CN105126067B - A kind of composition of anti-trioxypurine and application thereof - Google Patents
A kind of composition of anti-trioxypurine and application thereof Download PDFInfo
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- CN105126067B CN105126067B CN201510642189.9A CN201510642189A CN105126067B CN 105126067 B CN105126067 B CN 105126067B CN 201510642189 A CN201510642189 A CN 201510642189A CN 105126067 B CN105126067 B CN 105126067B
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Abstract
The present invention relates to a kind of compositions of anti-trioxypurine and application thereof, the composition is using ocean fish oligopeptide powder, leaf of Moringa powder, acerola concentrate concentrate, plum extract as raw material, composition is made in collocation multiple eating auxiliary material, and percentage composition by weight is composed of the following components：Ocean fish oligopeptide powder 5 35%, leaf of Moringa powder 5 45%, acerola concentrate concentrate 2 15%, plum extract 5 30%, edible adjuvant surplus.The present invention selects raw-food material, and scientific compatibility passes through the synergistic effect of each raw material so that anti-trioxypurine speed is fast, significant effect, and safety is without side-effects.
Description
Technical field
The invention belongs to healthy food fields, and in particular to a kind of composition of anti-trioxypurine and application thereof more particularly to one
Food and new resource food composition of kind anti-trioxypurine and application thereof.
Background technology
Normal adult about generates uric acid 750mg daily, wherein 80% is endogenous, 20% is exogenous uric acid, these urine
Acid is into uric acid metabolism pond (about 1200mg), and the uric acid about 60% in daily metabolic pool is metabolized, wherein 1/3 about 200mg
Through enteron aisle catabolism, 2/3 about 400mg is through kidney excretion, so as to maintain the stabilization of internal uric acid level.Purine metabolic disturbance is led
The uric acid generation of cause increases or underexcretion can cause hyperuricemia.The modern medicine morbidity of clear and definite gout with
Hyperuricemia is directly related, is a kind of serious metabolic disease for endangering human health.Urarthritis is due to body
Interior uric acid, which increases, causes lithate to be deposited on capsular ligament, synovial membrane, cartilage, kidney, a kind of tissue caused by subcutaneous, its hetero-organization
Disease damage and inflammatory reaction.Blood uric acid rise is the key character of urarthritis.
As the improvement of people's living standards, the variation of dietary structure, sugar, albumen, the intake of fat substantially increase, pain
The incidence of wind increases year by year.At present, the measure for treating gout mainly inhibits uric acid generation and promotes uric acid excretion.It is clinical normal
There are nonsteroidal anti-inflammatory agent, colchicin, glucocorticoid, probenecid, benzene Australia Ma Long, allopurinol with drug, therapeutic effect is shown
Write, but they are all there are different degrees of toxic side effect and adverse reaction, damage liver, nervous system, cause skin allergy,
Super quick allergy of life-threatening etc..However there is no toxic side effect with the anti-trioxypurine product that raw-food material is developed, thus have
The very high market advantage.
Have some at present using food as raw material to prepare the research of anti-trioxypurine product, for example, CN104758920A is disclosed
A kind of gout health care product based on integration of drinking and medicinal herbs, containing ocean fish oligopeptide powder, Poria cocos and lophatherum gracile, weight ratio is 1:
0.5-1.5:0.5-1.5；The ventilation health products can effectively inhibit high lithemia, remove tophus, and strengthen immunity has to adjust and exempt from
Epidemic disease power, the effect of anti-trioxypurine, and also it is without side-effects.However its realize blood uric acid value is normal and ventilation stone is removed cycle compared with
Long, after 3 months edible, total effective rate is only capable of reaching 96.1%.CN104829743A discloses a kind of Polysaccharides from Leaves of Moringa oleifera
Preparation method and its purposes on anti-trioxypurine.The polysaccharide of the leaf of Moringa obtained of the present invention, which has high lithemia disease, significantly to be controlled
Therapeutic effect, the leaf of Moringa are reached by reducing the content of cholesterol, triacylglycerol, urea nitrogen, creatinine and xanthine oxidase
It is generated to uric acid is reduced, while can also directly decompose uric acid, improved renal function, promote the functions such as uric acid excretion, protection blood vessel,
It is more advantageous to the rehabilitation of Patients with Hyperuricemia.CN103637105A is related to a kind of cherry capsule, including cherry fruit powder and cherry
Peach medicinal extract, the capsule product being made from it are pure natural cherry fruit extract, have good effect to rheumatic lumbocrural pain pain, especially suitable
For high lithemia and patient with gout.CN104824313A discloses a kind of fermented type green plum fruit product with plurality of health care functions
And its production technology, the green plum fruit product are made of green plum, Pu'er tea, lotus leaf, Radix Glycyrrhizae compatibility, containing abundant organic acid,
The functional components such as polysaccharide, green plum flavones, tea polyphenols, licoflavone, Nuciferine can play cleaning enteron aisle, lowering blood-fat and reducing weight, reduction
The plurality of health care functions of uric acid, prevention cardiovascular and cerebrovascular disease etc..
