WO2009125071A2 - Extrait avec une quantité élevée de composants bioactifs, et son utilisation - Google Patents

Extrait avec une quantité élevée de composants bioactifs, et son utilisation Download PDF

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Publication number
WO2009125071A2
WO2009125071A2 PCT/FI2009/050273 FI2009050273W WO2009125071A2 WO 2009125071 A2 WO2009125071 A2 WO 2009125071A2 FI 2009050273 W FI2009050273 W FI 2009050273W WO 2009125071 A2 WO2009125071 A2 WO 2009125071A2
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WO
WIPO (PCT)
Prior art keywords
weight
extract
extraction
extract according
quebrachitol
Prior art date
Application number
PCT/FI2009/050273
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English (en)
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WO2009125071A3 (fr
Inventor
Baoru Yang
Heikki Kallio
Vesa-Pekka Judin
Veli-Markku Korteniemi
Original Assignee
Aromtech Ltd
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Publication date
Application filed by Aromtech Ltd filed Critical Aromtech Ltd
Priority to EP09729615A priority Critical patent/EP2282750A2/fr
Publication of WO2009125071A2 publication Critical patent/WO2009125071A2/fr
Publication of WO2009125071A3 publication Critical patent/WO2009125071A3/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/45—Ericaceae or Vacciniaceae (Heath or Blueberry family), e.g. blueberry, cranberry or bilberry
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin

Definitions

  • the present invention relates to an extract with high amount of bioactive components according to the preambles of the enclosed claims.
  • the invention relates also to use of the extract.
  • Plant materials are rich sources of bioactive components that have beneficial effects for human health. Herbs and herbal extracts are used globally in traditional medicines and remedies. Plant extracts manufactured by different technologies have been used in products for health care and personal care.
  • Carbon dioxide (CO2) extraction is a modern technology for isolating sensitive components from valuable raw materials. Instead of conventional solvents, carbon dioxide in the form of fluid or supercritical fluid is used for extracting the components of interest from the natural raw material. Due to the absence of organic solvents and oxygen the extracts are free of solvent residues and oxidative damages.
  • CO2 extraction technology is used for manufacturing of essential oils, natural fragrances, specialty oils and lipid extracts.
  • Carbon dioxide extracts from plant materials are widely used as ingredients of food, food supplements, personal care products and medicines.
  • An object of this invention is to minimise or even eliminate the problems and disadvantages existing in the prior art.
  • Another object of the present invention is to provide an extract which is rich in selected bioactive components and which is suitable for use in food supplements and cosmetic products without extensive purification steps.
  • Still another object of the present invention is to provide an extract which is ecologically safe.
  • Typical berry extract according to the present invention comprises at least 0.01 weight-%, preferably at least 1 weight-% of L-quebrachitol, i.e. (-)-2-O-methyl-L- c/7/ro-inositol.
  • Typical use of the extract according to the present invention is for manufacturing of functional foods, food supplements, cosmetics, health care and personal care products.
  • bioactive compounds are released from the cellular structure of the plant material, especially from berries, and enriched, for example, during CO2 extraction process to the residual material, whereby some of the compounds are enriched and present in the forms of high biological activity and bioavailability in the residual material.
  • the extracts according to the present invention comprise typically a high content of selected bioactive compounds and/or a reduced content of undesirable substances that interfere with the formulation process, and they typically improve the stability or sensory properties, such as taste, of the final products.
  • the extract is obtained by extracting a residue from a CO2 extraction process by using a solvent different from CO2.
  • the extracts obtained by further extracting the residual material have composition significantly different from those obtainable by extraction of native plant raw material.
  • the enriched compounds may be recovered simply and fast by a further extraction with a different solvent. It has been found out that especially the extraction of polar, hydrophilic components such as sugars, sugar alcohols, sugar derivatives, phenolic compounds, proteins, peptides, amino acids, fibres, oligosaccharides or polysaccharides, from the residues is more efficient compared to the extraction from the corresponding native raw material. In other words, extracts rich in these bioactive compounds may be obtained easily. In addition, many steps of further cleaning may be omitted due to the low content of disturbing substances in the residue used as raw material.
