WO2012039402A1 - 血液処理フィルター、及び血液処理フィルターの製造方法 - Google Patents
血液処理フィルター、及び血液処理フィルターの製造方法 Download PDFInfo
- Publication number
- WO2012039402A1 WO2012039402A1 PCT/JP2011/071396 JP2011071396W WO2012039402A1 WO 2012039402 A1 WO2012039402 A1 WO 2012039402A1 JP 2011071396 W JP2011071396 W JP 2011071396W WO 2012039402 A1 WO2012039402 A1 WO 2012039402A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- outlet
- blood
- inlet
- flexible container
- filter element
- Prior art date
Links
- 210000004369 blood Anatomy 0.000 title claims abstract description 186
- 239000008280 blood Substances 0.000 title claims abstract description 186
- 238000011282 treatment Methods 0.000 title claims abstract description 38
- 238000004519 manufacturing process Methods 0.000 title claims description 21
- 238000000034 method Methods 0.000 title description 19
- 238000007789 sealing Methods 0.000 claims description 27
- 238000009434 installation Methods 0.000 claims description 3
- 238000001914 filtration Methods 0.000 description 41
- 210000000265 leukocyte Anatomy 0.000 description 24
- 239000007788 liquid Substances 0.000 description 22
- 238000003466 welding Methods 0.000 description 22
- 239000004745 nonwoven fabric Substances 0.000 description 18
- 230000037452 priming Effects 0.000 description 16
- 239000000463 material Substances 0.000 description 15
- 230000017531 blood circulation Effects 0.000 description 14
- 239000010836 blood and blood product Substances 0.000 description 12
- 229940125691 blood product Drugs 0.000 description 12
- 238000002360 preparation method Methods 0.000 description 12
- 238000003860 storage Methods 0.000 description 11
- 230000005484 gravity Effects 0.000 description 9
- 230000035699 permeability Effects 0.000 description 7
- 230000000052 comparative effect Effects 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- 210000003743 erythrocyte Anatomy 0.000 description 5
- 229920000728 polyester Polymers 0.000 description 5
- 238000011084 recovery Methods 0.000 description 5
- 239000012503 blood component Substances 0.000 description 4
- 238000010586 diagram Methods 0.000 description 4
- 238000000926 separation method Methods 0.000 description 4
- BZHJMEDXRYGGRV-UHFFFAOYSA-N Vinyl chloride Chemical compound ClC=C BZHJMEDXRYGGRV-UHFFFAOYSA-N 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 230000000740 bleeding effect Effects 0.000 description 3
- 238000005119 centrifugation Methods 0.000 description 3
- 239000000306 component Substances 0.000 description 3
- 238000007599 discharging Methods 0.000 description 3
- 230000002093 peripheral effect Effects 0.000 description 3
- 239000004800 polyvinyl chloride Substances 0.000 description 3
- 229920000915 polyvinyl chloride Polymers 0.000 description 3
- 238000011045 prefiltration Methods 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 229920002725 thermoplastic elastomer Polymers 0.000 description 3
- 230000009471 action Effects 0.000 description 2
- -1 polyethylene Polymers 0.000 description 2
- 229920000098 polyolefin Polymers 0.000 description 2
- 239000004814 polyurethane Substances 0.000 description 2
- 230000000630 rising effect Effects 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 238000011144 upstream manufacturing Methods 0.000 description 2
- 238000005493 welding type Methods 0.000 description 2
- QLZJUIZVJLSNDD-UHFFFAOYSA-N 2-(2-methylidenebutanoyloxy)ethyl 2-methylidenebutanoate Chemical compound CCC(=C)C(=O)OCCOC(=O)C(=C)CC QLZJUIZVJLSNDD-UHFFFAOYSA-N 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- FACXGONDLDSNOE-UHFFFAOYSA-N buta-1,3-diene;styrene Chemical compound C=CC=C.C=CC1=CC=CC=C1.C=CC1=CC=CC=C1 FACXGONDLDSNOE-UHFFFAOYSA-N 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 239000012611 container material Substances 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 239000005038 ethylene vinyl acetate Substances 0.000 description 1
- 229920006244 ethylene-ethyl acrylate Polymers 0.000 description 1
- 239000005042 ethylene-ethyl acrylate Substances 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 229920001477 hydrophilic polymer Polymers 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000011900 installation process Methods 0.000 description 1
- 229940127554 medical product Drugs 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920006124 polyolefin elastomer Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 229920003225 polyurethane elastomer Polymers 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 239000003761 preservation solution Substances 0.000 description 1
- 238000003908 quality control method Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 229920000468 styrene butadiene styrene block copolymer Polymers 0.000 description 1
- 238000013022 venting Methods 0.000 description 1
- 239000002759 woven fabric Substances 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/02—Blood transfusion apparatus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/02—Blood transfusion apparatus
- A61M1/0209—Multiple bag systems for separating or storing blood components
- A61M1/0218—Multiple bag systems for separating or storing blood components with filters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3627—Degassing devices; Buffer reservoirs; Drip chambers; Blood filters
- A61M1/3633—Blood component filters, e.g. leukocyte filters
- A61M1/3635—Constructional details
- A61M1/3636—Constructional details having a flexible housing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D29/00—Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor
- B01D29/0093—Making filtering elements not provided for elsewhere
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D29/00—Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor
- B01D29/01—Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor with flat filtering elements
- B01D29/05—Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor with flat filtering elements supported
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0413—Blood
- A61M2202/0429—Red blood cells; Erythrocytes
- A61M2202/0431—Gerocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0413—Blood
- A61M2202/0439—White blood cells; Leucocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/75—General characteristics of the apparatus with filters
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T29/00—Metal working
- Y10T29/49—Method of mechanical manufacture
- Y10T29/49826—Assembling or joining
Definitions
- the present invention relates to a blood treatment filter for removing undesirable components such as aggregates and leukocytes from blood.
- Precise and disposable blood treatment filters and blood treatments used for the purpose of removing microaggregates and leukocytes that cause side effects from whole blood preparations, red blood cell preparations, platelet preparations, plasma preparations, etc.
- the present invention relates to a method for manufacturing a filter.
- the most common method for removing leukocytes from a blood product is to treat the blood product with a leukocyte removal filter.
- the treatment of blood products by this leukocyte removal filter was often performed at the bedside when performing a blood transfusion operation, but in recent years for the purpose of quality control of leukocyte removal products and the improvement of the effectiveness of leukocyte removal processing, What is done at the blood center before storage (leukocyte removal before storage) is common, especially in developed countries.
- Blood collection sets that consist of blood collection needles, etc. have been used for some time, but a system that incorporates a leukocyte removal filter into these blood collection sets that can be suitably used for the above-mentioned “leukocyte removal before storage” Is widely used, and is called by a name such as “closed system” or “integrated system”. These are disclosed in JP-A-1-320064, International Publication No. 92/020428, etc.
