WO2009054439A1 - Pai-1産生抑制剤 - Google Patents

Pai-1産生抑制剤 Download PDF

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Publication number
WO2009054439A1
WO2009054439A1 PCT/JP2008/069207 JP2008069207W WO2009054439A1 WO 2009054439 A1 WO2009054439 A1 WO 2009054439A1 JP 2008069207 W JP2008069207 W JP 2008069207W WO 2009054439 A1 WO2009054439 A1 WO 2009054439A1
Authority
WO
WIPO (PCT)
Prior art keywords
pai
group
production inhibitor
benzene ring
alkyl group
Prior art date
Application number
PCT/JP2008/069207
Other languages
English (en)
French (fr)
Inventor
Susumu Muto
Akiko Itai
Original Assignee
Institute Of Medicinal Molecular Design, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institute Of Medicinal Molecular Design, Inc. filed Critical Institute Of Medicinal Molecular Design, Inc.
Priority to BRPI0816560-2A priority Critical patent/BRPI0816560A2/pt
Priority to JP2009538246A priority patent/JP5470046B2/ja
Priority to CA2703494A priority patent/CA2703494A1/en
Priority to EP08842108A priority patent/EP2201946A4/en
Priority to CN2008801133696A priority patent/CN101842093B/zh
Priority to AU2008314979A priority patent/AU2008314979A1/en
Publication of WO2009054439A1 publication Critical patent/WO2009054439A1/ja

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Vascular Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

　下記の一般式(I)で表される化合物は、PAI-1産生抑制作用を有する。 【化１】 （式中、R1は例えば水素原子、4-(モルホルニル)カルボニル基などを表し、環Dは例えばベンゼン環又は置換基を有するベンゼン環を表し、フェニル基Eは例えばハロゲン原子、ハロゲン化アルキル基、アルキル基、ハロゲン化アルコキシ基、アルコキシ基などの置換基を有する。）
PCT/JP2008/069207 2007-10-23 2008-10-23 Pai-1産生抑制剤 WO2009054439A1 (ja)

Priority Applications (6)

Application Number Priority Date Filing Date Title
BRPI0816560-2A BRPI0816560A2 (pt) 2007-10-23 2008-10-23 Método de inibição de produção de pai-1 método para prevenção ou melhora de uma doença causada por uma super-produção de pai-1"
JP2009538246A JP5470046B2 (ja) 2007-10-23 2008-10-23 Ｐａｉ−１産生抑制剤
CA2703494A CA2703494A1 (en) 2007-10-23 2008-10-23 Inhibitor of pai-1 production
EP08842108A EP2201946A4 (en) 2007-10-23 2008-10-23 HAMMER OF PAI-1 PRODUCTION
CN2008801133696A CN101842093B (zh) 2007-10-23 2008-10-23 Pai-1产生抑制剂
AU2008314979A AU2008314979A1 (en) 2007-10-23 2008-10-23 Inhibitor of PAI-1 production

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007275557 2007-10-23
JP2007-275557 2007-10-23

Publications (1)

Publication Number Publication Date
WO2009054439A1 true WO2009054439A1 (ja) 2009-04-30

Family

ID=40579541

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/069207 WO2009054439A1 (ja) 2007-10-23 2008-10-23 Pai-1産生抑制剤

Country Status (9)

Country Link
EP (1) EP2201946A4 (ja)
JP (1) JP5470046B2 (ja)
KR (1) KR20100097113A (ja)
CN (2) CN101842093B (ja)
AU (1) AU2008314979A1 (ja)
BR (1) BRPI0816560A2 (ja)
CA (1) CA2703494A1 (ja)
RU (1) RU2010120675A (ja)
WO (1) WO2009054439A1 (ja)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013501737A (ja) * 2009-08-14 2013-01-17 バイエル・クロップサイエンス・アーゲー 殺虫性カルボキサミド類
CN107207417A (zh) * 2014-11-13 2017-09-26 埃罗米克斯公司 新方法
US9827253B2 (en) 2013-11-06 2017-11-28 Aeromics, Inc. Prodrug salts
US9994514B2 (en) 2012-05-08 2018-06-12 Aeromics, Inc. Methods of treating cerebral edema and spinal cord edema

