DK3391902T3 - Plasminogen til anvendelse i behandlingen af diabetisk angiokardiopati - Google Patents
Plasminogen til anvendelse i behandlingen af diabetisk angiokardiopati Download PDFInfo
- Publication number
- DK3391902T3 DK3391902T3 DK16874928.1T DK16874928T DK3391902T3 DK 3391902 T3 DK3391902 T3 DK 3391902T3 DK 16874928 T DK16874928 T DK 16874928T DK 3391902 T3 DK3391902 T3 DK 3391902T3
- Authority
- DK
- Denmark
- Prior art keywords
- angiocardiopathy
- plasminogen
- diabetic
- treatment
- diabetic angiocardiopathy
- Prior art date
Links
- 102000013566 Plasminogen Human genes 0.000 title 1
- 108010051456 Plasminogen Proteins 0.000 title 1
- 206010012601 diabetes mellitus Diseases 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/484—Plasmin (3.4.21.7)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2015097947 | 2015-12-18 | ||
PCT/CN2016/110453 WO2017101871A1 (zh) | 2015-12-18 | 2016-12-16 | 一种预防和治疗心血管病的新方法 |
Publications (1)
Publication Number | Publication Date |
---|---|
DK3391902T3 true DK3391902T3 (da) | 2023-11-20 |
Family
ID=59055774
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK16874928.1T DK3391902T3 (da) | 2015-12-18 | 2016-12-16 | Plasminogen til anvendelse i behandlingen af diabetisk angiokardiopati |
Country Status (9)
Country | Link |
---|---|
US (1) | US11338022B2 (da) |
EP (1) | EP3391902B1 (da) |
JP (2) | JP6783870B2 (da) |
CN (1) | CN108778320A (da) |
CA (1) | CA3008186A1 (da) |
DK (1) | DK3391902T3 (da) |
ES (1) | ES2961967T3 (da) |
TW (1) | TWI624268B (da) |
WO (1) | WO2017101871A1 (da) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108463235A (zh) | 2015-12-18 | 2018-08-28 | 泰伦基国际有限公司 | 一种用于预防和治疗***的方法 |
CA3008466C (en) | 2015-12-18 | 2023-06-20 | Talengen International Limited | Method for preventing or treating radiation and chemical damage |
WO2018107694A1 (zh) | 2016-12-15 | 2018-06-21 | 深圳瑞健生命科学研究院有限公司 | 一种预防和治疗皮肤纤维化的方法 |
WO2018107686A1 (zh) * | 2016-12-15 | 2018-06-21 | 深圳瑞健生命科学研究院有限公司 | 一种治疗动脉粥样硬化及其并发症的方法 |
US11389515B2 (en) | 2016-12-15 | 2022-07-19 | Talengen International Limited | Method for mitigating heart disease |
EP3556379A4 (en) | 2016-12-15 | 2020-08-19 | Talengen International Limited | METHOD AND DRUG FOR THE PREVENTION AND TREATMENT OF OBESITY |
CA3067890A1 (en) * | 2017-06-19 | 2018-12-27 | Talengen International Limited | Method for regulating and controling glp-1/glp-1r and drug |
CN115551534A (zh) * | 2020-02-26 | 2022-12-30 | 泰伦基国际有限公司 | 一种预防和治疗血压异常病症的方法和药物 |
JP2023525257A (ja) * | 2020-05-11 | 2023-06-15 | タレンゲン インターナショナル リミテッド | 脊髄性筋萎縮症を治療する方法及び薬剤 |
Family Cites Families (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
IE52535B1 (en) | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
GB8721951D0 (en) * | 1987-09-18 | 1987-10-28 | Thrombosis Research Trust | Organic compounds |
JP2764264B2 (ja) * | 1987-10-01 | 1998-06-11 | 株式会社ミドリ十字 | 線溶活性増強剤 |
WO1994001128A1 (en) | 1992-07-01 | 1994-01-20 | Beth Israel Hospital Boston | Enhancement of thrombolytic therapy with deglycosylated plasminogen |
DK125693D0 (da) * | 1993-11-05 | 1993-11-05 | Novo Nordisk As | |
DE4411143C2 (de) * | 1994-03-30 | 1996-08-01 | Immuno Ag | Thrombosemittel |
EP1001985A1 (en) | 1997-06-26 | 2000-05-24 | Karolinska Innovations AB | Kringle domains 1-5 of plasminogen, capable of modulating angiogenesis in vivo |
DK1117437T3 (da) | 1998-09-29 | 2007-04-10 | Leuven Res & Dev Vzw | Anvendelse af forbindelser, der reducerer alfa2-antiplasmin in vivo, til fremstilling af en sammensætning til behandling af iskæmiske slagtilfælde |
