WO2009006686A1 - Synergistic mixture - Google Patents

Synergistic mixture Download PDF

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Publication number
WO2009006686A1
WO2009006686A1 PCT/AU2008/001003 AU2008001003W WO2009006686A1 WO 2009006686 A1 WO2009006686 A1 WO 2009006686A1 AU 2008001003 W AU2008001003 W AU 2008001003W WO 2009006686 A1 WO2009006686 A1 WO 2009006686A1
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WO
WIPO (PCT)
Prior art keywords
mixture
synergistic mixture
glutathione
vitamin
synergistic
Prior art date
Application number
PCT/AU2008/001003
Other languages
French (fr)
Inventor
Antoinette Foster
Original Assignee
Prosports Nutrition Pty. Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2007903715A external-priority patent/AU2007903715A0/en
Application filed by Prosports Nutrition Pty. Limited filed Critical Prosports Nutrition Pty. Limited
Priority to AU2008274893A priority Critical patent/AU2008274893A1/en
Publication of WO2009006686A1 publication Critical patent/WO2009006686A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/07—Retinol compounds, e.g. vitamin A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/401—Proline; Derivatives thereof, e.g. captopril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/26—Iron; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/30—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/42—Phosphorus; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A61K38/063—Glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Definitions

  • This invention relates to a synergistic mixture and, in particular, to one which can promote the feeling of wellness in the person who takes the mixture and can assist in generally maintaining various bodily functions.
  • the invention includes a synergistic mixture which incorporates one or more of vitamins, amino acids, minerals and herbal preparations.
  • the mixture may include L-Glutathione. Description of an Embodiment of the Invention
  • the vitamins (s) which are used in the mixture can be selected from the group comprising Vitamin A Vitamin E
  • amino acids from a group comprising
  • the preferred amino acid is L-Glutathione which is a tri-peptide, a protein comprised of one amino acid of Glutamic acid, Cysteine and Glycine.
  • Glutathione is found and manufactured in every cell in the body but is found in highest concentrations in the heart muscle tissue and the liver. Glutathione is critical for healthy immune system function. Glutathione helps the body fight almost any disease, because it is a powerful antioxidant that helps maintain cellular health and helps prevent oxidative stress. Glutathione has been heavily researched, and the findings on this substance have been nothing short of amazing.
  • glutathione helps produce, protect and repair deoxyribonucleic acid - DNA. In this protective role, glutathione boosts the immune system, thereby helping to power immune response and preventing the growth of cancerous cells.
  • glutathione levels are correlated with aging and physical function.
  • Boosting glutathione levels has been shown to boost sperm count in infertile men and non-weight training subjects saw increases in muscle mass by supplementing with glutathione, even without weight training.
  • Gluththione is essential for immune system function and muscle growth, and any athlete who is glutathione deficient will suffer from decreased performance and a lack of muscle growth.
  • Vitamins A and E are Vitamins A and E.
  • a further preferred amino acid is L-Proline. This is not an essential amino acid but may be synthesized by the body. It is one of the main components of collagen, the connective tissue structure that binds and supports all other tissues. Pauling 1 points out that there is evidence that vitamin C is required for conversion of prolyl residues or procollagen (the precursor of collagen) into the form that gives collagen its characteristic properties. The use of wound healing , and in the promotion of improved collagen status, as well as in cosmetic improvement of 'ageing 1 tissues has been proposed by researchers in California.
  • Hydroxyproline which the body incorporates into collagen, is readily transformed by the body from proline; it is incorporated into the structure of tendons and ligaments.
  • Proline is one of the aromatic amino acids such as phenylalanine and tryptophan. Supplementation would seem to be indicated in cases of persistent soft tissues strains; hypermobile joints; soft tissue healing requirement, and in lax and 'sagging' tissues associated with ageing. Combined with Vitamin C supplementation is more effective.
  • Pfeiffer states clearly that the protein collagen is neither properly formed, not maintained, if vitamin C is lacking.
  • Vitamin A is part of a larger team of antioxidant nutrients known as the carotenoids, which are the yellow and orange pigments found in fruits and vegetables. Since beta carotene converts in the body into vitamin A 1 it is often referred to a pro-vitamin A. However, being a tremendous immune system booster and a powerful antioxidant, beta-carotene provides many additional benefits. The antioxidant effect plays a very important role in the prevention of heart disease. A study of 333 patients who took 50 mg of beta-carotene showed that the nutrient reduced major cardiovascular events by 50% in comparison with people who did not take the supplement. Beta-carotene was also found to have a protective effect in angina patients, who experienced far less chest pain on diets that were high in natural beta-carotene. Beta carotene is also known .to increase the level of protective HDL cholesterol.
  • Vitamin E is a generic term for a group of related compounds called tocopherols occurring in four forms of which 'alpha' is the most potent. Found in only a few foods that are typically high in fat, supplementation becomes important especially in low fat diets.
  • One of the vitamins basic functions is to protect cell membranes and help the body to use selenium and vitamin K.
  • the staggering superiority of vitamin E therapy over the most concerted drug efforts was most convincingly demonstrated by conventional medicine, based on the findings of two Harvard studies : one of 40,000 male doctors, the other with more than 100,000 female nurses. The more vitamin E consumed, the lower the rate of cardiovascular disease.
  • vitamin E increases the amount of the artery-cleansing HDL cholesterol and works to eliminate triglycerides (another dangerous blood fat). It lowers insulin and spares the heart from damage caused by a magnesium deficiency or a lack of oxygen, thus improving the biochemical changes caused by stress in patients suffering congestive heart failure.
  • a preferred herb is Calendula Officinalis, which is a well known skin herb, is a main nutrient of the mixture.
  • the mixtures of the invention have a very powerful synergistic detoxifying effect on the body generally.
  • the glutathione help protect the body from oxidative stress and as oxidative stress is associated with aging it is believed that the mixture will have a general benefit both immediately and in the future.
  • a preferred particular specific formulation of the product is:

