WO2011149126A1 - 타이로신 카이네이즈 저해능을 가지는 항염증 화합물을 포함하는 약학적 조성물 - Google Patents

타이로신 카이네이즈 저해능을 가지는 항염증 화합물을 포함하는 약학적 조성물 Download PDF

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Publication number
WO2011149126A1
WO2011149126A1 PCT/KR2010/003332 KR2010003332W WO2011149126A1 WO 2011149126 A1 WO2011149126 A1 WO 2011149126A1 KR 2010003332 W KR2010003332 W KR 2010003332W WO 2011149126 A1 WO2011149126 A1 WO 2011149126A1
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WO
WIPO (PCT)
Prior art keywords
pharmaceutical composition
tyrosine kinase
kinase inhibiting
inhibiting function
inflammatory compound
Prior art date
Application number
PCT/KR2010/003332
Other languages
English (en)
French (fr)
Inventor
양범석
김용주
박태교
우성호
이향숙
김선영
조종운
이홍범
Original Assignee
한국과학기술연구원
(주)레고켐바이오사이언스
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 한국과학기술연구원, (주)레고켐바이오사이언스 filed Critical 한국과학기술연구원
Priority to PCT/KR2010/003332 priority Critical patent/WO2011149126A1/ko
Priority to JP2013512543A priority patent/JP5613323B2/ja
Priority to PCT/KR2011/003873 priority patent/WO2011149288A2/ko
Priority to KR1020127030670A priority patent/KR101478302B1/ko
Priority to EP11786920.6A priority patent/EP2578590B1/en
Priority to CN201180026042.7A priority patent/CN102971327B/zh
Priority to HUE11786920A priority patent/HUE035589T2/en
Priority to ES11786920.6T priority patent/ES2647586T3/es
Priority to US13/699,970 priority patent/US9062066B2/en
Priority to DK11786920.6T priority patent/DK2578590T3/da
Publication of WO2011149126A1 publication Critical patent/WO2011149126A1/ko

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

Abstract

본 발명은 타이로신 카이네이즈 저해능을 가지는 항염증 화합물을 유효성분으로 함유하는 약학적 조성물에 관한 것으로, 본 발명에 따른 화합물은 여러 타이로신 카이네이즈들의 활성을 억제할 수 있어, 이와 관련된 염증성 질환이나 자가면역질환 등을 예방 또는 치료하는데 유용하게 사용될 수 있다.
PCT/KR2010/003332 2010-05-26 2010-05-26 타이로신 카이네이즈 저해능을 가지는 항염증 화합물을 포함하는 약학적 조성물 WO2011149126A1 (ko)

Priority Applications (10)

Application Number Priority Date Filing Date Title
PCT/KR2010/003332 WO2011149126A1 (ko) 2010-05-26 2010-05-26 타이로신 카이네이즈 저해능을 가지는 항염증 화합물을 포함하는 약학적 조성물
JP2013512543A JP5613323B2 (ja) 2010-05-26 2011-05-26 複数のチロシンキナーゼに対する阻害活性を有する抗炎症化合物およびこれを含む薬学的組成物
PCT/KR2011/003873 WO2011149288A2 (ko) 2010-05-26 2011-05-26 복수의 타이로신 카이네이즈에 대한 저해 활성을 가지는 항염증 화합물 및 이를 포함하는 약학적 조성물
KR1020127030670A KR101478302B1 (ko) 2010-05-26 2011-05-26 복수의 타이로신 카이네이즈에 대한 저해 활성을 가지는 항염증 화합물 및 이를 포함하는 약학적 조성물
EP11786920.6A EP2578590B1 (en) 2010-05-26 2011-05-26 Anti-inflammatory compound having inhibitory activity against multiple tyrosine kinases, and pharmaceutical composition containing same
CN201180026042.7A CN102971327B (zh) 2010-05-26 2011-05-26 具有多种酪氨酸激酶抑制活性的抗炎化合物以及含有这些化合物的药物组成物
HUE11786920A HUE035589T2 (en) 2010-05-26 2011-05-26 An anti-inflammatory compound having an anti-tyrosine kinase inhibitory activity and a pharmaceutical composition containing it
ES11786920.6T ES2647586T3 (es) 2010-05-26 2011-05-26 Compuesto antiinflamatorio que tiene actividad inhibidora contra múltiples tirosina cinasas, y composición farmacéutica que contiene el mismo
US13/699,970 US9062066B2 (en) 2010-05-26 2011-05-26 Anti-inflammatory compound having inhibitory activity against multiple tyrosine kinases and pharmaceutical composition containing same
DK11786920.6T DK2578590T3 (da) 2010-05-26 2011-05-26 Anti-inflammatorisk forbindelse med inhibitorisk aktivitet mod flere tyrosinkinaser og farmaceutisk sammensætning indeholdende samme

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/KR2010/003332 WO2011149126A1 (ko) 2010-05-26 2010-05-26 타이로신 카이네이즈 저해능을 가지는 항염증 화합물을 포함하는 약학적 조성물

Publications (1)

Publication Number Publication Date
WO2011149126A1 true WO2011149126A1 (ko) 2011-12-01

Family

ID=45004106

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2010/003332 WO2011149126A1 (ko) 2010-05-26 2010-05-26 타이로신 카이네이즈 저해능을 가지는 항염증 화합물을 포함하는 약학적 조성물

Country Status (1)

Country Link
WO (1) WO2011149126A1 (ko)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6492383B1 (en) * 1997-11-11 2002-12-10 Pfizer Inc. Thienopyrimidine and thienopyridine derivatives useful as anticancer agents
WO2007056214A2 (en) * 2005-11-02 2007-05-18 Cytovia, Inc N-alkyl-n-aryl-thienopyrimidin-r-amines and uses thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6492383B1 (en) * 1997-11-11 2002-12-10 Pfizer Inc. Thienopyrimidine and thienopyridine derivatives useful as anticancer agents
WO2007056214A2 (en) * 2005-11-02 2007-05-18 Cytovia, Inc N-alkyl-n-aryl-thienopyrimidin-r-amines and uses thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BOSCHELLI, D.H. ET AL.: "Inhibition of Src kinase activity by 7-[(2,4-dichloro-5-methoxyphenyl)-amino]-2-heteroaryl-thieno[3,2-b] pyridine-6-carbonitriles", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 15, 2005, pages 4681 - 4684 *

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