US6899877B2 (en) * | 1999-03-09 | 2005-05-31 | Minu, L.L.C. | Process for generating plasmin in the vitreous of the eye and inducing separation of the posterior hyaloid from the retina |
EP1227833A1 (en) | 1999-10-07 | 2002-08-07 | Human Genome Sciences, Inc. | Plasminogen-like polynucleotides, polypeptides, and antibodies |
US6964764B2 (en) * | 1999-11-13 | 2005-11-15 | Talecris Biotherapeutics, Inc. | Method of thrombolysis by local delivery of reversibly inactivated acidified plasmin |
US20020159992A1 (en) * | 2000-09-29 | 2002-10-31 | Jack Henkin | Antiangiogenic polypeptides and methods for inhibiting angiogenesis |
US7067492B2 (en) | 2001-09-06 | 2006-06-27 | Omnio Ab | Method of promoting healing of a tympanic membrane perforation |
US7202066B2 (en) | 2002-01-29 | 2007-04-10 | Carrington Laboratories, Inc. | Combination of a growth factor and a protease enzyme |
MXPA04007585A (es) | 2002-02-06 | 2005-09-20 | N Zyme Biotec Gmbh | Metodo para la produccion de proteinas recombinantes en microorganismos. |
JP4740531B2 (ja) | 2003-09-30 | 2011-08-03 | 雪印乳業株式会社 | 骨吸収抑制剤 |
US20050250694A1 (en) | 2003-10-10 | 2005-11-10 | Ma Jian-Xing | Compounds useful in inhibiting vascular leakage, inflammation and fibrosis and methods of making and using same |
US20060257391A1 (en) * | 2005-05-11 | 2006-11-16 | Bausch & Lomb Incorporated | Non-surgical method for preventing or reducing the rate of the progression of non-proliferative diabetic retinopathy and the treatment of other ocular conditions |
CN101002888A (zh) | 2006-01-16 | 2007-07-25 | 陈维森 | 复方糖尿康 |
US20070196350A1 (en) | 2006-02-22 | 2007-08-23 | Bartels Stephen P | Compositions and Methods for Effecting Controlled Posterior Vitreous Detachment |
JP5566106B2 (ja) | 2006-08-28 | 2014-08-06 | オムニオ・ヒーラー・アクチボラゲット | 歯周病の阻止および治療、歯周創傷の治癒の改善および口腔衛生の促進を目的とする新規薬物 |
JP5566105B2 (ja) | 2006-08-28 | 2014-08-06 | オムニオ・ヒーラー・アクチボラゲット | 感染症に対する候補薬 |
CA2703494A1 (en) | 2007-10-23 | 2009-04-30 | Institute Of Medicinal Molecular Design, Inc. | Inhibitor of pai-1 production |
JP5539896B2 (ja) | 2007-11-29 | 2014-07-02 | グリフオルス・セラピユーテイクス・インコーポレーテツド | 組換え的に改変されたプラスミン |
US20090208448A1 (en) | 2008-02-15 | 2009-08-20 | Solomon Keith R | Inhibition of angiogenesis |
EP2424561A2 (en) * | 2009-04-30 | 2012-03-07 | Catherine Blondel | Methods for treating ocular conditions |
MX2012000475A (es) | 2009-07-10 | 2012-03-26 | Thrombogenics Nv | Variantes de plasminogeno y plasmina. |
CN102121023B (zh) | 2010-12-22 | 2012-07-04 | 中山大学 | 突变型人纤溶酶原kringle5及其制备方法及应用 |
WO2012093132A1 (en) | 2011-01-05 | 2012-07-12 | Thrombogenics Nv | Plasminogen and plasmin variants |
CN102154253A (zh) | 2011-01-06 | 2011-08-17 | 郑州大学 | 具有抑制血小板凝集功能的微小纤溶酶原突变体及其制备方法和用途 |
US9644196B2 (en) | 2011-08-12 | 2017-05-09 | Thrombogenics Nv | Plasminogen and plasmin variants |
HUE053325T2 (hu) | 2012-10-31 | 2021-06-28 | Univ Michigan Regents | Plazminogén aktivátor-1 gátlók és ezek alkalmazási eljárásai |
TWI592426B (zh) | 2013-08-13 | 2017-07-21 | 賽諾菲公司 | 胞漿素原活化素抑制劑-1(pai-1)之抗體及其用途 |
KR20160035077A (ko) | 2013-08-13 | 2016-03-30 | 사노피 | 플라스미노겐 활성인자 저해제-1(pai-1)에 대한 항체 및 그의 용도 |
CN104789544B (zh) | 2014-01-16 | 2019-11-26 | 中国科学院福建物质结构研究所 | 重组pai-1抑制剂、包含其的组合物及其用于治疗和检测用途 |
RU2711989C2 (ru) | 2014-12-19 | 2020-01-23 | Прометик Байо Терапьютикс, Инк. | Фармацевтическая композиция, содержащая плазминоген, и ее применение |
TWI801331B (zh) * | 2015-11-03 | 2023-05-11 | 美商波麥堤克生物治療股份有限公司 | 纖維蛋白溶酶原缺乏症之纖維蛋白溶酶原替代療法 |
CA3008185C (en) | 2015-12-18 | 2024-01-16 | Talengen International Limited | Method for prevention or treatment of acute and chronic thrombosis |
