WO2012043544A1 - 針付きシリンジ - Google Patents
針付きシリンジ Download PDFInfo
- Publication number
- WO2012043544A1 WO2012043544A1 PCT/JP2011/072040 JP2011072040W WO2012043544A1 WO 2012043544 A1 WO2012043544 A1 WO 2012043544A1 JP 2011072040 W JP2011072040 W JP 2011072040W WO 2012043544 A1 WO2012043544 A1 WO 2012043544A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- needle
- syringe
- needle tube
- tube
- tip
- Prior art date
Links
- 238000000465 moulding Methods 0.000 claims abstract description 25
- 239000003814 drug Substances 0.000 claims abstract description 19
- 229940079593 drug Drugs 0.000 abstract description 9
- 239000000853 adhesive Substances 0.000 description 13
- 230000001070 adhesive effect Effects 0.000 description 13
- 230000002093 peripheral effect Effects 0.000 description 13
- 238000000034 method Methods 0.000 description 7
- 238000000926 separation method Methods 0.000 description 6
- 229920005989 resin Polymers 0.000 description 5
- 239000011347 resin Substances 0.000 description 5
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- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 239000004743 Polypropylene Substances 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
- 125000004122 cyclic group Chemical group 0.000 description 2
- 229920001971 elastomer Polymers 0.000 description 2
- 229920000728 polyester Polymers 0.000 description 2
- 229920000306 polymethylpentene Polymers 0.000 description 2
- 229920000098 polyolefin Polymers 0.000 description 2
- 229920001155 polypropylene Polymers 0.000 description 2
- 229920000178 Acrylic resin Polymers 0.000 description 1
- 239000004925 Acrylic resin Substances 0.000 description 1
- 229910000838 Al alloy Inorganic materials 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
- JHWNWJKBPDFINM-UHFFFAOYSA-N Laurolactam Chemical compound O=C1CCCCCCCCCCCN1 JHWNWJKBPDFINM-UHFFFAOYSA-N 0.000 description 1
- 229920000299 Nylon 12 Polymers 0.000 description 1
- 229920002292 Nylon 6 Polymers 0.000 description 1
- 229920000305 Nylon 6,10 Polymers 0.000 description 1
- 229920002302 Nylon 6,6 Polymers 0.000 description 1
- 102000035195 Peptidases Human genes 0.000 description 1
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- 239000004952 Polyamide Substances 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 229910001069 Ti alloy Inorganic materials 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- XECAHXYUAAWDEL-UHFFFAOYSA-N acrylonitrile butadiene styrene Chemical compound C=CC=C.C=CC#N.C=CC1=CC=CC=C1 XECAHXYUAAWDEL-UHFFFAOYSA-N 0.000 description 1
- 229920000122 acrylonitrile butadiene styrene Polymers 0.000 description 1
- 239000004676 acrylonitrile butadiene styrene Substances 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229940035674 anesthetics Drugs 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 239000010836 blood and blood product Substances 0.000 description 1
- 229940125691 blood product Drugs 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 239000002872 contrast media Substances 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000000806 elastomer Substances 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 239000002532 enzyme inhibitor Substances 0.000 description 1
- 239000003925 fat Substances 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 239000003193 general anesthetic agent Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000004081 narcotic agent Substances 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920000139 polyethylene terephthalate Polymers 0.000 description 1
- 239000005020 polyethylene terephthalate Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- PHZLMBHDXVLRIX-UHFFFAOYSA-M potassium lactate Chemical compound [K+].CC(O)C([O-])=O PHZLMBHDXVLRIX-UHFFFAOYSA-M 0.000 description 1
- 239000001521 potassium lactate Substances 0.000 description 1
- 229960001304 potassium lactate Drugs 0.000 description 1
- 235000011085 potassium lactate Nutrition 0.000 description 1
- 229940071643 prefilled syringe Drugs 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 229920002050 silicone resin Polymers 0.000 description 1
- 238000009751 slip forming Methods 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 239000000021 stimulant Substances 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
- B29C45/14—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor incorporating preformed parts or layers, e.g. injection moulding around inserts or for coating articles
- B29C45/14065—Positioning or centering articles in the mould
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/34—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/34—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub
- A61M5/343—Connection of needle cannula to needle hub, or directly to syringe nozzle without a needle hub
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2207/00—Methods of manufacture, assembly or production
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/3202—Devices for protection of the needle before use, e.g. caps
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
- B29K2101/00—Use of unspecified macromolecular compounds as moulding material
- B29K2101/12—Thermoplastic materials
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
- B29K2705/00—Use of metals, their alloys or their compounds, for preformed parts, e.g. for inserts
- B29K2705/02—Aluminium
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
- B29K2705/00—Use of metals, their alloys or their compounds, for preformed parts, e.g. for inserts
- B29K2705/08—Transition metals
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
- B29K2705/00—Use of metals, their alloys or their compounds, for preformed parts, e.g. for inserts
- B29K2705/08—Transition metals
- B29K2705/12—Iron
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
- B29L2031/00—Other particular articles
- B29L2031/753—Medical equipment; Accessories therefor
- B29L2031/7544—Injection needles, syringes
Definitions
- the present invention relates to a syringe with a needle in which a syringe is formed on a needle tube by insert molding.