Although it is come the effect of realizing anti-trioxypurine, however, it is in clinic using raw-food material to have all multi-products at present
Above in application, in the prevalence of the deficiencies for the treatment of cycle is long, total effective rate is low, Absorption And Metabolism is poor, therefore how to improve drop urine
The therapeutic efficiency and nutrient absorption situation of acid product have become current urgent problem to be solved.
The content of the invention
To solve the deficiencies in the prior art, the object of the present invention is to provide a kind of compositions of anti-trioxypurine and application thereof.This
The composition for inventing the anti-trioxypurine provided selects raw-food material, reasonable formula, anti-trioxypurine significant effect.
For this purpose, the present invention is achieved by the following technical solutions：
In a first aspect, the present invention provides a kind of composition of anti-trioxypurine, the composition contain ocean fish oligopeptide powder,
Leaf of Moringa powder, acerola concentrate concentrate and plum extract.
" containing " of the present invention, it is intended that it can also include other components, these other components in addition to the component
Assign the composition different characteristics.In addition, " containing " of the present invention, may be replaced by enclosed " for "
Or " by ... form ".
Ocean fish oligopeptide powder in the present invention can be purchased from Japanese Kiyatsu Aquatic Product Chemical Co., Ltd., be with no dirt
Skin, the bone for contaminating or polluting relatively small deep-sea fish are raw material, refined to be process, and are a kind of new nutritious and healthy foods
Dispensing；They are mostly small molecule mixing be made of 2-6 amino acid, that molecular weight concentrates on 200-1000 dalton
Peptides can directly be absorbed by small intestine, human skin etc..
Leaf of Moringa powder in the present invention can be purchased from Guangzhou Neng Jing Bioisystech Co., Ltd, be by the selected tender Moringa of children
Leaf is formed through ultramicro grinding；It is rich in several mineral materials, vitamin, 20 kinds of amino acid, 46 kinds of antioxygen elements and 36 kinds of naturally anti-inflammation
Body and minerals；Sleep with hypoglycemic, lipid-loweringing, decompression, antitumor, anti-oxidant, defaecation, diuresis, expelling parasite, improvement and other effects,
Long-term consumption can enhance immune function of human body, slow down aging, prevention disease, especially to hypertension, hyperlipidemia, diabetes, gout
Etc. there is good effect.
Acerola concentrate concentrate in the present invention can be purchased from upper one raw-food material Co., Ltd of Haicheng, be acerola concentrate
Extract, acerola concentrate are the Chinese appellations of A Xi rollers cherry (Acerola cherry)；Since acerola concentrate is rich in dimension life
Plain C is the current fruit most abundant containing vitamin C known in the world；Acerola concentrate is also containing vitamin A, B simultaneously1、B2、E、P、
A variety of nutriments, the nutritive values such as niacin, the anti-aging factor (SOD), calcium, iron, zinc, potassium and protein are high.
Plum extract in the present invention can be purchased from Beijing Sheng Lun Food Co., Ltd, and plum extract contains abundant
The organic acids such as citric acid and malic acid and multivitamin and minerals can be alleviated, dispelling fatigue；Also containing flavone glycoside, three
The substances such as terpene saponin(e, polyphenol and alkene are tired of and antitumor, removing blood rubbish, anti-aging, antibacterial, weight-reducing with solution of calming the nerves
With the effect of hair tonic.