- leukocyte removal filters have been widely used in which a filter element made of nonwoven fabric or porous material is filled in a hard container such as polycarbonate.
- a hard container such as polycarbonate.
- the gas permeability of the container is low, it is used as a sterilization process for blood collection and separation sets.
- the centrifugation operation for component separation is performed, and the whole blood is separated into multiple blood components by centrifugation.
- the leukocyte removal filter is centrifuged together with the blood collection / separation set.
- the hard container may damage the bag or the conduit, or the hard container itself may not withstand the stress during centrifugation and may be damaged.
- a flexible leukocyte removal filter using a flexible and vapor-permeable material that is the same as or similar to that used for a bag of a blood collection separation set.
- the filter element is once welded to a sheet-like flexible frame, and then the frame is welded to the housing material.
- European Patent No. 0526678, Japanese Patent Laid-Open No. 11-216179 Japanese Patent Laid-Open No. 11-216179
- a flexible container welded directly to a filter element Japanese Patent Laid-Open No. 7-267871, International Publication No. 95/017236
- the bag containing the blood product to be processed which is connected to the blood inlet side of the filter via a conduit, is positioned 20 to 100 cm higher than the filter.
- the blood product is passed through the filter by the action of gravity, and the filtered blood product is stored in a collection bag connected to the blood outlet side of the filter via a conduit.
- pressure loss occurs due to the resistance of the filter element, and the space on the filter inlet side becomes positive pressure.
- this positive pressure causes the container to expand in a balloon shape and the filter element tends to be pressed against the container on the outlet side.
- a bag for storing blood after being processed by the blood filter is placed at a position 50 to 100 cm lower than the filter, but the blood moves in the downstream channel by the action of gravity.
- the outlet side of the filter tends to be negative pressure, and the flexible container tends to adhere to the filter element.
- the filter element has a strong tendency to be in close contact with the outlet side container due to double force, and there is a problem that the flow of blood is hindered and a sufficient flow rate cannot be obtained. It has been pointed out before.
- At least one of the inlet and the outlet as disclosed in the specification of European Patent No. 0526678, Japanese Patent Application Laid-Open No. 11-216179, and International Publication No. 04/050147 is sealed across the second seal portion. With filters, the tools and processes for sealing had to be complicated.
- the problem of the present invention is that the flow is obstructed by the close contact between the outlet side container of the flexible filter and the filter element without incurring the risk of poor welding, complicating the manufacturing process, or increasing the cost. It is an object to provide a blood treatment filter that can effectively use the entire filter element and can achieve a high flow rate and a high filtration performance at the same time.
- the inventors have studied the shape of the flexible container of the blood processing filter, the shape of the filter element, and the characteristics of the assembly method, and the outlet side container generated by the negative pressure on the filter outlet side
- the present inventors have found a blood treatment filter that can alleviate the decrease in flow caused by the close contact with the filter element and the decrease in leukocyte removal performance, and has solved the problem.
- the present invention includes a sheet-like filter element, an inlet-side flexible container sandwiched between and sealed with the filter element, and an outlet-side flexible container, and is provided in the inlet-side flexible container.
- a blood processing filter that receives blood before processing from an inlet port and discharges blood processed by the filter element from an outlet port provided in the outlet side flexible container, the inlet side flexible container and the filter element
- the first seal portion formed so as to surround the inlet port and at least the inlet-side flexible container and the outlet-side flexible container are sealed, and closer to the outer edge than the first seal portion.
- an outlet opening communicating is formed, at least a portion of the outlet opening, a blood processing filter, characterized by being arranged so as to overlap the valley.
- the blood in the present invention includes blood products such as whole blood preparations for blood transfusion, erythrocyte preparations, platelet preparations and plasma preparations.
- the filter element and the outlet side are formed by the valley formed on the outlet side of the filter element.
- a gap is formed between the flexible container and a blood flow path is secured by the gap.
- the inlet port is formed with an inlet opening that communicates with the inside of the inlet-side flexible container, and the outlet opening is positioned above the inlet opening in a standing state for blood processing. It can also be a blood processing filter provided in
- the outlet opening may be a blood processing filter provided in the uppermost position in a state where the outlet opening stands in the state of standing for blood processing.
- the present invention also includes a sheet-like filter element, an inlet-side flexible container sandwiched between and sealed with the filter element, and an outlet-side flexible container, and is provided in the inlet-side flexible container.
- a blood processing filter manufacturing method for receiving blood before processing from an inlet port and discharging blood processed by the filter element from an outlet port provided in an outlet side flexible container, with the filter element being sandwiched The installation step of arranging the inlet-side flexible container and the outlet-side flexible container, and the inlet-side flexible so as to surround the site where the inlet port is formed without closely contacting the filter element and the outlet-side flexible container.
- the first sealing step includes a strip-shaped valley portion on the back side corresponding to the first sealing portion on the outlet side of the filter element, and the outlet port has an outlet side flexibility.
- the present invention relates to a method for manufacturing a blood treatment filter, wherein an outlet opening communicating with the inside of a container is formed, and at least a part of the outlet opening is formed so as to overlap a valley.
- the inlet port is formed with an inlet opening communicating with the inside of the inlet-side flexible container, and the outlet opening of the outlet port is erected for blood processing. It can also be set as the manufacturing method of the blood processing filter provided in the position which becomes higher than the inlet opening part of an inlet port in a state.
- the outlet opening of the outlet port is a region of the blood treatment filter provided at the uppermost position in the state of standing for blood treatment in the region overlapping the valley. It can also be set as a manufacturing method.
- the present invention it is possible to alleviate the decrease in flow and the decrease in leukocyte removal performance caused by the close contact between the outlet side container and the filter element caused by the negative pressure on the filter outlet side.
- FIG. 1 is a plan view showing a part of the blood processing filter according to the first embodiment of the present invention in a cutaway manner.
- FIG. 2 is a sectional view taken along line II-II in FIG.
- FIG. 3 is a sectional view taken along line III-III in FIG.
- FIG. 4 is a diagram schematically showing a portion corresponding to a valley portion of the filter element in relation to other portions.
- FIG. 5 is a front view showing an outline of a blood processing system including the blood processing filter according to the first embodiment.
- FIG. 6 is a cross-sectional view showing a state in use of the blood treatment filter according to the first embodiment.
- FIG. 7 is a diagram schematically showing a blood flow in the outlet-side flexible container.
- FIG. 8 is a cross-sectional view of a blood treatment filter according to the second embodiment of the present invention.
- FIG. 9 is a cross-sectional view showing a state in use of the blood treatment filter according to the second embodiment.
- the blood described in the following embodiments includes blood products such as whole blood products for blood transfusion, erythrocyte products, platelet products, and plasma products.
- the outer shape of the blood treatment filter can adopt various forms such as a rectangular shape, a disc shape, an oblong disc shape, and an elliptical shape, but a rectangular shape is preferable in order to reduce material loss during manufacturing.
- a rectangular shape will be described as an example.