  • the extract rich in L-quebrachitol may be obtained by pressing of fresh berries.
  • berries of Hippophae rhamnoides ssp. sinensis are preferred as a raw material for fresh pressing.
  • the extract according to the present invention is rich in L-quebrachitol, the amount of L-quebrachitol being at least 0.1 weight-%, preferably 5 weight-%, more preferably at least 5 weight-%, very preferably 1 - 5 weight-%.
  • L-quebrachitol also known as (-)-2-O-methyl-L-c/?/ro- inositol, may provide for many of the advantageous effects associated with berries, such as antioxidative, detoxifying and/or tissue protective activities, as well as effects on sugar metabolism and insulin sensitivity.
  • the extract according to the present invention may be used for treating disorders of sugar metabolism and insulin sensitivity, such as type Il diabetes.
  • the extract may also be used for manufacturing medicaments for treating and reducing the risk of disorders of sugar metabolism and insulin sensitivity, such as obesity and type Il diabetes.
  • the extract may also be used for the manufacture of medicaments for disorders of sugar metabolism and insulin sensitivity, such as type Il diabetes and obesity.
  • the extract comprises in addition to L-quebrachitol also other methyl inositols and/or inositols, such as myoinositol, methyl myoinositol and/or c/7/roinositol.
  • the extract may comprise 0.01 - 99.9 weight % L-quebrachitol, 0.01 - 20 weight-% c ⁇ /ro-inositol, 0.01 - 20 weight-% myoinositol, and/or 0.01 - 20 weight-% methyl myoinositol.
  • the extract comprises 0.1 - 10 weight % L-quebrachitol, 0.01 - 1 weight-% c/7/roinositol, 0.01
  • the extract comprises 1 - 5 weight % L-quebrachitol, 0.1 - 1 weight-% c/7/roinositol and 0.1 - 1 weight-% myoinositol.
  • the extract may also comprise ethyl ⁇ -D-glucopyranose, phenolic compounds, fruit sugars, such as fructose and glucose, fruit acids, such as malic acid and quinic acid, and/or oligosaccharides.
  • the extract may comprise 1 - 5 weight-% phenolic compounds, 10 - 20 weight-% fruit sugars, 5 - 15 weight-% fruit acids, optionally peptides and/or oligosaccharides.
  • the extract may comprise phenolic compounds, such as ellagitannins and flavonol glycosides at ratio from 1 :10 to 10:1 , preferably 2:1 to 5:1.
  • the extract comprises less than 0.5 weight- % lipids or less than 0.01 weight-% carotenoids in order to obtain physical properties for the extract, which are optimal for formulation and manufacturing of different end products, such as cosmetic preparations.
  • the extract is preferably colourless or very lightly coloured, and transparent.
  • the extract comprises 1
  • the extract comprises 1 - 5 weight % L-quebrachitol, 0.01 - 1 weight-% c/7/ro-inositol, 0.01 - 1 weight-% myoinositol, 0.1 - 5 weight-% ethyl ⁇ -D-glucopyranose, 0.1 - 5 weight-% phenolic compounds, 1 - 20 weight-% fruit sugars, and 5 - 15 weight-% fruit acids.
  • the extract comprises additionally up to 10 weight-%, preferably up to 5 weight-%, preferably 1 - 5 weight-% ethyl ⁇ -D-glucopyranose.
  • the residue from a CO2 extraction which is used as a raw material for the extract originates from berry material selected from the group comprising Hippophae rhamnoides, Vaccinium myrtillus, Vaccinium vitis-idaea, Vaccinum macrocarpon, Vaccinium oxycoccos, Rubus chamaemorus, Rubus idaeus, Ribes nigrum, Ribes rubrum, and Fragaria ananassa.
