WO2010121576A3 - Nouveaux nucléosides 7-déazapurine à des fins thérapeutiques - Google Patents

Nouveaux nucléosides 7-déazapurine à des fins thérapeutiques Download PDF

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Publication number
WO2010121576A3
WO2010121576A3 PCT/CZ2010/000050 CZ2010000050W WO2010121576A3 WO 2010121576 A3 WO2010121576 A3 WO 2010121576A3 CZ 2010000050 W CZ2010000050 W CZ 2010000050W WO 2010121576 A3 WO2010121576 A3 WO 2010121576A3
Authority
WO
WIPO (PCT)
Prior art keywords
novel
therapeutic uses
compounds
deazapurine nucleosides
compositions
Prior art date
Application number
PCT/CZ2010/000050
Other languages
English (en)
Other versions
WO2010121576A2 (fr
Inventor
Aurelie Bourderioux
Michal Hocek
Petr Naus
Original Assignee
Institute Of Organic Chemistry And Biochemistry Ascr,V.V.I.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CA2759131A priority Critical patent/CA2759131C/fr
Priority to JP2012506333A priority patent/JP5721275B2/ja
Application filed by Institute Of Organic Chemistry And Biochemistry Ascr,V.V.I. filed Critical Institute Of Organic Chemistry And Biochemistry Ascr,V.V.I.
Priority to ES10734433.5T priority patent/ES2437917T3/es
Priority to NZ596301A priority patent/NZ596301A/en
Priority to EP10734433.5A priority patent/EP2421879B1/fr
Priority to CN201080027802.1A priority patent/CN102459300B/zh
Priority to US14/394,262 priority patent/US9321800B2/en
Priority to MX2011011160A priority patent/MX2011011160A/es
Priority to DK10734433.5T priority patent/DK2421879T3/da
Priority to PL10734433T priority patent/PL2421879T3/pl
Priority to SI201030450T priority patent/SI2421879T1/sl
Priority to AU2010238985A priority patent/AU2010238985B2/en
Publication of WO2010121576A2 publication Critical patent/WO2010121576A2/fr
Publication of WO2010121576A3 publication Critical patent/WO2010121576A3/fr
Priority to HK12107027.8A priority patent/HK1166325A1/xx
Priority to HRP20131021AT priority patent/HRP20131021T1/hr
Priority to AU2015205885A priority patent/AU2015205885B2/en
Priority to US15/073,502 priority patent/US9624257B2/en
Priority to US15/453,702 priority patent/US10294262B2/en
Priority to AU2017204148A priority patent/AU2017204148B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/14—Pyrrolo-pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

La présente invention concerne des composés de formule I, dans laquelle R1, R2 et R3 ont les valeurs définies dans la description, et leur sel pharmaceutiquement acceptable, ou leur isomère optique, ou un mélange d'isomères optiques, ainsi que des compositions comprenant lesdits composés et des procédés thérapeutiques qui utilisent lesdits composés et/ou lesdites compositions.
PCT/CZ2010/000050 2009-04-22 2010-04-19 Nouveaux nucléosides 7-déazapurine à des fins thérapeutiques WO2010121576A2 (fr)

Priority Applications (18)