- the blood treatment filter 1A is a sheet-like container in which a flexible container 3 having a blood inlet port 9a and an outlet port 11a is disposed, and the inside of the flexible container 3 is separated into an inlet port 9a side and an outlet port 11a side.
- the filter element 5 is provided.
- the flexible container 3 is a rectangular flat container.
- the flat shape is intended to be a shape with a small thickness and a wide surface.
- the flexible container 3 includes a rectangular sheet-shaped inlet-side container 9 and a rectangular sheet-shaped outlet-side container 11.
- the inlet-side container 9 is sealed with an inlet port 9a in which an inlet channel 9b that communicates the inside and the outside is formed.
- the outlet side container 11 is sealed with an outlet port 11a in which an outlet channel 11b that communicates the inside and the outside is formed. Note that sealing means fixing by adhesion (including welding) to the extent that leakage of liquid can be prevented.
- the inlet side container 9 is an example of an inlet side flexible container
- the outlet side container 11 is an example of an outlet side flexible container.
- the inlet side container 9 and the outlet side container 11 are overlapped via a rectangular filter element 5.
- the inlet side container 9 is sealed in a state of being in close contact with the filter element 5 along the periphery of the filter element 5.
- a band-shaped adhesive region along the periphery of the filter element 5 is an inner seal portion 13.
- the inner seal portion 13 surrounds the inlet port 9a in a rectangular ring shape, and the inner region inside the inner seal portion 13 is a filtration region where blood flows, and a part of the filter element 5 facing the filtration region is an effective filtration portion 5a. become.
- a protruding non-woven fabric portion 5 c that is an excess portion of the filter element 5 protrudes outside the inner seal portion 13 in the flexible container 3.
- the inner seal portion 13 corresponds to a first seal portion.
- a rectangular annular recess corresponding to the rectangular annular inner seal portion 13 is formed on the outlet side of the filter element 5, that is, on the back side of the filter element 5 (see FIG. 4). This dent is formed by the filter element 5 being in close contact with the inlet side container 9. This recess is a trough 6 provided on the outlet side of the filter element 5.
- the inlet side container 9 and the outlet side container 11 are sealed closer to the outer edge than the inner seal part 13 so that their peripheral edges overlap each other so as to surround the inner seal part 13 in an annular shape.
- a belt-like bonding region where the inlet side container 9 and the outlet side container 11 are directly bonded is an outer seal portion 15.
- the outer seal portion 15 corresponds to a second seal portion.
- the outlet side container 11 is not adhered to the filter element 5 and is in a state of being substantially separated from the valley 6 of the filter element 5 in a stationary state.
- a gap region (hereinafter referred to as “passage region”) is formed between the filter element 5 and the outlet side container 11 by the valley 6 of the filter element 5. S) is formed (see FIG. 6).
- FIG. 4 is a schematic view showing the filter element 5 in a stationary state, that is, a state in which blood is not flowing, and in particular, a diagram schematically showing a relationship between a part forming the valley 6 and other parts. is there.
- the valley portion 6 includes a bottom portion 6 a that overlaps the inner seal portion 13, an inner slope portion 6 b that rises from the bottom portion 6 a toward the inside of the inner seal portion 13, and an outer slope portion 6 c that rises toward the outside of the inner seal portion 13. And having.
- the inner slope portion 6 b smoothly communicates with the main region portion 8 on the outlet side of the filter element 5.
- the outer slope part 6c is an area
- the laminated filter elements have a certain thickness, and the surface of the filter elements is flat when the process such as welding is not performed. For example, when both sides of the filter element are sandwiched between PVC sheets by high frequency welding, the welded portion is crushed and welded, and the welded portion becomes thinner than the original thickness of the filter element.
- the filter element 5 according to the present embodiment in order to form the inner seal portion 13, for example, high-frequency welding is performed using a predetermined mold, and as a result, an annular welding portion is formed.
- the portions other than the welded portion are generally flat throughout, but only the vicinity of the welded portion is different, and focusing on the outlet side, the portion adjacent to the welded portion rises substantially vertically from the welded portion, and the filter element 5 To the flat portion (main region portion 8). That is, the region corresponding to the welded portion is the bottom portion 6a of the valley portion 6, the region rising substantially vertically from the bottom portion 6a toward the inside is the inner slope portion 6b, and from the bottom portion 6a toward the outside, The region rising vertically is the outer slope portion 6c.
- FIG. 4 is a diagram schematically showing a virtual cross section.
- the 1st line segment Sa which shows the exit side nonwoven fabric surface on a virtual section
- the 2nd line segment Sb which shows the field corresponding to the exit side nonwoven fabric surface among the inner surfaces of exit side container 11 on a virtual section
- the first line segment Sa is a line segment formed by connecting both ends of the exit-side nonwoven fabric surface and following the shape of the exit-side nonwoven fabric surface.
- the second line segment Sb first, the direction orthogonal to the longitudinal direction of the filter element 5 on the virtual cross section is assumed to be the corresponding direction, and the two ends along the corresponding direction from the both ends of the exit-side nonwoven fabric surface. Assuming a straight line extending.
- two points Pa and Pb at which the two straight lines intersect the inner surface of the outlet side container 11 are specified.
- These two points Pa and Pb are points Pa and Pb corresponding to both ends of the exit-side nonwoven fabric surface on the inner surface of the exit-side container 11.
- a line segment connecting these two points Pa and Pb following the inner surface shape of the outlet side container 11 is a second line segment Sb.
- the outlet side container 11 is not a material that can be extended to some extent although there is some expansion / contraction allowance, and the first line segment Sa is longer than the second line segment Sb, so that blood flows and sticks. Even in the state of being attached (attached by negative pressure), the outlet side container 11 does not contact the filter element 5 in the vicinity of the inner seal portion 13, particularly in the vicinity of the bottom portion 6 a of the valley portion 6, and as a result A passage region S is formed (see FIG. 6) and can be used as a blood flow path.
- the inlet port 9a sealed by the inlet side container 9 can be appropriately arranged in a region inside the inner seal portion 13.
- the inlet port 9a according to the present embodiment is arranged on one end side in the longitudinal direction of the flexible container 3, that is, on the upper side in a state where the blood processing filter 1A is erected for blood processing.
- the inlet port 9a is formed with an inlet channel 9b for receiving blood before processing when the inlet side circuit 102 (see FIG. 5) through which blood flows is formed.
- the inlet port 9a includes an inlet channel 9b and An inlet opening 9 c that communicates with the inside of the inlet side container 9 is formed.
- the outlet port 11 a sealed by the outlet side container 11 is arranged in an area inside the outer seal portion 15.
- the outlet port 11a is formed with an outlet channel 11b for discharging blood processed by the filter element 5 when the outlet side circuit 104 (see FIG. 5) through which blood flows is formed.
- the outlet port 11a is formed with an outlet opening 11c that communicates the inside of the outlet side container 11 with the outlet channel 11b.