  • These natural materials comprise especially important bioactive compounds that may be used in cosmetics and health care products.
  • Hippophae rhamnoides is preferred as a raw material. Berries of different subspieces of H.
  • rhamnoides are used, such as berries of H. rhamnoides ssp. sinensis, ssp. rhamnoides and ssp. mongolica.
  • the extract originates from a residue of a CO2 extraction of berries of H. rhamnoides ssp. rhamnoides, ssp. sinensis or their mixture, which is used as a raw material for the extraction.
  • the first extraction is carried out with CO2 and the residue from CO2 extraction is extracted with ethanol/water.
  • Berries of Hippophae rhamnoides ssp. sinensis are preferred as a raw material in order to achieve high content of L-quebrachitol in the extract.
  • solvent water it is possible to use as solvent water, ethanol, ethanol/water, acetone, butylene glycol, butylenes glycol/water, glycerine or their mixtures in the extraction of the residual material.
  • a mixture of butylene glycol and water, a mixture of glycerine and water or a mixture of ethanol and water may be used as a solvent.
  • the ratio between the two solvents in the above mentioned mixtures may vary from 9.9:0.1 to 0.1 :9.9, depending on the raw materials and components of interest.
  • a residue from CO2 extraction of sea buckthorn may be extracted by using water as a solvent, whereby the obtained extract comprises bioactive compounds, inositols, methyl inositols, oligosaccharides, small peptides, soluble phenolic acids and flavonol glycosides.
  • a solvent system comprising water and up to 70 volume-% of ethanol
  • an extract with increased amount of phenolic compounds is obtained.
  • the proportion of proanthocyanidins and tannins is also increased from about 1 % to about 70 % of the total phenolic compounds in the obtained extract, as well as the amount of phospholipids and glycolipids.
  • the fresh and dried berries may be extracted with water and polar solvents.
  • the raw material is a residue obtained from supercritical CO2 extraction process of dried berries.
  • the extract is essentially free of disturbing solid particles originating from raw materials.
  • Possible disturbing solid material may be separated from the obtained extract after the actual extraction with different solvent than CO2.
  • Disturbing solid material may be removed from the extract by for example filtration and/or centrifugation.
  • the obtained extracts are normally in form of liquid extracts.
  • the extract may also be obtained in particulate powder form after solvent removal.
  • the extract is dried and brought into solid, often powder-like, form.
  • the used solvent is first separated from the extract, which is then dried.
  • the drying may be performed by any suitable drying method, for example, by air drying, oven-drying, freeze-drying, vacuum-drying or spray drying.
  • the refining and purifying methods may include, but not be limited to, extraction with different solvents or chromatography in different columns.
  • Suitable solvents are e.g. water, ethanol, or mixtures of acid/water, water/ethanol or acid/water/ethanol.
  • Suitable column for chromatographic refining and purifying is e.g. an adsorption silica column or an ion exchange column.
  • bioactive components 0.01 - 30 weight-% sugar alcohols; 0.01 - 30 weight-% sugar derivatives; 0.01 - 30 weight-% phenolic compounds; proteins; peptides; amino acids; acids; monosaccharides
  • the total amount of phenolic compounds, such as flavonoids, phenolic acids and tannins in extracts may be in the range of 0.1 weight-% to 99.9 weight-%, typically from 0.5 - 70 weight-%, preferably 0.5 - 50 weight-%, more preferably 1 - 10 weight-%, still more preferably 1 - 5 weight-%.
  • the phenolic compounds in the extract provide effective antioxidant and protective activity when the extract is used for example, in food supplements or cosmetic products.
  • the extract composition may be controlled by careful selection of the raw materials. Different berry residues from the CO2 extraction comprise different chemical compounds in different amounts. By careful selection of the berry raw material used the chemical composition of the extract may be tailored after requirements.
