと等しい充填 材料を包むシェル材料を有するシームレスカプセルの製造方法。 2.前記充填材料に対するシェル材料の重量比が、内側ノズル面積対外側環状 ノズルオリフィス面積に対する比を変化させることによって制御される請求項1 に記載のシームレスカプセルの製造方法。 3.充填材料対シェル材料に対する重量比が、内側ノズル面積及び/または外 側ノズルオリフィス面積の寸法を変化させることによって制御される請求項1に 記載のシームレスカプセルの製造方法。 4.表面活性剤が、シェル材料に付加される請求項1に記載のシームレスカプ セルの製造方法。 5.前記カプセルを洗浄及び乾燥する工程を有する請求項1に記載のシームレ スカプセルの製造方法。 6.乾燥工程の前に前記シェル材料を架橋するように前記カプセルを化学的に 処理する行程を有する請求項5に記載のシームレスカプセルの製造方法。 7.前記充填材料対シェル材料の重量比が、約9:1〜1.5:1である請求 項7に記載のシームレスカプセルの製造方法。 8.前記充填材料対シェル材料の重量比が、約3.5:1〜1.7:1である 請求項7に記載のシームレスカプセルの製造方法。 9.前記シェル材料が、ゼラチンである請求項1に記載のシームレスカプセル 。 10.前記充填材料は中位鎖トリグリセライドオイルである請求項1に記載の シームレスカプセルの製造方法。 11.前記シームレスカプセルが、約1mm〜約8mmの範囲の外径を有する 請求項1に記載のシームレスカプセルの製造方法。 12.前記シームレスカプセルが、約4mm〜約6mmの範囲の外径を有する 請求項11に記載のシームレスカプセルの製造方法。 13.前記内側ノズルが、約0.79〜約4.69mm2の内側のオリフィス 面積を有し、前記外側ノズルは約1.7〜約18.31mm2の内側のオリフィ ス面積を有する請求項1に記載のシームレスカプセルの製造方法。 14.同心円的に整列した複合ノズル装置の内側ノズルと外側ノズルとの間に 配置された少なくとも1つの中間のノズルを通って少なくとも1つの中間のシェ ル材料を供給する工程と、 同じ流量フラックスで前記中間ノズルを通って前記中間のシェル材料を同時に 押し出す行程とを有する請求項1に記載のシームレスカプセルの製造方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/325,722 US5650232A (en) | 1994-10-07 | 1994-10-07 | Method for making seamless capsules |
US08/325,722 | 1994-10-07 | ||
PCT/US1995/010949 WO1996011053A1 (en) | 1994-10-07 | 1995-08-30 | Method for making seamless capsules |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH10506841A true JPH10506841A (ja) | 1998-07-07 |
JP4236280B2 JP4236280B2 (ja) | 2009-03-11 |
Family
ID=23269143
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP51256696A Expired - Lifetime JP4236280B2 (ja) | 1994-10-07 | 1995-08-30 | シームレスカプセルの製造方法 |
Country Status (11)
Country | Link |
---|---|
US (1) | US5650232A (ja) |
EP (1) | EP0785822B1 (ja) |
JP (1) | JP4236280B2 (ja) |
BR (1) | BR9509265A (ja) |
CA (1) | CA2197480C (ja) |
CO (1) | CO4440639A1 (ja) |
ES (1) | ES2132703T3 (ja) |
GR (1) | GR3030420T3 (ja) |
MX (1) | MX9701659A (ja) |
PE (1) | PE28089695A1 (ja) |
WO (1) | WO1996011053A1 (ja) |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009004999A1 (ja) | 2007-06-29 | 2009-01-08 | Takeda Pharmaceutical Company Limited | シームレスカプセル |
WO2009087938A1 (ja) | 2008-01-10 | 2009-07-16 | Takeda Pharmaceutical Company Limited | カプセル製剤 |
WO2014171433A1 (ja) | 2013-04-15 | 2014-10-23 | 三生医薬株式会社 | 崩壊可能なカプセル及びその製造方法並びに崩壊可能なカプセルを含む喫煙器具 |
JP2015199750A (ja) * | 2007-04-26 | 2015-11-12 | シグモイド・ファーマ・リミテッドSigmoid Pharma Limited | 複数のミニカプセルの製造 |
WO2018180199A1 (ja) * | 2017-03-30 | 2018-10-04 | 株式会社ロッテ | 容器入り氷菓およびその製造方法 |
US10905156B2 (en) | 2019-01-18 | 2021-02-02 | Sunsho Pharmaceutical Co., Ltd. | Seamless capsule, filter and smoking equipment containing same |
WO2021201059A1 (ja) | 2020-03-30 | 2021-10-07 | 三生医薬株式会社 | メントールを含有する組成物 |
WO2022097601A1 (ja) | 2020-11-06 | 2022-05-12 | 学校法人近畿大学 | 血管疾患治療用組成物、血管疾患予防用組成物、高血圧治療用組成物、及び高血圧予防用組成物 |