- the outlet opening 11c of the outlet port 11a is arranged so that at least a part thereof overlaps the valley 6 of the filter element 5 in plan view.
- the outlet opening 11c is provided at a position above the inlet opening 9c of the inlet port 9a in a state where the blood processing filter 1A is stood for blood processing. Of the region overlapping the valley 6, it is provided at a position overlapping a part of the uppermost side.
- the outlet side container 11 is not included in the inner seal portion 13, and as a result, the passage region S is formed by the valley portion 6 of the filter element 5, and therefore, the vicinity of the inner seal portion 13 is formed. It can prevent that the filter element 5 is pinched
- the valley 6 corresponding to the inner seal portion 13 is connected in a rectangular ring shape, the valley 6 can be used as a blood passage between the filter element 5 and the outlet side container 11 (FIG. 7). reference).
- the filter medium at the peripheral portion of the filter element 5 in the vicinity of the inner seal portion 13 where blood tends to hardly flow.
- the inner seal portion 13 since the inner seal portion 13 is located at the peripheral edge of the effective filtration portion 5a of the filter element 5, the flow toward the outlet port 11a between the filter element 5 and the outlet side container 11 flows from the center of the filter medium. It becomes the direction which spreads to the circumference, and it is opposite to the flow where blood collects toward the center as in the case where the outlet port is arranged inside the inner seal portion, and the blood flow is hardly hindered.
- outlet opening portion 11c is provided at a position above the inlet opening portion 9c and further at the uppermost position in the region overlapping the valley portion 6.
- the vicinity of the uppermost part when performing filtration by gravity drop is a portion having the relatively lowest pressure between the filter element 5 and the outlet side container 11. That is, when the outlet port 11a (exit opening 11c) is arranged at the uppermost position in the region overlapping the valley 6, the vicinity of the lowermost portion when performing filtration by a gravity drop distal from the outlet opening 11c is The pressure can be relatively increased between the filter element 5 and the outlet side container 11. Therefore, good blood flow and effective utilization of the filter medium can be achieved even at the distal portion from the outlet port 11a where the filter medium is not effectively utilized in the prior art.
- the blood processing filter 1A is filled with blood from below at the time of priming at the start of blood processing, and air easily escapes from the outlet port 11a located above. Therefore, it is possible to perform more complete priming and air bleeding without paying special attention to the gravity head setting and the flow velocity during priming.
- the filter element 5 can be utilized more effectively as a filter medium, and a higher flow rate and filtration performance can be obtained.
- the blood does not flow out of the blood processing filter 1A until the priming is completed, and the whole blood processing filter 1A swells. Therefore, at first glance, it seems that priming of the blood processing filter 1A takes time.
- the blood collected on the outlet side after priming is discharged out of the blood processing filter 1A at a stretch by gravity, and the filter medium is more effectively utilized by more complete priming, so that the time required for the whole blood processing can be shortened. it can.
- the flexible container 3 is formed by the inlet side container 9 and the outlet side container 11. If the flexible resin used for the flexible container 3 is a material marketed as a sheet
- Suitable materials include thermoplastic elastomers such as products, and mixtures of thermoplastic elastomers and softeners such as polyolefin and ethylene-ethyl acrylate. Since contact with blood is considered, soft vinyl chloride, polyurethane, polyolefin, and thermoplastic elastomers based on these are preferably used as materials for medical products such as blood bags, and more preferably Soft vinyl chloride.
- the flexible container 3 for example, a container described in JP-A-7-267871 or a container described in International Publication No. 95/017236 can be used.
- the filter element 5 is manufactured using a filter material made of a fibrous body such as a nonwoven fabric or a woven fabric or a porous body such as a sponge.
- a filter material made of a fibrous body such as a nonwoven fabric or a woven fabric or a porous body such as a sponge.
- you may coat a hydrophilic polymer.
- a filter material coated with a polymer may be used in order to make leukocytes easily adhere to the filter element 5.
- an inlet side container 9 with an inlet port 9a sealed at a predetermined position, an outlet side container 11 with an outlet port 11a sealed at a predetermined position, and a filter element 5 are prepared, and the filter element 5 is sandwiched between them.
- positions the inlet side container 9 and the outlet side container 11 in a predetermined position is performed.
- the outlet port 11a is provided so that at least a part of the outlet opening 11c overlaps the valley 6 after the completion of the blood processing filter 1A.
- the inlet port 9a is formed with an inlet opening 9c communicating with the inside of the inlet-side container 9, and the outlet opening 11c is in a standing state for blood processing after the blood processing filter 1A is completed. It is provided at a position above the inlet opening 9c. Further, the outlet opening 11c is provided at the uppermost position in the state of standing for blood processing in the region overlapping the valley 6 after completion of the blood processing filter 1A.
- the inlet side container 9 and the filter element 5 are sealed in a band shape so as to surround the site where the inlet port 9a is formed, and the inner seal portion 13 is formed.
- a first sealing step to be formed and an annular outer seal portion (second seal portion) 15 are formed by sealing so as to surround the inner seal portion 13 closer to the outer edge than the inner seal portion (first seal portion) 13.
- a strip-shaped valley portion 6 corresponding to the inner seal portion 13 is formed on the outlet side of the filter element 5, and a passage region is formed between the outlet side container 11 and the filter element 5 by the valley portion 6. S is formed.
- the formation of the inner seal portion 13 in the first sealing step that is, the sealing of the inlet side container 9 and the filter element 5 can be performed using high-frequency welding, but is not limited to this. Any bonding technique such as welding or heat welding can be used.
- the formation of the outer seal portion 15 in the second sealing step that is, the sealing between the inlet side container 9 and the outlet side container 11 can be performed using high frequency welding, but is not limited thereto. Any bonding technique such as ultrasonic welding or heat welding can be used.
- the inlet port 9a and the outlet port 11a have been described as being sealed in advance in the flexible container 3. However, the sealing may be performed after the inner seal portion 13 and the outer seal portion 15 are formed. You may go well or in the middle of them. Further, in order to seal the inlet port 9a as the blood inlet and the outlet port 11a as the outlet to the flexible container 3, not only high-frequency welding but also any bonding technique such as heat welding can be used. As materials for the inlet port 9 a and the outlet port 11 a, various conventionally known materials can be used as in the flexible container 3.
- the outlet side container 11 is not included in the inner seal portion 13, that is, is not sealed by the filter element 5, and therefore the outlet in the step of sealing the outlet port 11 a to the outlet side container 11.
- the arrangement of the port 11a is advantageous because it has a relatively high degree of freedom. That is, sealing the inlet port 9a and the outlet port 11a in the flexible container 3 forms the inner seal portion 13 and the outer seal portion 15 in a simple step, and is a container-welded blood processing filter 1A.
- the inner seal portion 13 does not seal the outlet side container 11, so that it is possible to provide more freedom in the arrangement of the outlet port 11a. As a result, the outlet opening portion can be provided. It becomes easy to perform an optimal arrangement such that 11c overlaps the valley 6.