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A synergistic mixture and, in particular, one which can promote the feel ing of wellness in the person who takes the mixture and can assist in generally maintaining various bodily functions, the mixture including one or more of vitamins, amino acids, minerals and herbal preparations. Preferably the mixture includes L-Glutathione.

Description

SYNERGISTIC MIXTURE Technical Area
This invention relates to a synergistic mixture and, in particular, to one which can promote the feeling of wellness in the person who takes the mixture and can assist in generally maintaining various bodily functions.
Background to the Invention
There have been, over the centuries, various tonics which, at their time of adoption were believed to be beneficial to the user, either against specific symptoms, or generally.
Most of these have, over the years, been proved to have little or no positive effect and some, at least, were effectively poisons.
Outline of the Invention
It is the object of this invention to provide a synergistic mixture which is beneficial to users, tends to promote a feeling of wellness, and is certainly non toxic, when taken in normal doses.
The invention includes a synergistic mixture which incorporates one or more of vitamins, amino acids, minerals and herbal preparations.
The mixture may include L-Glutathione. Description of an Embodiment of the Invention
In order that the invention may be more readily understood we shall describe one particular embodiment of the invention.
The vitamins (s) which are used in the mixture can be selected from the group comprising Vitamin A Vitamin E
The amino acids from a group comprising
L-Glutathione
L-Proiine
The minerals from the group comprising Calcium salts Iron salts Zinc salts Magnesium salts
The herbal preparations from the group Calendula Officialis.
The preferred amino acid is L-Glutathione which is a tri-peptide, a protein comprised of one amino acid of Glutamic acid, Cysteine and Glycine.
Glutathione is found and manufactured in every cell in the body but is found in highest concentrations in the heart muscle tissue and the liver. Glutathione is critical for healthy immune system function. Glutathione helps the body fight almost any disease, because it is a powerful antioxidant that helps maintain cellular health and helps prevent oxidative stress. Glutathione has been heavily researched, and the findings on this substance have been nothing short of amazing.
Aside from being a powerful antioxidant booster and system detoxifier, glutathione helps produce, protect and repair deoxyribonucleic acid - DNA. In this protective role, glutathione boosts the immune system, thereby helping to power immune response and preventing the growth of cancerous cells.
Thus, glutathione levels are correlated with aging and physical function. The only way to drastically increase glutathione levels, aside from consuming glutathione precursors, is through the ingestion of ascorbic acid - vitamin C. Boosting glutathione levels has been shown to boost sperm count in infertile men and non-weight training subjects saw increases in muscle mass by supplementing with glutathione, even without weight training.
Gluththione is essential for immune system function and muscle growth, and any athlete who is glutathione deficient will suffer from decreased performance and a lack of muscle growth.
Declines in glutathione levels are associated with ageing, and studies have shown that adults who took glutathione had better health than those who did not. Deficiencies of glutathione do not produce diseases, but low glutathione levels can accelerate ageing, can lead to functional decline and weaken the immune system.
There have been a large number of papers which refer to the action of Glutathione..
The preferred Vitamins are Vitamins A and E. A further preferred amino acid is L-Proline. This is not an essential amino acid but may be synthesized by the body. It is one of the main components of collagen, the connective tissue structure that binds and supports all other tissues. Pauling 1 points out that there is evidence that vitamin C is required for conversion of prolyl residues or procollagen (the precursor of collagen) into the form that gives collagen its characteristic properties. The use of wound healing , and in the promotion of improved collagen status, as well as in cosmetic improvement of 'ageing1 tissues has been proposed by researchers in California.
Hydroxyproline, which the body incorporates into collagen, is readily transformed by the body from proline; it is incorporated into the structure of tendons and ligaments.
Proline is one of the aromatic amino acids such as phenylalanine and tryptophan. Supplementation would seem to be indicated in cases of persistent soft tissues strains; hypermobile joints; soft tissue healing requirement, and in lax and 'sagging' tissues associated with ageing. Combined with Vitamin C supplementation is more effective.
Pfeiffer states clearly that the protein collagen is neither properly formed, not maintained, if vitamin C is lacking.
References :
1. Pauling, Linus, Vitamin C-The Common Cold and Flu, Freeman and Co 1976