Application Number Priority Date Filing Date Title
SI201030450T SI2421879T1 (sl) 2009-04-22 2010-04-19 Novi 7-deazapurinski nukleozidi za terapevtske uporabe
PL10734433T PL2421879T3 (pl) 2009-04-22 2010-04-19 Nowe nukleozydy 7-deazapurynowe do zastosowań terapeutycznych
AU2010238985A AU2010238985B2 (en) 2009-04-22 2010-04-19 Novel 7-deazapurine nucleosides for therapeutic uses
JP2012506333A JP5721275B2 (ja) 2009-04-22 2010-04-19 治療的使用のための新規７−デアザプリンヌクレオシド
EP10734433.5A EP2421879B1 (fr) 2009-04-22 2010-04-19 Nouveaux nucléosides 7-déazapurine à des fins thérapeutiques
CN201080027802.1A CN102459300B (zh) 2009-04-22 2010-04-19 用于治疗用途的新的7-脱氮嘌呤核苷
US14/394,262 US9321800B2 (en) 2009-04-22 2010-04-19 7-deazapurine nucleosides for therapeutic uses
MX2011011160A MX2011011160A (es) 2009-04-22 2010-04-19 Nuevos nucleosidos de 7-desazapurina para usos terapeuticos.
DK10734433.5T DK2421879T3 (da) 2009-04-22 2010-04-19 Nye 7-deazapurinnukleotider til terapeutiske anvendelser
CA2759131A CA2759131C (fr) 2009-04-22 2010-04-19 Nucleosides de 7-deazapurine destines a des usages therapeutiques
NZ596301A NZ596301A (en) 2009-04-22 2010-04-19 Novel 7-deazapurine nucleosides for therapeutic uses
ES10734433.5T ES2437917T3 (es) 2009-04-22 2010-04-19 Nuevos nucleósidos de 7-desazapurina para usos terapéuticos
HK12107027.8A HK1166325A1 (en) 2009-04-22 2012-07-18 Novel 7-deazapurine nucleosides for therapeutic uses
HRP20131021AT HRP20131021T1 (hr) 2009-04-22 2013-10-28 Novi 7-deazapurin nukleozidi za terapijske uporabe
AU2015205885A AU2015205885B2 (en) 2009-04-22 2015-07-22 Novel 7-deazapurine nucleosides for therapeutic uses
US15/073,502 US9624257B2 (en) 2009-04-22 2016-03-17 7-deazapurine nucleosides for therapeutic uses
US15/453,702 US10294262B2 (en) 2009-04-22 2017-03-08 7-deazapurine nucleosides for therapeutic uses
AU2017204148A AU2017204148B2 (en) 2009-04-22 2017-06-19 Novel 7-deazapurine nucleosides for therapeutic uses

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17165609P 2009-04-22 2009-04-22
US61/171,656 2009-04-22

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US14/394,262 A-371-Of-International US9321800B2 (en) 2009-04-22 2010-04-19 7-deazapurine nucleosides for therapeutic uses
US15/073,502 Continuation US9624257B2 (en) 2009-04-22 2016-03-17 7-deazapurine nucleosides for therapeutic uses

Publications (2)

Publication Number Publication Date
WO2010121576A2 WO2010121576A2 (fr) 2010-10-28
WO2010121576A3 true WO2010121576A3 (fr) 2011-06-16

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CZ2010/000050 WO2010121576A2 (fr) 2009-04-22 2010-04-19 Nouveaux nucléosides 7-déazapurine à des fins thérapeutiques

Country Status (16)

Country Link
US (3) US9321800B2 (fr)
EP (1) EP2421879B1 (fr)
JP (2) JP5721275B2 (fr)
CN (2) CN104497084B (fr)
AU (3) AU2010238985B2 (fr)
CA (2) CA2759131C (fr)
DK (1) DK2421879T3 (fr)
ES (1) ES2437917T3 (fr)
HK (2) HK1166325A1 (fr)
HR (1) HRP20131021T1 (fr)
MX (1) MX2011011160A (fr)
NZ (2) NZ596301A (fr)
PL (1) PL2421879T3 (fr)
PT (1) PT2421879E (fr)
SI (1) SI2421879T1 (fr)
WO (1) WO2010121576A2 (fr)