- FIG. 5 is a front view showing an outline of the blood processing system
- FIG. 6 is a cross-sectional view showing a state when the blood processing filter is used.
- the blood treatment filter 1A can be used for filtration using gravity.
- the blood processing system 100 to which the blood processing filter 1A is applied includes a storage bag 101 that contains blood after blood collection, a blood processing filter 1A, and a collection bag 103 that stores blood after filtration.
- the storage bag 101 and the inlet port 9a of the blood processing filter 1A are connected to each other by a conduit 102a such as a blood tube, and the recovery bag 103 and the outlet port 11a of the blood processing filter 1A are connected to each other by a conduit 104a such as a blood tube.
- a conduit 102a such as a blood tube
- the recovery bag 103 and the outlet port 11a of the blood processing filter 1A are connected to each other by a conduit 104a such as a blood tube.
- the upstream side conduit 102a is provided with an opening / closing means 102b such as a roller clamp for opening and closing the flow path, a chamber 102c, and the like, and the inlet side circuit 102 is formed by the conduit 102a, the opening / closing means 102b, the chamber 102c, and the like. Is done. Further, the outlet side circuit 104 is formed by the downstream side conduit 104a and the like.
- the storage bag 101 containing the collected blood is placed at a position about 50 cm higher than the blood treatment filter 1A, and the collection bag 103 for collecting the filtered blood is placed at a position about 100 cm lower than the blood treatment filter 1A.
- Blood is filtered by opening the flow path of the blood processing system 100. During the filtration process (during use), a negative pressure is generated on the outlet side of the flexible container 3 of the blood processing filter 1A, and the outlet side container 11 is bent to be in close contact with the filter element 5.
- a trough 6 that is recessed with respect to the main region portion 8 is formed on the outlet side of the filter element 5, and the outer slope 6 c (the protruding non-woven fabric portion 5 c) of the trough 6 is the outlet side container 11.
- the close contact with the filter element 5 may be partially restricted due to interference between the filter element 5 and the outlet side container 11, so that a gap region (passage region) S is formed by the valley portion 6. .
- the outlet opening portion 11c is disposed so as to overlap the valley portion 6, the blood channel is stably maintained without being blocked.
- the function and effect of the blood processing filter 1A according to this embodiment will be described.
- the outlet side container 11 is not included in the inner seal portion 13, and as a result, a valley portion 6 that is partially depressed is formed in the filter element 5.
- a passage region S is formed by the valley 6 in a state where blood is flowing, and the passage region S is used as a blood passage (see FIG. 7).
- the trough part 6 is located in the periphery of the effective filtration part 5a of the filter element 5, the flow of the blood from the filter element 5 to the trough part 6 which is a blood flow path concentrates on one point in an exit side. It ’s not something you do.
- the outlet opening portion 11c of the outlet port 11a is disposed so as to overlap the valley portion 6, the valley portion 6 that is a blood flow path and the outlet port. 11a is connected to enable effective drainage of blood, and at the same time, the concern that the outlet opening 11c is blocked by the filter element 5 can be eliminated.
- the outlet opening 11c is provided at a position above the inlet opening 9c in a state where the blood processing filter 1A is stood for blood processing.
- the outlet opening 11 c is provided at the uppermost position in the region overlapping the valley 6.
- the effects of the blood processing filter 1A and the manufacturing method of the blood processing filter 1A according to this embodiment can be summarized without incurring the risk of poor welding, complicating the manufacturing process, or increasing the cost.
- the passage region S formed by the trough 6 on the outlet side of the flexible container 3 can be used as a blood flow path, and as a result, it is possible to avoid that the blood flow is obstructed or the filtration performance is lowered, and is more complete. Priming and air bleeding can be realized, and the entire filter element 5 can be used effectively, and a high flow rate and a high filtration performance can be achieved simultaneously. Moreover, the blood processing filter 1A that exhibits such an effect can be manufactured.
- FIG. 8 is a cross-sectional view of a blood processing filter according to a second embodiment of the present invention
- FIG. 9 is a cross-sectional view showing a state when the blood processing filter according to the second embodiment is in use.
- the blood processing filter 1B according to the second embodiment includes substantially the same elements and structures as the blood processing filter 1A according to the first embodiment, and therefore the same elements and structures are denoted by the same reference numerals. Therefore, detailed description is omitted, and in the following description, different elements and structures will be mainly described.
- the blood treatment filter 1B is a sheet-like container in which a flexible container 3 having a blood inlet port 9a and an outlet port 11g and the inside of the flexible container 3 are separated into an inlet port 9a side and an outlet port 11g side.
- the filter element 5 and the welding sheet 31 disposed on the outlet side of the filter element 5 corresponding to the position where the inner seal portion 13 is formed are provided.
- the flexible container 3 includes a rectangular sheet-shaped inlet-side container 9 and a rectangular sheet-shaped outlet-side container 11.
- the inlet side container 9 and the outlet side container 11 are overlapped via a rectangular filter element 5.
- the inlet side container 9, the filter element 5, and the welding sheet 31 are in close contact with each other and sealed, and as a result, a band-shaped inner seal portion 13 is formed along the periphery of the filter element 5.
- a trough 6 is formed in the filter element 5 by the inner seal portion 13, and a passage region S is formed between the trough 6 and the outlet side container 11 in a state in which blood is flowing (a state in use). It is formed.
- the outlet port 11g is disposed below the blood treatment filter 1B for blood treatment, specifically, below the inlet port 9a when performing filtration by a gravity drop. At least a part of the outlet opening 11 h is disposed so as to overlap the valley 6.
- the blood treatment filter 1B even if a double force is applied by the positive pressure on the inlet side and the negative pressure on the outlet side during filtration, the blood treatment filter 1B between the outlet side container 11 and the filter element 5 is filtered. This prevents the flow from being hindered by the close contact or the like and reduces the filtration performance, which is advantageous in effectively using the entire filter element 5, and can achieve both a high filtration flow rate and a high filtration performance.
- Example 1 Using a filter comprising an inlet side container (inlet side flexible container), an outlet side container (outlet side flexible container), and a filter element, the inlet port is filtered before passing through a 50 cm long inlet side circuit. Connected to liquid storage bag. Further, the outlet port of the filter was connected to the liquid recovery bag after filtration through an outlet side circuit having a length of 100 cm. A tube made of soft vinyl chloride having an inner diameter of 2.9 mm and an outer diameter of 4.2 mm was used for the inlet side circuit and the outlet side circuit.
- the vertical dimension inside the inner seal part is 74 cm
- the horizontal dimension is 57 cm
- the effective filtration part is rectangular
- the corner part is curved
- the effective filtration area is 42 ⁇ 10. -4 (m 2 ).