- a syringe with a needle is composed of a needle tube having a needle tip that can puncture a living body at the tip, and a needle hub that holds the needle tube with the needle tip of the needle tube protruding.
- hook is comprised by connecting a syringe to a needle hub.
- the needle tube is fixed to the needle hub using an adhesive in a state where the needle tube is inserted into the insertion hole of the needle hub (see, for example, Patent Document 1).
- a syringe with a needle has been proposed in which the needle hub is eliminated and the needle tube is directly fixed to a syringe filled with a medicine. Also in this syringe with a needle, it is fixed to the syringe using an adhesive as in the conventional syringe with a needle.
- the medicine may be filled in the syringe. Therefore, there is a possibility that the adhesive that fixes the needle tube and the syringe may come into contact (wetted) with the medicine filled in the syringe, which may adversely affect the medicine. Therefore, in recent years, a technique for integrally forming a needle tube and a syringe by insert molding is required as a new fixing method that does not use an adhesive.
- An object of the present invention is to provide a syringe with a needle that can integrally form a needle tube and a syringe by insert molding without using an adhesive in consideration of the above problems.
- a syringe with a needle of the present invention includes a needle tube having a needle tip that can be punctured into a living body, and a syringe formed integrally with the needle tube by insert molding. ing.
- the syringe has a main body that is filled with a medicine and a fixing portion that is formed continuously with the main body and that fixes the needle tube in a state where the needle tip of the needle tube protrudes.
- fixed part of a syringe has a holding hole by which the chuck member which supports and fixes the surrounding surface of a needle tube at the time of insert molding is penetrated.
- the needle tube is held not from both ends in the axial direction but from the peripheral surface. be able to.
- the needle tube can be securely held by the chuck member at the time of molding, so that the needle tube and the syringe can be fixed integrally at an accurate position without using an adhesive.
- the needle tube and the syringe can be integrally formed by insert molding, the bonding process between the needle tube and the syringe can be reduced, and the cost can be reduced.
- the chuck member comes into contact with a portion of the needle tube that is covered with the fixed portion of the syringe, and does not contact a portion of the needle tube that is punctured by the living body (puncture site). Therefore, it is possible to prevent the puncture site of the needle tube from being damaged or contaminated.
- FIG. 1 It is a perspective view which shows the example of embodiment of the syringe with a needle
- FIG. 1 is a perspective view showing a syringe with a needle of this example
- FIG. 2 is a perspective view showing a main part of the syringe with a needle of this example.
- FIG. 3 is a side view showing a syringe with a needle of this example
- FIGS. 4 and 5 are cross-sectional views showing the syringe with a needle of this example.
- the syringe with needle 1 is used to puncture the needle tip from the surface of the skin and inject the drug into the living body.
- the syringe with needle 1 includes a syringe 2 filled with a medicine, a needle tube 3 fixed to the syringe 2, and a cap 4 (see FIGS. 6 and 7).
- the needle tube 3 uses a standard of ISO medical needle tube (ISO9626: 1991 / Amd.1: 2001 (E)) having a size of 10 to 33 gauge (outer diameter: ⁇ 3.5 to 0.2 mm), A 16 to 33 gauge (outer diameter: ⁇ 1.7 to 0.2 mm) is preferably used.
- a blade surface for making the needle tip 3a an acute angle is formed at one end in the axial direction of the needle tube 3. Then, the needle tip 3a on one side in the axial direction of the needle tube 3 is punctured into the living body.