The present invention is to use to carry out ocean fish oligopeptide powder, leaf of Moringa powder, acerola concentrate concentrate and plum extract
Combination forms composition.It is demonstrated experimentally that ocean fish oligopeptide powder can control rapidly, Uric Acid is horizontal, alleviates inflammation and pain；
Leaf of Moringa powder has anti-inflammatory, diuresis and other effects, and uric acid is promoted to excrete；Plum extract can improve the immunity of the human body, drop
Low uric acid in blood content；Acerola concentrate concentrate can adjust sleep, anti-inflammatory and antalgic.It acts synergistically, makes between this 4 kinds of components
The with obvious effects better than single or two or three kind of feedstock composition of the composition anti-trioxypurine is obtained, patient can be made to take this drop urine
After acid composition 8 weeks, the effective percentage of anti-trioxypurine reaches more than 97%, and has no toxic side effect.
In the present invention, composition percentage composition by weight contains the following raw material component：Ocean fish oligopeptide powder 5-
35%th, leaf of Moringa powder 5-45%, acerola concentrate concentrate 2-15%, plum extract 5-30%.
The present invention is according to composition anti-trioxypurine effect, the content proportioning of each raw material in optimum organization object so that each component is more
Play to big degree the effect of anti-trioxypurine.
As further improvement of the invention, composition percentage composition by weight contains the following raw material component：Ocean
Fish oligopeptide powder 5-35%, leaf of Moringa powder 5-45%, acerola concentrate concentrate 2-15%, plum extract 5-30%, surplus are
Edible adjuvant.
The content that " surplus " of the present invention is only intended to meet the composition reaches 100%.That is, only
When the raw material components are unsatisfactory for 100%, " surplus " herein means various edible adjuvants, is mended by the edible adjuvant component
The content for being enough to realize the composition is 100%；If the sum of described raw material components have reached 100%, without adding in
Edible adjuvant.No matter composition of the present invention is including the sum of which kind of ingredient, the weight percentage of the composition
100%.
In the composition of the present invention, the weight percentage shared by the ocean fish oligopeptide powder is 5-35%, such as can
It is excellent to be 5%, 6%, 7%, 8%, 10%, 12%, 15%, 18%, 20%, 22%, 25%, 28%, 30%, 32%, 35%
Elect 10-30% as, further preferably 25-30%.
In the composition of the present invention, the weight percentage shared by the leaf of Moringa powder is 5-45%, such as can be
5%th, 6%, 7%, 8%, 10%, 12%, 15%, 18%, 20%, 22%, 25%, 28%, 30%, 32%, 35%, 38%,
40%th, 42%, 45%, it is preferably 15-25%, further preferably 15-20%.
In the composition of the present invention, the weight percentage shared by the acerola concentrate concentrate is 2-15%, such as can
It is preferably 4-12%, further to be 2%, 3%, 4%, 5%, 6%, 8%, 10%, 11%, 12%, 13%, 14%, 15%
Preferably 8-10%.
In the composition of the present invention, the weight percentage shared by the plum extract is 5-30%, such as can be
5%th, 6%, 7%, 8%, 10%, 12%, 15%, 18%, 20%, 22%, 25%, 28%, 30%, it is preferably 5-15%, into
One step is preferably 10-15%.
As further improvement of the present invention, composition percentage composition by weight is made of the following raw material component：
Ocean fish oligopeptide powder 10-30%, leaf of Moringa powder 10-25%, acerola concentrate concentrate 4-12%, plum extract 5-15%,
Surplus is edible adjuvant.
As further improvement of the present invention, composition percentage composition by weight is made of the following raw material component：
Ocean fish oligopeptide powder 25-30%, leaf of Moringa powder 15-20%, acerola concentrate concentrate 8-10%, plum extract 10-15%,
Surplus is edible adjuvant.