- the filter element has an air permeability of 237.3 (cc / cm 2 / sec) and four polyester non-woven fabrics having a thickness of 0.2 mm and an air permeability of 8.4 (cc / cm) from the inlet to the outlet when blood is filtered.
- the inlet port and outlet port were sealed to the inlet side flexible container and the outlet side flexible container, respectively.
- the inlet side flexible container and the filter element were overlapped to form a first seal part, and then the outlet side flexible container was overlapped to form a second seal part.
- the inlet opening for blood to flow out from the inlet port to the inside of the inlet side flexible container is located 2.4 cm below the end of the uppermost effective filtration part side of the first seal part (valley part). Sealing and assembling was performed as described above. Sealing and assembly were performed so that the outlet opening for blood to flow out from the inside of the outlet side flexible container to the outlet port overlapped with the lowermost part of the first seal part (valley part).
- the liquid to be treated (substitute for blood) has a viscosity of 17 mPa ⁇ s (25 ° C.), pH 3.
- 300 g of the aqueous solution of polyvinylpyrrolidone (molecular weight 360,000) prepared in No. 8 was poured into a pre-filtration liquid storage bag and allowed to flow at room temperature using gravity. After filtration, the liquid recovery bag was previously placed on a pan balance so that the change in weight could be confirmed.
- the time required to reach the inlet of the liquid recovery bag after the first filtration after starting to flow the liquid to be treated was measured, and this was defined as the priming time (minutes).
- the time required from the start of flowing the liquid to be treated until all the liquid to be treated in the pre-filtration liquid storage bag is discharged and the weight increase of the weight conversion of the liquid recovery bag after filtration stops was measured and taken as the total processing time (minutes).
- the weight of the liquid collected in the liquid storage bag after filtration was measured, and the amount was collected (g).
- An average processing speed (g / min) was calculated from the amount recovered and the total processing time. The difference between 300 g injected into the pre-filtration liquid storage bag and the recovered amount was obtained by calculation and used as the loss amount (g).
- Example 2 A filter was assembled and filtered in the same manner as in Example 1 except that the outlet opening of the outlet port was sealed and assembled so as to overlap the uppermost part of the first seal part (valley part).
- Example 1 The same method as in Example 1, except that the outlet opening of the outlet port was sealed and assembled so as to be disposed at a location 2.4 cm above the end of the first seal portion on the lowermost effective filtration portion side. The filter was assembled and filtered.
- Comparative Example 2 In the same manner as in Comparative Example 1, except that the inlet side flexible container, the filter element, and the outlet side flexible container are overlapped to form the first seal portion and subsequently the second seal portion is formed. The filter was assembled and filtered. The results of Examples 1 and 2 and Comparative Examples 1 and 2 are shown together in Table 1.
- Example 1 the total processing time is shortened and the average processing speed is improved as compared with Comparative Example 1. This is because the outlet port of Example 1 is arranged lower than that of Comparative Example 1, but its position is on the first seal part (valley part), so it passes through the effective filtration part. Rather than concentrating toward one point of the outlet port, the blood once flowed in the direction of diffusion toward the first seal portion outside the effective filtration portion, and flows as a flow path through the valley corresponding to the first seal portion, This is because it can flow toward the outlet opening of the outlet port connected to this flow path.
- Priming time is confirmed to be longer in Example 2.
- this is not a substantial extension of the priming time, but is related to the fact that the outlet port is located in the upper part of the filter for more complete priming and bleeding. That is, the outlet side of the filter is filled with the liquid without discharging the liquid outside the filter during the priming. Once the liquid begins to flow out of the filter and the outlet side circuit is filled with the liquid, the liquid quickly accumulated on the filter outlet side due to the negative pressure is discharged out of the filter. Thus, the apparent extension of the priming time does not extend the total processing time.
- the total processing time is the shortest time in Example 2. This is because the filter element of the effective filtration part is not clogged with residual air by complete air venting and priming, and it is completely filled with liquid, and more than the inlet port (inlet opening). Since the outlet port (outlet opening) is arranged above, the pressure difference between the inlet side and outlet side of the filter is minimized, and sticking between the outlet side flexible container and the filter element is reduced. This is because the filter element is effectively utilized.
Landscapes