WO2023042820A1 (ja) | 2021-09-14 | 2023-03-23 | 三生医薬株式会社 | カリオフィレン含有組成物 |
WO2023042819A1 (ja) | 2021-09-14 | 2023-03-23 | 三生医薬株式会社 | カリオフィレン含有組成物 |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0826976A (ja) * | 1994-07-21 | 1996-01-30 | Freunt Ind Co Ltd | 食品状医薬品 |
JP3759986B2 (ja) * | 1995-12-07 | 2006-03-29 | フロイント産業株式会社 | シームレスカプセルおよびその製造方法 |
US6174466B1 (en) | 1998-05-08 | 2001-01-16 | Warner-Lambert Company | Methods for making seamless capsules |
JP4778639B2 (ja) * | 2000-08-17 | 2011-09-21 | 中外製薬株式会社 | シームレスカプセルの製造方法 |
DE10160975A1 (de) * | 2001-12-10 | 2003-06-18 | Univ Schiller Jena | Probenplatte zur Verwendung in Dialysesystemen |
DE10206083B4 (de) * | 2002-02-13 | 2009-11-26 | INSTITUT FüR MIKROTECHNIK MAINZ GMBH | Verfahren zum Erzeugen monodisperser Nanotropfen sowie mikrofluidischer Reaktor zum Durchführen des Verfahrens |
JP2004105282A (ja) * | 2002-09-13 | 2004-04-08 | Freunt Ind Co Ltd | 口腔内即溶シームレスカプセルの製造方法 |
US7025911B2 (en) * | 2002-09-13 | 2006-04-11 | Freund Corporation | Manufacturing method for oral quick-dissolving seamless capsule |
JP2006521366A (ja) * | 2003-03-28 | 2006-09-21 | シグモイド・バイオテクノロジーズ・リミテッド | シームレスマイクロカプセルを含む固形経口剤形 |
CA2581816A1 (en) * | 2004-09-27 | 2006-04-06 | Sigmoid Biotechnologies Limited | Microcapsules comprising a methylxanthine and a corticosteroid |
EP1868567A4 (en) * | 2005-03-29 | 2010-09-29 | Mcneil Ppc Inc | COMPOSITIONS WITH HYDROPHILIC DRUGS IN A HYDROPHOBIC MEDIUM |
CA2683409A1 (en) | 2007-04-04 | 2008-10-16 | Sigmoid Pharma Limited | A pharmaceutical composition of tacrolimus |
US20100239665A1 (en) * | 2007-05-01 | 2010-09-23 | Ivan Coulter | Pharmaceutical nimodipine compositions |
US20090162475A1 (en) * | 2007-12-21 | 2009-06-25 | Cadbury Adams Usa Llc | Gum Structure Mixing Systems And Methods |
FR2939012B1 (fr) * | 2008-12-01 | 2015-03-27 | Capsum | Procede de fabrication d'une serie de capsules, et serie de capsules associee |
NO2379115T3 (ja) | 2008-12-17 | 2018-03-24 | ||
EP2432455B1 (en) | 2009-05-18 | 2014-11-12 | Sigmoid Pharma Limited | Composition comprising oil drops |
CA2770570A1 (en) | 2009-08-12 | 2011-02-17 | Sigmoid Pharma Limited | Immunomodulatory compositions comprising a polymer matrix and an oil phase |
FR2955257B1 (fr) * | 2010-01-15 | 2012-06-01 | Capsum | Procede de fabrication de capsules avec une hauteur de chute controlee. |
ES2392150T3 (es) | 2010-01-22 | 2012-12-05 | Unilever N.V. | Procedimiento de fabricación de partículas congeladas |
FR2964017B1 (fr) * | 2010-09-01 | 2013-05-31 | Capsum | Procede de fabrication d'une serie de capsules de taille submillimetrique |
DE102010045479A1 (de) | 2010-09-16 | 2014-10-30 | Brace Capital Gmbh | Verfahren zur Mikroverkapselung, Herstellung von festen Formen mehrphasiger mischbarer und nichtmischbarer Materialien und Methode zur Herstellung vorgenannter Systeme |
