WO2009054423A1 - オキサジアゾリジンジオン化合物 - Google Patents

オキサジアゾリジンジオン化合物 Download PDF

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Publication number
WO2009054423A1
WO2009054423A1 PCT/JP2008/069164 JP2008069164W WO2009054423A1 WO 2009054423 A1 WO2009054423 A1 WO 2009054423A1 JP 2008069164 W JP2008069164 W JP 2008069164W WO 2009054423 A1 WO2009054423 A1 WO 2009054423A1
Authority
WO
WIPO (PCT)
Prior art keywords
compound
oxadiazolidinedione
insulin secretion
activity
agonistic activity
Prior art date
Application number
PCT/JP2008/069164
Other languages
English (en)
French (fr)
Inventor
Kenji Negoro
Fumiyoshi Iwasaki
Kei Ohnuki
Toshio Kurosaki
Kazuyuki Tsuchiya
Kazuyuki Kuramoto
Shigeru Yoshida
Takatoshi Soga
Original Assignee
Astellas Pharma Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Inc. filed Critical Astellas Pharma Inc.
Priority to US12/739,501 priority Critical patent/US20100267775A1/en
Priority to EP08842584A priority patent/EP2216330A4/en
Priority to JP2009538239A priority patent/JPWO2009054423A1/ja
Priority to MX2010004503A priority patent/MX2010004503A/es
Priority to NZ584811A priority patent/NZ584811A/en
Priority to CN200880113158A priority patent/CN101835763A/zh
Priority to AU2008314963A priority patent/AU2008314963A1/en
Priority to CA2703793A priority patent/CA2703793A1/en
Publication of WO2009054423A1 publication Critical patent/WO2009054423A1/ja
Priority to IL205066A priority patent/IL205066A0/en
Priority to ZA2010/02605A priority patent/ZA201002605B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • C07D271/07—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

【課題】GPR40受容体アゴニスト作用を有する医薬、特にインスリン分泌促進剤、糖尿病の予防及び／又は治療剤として有用な化合物を提供する。 【解決手段】本発明者らは、GPR40受容体アゴニスト作用を有する化合物について検討し、オキサジアゾリジンジオン環の2位に、リンカーを介してフェニル基等の置換基と結合しているベンジル基等の置換基を有することを特徴とするオキサジアゾリジンジオン化合物またはその製薬学的に許容される塩が優れたGPR40アゴニスト活性を有することを確認し、本発明を完成した。本発明のオキサジアゾリジンジオン化合物は優れたインスリン分泌促進作用、血糖上昇抑制作用を有し、インスリン分泌促進剤若しくは糖尿病の予防及び／又は治療剤として使用しうる。
PCT/JP2008/069164 2007-10-24 2008-10-22 オキサジアゾリジンジオン化合物 WO2009054423A1 (ja)

Priority Applications (10)

Application Number Priority Date Filing Date Title
US12/739,501 US20100267775A1 (en) 2007-10-24 2008-10-22 Oxadiazolidinedione compound
EP08842584A EP2216330A4 (en) 2007-10-24 2008-10-22 OXADIAZOLIDINEDIONE COMPOUND
JP2009538239A JPWO2009054423A1 (ja) 2007-10-24 2008-10-22 オキサジアゾリジンジオン化合物
MX2010004503A MX2010004503A (es) 2007-10-24 2008-10-22 Compuesto de oxadiazolidinediona.
NZ584811A NZ584811A (en) 2007-10-24 2008-10-22 Oxadiazolidinedione compound
CN200880113158A CN101835763A (zh) 2007-10-24 2008-10-22 *二唑烷二酮化合物
AU2008314963A AU2008314963A1 (en) 2007-10-24 2008-10-22 Oxadiazolidinedione compound
CA2703793A CA2703793A1 (en) 2007-10-24 2008-10-22 Oxadiazolidinedione compound
IL205066A IL205066A0 (en) 2007-10-24 2010-04-14 Oxadiazolidinedione compound
ZA2010/02605A ZA201002605B (en) 2007-10-24 2010-04-14 Oxadiazolidinedione compound

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007275840 2007-10-24
JP2007-275840 2007-10-24

Publications (1)

Publication Number Publication Date
WO2009054423A1 true WO2009054423A1 (ja) 2009-04-30

Family

ID=40579527

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/069164 WO2009054423A1 (ja) 2007-10-24 2008-10-22 オキサジアゾリジンジオン化合物

Country Status (16)