2. Levine, Stephen, Allergy Research Group Pamphlet Concord, California
3. Anthony Harris, Your Body Futura 1979
4. Pfeiffer, Carl Mental and Elemental Nutrients, Keats 1975.
Vitamin A is part of a larger team of antioxidant nutrients known as the carotenoids, which are the yellow and orange pigments found in fruits and vegetables. Since beta carotene converts in the body into vitamin A1 it is often referred to a pro-vitamin A. However, being a tremendous immune system booster and a powerful antioxidant, beta-carotene provides many additional benefits. The antioxidant effect plays a very important role in the prevention of heart disease. A study of 333 patients who took 50 mg of beta-carotene showed that the nutrient reduced major cardiovascular events by 50% in comparison with people who did not take the supplement. Beta-carotene was also found to have a protective effect in angina patients, who experienced far less chest pain on diets that were high in natural beta-carotene. Beta carotene is also known .to increase the level of protective HDL cholesterol.
Vitamin E is a generic term for a group of related compounds called tocopherols occurring in four forms of which 'alpha' is the most potent. Found in only a few foods that are typically high in fat, supplementation becomes important especially in low fat diets. One of the vitamins basic functions is to protect cell membranes and help the body to use selenium and vitamin K. The staggering superiority of vitamin E therapy over the most concerted drug efforts was most convincingly demonstrated by conventional medicine, based on the findings of two Harvard studies : one of 40,000 male doctors, the other with more than 100,000 female nurses. The more vitamin E consumed, the lower the rate of cardiovascular disease.
It is an excellent antioxidant shield, which prevents LDL cholesterol from sticking to the artery walls and at the same time, reduces the amount of the LDL cholesterol in the blood. At the same time, vitamin E increases the amount of the artery-cleansing HDL cholesterol and works to eliminate triglycerides (another dangerous blood fat). It lowers insulin and spares the heart from damage caused by a magnesium deficiency or a lack of oxygen, thus improving the biochemical changes caused by stress in patients suffering congestive heart failure.
A preferred herb is Calendula Officinalis, which is a well known skin herb, is a main nutrient of the mixture.
A particular mixture which we have found to be particularly efficacious has the constituents as follows:- L-Glutathioπe L-Proline
Calendula Officinalis Calcium Ascorbate Iron Phosphate Vitamin A Vitamin E
Calcium Phosphate Zinc Sulphate Magnesium Phosphate Seleno-Methioniπe.
For the best results we believe that the user should take about 500 mg Once or twice a day. The mixtures of the invention have a very powerful synergistic detoxifying effect on the body generally.
The glutathione help protect the body from oxidative stress and as oxidative stress is associated with aging it is believed that the mixture will have a general benefit both immediately and in the future.
A preferred particular specific formulation of the product is:
Figure imgf000008_0001
Total 679.40 Whilst there has been herein described certain embodiments of the invention, it is to be understood that the elements of the mixture, and their proportions can be varied as required for different applications and at different times and ail such variations are deemed to be within the scope of the invention.

Claims

We claim:
1. A synergistic mixture which incorporates one or more of vitamins, amino acids, minerals and herbal preparations.
2. A synergistic mixture as claimed in claim 1 wherein the vitamins (s) which are used in the mixture are selected from the groups comprising Vitamin A and Vitamin E.
3. A synergistic mixture as claimed in claim 1 or claim 2 wherein the amino acids are selected from a group comprising L-Glutathione and L-Proline.
4. A synergistic mixture as claimed in claim 1 or claim 2 wherein the amino acid is L-Glutathione.
5. A synergistic mixture as claimed in any one of claims 1 to 4 wherein the minerals are selected from the group comprising calcium salts, iron salts, zinc salts and magnesium salts.
6. A synergistic mixture as claimed in any preceding claim wherein the herbal preparation includes Calendula Officialis
7. A synergistic mixture as claimed in any preceding claim wherein the mixture includes:
L-Glutathione L-Proline
Calendula Officinalis Calcium Ascorbate Iron Phosphate Vitamin A Vitamin E Calcium Phosphate Zinc Sulphate
Magnesium Phosphate Seleno-Methionine
8. A synergistic mixture as claimed in any preceding claim and as described in relation to the specific formulation set out herein.
9. A synergistic mixture substantially as hereinbefore described.
PCT/AU2008/001003 2007-07-10 2008-07-10 Synergistic mixture WO2009006686A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
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Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AU2007903715A AU2007903715A0 (en) 2007-07-10 Synergistic mixture
AU2007903715 2007-07-10