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US11400142B2 (en) 2015-12-18 2022-08-02 Talengen International Limited Treatment of diabetic nerve injury comprising administering plasminogen
DK3391902T3 (da) 2015-12-18 2023-11-20 Talengen Int Ltd Plasminogen til anvendelse i behandlingen af diabetisk angiokardiopati
CN108463240A (zh) 2015-12-18 2018-08-28 泰伦基国际有限公司 一种预防或治疗糖尿病性视网膜病变的方法
EP3395354B1 (en) 2015-12-18 2024-05-22 Talengen International Limited Plasminogen for use in treating diabetic nephropathy
TW201829448A (zh) 2016-12-15 2018-08-16 大陸商深圳瑞健生命科學硏究院有限公司 纖溶酶原在製備預防或治療肥胖症及疾病倂發的肥胖的藥物中的用途
CN108210895A (zh) * 2016-12-15 2018-06-29 深圳瑞健生命科学研究院有限公司 预防动脉粥样硬化及其并发症的药物及其用途
TWI684459B (zh) 2016-12-15 2020-02-11 大陸商深圳瑞健生命科學研究院有限公司 一種治療動脈粥樣硬化及其併發症的方法
EP3556384B1 (en) 2016-12-15 2024-04-10 Talengen International Limited Plasminogen for use in treating diabetes
CN115504940A (zh) * 2021-06-23 2022-12-23 中国科学院上海药物研究所 一种酰胺类化合物、其制备方法和制药用途
CN113519544A (zh) * 2021-08-27 2021-10-22 皖南医学院 一种植物源杀螨剂及其制备方法和应用

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Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013501737A (ja) * 2009-08-14 2013-01-17 バイエル・クロップサイエンス・アーゲー 殺虫性カルボキサミド類
US9227923B2 (en) 2009-08-14 2016-01-05 Bayer Intellectual Property Gmbh Pesticidal carboxamides
US9994514B2 (en) 2012-05-08 2018-06-12 Aeromics, Inc. Methods of treating cerebral edema and spinal cord edema
US11084778B2 (en) 2012-05-08 2021-08-10 Aeromics, Inc. Methods of treating cardiac edema, neuromyelitis optica, and hyponatremia
US11873266B2 (en) 2012-05-08 2024-01-16 Aeromics, Inc. Methods of treating or controlling cytotoxic cerebral edema consequent to an ischemic stroke
US9827253B2 (en) 2013-11-06 2017-11-28 Aeromics, Inc. Prodrug salts
US10258636B2 (en) 2013-11-06 2019-04-16 Aeromics, Inc. Prodrug salts
US10894055B2 (en) 2013-11-06 2021-01-19 Aeromics, Inc. Pharmaceutical compositions, methods of making pharmaceutical compositions, and kits comprising 2-{[3,5-bis(trifluoromethyl)phenyl]carbamoyl}4-chlorophenyl dihydrogen phosphate
US11071744B2 (en) 2013-11-06 2021-07-27 Aeromics, Inc. Prodrug salts
US11801254B2 (en) 2013-11-06 2023-10-31 Aeromics, Inc. Pharmaceutical compositions and methods of making pharmaceutical compositions comprising 2-{[3,5-bis(trifluoromethyl)phenyl]carbamoyl}-4-chlorophenyl dihydrogen phosphate
CN107207417A (zh) * 2014-11-13 2017-09-26 埃罗米克斯公司 新方法

Also Published As

Publication number Publication date
KR20100097113A (ko) 2010-09-02
RU2010120675A (ru) 2011-11-27
AU2008314979A1 (en) 2009-04-30
JP5470046B2 (ja) 2014-04-16
EP2201946A4 (en) 2012-01-25
EP2201946A1 (en) 2010-06-30
CN101842093B (zh) 2012-08-22
BRPI0816560A2 (pt) 2015-09-01
CA2703494A1 (en) 2009-04-30
JPWO2009054439A1 (ja) 2011-03-03
CN101842093A (zh) 2010-09-22
CN102872020A (zh) 2013-01-16

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