Country Link
US (1) US20100267775A1 (ja)
EP (1) EP2216330A4 (ja)
JP (1) JPWO2009054423A1 (ja)
KR (1) KR20100075539A (ja)
CN (1) CN101835763A (ja)
AR (1) AR069041A1 (ja)
AU (1) AU2008314963A1 (ja)
CA (1) CA2703793A1 (ja)
IL (1) IL205066A0 (ja)
MX (1) MX2010004503A (ja)
NZ (1) NZ584811A (ja)
RU (1) RU2010120681A (ja)
SA (1) SA08290669B1 (ja)
TW (1) TW200932219A (ja)
WO (1) WO2009054423A1 (ja)
ZA (1) ZA201002605B (ja)

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010143733A1 (en) 2009-06-09 2010-12-16 Takeda Pharmaceutical Company Limited Novel fused cyclic compound and use thereof
WO2011052756A1 (ja) 2009-10-30 2011-05-05 持田製薬株式会社 新規３－ヒドロキシ－５－アリールイソキサゾール誘導体
WO2011078371A1 (ja) 2009-12-25 2011-06-30 持田製薬株式会社 新規３－ヒドロキシ－５－アリールイソチアゾール誘導体
WO2012046869A1 (ja) 2010-10-08 2012-04-12 持田製薬株式会社 環状アミド誘導体
WO2012147518A1 (ja) 2011-04-27 2012-11-01 持田製薬株式会社 新規３－ヒドロキシイソチアゾール １－オキシド誘導体
WO2012147516A1 (ja) 2011-04-28 2012-11-01 持田製薬株式会社 環状アミド誘導体
WO2014011926A1 (en) 2012-07-11 2014-01-16 Elcelyx Therapeutics, Inc. Compositions comprising statins, biguanides and further agents for reducing cardiometabolic risk
WO2015097713A1 (en) 2013-11-14 2015-07-02 Cadila Healthcare Limited Novel heterocyclic compounds
US9872852B2 (en) 2013-09-04 2018-01-23 Bristol-Myers Squibb Company Compounds useful as immunomodulators
US9957219B2 (en) 2013-12-04 2018-05-01 Merck Sharp & Dohme Corp. Antidiabetic bicyclic compounds
US10059667B2 (en) 2014-02-06 2018-08-28 Merck Sharp & Dohme Corp. Antidiabetic compounds
US11279702B2 (en) 2020-05-19 2022-03-22 Kallyope, Inc. AMPK activators
US11407768B2 (en) 2020-06-26 2022-08-09 Kallyope, Inc. AMPK activators
US11512065B2 (en) 2019-10-07 2022-11-29 Kallyope, Inc. GPR119 agonists