- the material of the needle tube 3 examples include stainless steel, but are not limited thereto, and aluminum, aluminum alloy, titanium, titanium alloy, and other metals can be used.
- the needle tube 3 can be not only a straight needle but also a tapered needle having at least a part tapered.
- the proximal end portion has a larger diameter than the end portion of the needle tip 3a, and the intermediate portion may have a taper structure.
- the cross-sectional shape of the needle tube 3 may be not only a circle but also a polygon such as a triangle.
- a coating agent made of, for example, a silicone resin or a fluorine resin is applied to the surface of the needle tube 3 on the needle tip 3a side.
- the needle tube 3 is fixed to the syringe 2 with the needle tip 3a protruding outward. Then, the needle tip 3a on one side in the axial direction of the needle tube 3 protrudes from the distal end of the fixing portion 7 of the syringe 2 described later.
- the syringe 2 includes a main body 6 filled with a medicine and a fixing portion 7 continuous with the main body 6.
- the main body 6 is formed in a substantially cylindrical shape, and a fixing portion 7 is continuously formed on one side of the main body 6 in the axial direction, and the other end in the axial direction is opened.
- the cylindrical hole 6a (see FIG. 2) of the main body 6 is filled with a medicine, and a pusher gasket is plugged from the other side in the axial direction of the main body 6.
- a base end portion 3 b which is the other end in the axial direction of the needle tube 3 fixed to the fixing portion 7 communicates with the cylindrical hole 6 a of the main body 6.
- the shape of the main body 6 of the syringe 2 in the substantially cylindrical shape was demonstrated in this example, the shape of the main body 6 may be a hollow square column shape or a hexagonal column shape.
- the fixing portion 7 protrudes along the axial direction from one side of the main body 6 in the axial direction.
- the fixing portion 7 is integrally formed with the needle tube 3 by insert molding in a state where the needle tip 3a of the needle tube 3 is projected.
- the bonding step using an adhesive can be omitted. Further, since no adhesive is used, there is no possibility that the adhesive contacts the medicine filled in the syringe 2 and has an adverse effect.
- the needle tube 3 is disposed at the axial center of the fixed portion 7 and along the axial direction thereof.
- the fixing portion 7 includes a connection portion 8 that is continuous from one end of the main body 6 in the axial direction and a close contact portion 9 that is continuous from the connection portion.
- the connecting portion 8 has a cross shape in a cross-section in a direction orthogonal to the axial direction of the main body 6. Further, the diameter of the connecting portion 8 on the close contact portion 9 side is smaller than the outer diameter of the close contact portion 9. Therefore, the fixed part 7 has a shape in which the connection part between the connection part 8 and the close contact part 9 is constricted.
- the connection part 8 is formed so that it may become thin as it leaves
- a holding hole 11 communicating with the needle tube 3 fixed from the peripheral surface is formed in the connection portion 8.
- the holding hole 11 is a through hole orthogonal to the axis of the connection portion 8.
- a chuck member 26 that supports and fixes the peripheral surface of the needle tube 3 is inserted into the holding hole 11 (see FIG. 8).
- the example which provided the one holding hole 11 was demonstrated in this example, it is not limited to this, You may provide two or more holding holes. When there are a plurality of holding holes, it is preferable to form the holding holes at substantially equal intervals along the axial direction of the needle tube 3 in the connecting portion 8.
- a separation hole 12 is formed in the end portion of the connection portion 8 on the main body 6 side, that is, the other end portion 8 b in the axial direction of the connection portion 8.
- the spacing hole 12 is provided in the axial center of the other end portion 8 b in the connection portion 8.
- the proximal end 3 b of the needle tube 3 is disposed in the spacing hole 12.
- the separation hole 12 is separated from the outer peripheral surface of the needle tube 3.
- the distance S from the inner surface of the separation hole 12 to the outer peripheral surface of the needle tube 3 is set in the range of 0.3 mm to 1.0 mm, for example.
- the shape of the connecting portion 8 may be a substantially cylindrical shape, a quadrangular prism shape, or a hexagonal prism shape.
- a close contact portion 9 is provided at one end of the connecting portion 8 in the axial direction, that is, at the distal end side of the fixed portion 7.
- the close contact portion 9 is formed in a substantially cylindrical shape.