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- External Artificial Organs (AREA)
Abstract
Description
入口側容器(入口側可撓性容器)と出口側容器(出口側可撓性容器)とフィルター要素からなるフィルターを用いて、その入口ポートを、長さ50cmの入口側回路を介して濾過前液体貯留バッグと接続した。また該フィルターの出口ポートを、長さ100cmの出口側回路を介して濾過後液体回収バッグに接続した。入口側回路、出口側回路には、内径2.9mm、外径4.2mmの軟質塩化ビニル製のチューブを使用した。
出口ポートの出口開口部を、第一シール部(谷部)の最上部に重なるようにシールおよび組み立てを行ったこと以外は、実施例1と同じ方法でフィルターを組み立て、濾過を行った。
出口ポートの出口開口部を、第一シール部の最下部の有効濾過部分側の端から2.4cm上方の場所に配するようにシールおよび組み立てを行ったこと以外は、実施例1と同じ方法でフィルターを組み立て、濾過を行った。
入口側可撓性容器、フィルター要素、及び出口側可撓性容器とを重ねて第一シール部を形成し、その後に引き続き第二シール部を形成したこと以外は、比較例1と同じ方法でフィルターを組み立て、濾過を行った。
実施例1、及び2、比較例1、及び2の結果をまとめて表1に示す。
Claims (6)
- シート状のフィルター要素と、前記フィルター要素を挟み、且つシールされた入口側可撓性容器、及び出口側可撓性容器とを備え、前記入口側可撓性容器に設けられた入口ポートから処理前の血液を受け入れ、前記フィルター要素で処理された血液を、前記出口側可撓性容器に設けられた出口ポートから排出する血液処理フィルターであって、
前記入口側可撓性容器と前記フィルター要素とを帯状にシールし、前記入口ポートを囲むように形成された第一シール部と、
少なくとも前記入口側可撓性容器と前記出口側可撓性容器とをシールし、前記第一シール部よりも外縁寄りで、前記第一シール部を囲むように形成された環状の第二シール部と備え、
前記フィルター要素の出口側には、前記第一シール部に対応する谷部が設けられ、
前記出口ポートには、前記出口側可撓性容器の内部に連通する出口開口部が形成され、
前記出口開口部の少なくとも一部分は、前記谷部に重なるように配置されていることを特徴とする血液処理フィルター。 - 前記入口ポートには、前記入口側可撓性容器の内部に連通する入口開口部が形成され、
前記出口開口部は、血液処理のために立てた状態で前記入口開口部よりも上方となる位置に設けられていることを特徴とする請求項1記載の血液処理フィルター。 - 前記出口開口部は、前記谷部に重なる領域のうち、血液処理のために立てた状態で、最も上方となる位置に設けられていることを特徴とする請求項1または2記載の血液処理フィルター。
- シート状のフィルター要素と、前記フィルター要素を挟み、且つシールされた入口側可撓性容器、及び出口側可撓性容器とを備え、前記入口側可撓性容器に設けられた入口ポートから処理前の血液を受け入れ、前記フィルター要素で処理された血液を、前記出口側可撓性容器に設けられた出口ポートから排出する血液処理フィルターの製造方法であって、
前記フィルター要素を挟むように前記入口側可撓性容器と前記出口側可撓性容器とを配置する設置工程と、
前記フィルター要素と前記出口側可撓性容器とを密着することなく、前記入口ポートの形成部位を囲むように前記入口側可撓性容器と前記フィルター要素とを帯状にシールして第一シール部を形成する第一シール工程と、
前記第一シール部よりも外縁寄りで、前記第一シール部を囲むようにシールして環状の第二シール部を形成する第ニシール工程と、を含み、
前記第一シール工程によって、前記フィルター要素の出口側には、前記第一シール部に対応する帯状の谷部が生じ、
前記出口ポートには、前記出口側可撓性容器の内部に連通する出口開口部が形成されており、
前記出口開口部の少なくとも一部分は、前記谷部に重なるように形成されることを特徴とする血液処理フィルターの製造方法。 - 前記入口ポートには、前記入口側可撓性容器の内部に連通する入口開口部が形成され、
前記出口ポートの前記出口開口部は、血液処理のために立てた状態で前記入口ポートの前記入口開口部よりも上方となる位置に設けられることを特徴とする請求項4記載の血液処理フィルターの製造方法。 - 前記出口ポートの前記出口開口部は、前記谷部に重なる領域のうち、血液処理のために立てた状態で、最も上方となる位置に設けられることを特徴とする請求項4または5記載の血液処理フィルターの製造方法。
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020137002916A KR101479880B1 (ko) | 2010-09-21 | 2011-09-20 | 혈액 처리 필터, 및 혈액 처리 필터의 제조 방법 |
EP11826847.3A EP2620170B1 (en) | 2010-09-21 | 2011-09-20 | Blood treatment filter and method for manufacturing blood treatment filter |
JP2012535041A JP5487315B2 (ja) | 2010-09-21 | 2011-09-20 | 血液処理フィルター、及び血液処理フィルターの製造方法 |
CN201180045536.XA CN103118717B (zh) | 2010-09-21 | 2011-09-20 | 血液处理过滤器及血液处理过滤器的制造方法 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US38490410P | 2010-09-21 | 2010-09-21 | |
US61/384904 | 2010-09-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2012039402A1 true WO2012039402A1 (ja) | 2012-03-29 |
Family
ID=45816780
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2011/071396 WO2012039402A1 (ja) | 2010-09-21 | 2011-09-20 | 血液処理フィルター、及び血液処理フィルターの製造方法 |
Country Status (6)
Country | Link |
---|---|
US (1) | US8851296B2 (ja) |
EP (1) | EP2620170B1 (ja) |
JP (1) | JP5487315B2 (ja) |
KR (1) | KR101479880B1 (ja) |
CN (1) | CN103118717B (ja) |
WO (1) | WO2012039402A1 (ja) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2015050213A1 (ja) * | 2013-10-03 | 2015-04-09 | 旭化成メディカル株式会社 | 血液処理フィルター及び血液処理フィルターの製造方法 |
WO2015050215A1 (ja) * | 2013-10-03 | 2015-04-09 | 旭化成メディカル株式会社 | 血液処理フィルター及び血液処理フィルターの製造方法 |
WO2015137307A1 (ja) * | 2014-03-10 | 2015-09-17 | 旭化成メディカル株式会社 | 血液処理フィルター |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012090563A1 (ja) * | 2010-12-27 | 2012-07-05 | 旭化成メディカル株式会社 | 血液処理フィルター、及び血液処理フィルターのプライミング方法 |
US10159778B2 (en) | 2014-03-24 | 2018-12-25 | Fenwal, Inc. | Biological fluid filters having flexible walls and methods for making such filters |
USD734467S1 (en) | 2014-03-24 | 2015-07-14 | Fenwal, Inc. | Blood filter |
US9782707B2 (en) | 2014-03-24 | 2017-10-10 | Fenwal, Inc. | Biological fluid filters having flexible walls and methods for making such filters |
US9968738B2 (en) * | 2014-03-24 | 2018-05-15 | Fenwal, Inc. | Biological fluid filters with molded frame and methods for making such filters |
US9796166B2 (en) | 2014-03-24 | 2017-10-24 | Fenwal, Inc. | Flexible biological fluid filters |
US10376627B2 (en) | 2014-03-24 | 2019-08-13 | Fenwal, Inc. | Flexible biological fluid filters |
CN208684945U (zh) * | 2016-12-01 | 2019-04-02 | 生命科技股份有限公司 | 过滤袋总成和过滤*** |
Citations (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH01320064A (ja) | 1988-06-23 | 1989-12-26 | Asahi Medical Co Ltd | 血液成分分離方法 |
WO1990015660A1 (en) * | 1989-06-13 | 1990-12-27 | Atsunobu Sakamoto | Bag-like filter |
WO1992020428A1 (en) | 1991-05-22 | 1992-11-26 | Baxter International Inc. | Systems and methods for removing undesired matter from blood cells |
EP0526678A1 (fr) | 1991-06-24 | 1993-02-10 | Maco Pharma | Poche filtrante destinée à permettre la filtration stérile du sang et ensemble de poches de prélèvement du sang |
WO1995017236A1 (en) | 1993-12-22 | 1995-06-29 | Baxter International Inc. | Filtration media and device for filtering leukocytes |
JPH07267871A (ja) | 1994-03-28 | 1995-10-17 | Kawasumi Lab Inc | 白血球除去用ロ過器 |
JPH11216179A (ja) | 1997-11-28 | 1999-08-10 | Terumo Corp | 白血球除去器、血液処理回路および血液処理方法 |
WO2002004045A1 (fr) * | 2000-07-10 | 2002-01-17 | Asahi Medical Co., Ltd. | Filtre de traitement du sang |
WO2004050147A1 (de) | 2002-12-02 | 2004-06-17 | Fresenius Hemocare Deutschland Gmbh | Filter |
JP2008086352A (ja) * | 2006-09-29 | 2008-04-17 | Asahi Kasei Medical Co Ltd | 血液処理フィルター |