  • the amount of sugar alcohols, sugar derivatives and/or phenolic compounds may also be controlled by suitable selection of the extraction parameters, such as extracting solvent. For example, by changing the solvent from water to mixtures of ethanol/water with increasing proportion of ethanol, the amount of sugar alcohols and sugar derivatives, as well as the amount and composition of phenolic compounds in the extract may be changed.
  • residues obtained by extracting seeds and berries of sea buckthorn or cloudberry with CO2 are further extracted by using a mixture of butylene glycol and water or a mixture of glycerine and water.
  • the possible solid material is then removed by filtration.
  • the final purified extract comprises multiple bioactive components, e.g. inositols, methyl inositols, sugar derivatives, phenolic compounds, proteins, peptides, amino acids, fruit acids, monosaccharides, oligosaccharides and polysaccharides, polar lipids, such as phospholipids, glycolipids, minerals, vitamins, and antioxidants.
  • the extract may also comprise high amounts of effective antioxidants.
  • the extract comprises cyclitol compounds, such as 1 -D-1 -O- methyl-muco-inositol, 3-O-methyl-D-c/?/ro-inositol (pinitol) and 1 -D-4-O-methyl- myo-inositol (ononitol). These compounds are important as effective scavengers of hydroxyl radicals and detoxifying compounds in biological systems.
  • the extract comprises 0.01 - 10 weight-% L- quebrachitol, and 0.01 -- 10 weight % inositols, preferably 0.5 - 5 weight-% L- quebrachitol, and 0.1 -- 1 weight % inositols.
  • the extract comprises 0.01 - 10 weight-% L-quebrachitol, 0.01 -- 10 weight % inositols and 0.01 - 10 weight-% ethyl ⁇ -D-glucopyranose; preferably 0.5 - 5 weight-% L-quebrachitol, 0.01 - 1 weight % inositols and 0.01 - 5 weight- % ethyl ⁇ -D-glucopyranose.
  • the extract may also comprise sugars, such as glucose and fructose.
  • sugars such as glucose and fructose.
  • the amount of fructose is typically 1 - 20 weight-%, more typically 1 - 10 weight-% and the amount of glucose is typically 1 - 20 weight-%, more typically 1 - 10 weight-%.
  • Fructose may exist as a mixture of ⁇ - and ⁇ -furanose and ⁇ -pyranose.
  • the glucose may exist as ⁇ - and ⁇ -anomers of pyranose.
  • the amount of sucrose is typically less than 0.1 weight-%.
  • the sugar composition of the extract is advantageous for use in different foods, food supplements and functional foods.
  • the extracts according to the present invention that are obtained by extracting a plant material comprising fresh and dried berries or berry residue from a CO2 extraction process may be used as food or in feed or food supplements as a source of macronutrients, micronutrients and/or other bioactive components.
  • the amount of the extract may vary at levels of 0.1 - 100 %, more typically 10 - 60 % and still more typically 30 - 50% of the end product.
  • the extracts may be used in the said products as sources of antioxidants, other bioactive components, proteins, fibres or nutrients with low energy values. They may also be used to improve the health of humans or animals or to improve the quality or quantity of products produced by animals, e.g. meat or milk.
  • the extracts that are preferably obtained by extracting a plant material comprising residue from a CO2 extraction may be used as ingredients for health care, cosmetic or personal care products. They may be used as skin nourishing components and natural antioxidants as well as peeling and scrubbing agents.
  • Examples of the products, where the extracts may be used, are orally administered products for skin care, topical creams and lotions, face scrubs, face gels, shower gels, shampoos and hair conditioners.
  • the extracts that are obtained by extracting a plant material or plant material residue from a CO2 extraction may also be used as antioxidants, anti-microbial agents, natural preservatives or as anti-inflammatory ingredients. They may also be used as functional ingredients for angiotensin convertase activity, for maintaining the health of the heart and the vascular system, for maintaining skin health and reducing skin ageing, for maintaining and improving skin elasticity, or as functional ingredients for promoting skin regeneration and wound healing.