- the needle tip 3a of the needle tube 3 projects from one side in the axial direction of the close contact portion 9.
- One side of the contact portion 9 in the axial direction is open except for the outer periphery and the periphery of the needle tube 3 in order to reduce the thickness thereof. However, even if this opening is not provided, the object can be achieved.
- adherence part 9 is a shape corresponding to the shape of the cylinder hole 4a of the cap 4, it will be square pillar shape or hexagonal note shape There may be.
- Examples of the material of the syringe 2 having the above-described structure include polyvinyl chloride, polyethylene, polypropylene, cyclic polyolefin, polystyrene, poly- (4-methylpentene-1), polycarbonate, acrylic resin, and acrylonitrile-butadiene-styrene.
- Examples thereof include various resins such as polymers, polyesters such as polyethylene terephthalate, butadiene-styrene copolymers, and polyamides (for example, nylon 6, nylon 6,6, nylon 6,10, nylon 12).
- a resin such as polypropylene, cyclic polyolefin, polyester, or poly- (4-methylpentene-1).
- the material of the syringe 2 is substantially transparent in order to ensure internal visibility.
- the drug filled in the syringe 2 may be any drug that is normally used as an injection.
- protein drugs such as antibodies, peptide drugs such as hormones, nucleic acid drugs, cell drugs, blood products, various drugs Vaccines to prevent infectious diseases, anticancer agents, anesthetics, narcotics, antibiotics, steroids, proteolytic enzyme inhibitors, sugar injection solutions such as heparin and glucose, and electrolyte correction injections such as sodium chloride and potassium lactate Liquids, vitamins, fat emulsions, contrast agents, stimulants and the like.
- protein drugs such as antibodies, peptide drugs such as hormones, nucleic acid drugs, cell drugs, blood products, various drugs Vaccines to prevent infectious diseases, anticancer agents, anesthetics, narcotics, antibiotics, steroids, proteolytic enzyme inhibitors, sugar injection solutions such as heparin and glucose, and electrolyte correction injections such as sodium chloride and potassium lactate Liquids, vitamins, fat emulsion
- the cap 4 is formed in a substantially cylindrical shape, and one end in the axial direction is open and the other end in the axial direction is closed.
- the cap 4 is formed of an elastic member such as rubber or elastomer.
- the cap 4 is attached to one side in the axial direction of the syringe 2 so as to cover the needle tip 3 a of the needle tube 3 and the fixing portion 7 of the syringe 2. Then, as shown in FIG. 7, the needle tip 3 a side of the needle tube 3 and the fixing portion 7 are inserted into the cylindrical hole 4 a of the cap 4.
- the inner diameter of the cylindrical hole 4a of the cap 4 is set to be approximately equal to or slightly smaller than the outer diameter of the contact portion 9 of the fixed portion 7. Therefore, when the cap 4 is attached to the syringe 2, the outer peripheral surface of the contact portion 9 in the fixing portion 7 is in close contact with the inner peripheral surface of the cap 4. As a result, the needle tip 3 a side of the needle tube 3, which is the tip side from the close contact portion 9 of the fixing portion 7, is sealed by the close contact portion 9 and the inner peripheral surface of the cap 4. As a result, bacteria can be prevented from adhering to the needle tip 3a.
- the inner peripheral surface of the cap 4 tightens the constricted portion and the connection portion between the contact portion 9 and the connection portion 8 in the fixing portion 7 by its elastic force. Thereby, the inner peripheral surface of the cap 4 and the constricted portion of the fixing portion 7 are engaged, and the cap 4 can be prevented from being detached from the syringe 2 during conveyance.
- FIG. 8 is a cross-sectional view showing a state in which a needle-equipped syringe is insert-molded.
- the mold 20 that forms the needle-equipped syringe 1 of this example will be described.
- the mold 20 includes a nest 21 that forms the cylindrical hole 6 a of the syringe 2, a first component 22, a second component 23 that faces the first component 22, and the syringe 2. And a third component 24 that forms the contact portion 9.
- the first component 22 and the second component 23 have a chuck member 26 that supports and fixes the side surface of the needle tube 3.
- the tip of the chuck member 26 is formed with a V-shaped groove so that the needle tube 3 can be easily supported.
- the tip of the chuck member 26 may have a curved surface that is slightly larger than the diameter of the needle tube 3 in addition to forming a V-shaped groove.