The composition of the anti-trioxypurine of the present invention percentage composition can include by weight：It is ocean fish oligopeptide powder 5-35%, peppery
Wooden leaf powder 5-45%, acerola concentrate concentrate 2-15%, plum extract 5-30%, further, by said composition
The content proportioning of each raw material optimizes, and finds weight percentage of the anti-trioxypurine composition in each raw material components of the present invention
For：Ocean fish oligopeptide powder 25-30%, leaf of Moringa powder 15-20%, acerola concentrate concentrate 8-10%, plum extract 10-
Under 15% proportioning, compared to each component of the invention in the value of other contents, optimal anti-trioxypurine effect can be reached.
Edible adjuvant in the present invention is food grade accessories, including foods such as excipient, stabilizer, flavoring agent, color stabilizers
Product additive, is not particularly limited herein.Its purpose added is to prepare the various dosage forms taken or meet different taste
The consumer demand of hobby.
Second aspect, the present invention also provides a kind of Chinese medicine preparation, the Chinese medicine preparation contains as described in relation to the first aspect
Composition.
The dosage form of the preparation of the present invention can be tablet, capsule, pulvis, pill or granule etc., not make herein especially
It limits, it can be depending on the needs and consumer demand of actual production.
The third aspect, the present invention also provides the composition according to first aspect for anti-trioxypurine health products,
Application in food or drug.
Compared with prior art, the present invention at least has the advantages that：
The present invention using ocean fish oligopeptide powder, leaf of Moringa powder, acerola concentrate concentrate and plum extract as Effect raw material,
Scientific compatibility, has played synergistic effect between each component, reasonably combined edible adjuvant, can be made into notable anti-trioxypurine effect,
The health products such as tablet, hard shell capsules, pulvis or Chinese medicine preparation etc. should can make trouble with the composition of the effect of notable anti-trioxypurine
For person after this anti-trioxypurine composition is taken 8 weeks, the effective percentage of anti-trioxypurine can reach more than 97%, and have no toxic side effect.
Specific embodiment
The technical solution further illustrated the present invention below by specific embodiment.
Those skilled in the art it will be clearly understood that the embodiment be only to aid in understand the present invention, be not construed as to this hair
Bright concrete restriction.
Embodiment 1：A kind of composition of anti-trioxypurine
(1) composition tablet is prepared
Formula：Ocean fish oligopeptide powder 25wt%, leaf of Moringa powder 20wt%, acerola concentrate concentrate 10wt%, green plum carry
Take object 15wt%, edible adjuvant 30wt%.
Film-making agent：Raw material is weighed by above-mentioned formula, is uniformly mixed, the tablet of 0.6g/ pieces is made.
(2) efficacy validation is tested
Patient data：Patient 198, wherein male 120, age distribution is at 39-77 Sui；Women 78, age distribution
At 53-74 Sui.
Diagnostic criteria：Patient articular's pain, night-time attack, it is difficult to fall asleep；Blood uric acid increases, and male is higher than 6.0mg/dL,
Women is higher than 5.0mg/dL；With tophus.
Instructions of taking：2 times a day, 2 tablets once, once in the morning and once at night, continuously takes 2 months.
Efficacy assessments standard：It cures：Laboratory examination blood uric acid value is normal, and symptoms of joint pain disappears, tophus removal；
It improves：Laboratory examination blood uric acid value reduces, and arthroncus is disappeared, and pain relief, tophus is obviously reduced；It is invalid：Laboratory
Check that blood uric acid value and symptom are unchanged, tophus is unchanged.
Result of the test is as shown in table 1.
Table 1
As shown in Table 1, the anti-trioxypurine composition of the present embodiment is taken after 6 weeks, 69% patient's blood uric acid recovers normal,
27% patient's blood uric acid is substantially reduced, and anti-trioxypurine effective percentage reaches 96%；Take the anti-trioxypurine composition of the present embodiment 8 weeks
Afterwards, 90% patient's blood uric acid recovers normal, and 7% patient's blood uric acid is substantially reduced, and anti-trioxypurine effective percentage reaches 97%.