  • the extract is used in a functional food or food supplement in amount corresponding to 0.01 - 100 weight-%, preferably 10 - 50 weight-% of the end product.
  • the extract is used in a cosmetics, such as face creams or body lotions, in amount corresponding to 0.01 - 20 weight-%, preferably 0.1 - 5 weight- % of the end product.
  • the extract is used in a personal care product, such as face scrubs, face gels, shower gels, shampoos and hair conditioners, in amount corresponding to 0.01 - 20 weight-%, preferably 0.05 - 10 weight-%, more preferably 0.1 - 5 weight-% of the end product.
  • the residue from a CO2 extraction and originating from berry plant material comprises at least one of the following: myricetin at least 4 mg/100 g residue, quercetin 20 mg/100 g residue, kamfaerol 10 mg/100 g residue, isorhamnetin 100 mg/100 g residue, or ellagitannins 800 mg/100 g residue.
  • the residues from the CO2 extraction are enriched in certain compounds compared to the original plant materials.
  • These enriched components comprise proteins, fibres, peptides, amino acids, phenolic compounds, phospholipids, glycolipids, polysaccharides, oligosaccharides, sugars, acids, minerals, water soluble vitamins and antioxidants. It is also possible to use the residues from the
  • CO2 extraction as such, as food or feed supplements, personal or health care products.
  • Residues comprising plant material and obtained from CO2 extraction are analysed.
  • Tables 1 and 2 show amounts of certain quantities and compounds in the different residues.
  • Table 1. Composition of CO 2 extraction residues of berries and berry seeds.
  • An extract is obtained by an extraction of a residue from CO2 extraction of sea buckthorn berries.
  • the extraction is carried out by using 50 % ethanol in water.
  • the obtained extract is spray dried into powder form.
  • the obtained extract comprises ethyl ⁇ -D-glucopyranose (3 weight-%) and L-quebrachitol, i.e. (-)-2-O- methyl-c/7/ro-inositol, (1.5 weight-%), phenolic compounds (1 weight-%) comprising especially flavonol glycosides and proanthocyanidins, sugars (5 weight-%), acids (20 weight-%), oligosaccharides and peptides.
  • the difference between the obtained extract according to the invention and conventional sea buckthorn extracts is the higher amount of ethyl ⁇ -glucopyranose and L- quebrachitol, soluble phenolic acids, proanthocyanidins of P1 -P3 and bioactive peptides.
  • the obtained extract is the absent of waxes, oily substances, colours, primarily carotenoids, and odours that may cause difficulties in formulation and instability of the final products.
  • the antioxidative activity of the obtained extract is investigated by using three different in vitro models:
  • Peroxyl radical scavenging capacity is determined by in vitro study, where peroxyl radicals are generated by thermal decomposition of 2,2'-azobis(2,4- dimethylvaleronitrile) and detected by chemiluminescence. Results are given as the stoichiometric factor, that is amount of test compounds required for scavenging of one mole of peroxyl radicals.
  • the peroxyl radical scavenging capacity of the obtained extract is 4.3 x 10 3 g /mol.
  • Inhibition of lipid peroxidation is indicative of the capacity of the extract to prevent microsomal lipid peroxidation in vitro. Peroxidation of microsomal lipids is initiated by te/t-butylhydroperoxide and lipid peroxidation is detected by chemiluminescence. Results are given as the IC50-values, i.e. concentration of test material that inhibits lipid peroxidation by 50 % under these conditions.
  • LDL oxidation is indicative of the capacity of the extract to prevent oxidation of human low density lipoprotein (LDL) in vitro.
  • Oxidation of isolated LDL is induced in vitro by copper.
  • Detection of oxidation is performed by spectrophotometric diene conjugation analysis. Results given are as the IC50- values, i.e. concentration of test material that inhibits LDL oxidation by 50% under these conditions.
