WO2011008053A3 - Ｎ,ｎ-디메틸 이미도디카르본이미딕 디아미드의 프로피온산염, 이의 제조방법, 이를 포함하는 약제학적 조성물 및 이를 포함하는 복합제제 - Google Patents

Ｎ,ｎ-디메틸 이미도디카르본이미딕 디아미드의 프로피온산염, 이의 제조방법, 이를 포함하는 약제학적 조성물 및 이를 포함하는 복합제제 Download PDF

Info

Publication number
WO2011008053A3
WO2011008053A3 PCT/KR2010/004673 KR2010004673W WO2011008053A3 WO 2011008053 A3 WO2011008053 A3 WO 2011008053A3 KR 2010004673 W KR2010004673 W KR 2010004673W WO 2011008053 A3 WO2011008053 A3 WO 2011008053A3
Authority
WO
WIPO (PCT)
Prior art keywords
propionate
same
metformin
pharmaceutical compositions
combinations containing
Prior art date
Application number
PCT/KR2010/004673
Other languages
English (en)
French (fr)
Other versions
WO2011008053A2 (ko
Inventor
김성욱
전성수
민창희
강민석
김용은
구자성
Original Assignee
한올바이오파마주식회사
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 한올바이오파마주식회사 filed Critical 한올바이오파마주식회사
Publication of WO2011008053A2 publication Critical patent/WO2011008053A2/ko
Publication of WO2011008053A3 publication Critical patent/WO2011008053A3/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/122—Propionic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C277/00—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/24—Y being a hetero atom
    • C07C279/26—X and Y being nitrogen atoms, i.e. biguanides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Endocrinology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

본 발명은 메트포르민 프로피온산염, 이의 제조방법, 이를 포함하는 약제학적 조성물 및 복합제제를 제공한다. 본 발명의 메트포르민 프로피온산염은 메트포르민 염산염에 비해 약리학적 효과가 우수할 뿐만 아니라 메트포르민 염산염보다 적은 용량을 투여하여 치료 목적을 달성할 수 있다. 또한 용해도, 안정성, 흡습성, 부착방지특성 같은 제형으로서의 가공성 등의 물리화학적 성질이 우수하여 메트포르민의 약제학적으로 허용되는 염으로써 유용하게 이용될 수 있다.
PCT/KR2010/004673 2009-07-17 2010-07-16 Ｎ,ｎ-디메틸 이미도디카르본이미딕 디아미드의 프로피온산염, 이의 제조방법, 이를 포함하는 약제학적 조성물 및 이를 포함하는 복합제제 WO2011008053A2 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2009-0065244 2009-07-17
KR20090065244 2009-07-17

Publications (2)

Publication Number Publication Date
WO2011008053A2 WO2011008053A2 (ko) 2011-01-20
WO2011008053A3 true WO2011008053A3 (ko) 2011-04-21

Family

ID=43449997

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2010/004673 WO2011008053A2 (ko) 2009-07-17 2010-07-16 Ｎ,ｎ-디메틸 이미도디카르본이미딕 디아미드의 프로피온산염, 이의 제조방법, 이를 포함하는 약제학적 조성물 및 이를 포함하는 복합제제

Country Status (2)

Country Link
KR (2) KR20110007984A (ko)
WO (1) WO2011008053A2 (ko)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL1848414T3 (pl) 2005-02-03 2011-10-31 Wyeth Llc Sposób leczenia nowotworu opornego na gefitinib
PE20070763A1 (es) 2005-11-04 2007-08-08 Wyeth Corp COMBINACIONES ANTINEOPLASICAS DE UN INHIBIDOR DE mTOR, TRASTUZUMAB Y/O HKI-272
US8022216B2 (en) 2007-10-17 2011-09-20 Wyeth Llc Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof
CN102641270A (zh) 2008-06-17 2012-08-22 惠氏有限责任公司 含有hki-272和长春瑞滨的抗肿瘤组合
CN102202667A (zh) 2008-08-04 2011-09-28 惠氏有限责任公司 4-苯胺基-3-氰基喹啉和卡培他滨的抗肿瘤组合
MX356593B (es) 2009-04-06 2018-06-05 Wyeth Llc Régimen de tratamiento que utiliza neratinib para cáncer de mama.
WO2011056741A2 (en) 2009-11-09 2011-05-12 Wyeth Llc Coated drug spheroids and uses thereof for eliminating or reducing conditions such as emesis and diarrhea

