WO2009064963A3 - Oxidized cationic polysaccharide-based polymer tissue adhesive for medical use - Google Patents

Oxidized cationic polysaccharide-based polymer tissue adhesive for medical use Download PDF

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Publication number
WO2009064963A3
WO2009064963A3 PCT/US2008/083522 US2008083522W WO2009064963A3 WO 2009064963 A3 WO2009064963 A3 WO 2009064963A3 US 2008083522 W US2008083522 W US 2008083522W WO 2009064963 A3 WO2009064963 A3 WO 2009064963A3
Authority
WO
WIPO (PCT)
Prior art keywords
tissue adhesive
cationic polysaccharide
oxidized
based polymer
polymer tissue
Prior art date
Application number
PCT/US2008/083522
Other languages
French (fr)
Other versions
WO2009064963A2 (en
Inventor
Helen S. M. Lu
Original Assignee
E. I. Du Pont De Nemours And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by E. I. Du Pont De Nemours And Company filed Critical E. I. Du Pont De Nemours And Company
Priority to EP08849966.0A priority Critical patent/EP2214731B1/en
Priority to US12/742,457 priority patent/US8426492B2/en
Publication of WO2009064963A2 publication Critical patent/WO2009064963A2/en
Publication of WO2009064963A3 publication Critical patent/WO2009064963A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0031—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/043—Mixtures of macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/26—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/041—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/145—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like

Abstract

A tissue adhesive formed by reacting an oxidized cationic polysaccharide containing aldehyde groups and amine groups with a multi-arm amine is described. The oxidized cationic polysaccharide-based polymer tissue adhesive may be useful for medical applications including wound closure, supplementing or replacing sutures or staples in internal surgical procedures such as intestinal anastomosis and vascular anastomosis, ophthalmic procedures, drug delivery, anti-adhesive applications and as a bulking agent to treat urinary incontinence. Additionally, due to the presence of the positively charged amine groups on the oxidized polysaccharide, the polymer tissue adhesive disclosed herein may promote wound healing and blood coagulation, and may possess antimicrobial properties.
PCT/US2008/083522 2007-11-14 2008-11-14 Oxidized cationic polysaccharide-based polymer tissue adhesive for medical use WO2009064963A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP08849966.0A EP2214731B1 (en) 2007-11-14 2008-11-14 Oxidized cationic polysaccharide-based polymer tissue adhesive for medical use
US12/742,457 US8426492B2 (en) 2007-11-14 2008-11-14 Oxidized cationic polysaccharide-based polymer tissue adhesive for medical use

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US305907P 2007-11-14 2007-11-14
US61/003,059 2007-11-14

Publications (2)

Publication Number Publication Date
WO2009064963A2 WO2009064963A2 (en) 2009-05-22
WO2009064963A3 true WO2009064963A3 (en) 2010-03-25

Family

ID=40329354

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/083522 WO2009064963A2 (en) 2007-11-14 2008-11-14 Oxidized cationic polysaccharide-based polymer tissue adhesive for medical use

Country Status (3)

Country Link
US (1) US8426492B2 (en)
EP (1) EP2214731B1 (en)
WO (1) WO2009064963A2 (en)

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JP4975627B2 (en) 2004-10-07 2012-07-11 アクタマックス サージカル マテリアルズ リミテッド ライアビリティ カンパニー Polysaccharide-based polymeric tissue adhesives for medical applications
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US20100015231A1 (en) * 2008-07-17 2010-01-21 E.I. Du Pont De Nemours And Company Low swell, long-lived hydrogel sealant
US8466327B2 (en) 2008-11-19 2013-06-18 Actamax Surgical Materials, Llc Aldehyde-functionalized polyethers and method of making same
CN105833337B (en) 2008-11-19 2020-01-21 阿克塔马克斯手术器材有限责任公司 Fibrous tissue sealant and method of use
EP2349357B1 (en) * 2008-11-19 2012-10-03 Actamax Surgical Materials LLC Hydrogel tissue adhesive formed from aminated polysaccharide and aldehyde-functionalized multi-arm polyether
US20100160960A1 (en) * 2008-12-19 2010-06-24 E. I. Du Pont De Nemours And Company Hydrogel tissue adhesive having increased degradation time
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US8580950B2 (en) 2009-07-02 2013-11-12 Actamax Surgical Materials, Llc Aldehyde-functionalized polysaccharides
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CN107406523B (en) 2015-03-20 2020-09-22 杨达志 Polysaccharide-polyurethane copolymer and application thereof in reducing uric acid concentration in blood plasma
NL2019650B1 (en) * 2017-09-29 2019-04-08 Polyganics Ip B V Improved tissue-adhesive polymers
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Also Published As

Publication number Publication date
US8426492B2 (en) 2013-04-23
EP2214731B1 (en) 2014-05-14
EP2214731A2 (en) 2010-08-11
US20100272804A1 (en) 2010-10-28
WO2009064963A2 (en) 2009-05-22

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