  • An inositol-rich extract is obtained by an extraction of a residue from CO2 extraction of cloudberry or cloudberry seeds.
  • the extract comprises ellagitannins and other phenolic compounds.
  • the extract does not comprise appreciable amounts of triglycerides, waxes or colouring substances that dominate in the extracts prepared from native materials.
  • Trolox C is a water soluble form of alpha tocopherol, a commonly used antioxidant
  • Table 6 Inhibition of ethanol/water extract of CO 2 extraction residue on zymosan- induced white cell activation, measured as expression of Mac-1 receptors. Dilution: 10 ⁇ 2 .
  • Extracts obtained from a further extraction of the plant material comprising residues from CO2 extraction may be used as food, food supplements, nutraceuticals, cosmetic and personal care products as well as ingredients in these product groups.
  • concentration level of the extracts in the final products may vary from 0.0001 weight-% to 100 weight-%.
  • a ready-to-drink juice rich in L-quebrachitol and other methyl inositols and/or inositols comprises an extract obtained by further extraction of a residue from CO2 extraction of sea buckthorn berries.
  • Juice ingredients are fruit juice 99 % by weight from fruits such as orange, lemon, grapefruit, apple, etc. and 1 % by weight spray dried sea buckthorn extract obtained by water/ethanol extraction.
  • a food supplement in capsule or tablet form comprises an extract rich in L- quebrachitol and other methyl inositols and/or inositols obtained by further extraction of a residue from CO2 extraction of sea buckthorn berries.
  • Food supplement ingredients are direct compressible starch 50 weight-%, spray dried sea buckthorn extract 48.5 weight-%, Vitamin C 1 weight-%, and Vitamin E 0.5 weight-%.
  • a food supplement rich in L-quebrachitol and other methyl inositols and/or inositols in capsule or tablet form comprises extracts obtained by further extraction of a residue from CO 2 extraction of cloudberry and sea buckthorn.
  • Food supplement ingredients are direct compressible starch 50 weight-%, spray dried cloudberry extract 45 weight-%, Vitamin C 1 weight-% and other ingredients 4 weight-%.
  • An anti-ageing and soothing emulsion cream composition for facial and throat skin care comprising spray dried extract rich in inositols obtained from further extraction of a residue from CO2 extraction of cloudberry seeds.
  • Cream ingredients are (in weight %): cyclopentasiloxane 6.0 %; steareth-2 4.0 %; steareth-21 2.0 %; octyldodecanol 2.0 %; stearic acid 2.0 %; cetearyl alcohol 1.5 %; peg-30 dipolyhydroxystearate 1.0 %; tocopheryl acetate 1.0 %; spray dried cloudberry seed extract 1 - 5 %; phenoxyethanol 0.80 %; ppg-15 stearyl ether 0.60 %; panthenol 0.50 %; perfume 0.20 %; dimethicone/vinyldimethicon crosspolymer 0.30 %; phospholipids 0.2 %; parabens 0.30 %; magnesium ascorbyl

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Abstract

L'invention porte sur un extrait de baies comprenant au moins 0,01 % en poids, de préférence au moins 1 % en poids de L-québrachiole, à savoir de (-)-2-O-méthyl-L-chiro-inositol. De préférence, l'extrait est obtenu par extraction d'un résidu à partir d'un procédé d'extraction de CO2 à l'aide d'un solvant différent de CO2. L'invention porte également sur l'utilisation de l'extrait pour la fabrication de suppléments alimentaires fonctionnels, de produits cosmétiques, de produits de soin de santé et de produits de soins personnels.