- an elastic body may be provided at the tip of the chuck member 26 to prevent the needle tube 3 from being crushed or scratched on the side surface. Note that by providing an elastic body at the tip of the chuck member 26, it is possible to flexibly cope with variations in the thickness of the needle tube 3.
- a support portion 21 a that supports and fixes the proximal end portion 3 b of the needle tube 3 is formed at the distal end of the insert 21.
- the third component 24 is formed with a guide hole 24a into which the needle tip 3a side of the needle tube 3 is inserted.
- the joint of the first component 22, the second component 23, and the third component 24 is located on the connection portion 8 of the fixed portion 7 in the syringe 2.
- the method for assembling the syringe 1 with the needle using the mold 20 described above is performed as follows. First, as shown in FIG. 8, the base end portion 3 b of the needle tube 3 is supported and fixed by the support portion 21 a of the insert 21. Similarly, the side surface of the needle tube 3 is supported and fixed by the chuck member 26 of the first component 22 and the second component 23. Next, the needle tip 3 a of the needle tube 3 is inserted into the guide hole 24 a of the third component 24, and the needle tube 3 is set straight with respect to the mold 20. Thereby, it can prevent that the needle tube 3 deform
- the resin is poured into the mold 20 and insert molding is performed. Thereby, the syringe 2 is formed around the needle tube 3. At this time, the holding hole 11 through which the chuck member 26 is inserted and the separation hole 12 are formed in the fixing portion 7 of the syringe 2. Then, the cap 4 is put on the needle tube 3 and the syringe 2. Thereby, the assembly of the syringe 1 with a needle is completed.
- the needle tube 3 and the syringe 2 can be integrally formed by insert molding, the bonding process using an adhesive can be omitted, and the assembling process can be simplified. Thus, cost reduction during assembly can be achieved.
- the place where the chuck member 26 supports and fixes the needle tube 3 is the middle part of the fixing part 7 of the syringe 2 after the insert molding. Furthermore, the place where the support portion of the insert 21 supports and fixes the needle tube 3 is a base end portion 3b opposite to the needle tip 3a. This location is not a location where the living body in the needle tube 3 is punctured (hereinafter referred to as a puncture location). Thereby, since the puncture location of the needle tube 3 is not supported and fixed, it is possible to prevent the puncture location from being contaminated by the chuck member 26 and the support portion 21a and the side surface from being damaged.
- the needle tube 3 is supported and fixed at three points by the chuck member 26 and the support portion 21a of the insert 21. Accordingly, since it is not necessary to support the needle tip 3a of the needle tube 3, the needle tip 3a is not likely to be damaged by the mold, the chuck member 26, or the like during molding.
- the joint between the first component 22, the second component 23, and the third component 24 is located on the connection portion 8 of the fixed portion 7 in the syringe 2. Therefore, the dividing line of the mold, so-called parting line, is not formed in the close contact portion 9 that is in close contact with the inner surface of the cap 4.