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999029314A1 (en) * 1997-12-08 1999-06-17 Bristol-Myers Squibb Company Novel salts of metformin and method
WO1999047128A1 (en) * 1998-03-19 1999-09-23 Bristol-Myers Squibb Company Biphasic controlled release delivery system for high solubility pharmaceuticals and method
KR100760430B1 (ko) * 2004-12-31 2007-10-04 한미약품 주식회사 당뇨병 치료제의 경구 투여용 서방성 복합 제제 및 이의제조 방법
KR20090013736A (ko) * 2007-08-02 2009-02-05 주식회사 한독약품 메트포르민 산 부가염을 포함하는 서방성 제제

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999029314A1 (en) * 1997-12-08 1999-06-17 Bristol-Myers Squibb Company Novel salts of metformin and method
WO1999047128A1 (en) * 1998-03-19 1999-09-23 Bristol-Myers Squibb Company Biphasic controlled release delivery system for high solubility pharmaceuticals and method
KR100760430B1 (ko) * 2004-12-31 2007-10-04 한미약품 주식회사 당뇨병 치료제의 경구 투여용 서방성 복합 제제 및 이의제조 방법
KR20090013736A (ko) * 2007-08-02 2009-02-05 주식회사 한독약품 메트포르민 산 부가염을 포함하는 서방성 제제

Also Published As

Publication number Publication date
KR20120031288A (ko) 2012-04-02
KR20110007984A (ko) 2011-01-25
WO2011008053A2 (ko) 2011-01-20

Similar Documents

Publication Publication Date Title
WO2011008054A3 (ko) Ｎ,ｎ-디메틸 이미도디카르본이미딕 디아미드의 부틸산염, 이의 제조방법, 이를 포함하는 약제학적 조성물 및 이를 포함하는 복합제제
WO2011008053A3 (ko) Ｎ,ｎ-디메틸 이미도디카르본이미딕 디아미드의 프로피온산염, 이의 제조방법, 이를 포함하는 약제학적 조성물 및 이를 포함하는 복합제제
WO2012047017A3 (ko) 2,3-디히드로-이소인돌-1-온 유도체 및 이를 포함하는 조성물
MX2015010971A (es) Derivado novedoso de pirazol.
WO2014151871A3 (en) Jak2 and alk2 inhibitors and methods for their use
WO2013188792A3 (en) Neuroactive steroids, compositions, and uses thereof
WO2013179307A3 (en) Stabilized pharmaceutical compositions of saxagliptin
MY149731A (en) Compounds
MY151986A (en) Adamantyl diamide derivatives and uses of same
MX2010006799A (es) Benzofuropirimidinonas como inhibidores de la proteina cinasa.
WO2011005811A8 (en) Combination therapy for the treatment of diabetes
EP3626253A3 (en) Stable formulations of linaclotide
IL195732A (en) Pharmaceutical compounds containing passoterodine, their use and method for their preparation
WO2007014619A8 (en) Novelimidazolecarboxamide derivatives as fructose-1,6-bisphosphatase inhibitors, and pharmaceutical compositions comprising same
TN2013000253A1 (en) Bicyclo[3.2.1]octyl amide derivatives and uses of same
WO2010132765A3 (en) Antibacterial aminoglycoside analogs
WO2011012816A3 (fr) Formulation pharmaceutique
WO2010092090A3 (en) Novel salts of sitagliptin
WO2011044501A3 (en) Antibacterial aminoglycoside analogs
WO2012048129A3 (en) Inhibitors of polo-like kinase
UA97348C2 (en) HETEROCYCLIC NF-kB INHIBITORS
NZ602450A (en) Agomelatine hydrochloride hydrate and preparation thereof
WO2012135615A3 (en) Enopeptins, uses thereof, and methods of synthesis thereto
WO2010049449A3 (en) Novel salts of sunitinib
WO2012053009A3 (en) Pharmaceutical compositions comprising nano size droplets of skin whitening agents

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 10800064

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 10800064

Country of ref document: EP

Kind code of ref document: A2