PCT/FI2009/050273 2008-04-11 2009-04-09 Extrait avec une quantité élevée de composants bioactifs, et son utilisation WO2009125071A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP09729615A EP2282750A2 (fr) 2008-04-11 2009-04-09 Extrait avec une quantité élevée de composants bioactifs, et son utilisation

Applications Claiming Priority (2)

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FI20085305A FI20085305A0 (fi) 2008-04-11 2008-04-11 Menetelmä uutteen saamiseksi jossa on korkea määrä bioaktiivisia yhdisteitä, jäännös, jäännöksen käyttö ja uute
FI20085305 2008-04-11

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WO2009125071A2 true WO2009125071A2 (fr) 2009-10-15
WO2009125071A3 WO2009125071A3 (fr) 2009-11-26

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CN102093175A (zh) * 2011-02-15 2011-06-15 华南农业大学 一种从无患子科植物荔枝、龙眼提取白坚木皮醇的方法
EP2567959A1 (fr) 2011-09-12 2013-03-13 Sanofi Dérivés d'amide d'acide 6-(4-Hydroxy-phényl)-3-styryl-1H-pyrazolo[3,4-b]pyridine-4-carboxylique en tant qu'inhibiteurs
KR20130138677A (ko) * 2012-06-11 2013-12-19 (주)아모레퍼시픽 항노화 화장료 조성물
WO2013187622A1 (fr) * 2012-06-11 2013-12-19 주식회사 아모레퍼시픽 Composition cosmétique anti-âge
EP3120712A1 (fr) * 2015-07-22 2017-01-25 Evonik Degussa GmbH Procede d'extraction amelioree de baies de genievre, de cynorhodons, de baies d'argousier et d'alisier
WO2017068234A1 (fr) * 2015-10-22 2017-04-27 Lumene Oy Compositions cosmétiques pour blanchiment de peau
CN108523051A (zh) * 2018-05-03 2018-09-14 太原工业学院 一种利用沙棘制作的高抗氧化活性的保健食品
US10144904B2 (en) 2015-12-04 2018-12-04 Evonik Degussa Gmbh Process for extraction of aroma chemicals from fat-containing and/or aqueous liquid phases
FR3071742A1 (fr) * 2017-10-03 2019-04-05 Basf Beauty Care Solutions France Sas Procede d'utilisation d'un inhibiteur de let-7b en cosmetique et/ou en nutraceutique
EP3566751A1 (fr) 2012-02-21 2019-11-13 Lumene Oy Compositions cosmétiques contenant une préparation de culture cellulaire de mûres arctiques
FR3097127A1 (fr) * 2017-10-03 2020-12-18 Basf Beauty Care Solutions France Sas Procédé d’utilisation d’un inhibiteur de Let-7b en cosmétique et/ou en nutraceutique
WO2020256625A1 (fr) * 2019-06-20 2020-12-24 Nutragreen - Technical & Research Solutions Procédé d'extraction d'une matière première pour produire une formulation riche en substances phytochimiques
IT201900019325A1 (it) * 2019-10-18 2021-04-18 Ghs Gemelli Health System S R L Miscela comprendente estratti di frutti, e polifenoli estratti da foglie o frutti di Olea Europaea L. e inulina e uso di tale composizione nel trattamento di malattie infiammatorie acute e croniche, localizzate o sistemiche, o conseguenti ad un’ischemia o a un’alterazione della funzionalità dell’endotelio vasale
EP3936111A1 (fr) * 2020-07-03 2022-01-12 Lumene Oy Utilisation de fragments de baies dans des compositions cosmétiques
FR3117372A1 (fr) 2020-12-15 2022-06-17 Basf Beauty Care Solutions France Sas Utilisations cosmétiques d’un hydrolysat de tourteau d’Hippophae rhamnoides