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Abstract
Description
なお、説明は以下の順序で行う。
1.針付きシリンジの構成例
2.針付きシリンジの組み立て
まず、図1~図7を参照して本発明の実施の形態例(以下、「本例」という。)にかかる針付きシリンジについて説明する。
図1は本例の針付きシリンジを示す斜視図、図2は本例の針付きシリンジの要部を示す斜視図である。図3は本例の針付きシリンジを示す側面図、図4及び図5は本例の針付きシリンジを示す断面図である。
まず、針管3について説明する。
針管3は、ISOの医療用針管の基準(ISO9626:1991/Amd.1:2001(E))で10~33ゲージのサイズ(外径:φ3.5~0.2mm)のものを使用し、好ましくは16~33ゲージ(外径:φ1.7~0.2mm)のものを使用する。この針管3の軸方向の一端には、針先3aを鋭角にするための刃面が形成されている。そして、針管3の軸方向の一側の針先3aが生体に穿刺される。
次に、シリンジ2について説明する。
シリンジ2は、薬剤が充填される本体6と、この本体6に連続する固定部7を備えている。本体6は、略円筒形に形成されており、この本体6の軸方向の一側に固定部7が連続して形成され、軸方向の他端が開口している。また、プレフィルドシリンジの場合は、この本体6の筒孔6a(図2参照)に薬剤が充填され、本体6の軸方向の他側から押し子のガスケットが打栓される。更に、図4に示すように、本体6の筒孔6aには、固定部7に固定された針管3の軸方向の他端である基端部3bが連通する。
次に、キャップ4について説明する。
図6及び図7に示すように、キャップ4は、略円筒状に形成されており、軸方向の一端が開口し、軸方向の他端が閉じている。このキャップ4は、例えばゴムやエラストマー等の弾性部材から形成される。そして、図6に示すように、キャップ4は、針管3の針先3a及びシリンジ2の固定部7を覆うようにして、シリンジ2の軸方向の一側に取り付けられる。そして、図7に示すように、キャップ4の筒孔4a内に針管3の針先3a側及び固定部7が挿入される。
次に、上述したような構成を有する針付きシリンジ1の組み立て方法について図8を参照して説明する。
図8は、針付きシリンジをインサート成形した状態を示す断面図である。
まず、図8に示すように、針管3の基端部3bを入れ子21の支持部21aによって支持固定する。同様に、針管3の側面を第1の部品22及び第2の部品23のチャック部材26によって支持固定する。次に、針管3の針先3aを第3の部品24のガイド孔24aに挿入し、針管3を金型20に対して真っ直ぐにセットする。これにより、針管3が成型時に変形したり、シリンジ2と針管3の相対的な位置がずれたりすることを防止できる。
Claims (5)
- 生体に穿刺可能な針先を有する針管と、
インサート成形によって前記針管と一体に形成されるシリンジと、を備え、
前記シリンジは、薬剤が充填される本体と、前記本体に連続して形成され、かつ前記針管の前記針先を突出させた状態で前記針管を固定する固定部と、を有し、
前記シリンジの前記固定部は、インサート成形時に前記針管の周面を支持固定するチャック部材が挿通される保持孔を有する
針付きシリンジ。 - 前記保持孔は、前記固定部に保持される前記針管の軸方向と直交して形成される
請求項1に記載の針付きシリンジ。 - 前記保持孔は、前記固定部に複数設けられている
請求項1に記載の針付きシリンジ。 - 前記針管の針先及び前記シリンジの固定部を覆うキャップを設け、
前記固定部は、前記針管の前記針先が突出する密着部と、前記密着部と前記本体とを接続する接続部とからなり、
前記密着部は、前記キャップの内面に密着し、
前記保持孔は、前記接続部に形成される
請求項1に記載の針付きシリンジ。 - インサート成形によって前記シリンジを形成する金型の分割位置は、前記固定部の前記密着部を除いた前記接続部上に位置する
請求項4に記載の針付きシリンジ。
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JP2012536467A JP5940978B2 (ja) | 2010-09-29 | 2011-09-27 | 針付きシリンジ及び針付きシリンジの製造方法 |
EP11829097.2A EP2623144B1 (en) | 2010-09-29 | 2011-09-27 | Syringe with needle |
US13/814,788 US20130138047A1 (en) | 2010-09-29 | 2011-09-27 | Syringe with needle |
CN201180040416.0A CN103096953B (zh) | 2010-09-29 | 2011-09-27 | 带针注射器 |
US15/162,790 US10384379B2 (en) | 2010-09-29 | 2016-05-24 | Syringe with needle |
US15/901,474 US20180178423A1 (en) | 2010-09-29 | 2018-02-21 | Syringe with needle |
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JP2010218300 | 2010-09-29 | ||
JP2010-218300 | 2010-09-29 |
Related Child Applications (2)
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US13/814,788 A-371-Of-International US20130138047A1 (en) | 2010-09-29 | 2011-09-27 | Syringe with needle |
US15/162,790 Continuation US10384379B2 (en) | 2010-09-29 | 2016-05-24 | Syringe with needle |
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WO2012043544A1 true WO2012043544A1 (ja) | 2012-04-05 |
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PCT/JP2011/072040 WO2012043544A1 (ja) | 2010-09-29 | 2011-09-27 | 針付きシリンジ |
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US (3) | US20130138047A1 (ja) |
EP (1) | EP2623144B1 (ja) |
JP (3) | JP5940978B2 (ja) |
CN (1) | CN103096953B (ja) |
WO (1) | WO2012043544A1 (ja) |
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US8496862B2 (en) | 2008-01-15 | 2013-07-30 | West Pharmaceutical Services, Inc. | Collet mechanism and method of molding cannula to a syringe barrel |