JP2011072814A (ja) * | 2010-04-09 | 2011-04-14 | Asahi Kasei Medical Co Ltd | 血液処理フィルター |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU6348801A (en) | 2000-05-26 | 2001-12-11 | Baxter Int | Improvements in blood filters, blood collection and processing systems, and methods therefor |
US20030209479A1 (en) * | 2000-07-10 | 2003-11-13 | Lynn Daniel R | Blood filters, blood collection and processing systems, and methods therefore |
JP4754377B2 (ja) * | 2006-03-22 | 2011-08-24 | 旭化成メディカル株式会社 | 血液処理用フィルター装置の製造方法及び血液処理用フィルター装置 |
US20110226691A1 (en) * | 2007-12-21 | 2011-09-22 | Lucas Jeffrey A | Filter device |
JP5524340B2 (ja) * | 2010-09-21 | 2014-06-18 | 旭化成メディカル株式会社 | 血液処理フィルター、及び血液処理フィルターの製造方法 |
WO2012090563A1 (ja) * | 2010-12-27 | 2012-07-05 | 旭化成メディカル株式会社 | 血液処理フィルター、及び血液処理フィルターのプライミング方法 |
KR101501047B1 (ko) * | 2010-12-27 | 2015-03-11 | 아사히 가세이 메디컬 가부시키가이샤 | 혈액 처리 필터 |
-
2011
- 2011-09-20 US US13/237,061 patent/US8851296B2/en active Active
- 2011-09-20 JP JP2012535041A patent/JP5487315B2/ja active Active
- 2011-09-20 EP EP11826847.3A patent/EP2620170B1/en active Active
- 2011-09-20 KR KR1020137002916A patent/KR101479880B1/ko active IP Right Grant
- 2011-09-20 CN CN201180045536.XA patent/CN103118717B/zh active Active
- 2011-09-20 WO PCT/JP2011/071396 patent/WO2012039402A1/ja active Application Filing
Patent Citations (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH01320064A (ja) | 1988-06-23 | 1989-12-26 | Asahi Medical Co Ltd | 血液成分分離方法 |
WO1990015660A1 (en) * | 1989-06-13 | 1990-12-27 | Atsunobu Sakamoto | Bag-like filter |
WO1992020428A1 (en) | 1991-05-22 | 1992-11-26 | Baxter International Inc. | Systems and methods for removing undesired matter from blood cells |
EP0526678A1 (fr) | 1991-06-24 | 1993-02-10 | Maco Pharma | Poche filtrante destinée à permettre la filtration stérile du sang et ensemble de poches de prélèvement du sang |
WO1995017236A1 (en) | 1993-12-22 | 1995-06-29 | Baxter International Inc. | Filtration media and device for filtering leukocytes |
JPH07267871A (ja) | 1994-03-28 | 1995-10-17 | Kawasumi Lab Inc | 白血球除去用ロ過器 |
JPH11216179A (ja) | 1997-11-28 | 1999-08-10 | Terumo Corp | 白血球除去器、血液処理回路および血液処理方法 |
WO2002004045A1 (fr) * | 2000-07-10 | 2002-01-17 | Asahi Medical Co., Ltd. | Filtre de traitement du sang |
WO2004050147A1 (de) | 2002-12-02 | 2004-06-17 | Fresenius Hemocare Deutschland Gmbh | Filter |
JP2006507881A (ja) * | 2002-12-02 | 2006-03-09 | フレセニウス・ヘモカレ・ドイチュラント・ゲーエムベーハー | フィルタ |
JP2008086352A (ja) * | 2006-09-29 | 2008-04-17 | Asahi Kasei Medical Co Ltd | 血液処理フィルター |
JP2011072814A (ja) * | 2010-04-09 | 2011-04-14 | Asahi Kasei Medical Co Ltd | 血液処理フィルター |
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2015050213A1 (ja) * | 2013-10-03 | 2015-04-09 | 旭化成メディカル株式会社 | 血液処理フィルター及び血液処理フィルターの製造方法 |
WO2015050215A1 (ja) * | 2013-10-03 | 2015-04-09 | 旭化成メディカル株式会社 | 血液処理フィルター及び血液処理フィルターの製造方法 |
JPWO2015050213A1 (ja) * | 2013-10-03 | 2017-03-09 | 旭化成メディカル株式会社 | 血液処理フィルター及び血液処理フィルターの製造方法 |
JPWO2015050215A1 (ja) * | 2013-10-03 | 2017-03-09 | 旭化成メディカル株式会社 | 血液処理フィルター及び血液処理フィルターの製造方法 |
US10064989B2 (en) | 2013-10-03 | 2018-09-04 | Asahi Kasei Medical Co., Ltd. | Blood processing filter and blood processing filter manufacturing method |
US10213534B2 (en) | 2013-10-03 | 2019-02-26 | Asahi Kasei Medical Co., Ltd. | Blood processing filter and blood processing filter manufacturing method |
WO2015137307A1 (ja) * | 2014-03-10 | 2015-09-17 | 旭化成メディカル株式会社 | 血液処理フィルター |
JPWO2015137307A1 (ja) * | 2014-03-10 | 2017-04-06 | 旭化成メディカル株式会社 | 血液処理フィルター |
JP2018089394A (ja) * | 2014-03-10 | 2018-06-14 | 旭化成メディカル株式会社 | 血液処理フィルター |
US10842927B2 (en) | 2014-03-10 | 2020-11-24 | Asahi Kasei Medical Co., Ltd. | Blood treatment filter |
US11504460B2 (en) | 2014-03-10 | 2022-11-22 | Asahi Kasei Medical Co., Ltd. | Blood treatment filter |
Also Published As
Publication number | Publication date |
---|---|
KR20130056281A (ko) | 2013-05-29 |
EP2620170A4 (en) | 2015-03-18 |
JPWO2012039402A1 (ja) | 2014-02-03 |
KR101479880B1 (ko) | 2015-01-06 |
CN103118717B (zh) | 2015-08-19 |
EP2620170A1 (en) | 2013-07-31 |
US20120067811A1 (en) | 2012-03-22 |
CN103118717A (zh) | 2013-05-22 |
JP5487315B2 (ja) | 2014-05-07 |
EP2620170B1 (en) | 2017-03-22 |
US8851296B2 (en) | 2014-10-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP5487315B2 (ja) | 血液処理フィルター、及び血液処理フィルターの製造方法 | |
JP5922687B2 (ja) | 血液処理フィルター、及び血液処理フィルターの製造方法 | |
US8857627B2 (en) | Blood processing filter | |
JP5680675B2 (ja) | 血液処理フィルター、及び血液処理フィルターのプライミング方法 | |
JP6190888B2 (ja) | 血液処理フィルター及び血液処理方法 | |
US20230077172A1 (en) | Blood treatment filter | |
JP2008086352A (ja) | 血液処理フィルター | |
JP2022018673A (ja) | 血液処理フィルター | |
JP2011235187A (ja) | 血液処理フィルター |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
WWE | Wipo information: entry into national phase |
Ref document number: 201180045536.X Country of ref document: CN |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 11826847 Country of ref document: EP Kind code of ref document: A1 |
|
ENP | Entry into the national phase |
Ref document number: 20137002916 Country of ref document: KR Kind code of ref document: A |
|
ENP | Entry into the national phase |
Ref document number: 2012535041 Country of ref document: JP Kind code of ref document: A |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
REEP | Request for entry into the european phase |
Ref document number: 2011826847 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2011826847 Country of ref document: EP |