WO2010059279A3 - Hydrogel tissue adhesive formed from aminated polysaccharide and aldehyde-functionalized multi-arm polyether - Google Patents
Hydrogel tissue adhesive formed from aminated polysaccharide and aldehyde-functionalized multi-arm polyether Download PDFInfo
- Publication number
- WO2010059279A3 WO2010059279A3 PCT/US2009/055485 US2009055485W WO2010059279A3 WO 2010059279 A3 WO2010059279 A3 WO 2010059279A3 US 2009055485 W US2009055485 W US 2009055485W WO 2010059279 A3 WO2010059279 A3 WO 2010059279A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- tissue adhesive
- aldehyde
- hydrogel tissue
- aminated polysaccharide
- hydrogel
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/043—Mixtures of macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
- A61L24/0031—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/046—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/08—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0019—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0023—Polysaccharides
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Surgery (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Dispersion Chemistry (AREA)
- Materials Engineering (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
Abstract
A hydrogel tissue adhesive formed by reacting an aminated polysaccharide with a water-dispersible, aldehyde-functionalized multi-arm polyether is described. The hydrogel tissue adhesive may be useful as a general tissue adhesive and sealant for medical and veterinary applications such as wound closure, supplementing or replacing sutures or staples in internal surgical procedures such as intestinal anastomosis and vascular anastomosis, tissue repair, ophthalmic procedures, drug delivery, and to prevent post-surgical adhesions. Additionally, due to the presence of the aminated polysaccharide, the hydrogel tissue adhesive may also promote wound healing and blood coagulation, and provide antimicrobial properties.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13/129,617 US9044529B2 (en) | 2008-11-19 | 2009-08-31 | Hydrogel tissue adhesive formed from aminated polysaccharide and aldehyde-functionalized multi-arm polyether |
EP09792096A EP2349357B1 (en) | 2008-11-19 | 2009-08-31 | Hydrogel tissue adhesive formed from aminated polysaccharide and aldehyde-functionalized multi-arm polyether |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11596708P | 2008-11-19 | 2008-11-19 | |
US61/115,967 | 2008-11-19 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2010059279A2 WO2010059279A2 (en) | 2010-05-27 |
WO2010059279A3 true WO2010059279A3 (en) | 2010-12-16 |
Family
ID=41343257
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2009/055485 WO2010059279A2 (en) | 2008-11-19 | 2009-08-31 | Hydrogel tissue adhesive formed from aminated polysaccharide and aldehyde-functionalized multi-arm polyether |
Country Status (3)
Country | Link |
---|---|
US (1) | US9044529B2 (en) |
EP (1) | EP2349357B1 (en) |
WO (1) | WO2010059279A2 (en) |
Families Citing this family (27)
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ES2369473T3 (en) | 2004-10-07 | 2011-12-01 | Actamax Surgical Materials Llc | POLYMER TISSUE POLYMERIC BASED ADHESIVE FOR MEDICAL USE. |
JP5539725B2 (en) | 2006-11-27 | 2014-07-02 | アクタマックス サージカル マテリアルズ リミテッド ライアビリティ カンパニー | Branched end reactants and polymer hydrogel tissue adhesives produced therefrom |
US8426492B2 (en) | 2007-11-14 | 2013-04-23 | Actamax Surgical Materials, Llc | Oxidized cationic polysaccharide-based polymer tissue adhesive for medical use |
US8551136B2 (en) | 2008-07-17 | 2013-10-08 | Actamax Surgical Materials, Llc | High swell, long-lived hydrogel sealant |
US9044529B2 (en) | 2008-11-19 | 2015-06-02 | Actamax Surgical Materials, Llc | Hydrogel tissue adhesive formed from aminated polysaccharide and aldehyde-functionalized multi-arm polyether |
US20100160960A1 (en) * | 2008-12-19 | 2010-06-24 | E. I. Du Pont De Nemours And Company | Hydrogel tissue adhesive having increased degradation time |
EP2416811B1 (en) | 2009-04-09 | 2015-09-09 | Actamax Surgical Materials LLC | Hydrogel tissue adhesive having reduced degradation time |
WO2011002888A2 (en) | 2009-07-02 | 2011-01-06 | E. I. Du Pont De Nemours And Company | Hydrogel tissue adhesive for medical use |
US8796242B2 (en) | 2009-07-02 | 2014-08-05 | Actamax Surgical Materials, Llc | Hydrogel tissue adhesive for medical use |
WO2011002956A1 (en) | 2009-07-02 | 2011-01-06 | E. I. Du Pont De Nemours And Company | Aldehyde-functionalized polysaccharides |
US8580950B2 (en) | 2009-07-02 | 2013-11-12 | Actamax Surgical Materials, Llc | Aldehyde-functionalized polysaccharides |
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CN110643032B (en) * | 2016-04-21 | 2022-01-28 | 厦门赛诺邦格生物科技股份有限公司 | Eight-arm polyethylene glycol, preparation method, functionalized derivative and modified biologically-relevant substance |
ES2919555T3 (en) * | 2016-09-12 | 2022-07-27 | Oreal | Treatment procedure for keratin materials from aminated and oxidized polysaccharide |
CN108498879B (en) | 2017-02-28 | 2021-12-28 | 苏州安德佳生物科技有限公司 | Composition and reagent combination for submucosal injection and application thereof |
CN110025821A (en) * | 2018-01-12 | 2019-07-19 | 北京环球利康科技有限公司 | Use the method for biocompatible hemostatic agent and the compositions-treated active hemorrhage of tissue sealant |
CN109646723B (en) * | 2019-02-02 | 2020-05-22 | 上海瑞凝生物科技有限公司 | Medical hydrogel with radiation protection effect |
CN113440647A (en) * | 2021-07-29 | 2021-09-28 | 中南大学湘雅三医院 | Preparation method and application of ozone hydrogel dressing |
CN113413483B (en) * | 2021-08-20 | 2022-07-05 | 四川大学 | Adhesive-non-adhesive integrated hydrogel, preparation method thereof and application thereof in wound repair |
CN114344555B (en) * | 2022-01-12 | 2022-06-28 | 西南交通大学 | Multifunctional hemostatic material and preparation method thereof |
CN114767922B (en) * | 2022-03-15 | 2023-09-12 | 青岛大学 | Hyaluronic acid hydrogel carrying probiotics and preparation method and application thereof |
CN114752066B (en) * | 2022-04-14 | 2023-06-02 | 江南大学 | Responsive cellulose nano whisker and preparation method thereof |
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- 2009-08-31 EP EP09792096A patent/EP2349357B1/en not_active Not-in-force
- 2009-08-31 WO PCT/US2009/055485 patent/WO2010059279A2/en active Application Filing
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Also Published As
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EP2349357B1 (en) | 2012-10-03 |
US9044529B2 (en) | 2015-06-02 |
EP2349357A2 (en) | 2011-08-03 |
US20110224724A1 (en) | 2011-09-15 |
WO2010059279A2 (en) | 2010-05-27 |
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