Embodiment 2：A kind of composition of anti-trioxypurine
(1) composition pulvis is prepared
Formula：Ocean fish oligopeptide powder 10wt%, leaf of Moringa powder 10wt%, acerola concentrate concentrate 8wt%, green plum extraction
Object 10wt%, edible adjuvant 62wt%.
Pulvis processed：Raw material is weighed by above-mentioned formula, is uniformly mixed, 2g/ bags of pulvis is made.
(2) efficacy validation is tested
Patient data：Patient 173, wherein male 106, age distribution is at 42-73 Sui；Women 67, age distribution
At 50-71 Sui.
Diagnostic criteria：Patient articular's pain, night-time attack, it is difficult to fall asleep；Blood uric acid increases, and male is higher than 6.0mg/dL,
Women is higher than 5.0mg/dL；With tophus.
Instructions of taking：2 times a day, every time 1 bag, once in the morning and once at night, continuously take 2 months.
Efficacy assessments standard：It cures：Laboratory examination blood uric acid value is normal, and symptoms of joint pain disappears, tophus removal；
It improves：Laboratory examination blood uric acid value reduces, and arthroncus is disappeared, and pain relief, tophus is obviously reduced；It is invalid：Laboratory
Check that blood uric acid value and symptom are unchanged, tophus is unchanged.
Result of the test is as shown in table 2.
Table 2
As shown in Table 2, the anti-trioxypurine composition of the present embodiment is taken after 6 weeks, 64% patient's blood uric acid recovers normal,
20% patient's blood uric acid is substantially reduced, and anti-trioxypurine effective percentage reaches 84%；Take the anti-trioxypurine composition of the present embodiment 8 weeks
Afterwards, 82% patient's blood uric acid recovers normal, and 8% patient's blood uric acid is substantially reduced, and anti-trioxypurine effective percentage reaches 90%.
Embodiment 3：A kind of composition of anti-trioxypurine
(1) composition hard shell capsules are prepared
Formula：Ocean fish oligopeptide powder 30wt%, leaf of Moringa powder 15wt%, acerola concentrate concentrate 10wt%, green plum carry
Take object 10wt%, edible adjuvant 35wt%.
Hard shell capsules processed：Raw material is weighed by above-mentioned formula, is uniformly mixed, the hard shell capsules of 0.5g/ are made.
(2) efficacy validation is tested
Patient data：Patient 181, wherein male 101, age distribution is at 40-69 Sui；Women 80, age distribution
At 51-73 Sui.
Diagnostic criteria：Patient articular's pain, night-time attack, it is difficult to fall asleep；Blood uric acid increases, and male is higher than 6.0mg/dL,
Women is higher than 5.0mg/dL；With tophus.
Instructions of taking：2 times a day, 2 tablets each time, once in the morning and once at night, continuously take 2 months.
Efficacy assessments standard：It cures：Laboratory examination blood uric acid value is normal, and symptoms of joint pain disappears, tophus removal；
It improves：Laboratory examination blood uric acid value reduces, and arthroncus is disappeared, and pain relief, tophus is obviously reduced；It is invalid：Laboratory
Check that blood uric acid value and symptom are unchanged, tophus is unchanged.
Result of the test is as shown in table 3.
Table 3
As shown in Table 3, the anti-trioxypurine composition of the present embodiment is taken after 6 weeks, 61% patient's blood uric acid recovers normal,
24% patient's blood uric acid is substantially reduced, and anti-trioxypurine effective percentage reaches 85%；Take the anti-trioxypurine composition of the present embodiment 8 weeks
Afterwards, 83% patient's blood uric acid recovers normal, and 12% patient's blood uric acid is substantially reduced, and anti-trioxypurine effective percentage reaches 95%.
Embodiment 4：A kind of composition of anti-trioxypurine
(1) composition hard shell capsules are prepared
Formula：Ocean fish oligopeptide powder 25wt%, leaf of Moringa powder 20wt%, edible adjuvant 55wt%.
Hard shell capsules processed：Raw material is weighed by above-mentioned formula respectively, is uniformly mixed, the hard shell capsules of 0.5g/ are made.
(2) efficacy validation is tested
Patient data：Patient 154, wherein male 86, age distribution is at 41-65 Sui；Women 68, age distribution exists
50-65 Sui.