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JP2013514781A (ja) * 2009-12-18 2013-05-02 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ β細胞複製促進化合物およびそれらの使用法
CN102319254B (zh) * 2011-07-20 2013-06-19 上海交通大学 5-碘代杀菌核素在制备抗肿瘤药物中的应用
CZ305466B6 (cs) * 2013-11-04 2015-10-14 Ústav organické chemie a biochemie Akademie věd České republiky, v. v. i. Substituované 7-deazapurinové ribonukleosidy pro terapeutické použití
WO2016075224A1 (fr) 2014-11-14 2016-05-19 Nerviano Medical Sciences S.R.L. Dérivés 6-amino -7-bicyclo -7-déazapurine utiles en tant qu'inhibiteurs de protéine kinase
EP3454856A4 (fr) 2016-05-10 2019-12-25 C4 Therapeutics, Inc. Dégronimères hétérocycliques pour la dégradation de protéines cibles
EP3455218A4 (fr) 2016-05-10 2019-12-18 C4 Therapeutics, Inc. Dégronimères de type glutarimide liés au carbone c3 pour la dégradation de protéines cibles
CN109562113A (zh) 2016-05-10 2019-04-02 C4医药公司 用于靶蛋白降解的螺环降解决定子体
US10414788B2 (en) 2016-06-29 2019-09-17 Ustav Organicke Chemie A Biochemie Av Cr, V.V.I. Substituted thienopyrrolopyrimidine ribonucleosides for therapeutic use
CZ307334B6 (cs) 2016-08-02 2018-06-13 Ăšstav organickĂ© chemie a biochemie AV ÄŚR, v.v.i. Substituované heteropentadieno-pyrrolopyrimidinové ribonukleosidy pro terapeutické použití
EP3571203B1 (fr) 2017-01-18 2023-06-07 Array BioPharma Inc. Composés de pyrazolo[1,5-a]pyrazine substitués utilisés en tant qu'inhibiteurs de la kinase ret
US11072628B2 (en) 2017-10-19 2021-07-27 Universiteit Gent Nucleoside analogues for the treatment of parasitic infections
TWI802635B (zh) 2018-01-18 2023-05-21 美商亞雷生物製藥股份有限公司 作為ｒｅｔ激酶抑制劑之經取代吡咯并[2,3-d]嘧啶化合物
JP6997876B2 (ja) * 2018-01-18 2022-02-04 アレイ バイオファーマ インコーポレイテッド Ｒｅｔキナーゼ阻害剤としての置換ピラゾリル［４，３－ｃ］ピリジン化合物
US11524963B2 (en) 2018-01-18 2022-12-13 Array Biopharma Inc. Substituted pyrazolo[3,4-d]pyrimidines as RET kinase inhibitors
CZ308104B6 (cs) 2018-03-12 2020-01-08 Ăšstav organickĂ© chemie a biochemie AV ÄŚR, v. v. i. Pyridinopyrrolopyrimidinové ribonukleosidy pro terapeutické použití
WO2020033288A1 (fr) * 2018-08-07 2020-02-13 Merck Sharp & Dohme Corp. Inhibiteurs de prmt5
WO2020255979A1 (fr) * 2019-06-18 2020-12-24 大鵬薬品工業株式会社 Nouveau compose carbonate possedant un squelette pyrolo-pyrimidine ou sel pharmaceutiquement acceptable de celui-ci
US20230104311A1 (en) * 2020-02-17 2023-04-06 Katholieke Universiteit Leuven Novel 6-substituted 7-deazapurines and corresponding nucleosides as medicaments
JP7185073B1 (ja) 2021-02-26 2022-12-06 株式会社日立インダストリアルプロダクツ 回転電機
WO2023052468A1 (fr) 2021-09-28 2023-04-06 Universiteit Antwerpen Analogues de nucléosides pour le traitement d'infections parasitaires

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Also Published As

Publication number Publication date
US9624257B2 (en) 2017-04-18
EP2421879B1 (fr) 2013-09-04
HK1166325A1 (en) 2012-12-14
AU2015205885A1 (en) 2015-09-03
SI2421879T1 (sl) 2014-01-31
US20150218201A1 (en) 2015-08-06
PL2421879T3 (pl) 2014-02-28
AU2010238985B2 (en) 2015-04-23
ES2437917T3 (es) 2014-01-15
US20160318970A1 (en) 2016-11-03
AU2015205885B2 (en) 2017-04-06
HK1209129A1 (en) 2016-03-24
US9321800B2 (en) 2016-04-26
DK2421879T3 (da) 2013-11-25
PT2421879E (pt) 2013-12-09
CN102459300B (zh) 2014-12-10
JP5721275B2 (ja) 2015-05-20
AU2017204148A1 (en) 2017-07-06
JP2015013901A (ja) 2015-01-22
CA2966647A1 (fr) 2010-10-28
MX2011011160A (es) 2012-01-27
CA2759131A1 (fr) 2010-10-28
AU2017204148B2 (en) 2018-12-06
US20170240584A1 (en) 2017-08-24
CN104497084B (zh) 2018-06-05
NZ700583A (en) 2016-04-29
HRP20131021T1 (hr) 2014-01-31
CN102459300A (zh) 2012-05-16
US10294262B2 (en) 2019-05-21
JP2012524731A (ja) 2012-10-18
NZ596301A (en) 2014-10-31
JP6087889B2 (ja) 2017-03-01
WO2010121576A2 (fr) 2010-10-28
EP2421879A2 (fr) 2012-02-29
CN104497084A (zh) 2015-04-08
CA2759131C (fr) 2017-06-20
AU2010238985A1 (en) 2011-12-01

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