USD689188S1 (en) | 2012-07-19 | 2013-09-03 | West Pharmaceutical Services, Inc. | Syringe plunger rod |
USD693002S1 (en) | 2011-09-21 | 2013-11-05 | West Pharmaceutical Services, Inc. | Hub for medical container |
CH706504A1 (de) * | 2012-05-14 | 2013-11-15 | Schoettli Ag | Verfahren zur Herstellung eines Spritzenzylinders für medizinische Zwecke sowie eine Vorrichtung zur Durchführung des Verfahrens. |
US8721603B2 (en) | 2008-01-15 | 2014-05-13 | West Pharmaceutical Services, Inc. | Syringe with co-molded hub and cannula |
JP2014518786A (ja) * | 2011-05-03 | 2014-08-07 | エス・ホー・エル・グループ・アクチボラゲット | 注射器容器を製造するための成形型組立体および方法 |
WO2015040718A1 (ja) | 2013-09-19 | 2015-03-26 | テルモ株式会社 | 針付きシリンジ及びその射出成型用金型 |
EP2992917A4 (en) * | 2013-05-02 | 2017-01-11 | Terumo Kabushiki Kaisha | Outer cylinder with needle and method for producing same |
JP2017169896A (ja) * | 2016-03-24 | 2017-09-28 | テルモ株式会社 | 医療用針及びその製造方法 |
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EP3354308B1 (en) * | 2003-08-28 | 2020-11-11 | Becton, Dickinson and Company | Intradermal injection device |
USD755371S1 (en) * | 2012-04-09 | 2016-05-03 | Becton, Dickinson And Company | Needle hub for medical syringe |
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JP6510492B2 (ja) * | 2014-03-31 | 2019-05-08 | テルモ株式会社 | 射出成型用金型 |
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US8721603B2 (en) | 2008-01-15 | 2014-05-13 | West Pharmaceutical Services, Inc. | Syringe with co-molded hub and cannula |
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US8496862B2 (en) | 2008-01-15 | 2013-07-30 | West Pharmaceutical Services, Inc. | Collet mechanism and method of molding cannula to a syringe barrel |
JP2014518786A (ja) * | 2011-05-03 | 2014-08-07 | エス・ホー・エル・グループ・アクチボラゲット | 注射器容器を製造するための成形型組立体および方法 |
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WO2013170393A1 (de) * | 2012-05-14 | 2013-11-21 | Schöttli AG | Verfahren zur herstellung eines spritzenzylinders für medizinische zwecke sowie eine vorrichtung zur durchführung des verfahrens |
CH706504A1 (de) * | 2012-05-14 | 2013-11-15 | Schoettli Ag | Verfahren zur Herstellung eines Spritzenzylinders für medizinische Zwecke sowie eine Vorrichtung zur Durchführung des Verfahrens. |
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EP2992917A4 (en) * | 2013-05-02 | 2017-01-11 | Terumo Kabushiki Kaisha | Outer cylinder with needle and method for producing same |
WO2015040718A1 (ja) | 2013-09-19 | 2015-03-26 | テルモ株式会社 | 針付きシリンジ及びその射出成型用金型 |
US10525209B2 (en) | 2013-09-19 | 2020-01-07 | Terumo Kabushiki Kaisha | Needle-equipped syringe and injection molding die for the same |
JP2017169896A (ja) * | 2016-03-24 | 2017-09-28 | テルモ株式会社 | 医療用針及びその製造方法 |
Also Published As
Publication number | Publication date |
---|---|
JP2016144745A (ja) | 2016-08-12 |
JPWO2012043544A1 (ja) | 2014-02-24 |
US10384379B2 (en) | 2019-08-20 |
JP5940978B2 (ja) | 2016-06-29 |
CN103096953A (zh) | 2013-05-08 |
EP2623144B1 (en) | 2017-02-22 |
JP6689302B2 (ja) | 2020-04-28 |
EP2623144A4 (en) | 2014-04-09 |
US20130138047A1 (en) | 2013-05-30 |
JP6280158B2 (ja) | 2018-02-14 |
US20180178423A1 (en) | 2018-06-28 |
EP2623144A1 (en) | 2013-08-07 |
US20160271848A1 (en) | 2016-09-22 |
CN103096953B (zh) | 2016-03-16 |
JP2018061856A (ja) | 2018-04-19 |
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