WO2011118954A3 - 사람 하비갑개 유래 중간엽 기질세포로부터 연골, 골, 신경세포 또는 지방세포를 분화시키는 방법 - Google Patents

사람 하비갑개 유래 중간엽 기질세포로부터 연골, 골, 신경세포 또는 지방세포를 분화시키는 방법 Download PDF

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WO2011118954A3
WO2011118954A3 PCT/KR2011/001947 KR2011001947W WO2011118954A3 WO 2011118954 A3 WO2011118954 A3 WO 2011118954A3 KR 2011001947 W KR2011001947 W KR 2011001947W WO 2011118954 A3 WO2011118954 A3 WO 2011118954A3
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cells
inferior turbinate
bone
nerve
mesenchymal stromal
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PCT/KR2011/001947
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French (fr)
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WO2011118954A2 (ko
WO2011118954A9 (ko
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김성원
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가톨릭대학교 산학협력단
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Priority to EP11759703.9A priority Critical patent/EP2551342B1/en
Priority to US13/636,660 priority patent/US20130122587A1/en
Publication of WO2011118954A2 publication Critical patent/WO2011118954A2/ko
Publication of WO2011118954A9 publication Critical patent/WO2011118954A9/ko
Publication of WO2011118954A3 publication Critical patent/WO2011118954A3/ko

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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0668—Mesenchymal stem cells from other natural sources
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells

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Abstract

본 발명은 사람 하비갑개 유래 중간엽 기질세포로부터 골, 연골 또는 신경세포로 분화를 유도하는 방법에 관한 것으로서, 보다 구체적으로 본 발명은 사람 하비갑개 조직에서 분리한 중간엽 기질세포를 성장인자가 포함된 배지에서 배양하는 단계를 포함하는 사람 하비갑개 유래 중간엽 기질세포로부터 골, 연골, 신경세포 또는 지방세포로 분화를 유도하는 방법 및 상기 방법으로 분화된 세포를 유효성분으로 포함하는 연골손상 질환, 뼈 손상 또는 골대사성 질환, 또는 신경손상 질환의 예방 또는 치료용 조성물에 관한 것이다. 본 발명에 따라 사람 하비갑개 유래의 중간엽 기질세포로부터 분화된 골, 연골, 신경세포 또는 지방세포는 상기 세포들의 손상으로 야기되는 질환을 치료하기 위한 세포 대체 요법 및 재생의학 분야에 사용될 수 있는 효과가 있고, 본 발명에서 사용하는 사람 하비갑개 조직은 하비갑개 수술 과정에서 폐기 처리되는 조직을 사용한 것으로서 용이하게 세포 공급원을 수득할 수 있는 장점이 있다.
PCT/KR2011/001947 2010-03-22 2011-03-22 사람 하비갑개 유래 중간엽 기질세포로부터 연골, 골, 신경세포 또는 지방세포를 분화시키는 방법 WO2011118954A2 (ko)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP11759703.9A EP2551342B1 (en) 2010-03-22 2011-03-22 Method for differentiating cartilage cells, bone cells, nerve cells or fat cells from human inferior turbinate mesenchymal stromal cells
US13/636,660 US20130122587A1 (en) 2010-03-22 2011-03-22 Method for differentiating cartilage cells, bone cells, nerve cells or fat cells from human inferior turbinate mesenchymal stromal cells

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR10-2010-0025207 2010-03-22
KR20100025207 2010-03-22
KR10-2011-0019208 2011-03-04
KR1020110019208A KR101327076B1 (ko) 2010-03-22 2011-03-04 사람 하비갑개 유래 중간엽 기질세포로부터 연골, 골, 신경세포 또는 지방세포를 분화시키는 방법

Publications (3)

Publication Number Publication Date
WO2011118954A2 WO2011118954A2 (ko) 2011-09-29
WO2011118954A9 WO2011118954A9 (ko) 2011-11-17
WO2011118954A3 true WO2011118954A3 (ko) 2012-03-15

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PCT/KR2011/001947 WO2011118954A2 (ko) 2010-03-22 2011-03-22 사람 하비갑개 유래 중간엽 기질세포로부터 연골, 골, 신경세포 또는 지방세포를 분화시키는 방법

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US (1) US20130122587A1 (ko)
EP (1) EP2551342B1 (ko)
KR (1) KR101327076B1 (ko)
WO (1) WO2011118954A2 (ko)

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KR102175468B1 (ko) * 2014-01-20 2020-11-06 (주)아모레퍼시픽 히드록시 피라논 유도체 화합물을 포함하는 지방세포 분화 촉진용 화장료 조성물
WO2018203651A2 (ko) * 2017-05-02 2018-11-08 가톨릭대학교 산학협력단 사람 코 하비갑개 유래 중간엽 줄기세포 기반 3d 바이오프린팅 조직체 및 이의 이용
KR102104120B1 (ko) * 2017-05-02 2020-04-23 가톨릭대학교 산학협력단 사람 코 하비갑개 유래 중간엽 줄기세포 기반 3d 바이오프린팅 조직체 및 이의 이용
KR102348696B1 (ko) * 2017-05-17 2022-01-07 주식회사 엘지생활건강 테프레논을 포함하는 화장료 조성물
KR102167819B1 (ko) * 2017-07-28 2020-10-20 가톨릭대학교 산학협력단 코 하비갑개 유래 중간엽 줄기세포를 유효성분으로 포함하는 류마티스 관절염 예방 또는 치료용 약학적 조성물
KR102053868B1 (ko) * 2018-01-31 2020-01-22 가톨릭대학교 산학협력단 하비갑개 유래 중간엽 줄기세포를 유효성분으로 포함하는 퇴행성 신경계질환 예방 또는 치료용 약학적 조성물
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Also Published As

Publication number Publication date
KR101327076B1 (ko) 2013-11-08
EP2551342B1 (en) 2018-05-02
WO2011118954A2 (ko) 2011-09-29
US20130122587A1 (en) 2013-05-16
WO2011118954A9 (ko) 2011-11-17
KR20110106235A (ko) 2011-09-28
EP2551342A4 (en) 2013-08-28
EP2551342A2 (en) 2013-01-30

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