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Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0060565B1 (en) * 1981-03-18 1986-06-25 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Fully synthetic cell culture medium
DE19653100A1 (en) * 1996-12-19 1998-07-23 Adolf Metz Improved lactose-containing magnetic capsules for intestinal use
JP2000229827A (en) * 1999-02-05 2000-08-22 Kose Corp Skin lotion
US20040001817A1 (en) * 2002-05-14 2004-01-01 Giampapa Vincent C. Anti-aging nutritional supplement
US20040146539A1 (en) * 2003-01-24 2004-07-29 Gupta Shyam K. Topical Nutraceutical Compositions with Selective Body Slimming and Tone Firming Antiaging Benefits
US20040208902A1 (en) * 2003-04-18 2004-10-21 Gupta Shyam K. Controlled-release nano-diffusion delivery systems for cosmetic and pharmaceutical compositions
WO2005063266A1 (en) * 2003-12-31 2005-07-14 Vladimir Yosifov Naydenov Therapeutical composition for the treatment of dermatosis comprising an extract of calendula officinalis and hypericum perforatum
JP2005220084A (en) * 2004-02-06 2005-08-18 Kose Corp Acerola seed extract-containing composition
RO120314B1 (en) * 1998-02-26 2005-12-30 S.C. Centrul De Cercetare Şi Prelucrare Plante Medicinale "Plantavorel" S.A. Face skin care cosmetic composition
WO2007144518A2 (en) * 2006-06-16 2007-12-21 Laboratoire Nuxe Use of a mimosa seed extract in a cosmetic composition
US20080038367A1 (en) * 2006-08-11 2008-02-14 Sal Saloum Nutritional supplement compositions and methods of preparing
WO2008079898A1 (en) * 2006-12-20 2008-07-03 Pharmwest, Inc. Methods and topical formulations comprising colloidal metal for treating or preventing skin conditions

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0060565B1 (en) * 1981-03-18 1986-06-25 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Fully synthetic cell culture medium
DE19653100A1 (en) * 1996-12-19 1998-07-23 Adolf Metz Improved lactose-containing magnetic capsules for intestinal use
RO120314B1 (en) * 1998-02-26 2005-12-30 S.C. Centrul De Cercetare Şi Prelucrare Plante Medicinale "Plantavorel" S.A. Face skin care cosmetic composition
JP2000229827A (en) * 1999-02-05 2000-08-22 Kose Corp Skin lotion
US20040001817A1 (en) * 2002-05-14 2004-01-01 Giampapa Vincent C. Anti-aging nutritional supplement
US20040146539A1 (en) * 2003-01-24 2004-07-29 Gupta Shyam K. Topical Nutraceutical Compositions with Selective Body Slimming and Tone Firming Antiaging Benefits
US20040208902A1 (en) * 2003-04-18 2004-10-21 Gupta Shyam K. Controlled-release nano-diffusion delivery systems for cosmetic and pharmaceutical compositions
WO2005063266A1 (en) * 2003-12-31 2005-07-14 Vladimir Yosifov Naydenov Therapeutical composition for the treatment of dermatosis comprising an extract of calendula officinalis and hypericum perforatum
JP2005220084A (en) * 2004-02-06 2005-08-18 Kose Corp Acerola seed extract-containing composition
WO2007144518A2 (en) * 2006-06-16 2007-12-21 Laboratoire Nuxe Use of a mimosa seed extract in a cosmetic composition
US20080038367A1 (en) * 2006-08-11 2008-02-14 Sal Saloum Nutritional supplement compositions and methods of preparing
WO2008079898A1 (en) * 2006-12-20 2008-07-03 Pharmwest, Inc. Methods and topical formulations comprising colloidal metal for treating or preventing skin conditions

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Derwent World Patents Index; AN 1998-399777 *
DATABASE WPI Derwent World Patents Index; AN 2000-631401 *
DATABASE WPI Derwent World Patents Index; AN 2005-559427 *

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