CN115232852A (zh) * 2022-09-07 2022-10-25 青海伊纳维康生物科技有限公司 一种具有ace抑制活性的沙棘低聚肽的制备方法

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CN102093175A (zh) * 2011-02-15 2011-06-15 华南农业大学 一种从无患子科植物荔枝、龙眼提取白坚木皮醇的方法
EP2567959A1 (fr) 2011-09-12 2013-03-13 Sanofi Dérivés d'amide d'acide 6-(4-Hydroxy-phényl)-3-styryl-1H-pyrazolo[3,4-b]pyridine-4-carboxylique en tant qu'inhibiteurs
EP3566751A1 (fr) 2012-02-21 2019-11-13 Lumene Oy Compositions cosmétiques contenant une préparation de culture cellulaire de mûres arctiques
KR20130138677A (ko) * 2012-06-11 2013-12-19 (주)아모레퍼시픽 항노화 화장료 조성물
WO2013187622A1 (fr) * 2012-06-11 2013-12-19 주식회사 아모레퍼시픽 Composition cosmétique anti-âge
CN104394839A (zh) * 2012-06-11 2015-03-04 株式会社爱茉莉太平洋 抗老化化妆品组合物
KR102101810B1 (ko) * 2012-06-11 2020-04-20 (주)아모레퍼시픽 항노화 화장료 조성물
EP3120712A1 (fr) * 2015-07-22 2017-01-25 Evonik Degussa GmbH Procede d'extraction amelioree de baies de genievre, de cynorhodons, de baies d'argousier et d'alisier
WO2017068234A1 (fr) * 2015-10-22 2017-04-27 Lumene Oy Compositions cosmétiques pour blanchiment de peau
US10144904B2 (en) 2015-12-04 2018-12-04 Evonik Degussa Gmbh Process for extraction of aroma chemicals from fat-containing and/or aqueous liquid phases
WO2019069007A1 (fr) * 2017-10-03 2019-04-11 Basf Beauty Care Solutions France Sas Procédé d'utilisation d'un inhibiteur de let-7b en cosmétique et/ou en nutraceutique
FR3071742A1 (fr) * 2017-10-03 2019-04-05 Basf Beauty Care Solutions France Sas Procede d'utilisation d'un inhibiteur de let-7b en cosmetique et/ou en nutraceutique
CN111148506A (zh) * 2017-10-03 2020-05-12 巴斯夫美容护理法国公司 在化妆品和/或营养保健品中使用Let-7b抑制剂的方法
FR3097127A1 (fr) * 2017-10-03 2020-12-18 Basf Beauty Care Solutions France Sas Procédé d’utilisation d’un inhibiteur de Let-7b en cosmétique et/ou en nutraceutique
CN108523051A (zh) * 2018-05-03 2018-09-14 太原工业学院 一种利用沙棘制作的高抗氧化活性的保健食品
WO2020256625A1 (fr) * 2019-06-20 2020-12-24 Nutragreen - Technical & Research Solutions Procédé d'extraction d'une matière première pour produire une formulation riche en substances phytochimiques
IT201900019325A1 (it) * 2019-10-18 2021-04-18 Ghs Gemelli Health System S R L Miscela comprendente estratti di frutti, e polifenoli estratti da foglie o frutti di Olea Europaea L. e inulina e uso di tale composizione nel trattamento di malattie infiammatorie acute e croniche, localizzate o sistemiche, o conseguenti ad un’ischemia o a un’alterazione della funzionalità dell’endotelio vasale
EP3936111A1 (fr) * 2020-07-03 2022-01-12 Lumene Oy Utilisation de fragments de baies dans des compositions cosmétiques
FR3117372A1 (fr) 2020-12-15 2022-06-17 Basf Beauty Care Solutions France Sas Utilisations cosmétiques d’un hydrolysat de tourteau d’Hippophae rhamnoides
WO2022129750A1 (fr) 2020-12-15 2022-06-23 Basf Beauty Care Solutions France Sas Utilisations cosmétiques d'un hydrolysat de tourteau d'Hippophae rhamnoides
CN115232852A (zh) * 2022-09-07 2022-10-25 青海伊纳维康生物科技有限公司 一种具有ace抑制活性的沙棘低聚肽的制备方法

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