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ES2928164T3 (es) 2015-10-19 2022-11-15 Incyte Corp Compuestos heterocíclicos como inmunomoduladores
AU2016358100B2 (en) 2015-11-19 2021-05-27 Incyte Corporation Heterocyclic compounds as immunomodulators
KR20180100585A (ko) 2015-12-22 2018-09-11 인사이트 코포레이션 면역조절제로서의 헤테로사이클릭 화합물
TW201808950A (zh) 2016-05-06 2018-03-16 英塞特公司 作為免疫調節劑之雜環化合物
EP3464279B1 (en) 2016-05-26 2021-11-24 Incyte Corporation Heterocyclic compounds as immunomodulators
LT3472167T (lt) 2016-06-20 2022-11-10 Incyte Corporation Heterocikliniai junginiai kaip imunomoduliatoriai
US20180016260A1 (en) 2016-07-14 2018-01-18 Incyte Corporation Heterocyclic compounds as immunomodulators
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US10144706B2 (en) * 2016-09-01 2018-12-04 Bristol-Myers Squibb Company Compounds useful as immunomodulators
WO2018119266A1 (en) 2016-12-22 2018-06-28 Incyte Corporation Benzooxazole derivatives as immunomodulators
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HUE060233T2 (hu) 2016-12-22 2023-02-28 Incyte Corp Tetrahidro imidazo[4,5-c]piridin-származékok mint a PD-L1 internalizációját indukáló szerek
CN108003074B (zh) * 2017-12-21 2019-07-05 四川大学华西医院 联苯羧酸类化合物及其制备方法和用途
KR20200118005A (ko) * 2018-02-05 2020-10-14 위니베르시떼 드 스트라스부르 통증 치료용 화합물 및 조성물
MD3774791T2 (ro) 2018-03-30 2023-06-30 Incyte Corp Compuși heterociclici ca imunomodulatori
SI3790877T1 (sl) 2018-05-11 2023-06-30 Incyte Corporation Tetrahidro-imidazo(4,5-c)piridinski derivati kot imunomodulatorji pd-l1
WO2020104578A2 (en) * 2018-11-21 2020-05-28 University Of Copenhagen Modulators of free fatty acid receptor 1 and their use for treatment of diseases
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Cited By (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010143733A1 (en) 2009-06-09 2010-12-16 Takeda Pharmaceutical Company Limited Novel fused cyclic compound and use thereof
US8455500B2 (en) 2009-10-30 2013-06-04 Mochida Pharmaceutical Co., Ltd. 3-hydroxy-5-arylisoxazole derivative
WO2011052756A1 (ja) 2009-10-30 2011-05-05 持田製薬株式会社 新規３－ヒドロキシ－５－アリールイソキサゾール誘導体
WO2011078371A1 (ja) 2009-12-25 2011-06-30 持田製薬株式会社 新規３－ヒドロキシ－５－アリールイソチアゾール誘導体
US8476287B2 (en) 2009-12-25 2013-07-02 Mochida Pharmaceutical Co., Ltd. 3-hydroxy-5-arylisothiazole derivative
US9040525B2 (en) 2010-10-08 2015-05-26 Mochida Pharmaceutical Co., Ltd. Cyclic amide derivative
WO2012046869A1 (ja) 2010-10-08 2012-04-12 持田製薬株式会社 環状アミド誘導体
WO2012147518A1 (ja) 2011-04-27 2012-11-01 持田製薬株式会社 新規３－ヒドロキシイソチアゾール １－オキシド誘導体
US8557766B2 (en) 2011-04-27 2013-10-15 Mochida Pharmaceutical Co., Ltd. 3-hydroxyisothiazole 1-oxide derivatives
US8629102B2 (en) 2011-04-27 2014-01-14 Mochida Pharmaceutical Co., Ltd. 3-hydroxyisothiazole 1-oxide derivatives
US8765752B2 (en) 2011-04-27 2014-07-01 Mochida Pharmaceutical Co., Ltd. 3-hydroxyisothiazole 1-oxide derivatives
US9072758B2 (en) 2011-04-28 2015-07-07 Mochida Pharmaceutical Co., Ltd. Cyclic amide derivative
WO2012147516A1 (ja) 2011-04-28 2012-11-01 持田製薬株式会社 環状アミド誘導体
WO2014011926A1 (en) 2012-07-11 2014-01-16 Elcelyx Therapeutics, Inc. Compositions comprising statins, biguanides and further agents for reducing cardiometabolic risk
US9872852B2 (en) 2013-09-04 2018-01-23 Bristol-Myers Squibb Company Compounds useful as immunomodulators
WO2015097713A1 (en) 2013-11-14 2015-07-02 Cadila Healthcare Limited Novel heterocyclic compounds
US10011609B2 (en) 2013-11-14 2018-07-03 Cadila Healthcare Limited Heterocyclic compounds
US10246470B2 (en) 2013-11-14 2019-04-02 Cadila Healthcare Limited Heterocyclic compounds
US9957219B2 (en) 2013-12-04 2018-05-01 Merck Sharp & Dohme Corp. Antidiabetic bicyclic compounds
US10059667B2 (en) 2014-02-06 2018-08-28 Merck Sharp & Dohme Corp. Antidiabetic compounds
US11512065B2 (en) 2019-10-07 2022-11-29 Kallyope, Inc. GPR119 agonists
US11279702B2 (en) 2020-05-19 2022-03-22 Kallyope, Inc. AMPK activators
US11851429B2 (en) 2020-05-19 2023-12-26 Kallyope, Inc. AMPK activators
US11407768B2 (en) 2020-06-26 2022-08-09 Kallyope, Inc. AMPK activators

Also Published As

Publication number Publication date
ZA201002605B (en) 2011-06-29
EP2216330A4 (en) 2011-09-14
RU2010120681A (ru) 2011-11-27
CN101835763A (zh) 2010-09-15
NZ584811A (en) 2011-06-30
US20100267775A1 (en) 2010-10-21
JPWO2009054423A1 (ja) 2011-03-03
SA08290669B1 (ar) 2011-07-20
MX2010004503A (es) 2010-07-06
IL205066A0 (en) 2010-11-30
AR069041A1 (es) 2009-12-23
EP2216330A1 (en) 2010-08-11
CA2703793A1 (en) 2009-04-30
AU2008314963A1 (en) 2009-04-30
KR20100075539A (ko) 2010-07-02
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