GB201020032D0 (en) | 2010-11-25 | 2011-01-12 | Sigmoid Pharma Ltd | Composition |
US10300006B2 (en) * | 2011-03-08 | 2019-05-28 | Capsum | Method for forming drops of a first phase, dispersed in a second phase substantially immiscible with the first phase |
JP2014510525A (ja) | 2011-03-11 | 2014-05-01 | インターコンチネンタル グレート ブランズ エルエルシー | 多層菓子の形成システムおよび形成方法 |
MX2014000819A (es) | 2011-07-21 | 2014-02-27 | Intercontinental Great Brands Llc | Conformacion y enfriamiento de goma avanzados. |
KR101974680B1 (ko) * | 2011-11-16 | 2019-05-02 | 모리시타 진탄 가부시키가이샤 | 해충 구제제 |
GB201212010D0 (en) | 2012-07-05 | 2012-08-22 | Sigmoid Pharma Ltd | Formulations |
GB201319791D0 (en) | 2013-11-08 | 2013-12-25 | Sigmoid Pharma Ltd | Formulations |
MX2016011041A (es) | 2014-03-03 | 2016-11-29 | Intercontinental Great Brands Llc | Metodo para fabricar un comestible. |
PL3215127T3 (pl) | 2014-11-07 | 2021-05-17 | Sublimity Therapeutics Limited | Kompozycje zawierające cyklosporynę |
DE102017105194A1 (de) | 2017-03-10 | 2018-09-13 | Little Things Factory Gmbh | Fokussiereinrichtung, Tropfengenerator und Verfahren zum Erzeugen einer Vielzahl von Tröpfchen |
US20220280436A1 (en) * | 2019-07-23 | 2022-09-08 | R.P. Scherer Technologies, Llc | Softshell capsule formulations, and methods of preparation and use thereof |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1096640A (en) * | 1964-12-07 | 1967-12-29 | Monsanto Co | Micro-fiber spinning process |
US3423489A (en) * | 1966-11-01 | 1969-01-21 | Minnesota Mining & Mfg | Encapsulation process |
US3779942A (en) * | 1970-12-04 | 1973-12-18 | Minnesota Mining & Mfg | Capsules and process for forming capsules |
JPS518876B2 (ja) * | 1972-10-03 | 1976-03-22 | ||
NL180807C (nl) * | 1975-12-26 | 1987-05-04 | Morishita Jintan Co | Inrichting voor het vervaardigen van naadloze, met materiaal gevulde capsules. |
DE2746489C2 (de) * | 1977-10-15 | 1982-12-30 | Hans Dr. 3300 Braunschweig Junginger | Verfahren zum Herstellen von Mikrokapseln mit Flüssigkeits- und/oder mit Feststoff-Füllungen durch Sprühtrocknung unter Verwendung einer Dreifachdüse |
US4422985A (en) * | 1982-09-24 | 1983-12-27 | Morishita Jintan Co., Ltd. | Method and apparatus for encapsulation of a liquid or meltable solid material |
JPS59131355A (ja) * | 1983-01-17 | 1984-07-28 | 森下仁丹株式会社 | 多重軟カプセルの製法 |
US4888140A (en) * | 1987-02-11 | 1989-12-19 | Chesebrough-Pond's Inc. | Method of forming fluid filled microcapsules |
JP2806564B2 (ja) * | 1989-07-20 | 1998-09-30 | 森下仁丹株式会社 | 親水性物質を内容物とするシームレスカプセルおよびその製法 |
JP3313124B2 (ja) * | 1991-07-31 | 2002-08-12 | 森下仁丹株式会社 | 親水性物質を内容物とするシームレスカプセルおよびその製法 |