WO2017101870A1 (zh) | 2015-12-18 | 2017-06-22 | 深圳瑞健生命科学研究院有限公司 | 一种预防或治疗糖尿病性视网膜病变的方法 |
WO2018107686A1 (zh) * | 2016-12-15 | 2018-06-21 | 深圳瑞健生命科学研究院有限公司 | 一种治疗动脉粥样硬化及其并发症的方法 |
TWI763680B (zh) | 2016-12-15 | 2022-05-11 | 大陸商深圳瑞健生命科學硏究院有限公司 | 纖溶酶原在製備藥物中的用途 |
-
2016
- 2016-12-16 CA CA3008186A patent/CA3008186A1/en active Pending
- 2016-12-16 CN CN201680073583.8A patent/CN108778320A/zh active Pending
- 2016-12-16 DK DK16874928.1T patent/DK3391902T3/da active
- 2016-12-16 US US16/063,569 patent/US11338022B2/en active Active
- 2016-12-16 ES ES16874928T patent/ES2961967T3/es active Active
- 2016-12-16 EP EP16874928.1A patent/EP3391902B1/en active Active
- 2016-12-16 TW TW105141900A patent/TWI624268B/zh active
- 2016-12-16 WO PCT/CN2016/110453 patent/WO2017101871A1/zh active Application Filing
- 2016-12-16 JP JP2018550638A patent/JP6783870B2/ja active Active
-
2020
- 2020-10-22 JP JP2020177351A patent/JP2021020933A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
TWI624268B (zh) | 2018-05-21 |
TW201722467A (zh) | 2017-07-01 |
JP6783870B2 (ja) | 2020-11-11 |
CA3008186A1 (en) | 2017-06-22 |
EP3391902A4 (en) | 2019-06-12 |
EP3391902B1 (en) | 2023-10-18 |
US11338022B2 (en) | 2022-05-24 |
CN108778320A (zh) | 2018-11-09 |
JP2021020933A (ja) | 2021-02-18 |
JP2019501218A (ja) | 2019-01-17 |
WO2017101871A1 (zh) | 2017-06-22 |
EP3391902A1 (en) | 2018-10-24 |
US20190083586A1 (en) | 2019-03-21 |
ES2961967T3 (es) | 2024-03-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK3785717T3 (da) | Fremgangsmåder til behandling af coronaviridae-infektioner | |
DK3334422T3 (da) | Anvendelse af cannabidiolsyre i behandling af epilepsi | |
DK3119397T3 (da) | Heterocykliske forbindelser til anvendelse i behandling af PI3K-gamma-medierede lidelser | |
DK3191144T3 (da) | Medicinsk forbinding | |
DK3134530T3 (da) | Behandling af hyperbilirubinæmi | |
DK3391902T3 (da) | Plasminogen til anvendelse i behandlingen af diabetisk angiokardiopati | |
DK3481846T3 (da) | 11-substituerede 24-hydroxysteroler til anvendelse til behandling af nmda-relaterede tilstande | |
DK3778595T3 (da) | Pancreatitisbehandling | |
DK3197472T3 (da) | Rekombinante phe-frie proteiner til anvendelse i behandlingen af phenylketonuri | |
DK3811943T3 (da) | Forbindelse til anvendelse til behandling af øjenlidelser | |
DK3362066T3 (da) | Kombinationsterapi til behandling af maligniteter | |
DK3307296T3 (da) | Timp2 til anvendelse til behandling af aldringsassocierede tilstande | |
DK3395353T3 (da) | Plasminogen til anvendelse til behandling eller forebyggelse af diabetes-mellitus-nerveskade | |
DK3882250T3 (da) | Tetrahydropyranyl-amino-pyrrolopyrimidinon til anvendelse i behandling af btk-medierede forstyrrelser | |
DK3240612T3 (da) | Fremgangsmåder til behandling af nethindesygdomme | |
DK3474802T3 (da) | Medicinsk forbinding | |
DK3524255T3 (da) | Sammensætning til behandling af acne | |
DK3265087T3 (da) | Fremgangsmåde til behandling med tradipitant | |
DK3456330T3 (da) | Cortexolon-17alpha-valerat til anvendelse ved behandling af tumorer | |
DK3374497T3 (da) | Modificerede makrofager til anvendelse i behandlingen af kræft | |
DK3204038T3 (da) | Sammensætninger omfattende amylase til anvendelse i behandlingen af pruritus | |
DK3242947T3 (da) | Genterapi og elektroporese til behandling af maligniteter | |
DK3373874T3 (da) | Medicinsk forbinding | |
DK3302519T3 (da) | Ornithodoros-moubata-komplement-inhibitor til anvendelse i behandlingen af akut graft-versus-host-sygdom | |
DK2994157T3 (da) | Tafa4-forbindelser og anvendelser deraf til behandling af smerte |