JPH0673629B2 (ja) * | 1991-12-20 | 1994-09-21 | 大正製薬株式会社 | シームレスカプセル形成物質の押出装置 |
-
1994
- 1994-10-07 US US08/325,722 patent/US5650232A/en not_active Expired - Lifetime
-
1995
- 1995-08-30 BR BR9509265A patent/BR9509265A/pt not_active IP Right Cessation
- 1995-08-30 ES ES95930302T patent/ES2132703T3/es not_active Expired - Lifetime
- 1995-08-30 CA CA002197480A patent/CA2197480C/en not_active Expired - Fee Related
- 1995-08-30 WO PCT/US1995/010949 patent/WO1996011053A1/en active IP Right Grant
- 1995-08-30 MX MX9701659A patent/MX9701659A/es unknown
- 1995-08-30 JP JP51256696A patent/JP4236280B2/ja not_active Expired - Lifetime
- 1995-08-30 EP EP95930302A patent/EP0785822B1/en not_active Expired - Lifetime
- 1995-10-04 CO CO95046237A patent/CO4440639A1/es unknown
- 1995-10-05 PE PE1995280896A patent/PE28089695A1/es not_active Application Discontinuation
-
1999
- 1999-06-03 GR GR990401504T patent/GR3030420T3/el unknown
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2015199750A (ja) * | 2007-04-26 | 2015-11-12 | シグモイド・ファーマ・リミテッドSigmoid Pharma Limited | 複数のミニカプセルの製造 |
WO2009004999A1 (ja) | 2007-06-29 | 2009-01-08 | Takeda Pharmaceutical Company Limited | シームレスカプセル |
WO2009087938A1 (ja) | 2008-01-10 | 2009-07-16 | Takeda Pharmaceutical Company Limited | カプセル製剤 |
EP2455070A1 (en) | 2008-01-10 | 2012-05-23 | Takeda Pharmaceutical Company Limited | Capsule Formulation |
EP2455071A1 (en) | 2008-01-10 | 2012-05-23 | Takeda Pharmaceutical Company Limited | Capsule Formulation |
WO2014171433A1 (ja) | 2013-04-15 | 2014-10-23 | 三生医薬株式会社 | 崩壊可能なカプセル及びその製造方法並びに崩壊可能なカプセルを含む喫煙器具 |
WO2018180199A1 (ja) * | 2017-03-30 | 2018-10-04 | 株式会社ロッテ | 容器入り氷菓およびその製造方法 |
JPWO2018180199A1 (ja) * | 2017-03-30 | 2020-02-06 | 株式会社ロッテ | 容器入り氷菓およびその製造方法 |
US10905156B2 (en) | 2019-01-18 | 2021-02-02 | Sunsho Pharmaceutical Co., Ltd. | Seamless capsule, filter and smoking equipment containing same |
WO2021201059A1 (ja) | 2020-03-30 | 2021-10-07 | 三生医薬株式会社 | メントールを含有する組成物 |
WO2022097601A1 (ja) | 2020-11-06 | 2022-05-12 | 学校法人近畿大学 | 血管疾患治療用組成物、血管疾患予防用組成物、高血圧治療用組成物、及び高血圧予防用組成物 |
WO2023042820A1 (ja) | 2021-09-14 | 2023-03-23 | 三生医薬株式会社 | カリオフィレン含有組成物 |
WO2023042819A1 (ja) | 2021-09-14 | 2023-03-23 | 三生医薬株式会社 | カリオフィレン含有組成物 |
Also Published As
Publication number | Publication date |
---|---|
CO4440639A1 (es) | 1997-05-07 |
US5650232A (en) | 1997-07-22 |
BR9509265A (pt) | 1998-07-07 |
EP0785822B1 (en) | 1999-04-07 |
PE28089695A1 (es) | 1996-12-05 |
CA2197480C (en) | 2005-05-10 |
GR3030420T3 (en) | 1999-09-30 |
JP4236280B2 (ja) | 2009-03-11 |
EP0785822A1 (en) | 1997-07-30 |
ES2132703T3 (es) | 1999-08-16 |
MX9701659A (es) | 1997-06-28 |
WO1996011053A1 (en) | 1996-04-18 |
CA2197480A1 (en) | 1996-04-18 |
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