Diagnostic criteria：Patient articular's pain, night-time attack, it is difficult to fall asleep；Blood uric acid increases, and male is higher than 6.0mg/dL,
Women is higher than 5.0mg/dL；With tophus.
Instructions of taking：2 times a day, 2 tablets each time, once in the morning and once at night, continuously take 2 months.
Efficacy assessments standard：It cures：Laboratory examination blood uric acid value is normal, and symptoms of joint pain disappears, tophus removal；
It improves：Laboratory examination blood uric acid value reduces, and arthroncus is disappeared, and pain relief, tophus is obviously reduced；It is invalid：Laboratory
Check that blood uric acid value and symptom are unchanged, tophus is unchanged.
Result of the test is as shown in table 4.
Table 4
As shown in Table 4, the anti-trioxypurine composition of the present embodiment is taken after 6 weeks, 54% patient's blood uric acid recovers normal,
17% patient's blood uric acid is substantially reduced, and anti-trioxypurine effective percentage reaches 71%；Take the anti-trioxypurine composition of the present embodiment 8 weeks
Afterwards, 63% patient's blood uric acid recovers normal, and 19% patient's blood uric acid is substantially reduced, and anti-trioxypurine effective percentage reaches 82%.
Embodiment 5：A kind of composition of anti-trioxypurine
(1) composition hard shell capsules are prepared
Formula：Ocean fish oligopeptide powder 25wt%, leaf of Moringa powder 20wt%, acerola concentrate concentration powder 10%, edible adjuvant
45wt%.
Hard shell capsules processed：Raw material is weighed by above-mentioned formula respectively, is uniformly mixed, the hard shell capsules of 0.5g/ are made.
(2) efficacy validation is tested
Patient data：Patient 163, wherein male 87, age distribution is at 43-69 Sui；Women 76, age distribution exists
47-71 Sui.
Diagnostic criteria：Patient articular's pain, night-time attack, it is difficult to fall asleep；Blood uric acid increases, and male is higher than 6.0mg/dL,
Women is higher than 5.0mg/dL；With tophus.
Instructions of taking：2 times a day, 2 tablets each time, once in the morning and once at night, continuously take 2 months.
Efficacy assessments standard：It cures：Laboratory examination blood uric acid value is normal, and symptoms of joint pain disappears, tophus removal；
It improves：Laboratory examination blood uric acid value reduces, and arthroncus is disappeared, and pain relief, tophus is obviously reduced；It is invalid：Laboratory
Check that blood uric acid value and symptom are unchanged, tophus is unchanged.
Result of the test is as shown in table 5.
Table 5
As shown in Table 5, the anti-trioxypurine composition of the present embodiment is taken after 6 weeks, 56% patient's blood uric acid recovers normal,
19% patient's blood uric acid is substantially reduced, and anti-trioxypurine effective percentage reaches 75%；Take the anti-trioxypurine composition of the present embodiment 8 weeks
Afterwards, 67% patient's blood uric acid recovers normal, and 20% patient's blood uric acid is substantially reduced, and anti-trioxypurine effective percentage reaches 87%.
Embodiment 6：A kind of composition of anti-trioxypurine
(1) composition tablet is prepared
Formula：Ocean fish oligopeptide powder 5wt%, leaf of Moringa powder 45wt%, acerola concentrate concentrate 2wt%, green plum extraction
Object 5wt%, edible adjuvant 43wt%.
Film-making agent：Raw material is weighed by above-mentioned formula, is uniformly mixed, the tablet of 0.6g/ pieces is made.
(2) efficacy validation is tested
107 patients took the anti-trioxypurine composition of the present embodiment after 8 weeks, and 27% patient's blood uric acid recovers normal,
18% patient's blood uric acid is substantially reduced, and anti-trioxypurine effective percentage reaches 45%.
Embodiment 7：A kind of composition of anti-trioxypurine
(1) composition tablet is prepared
Formula：Ocean fish oligopeptide powder 35wt%, leaf of Moringa powder 5wt%, acerola concentrate concentrate 15wt%, green plum extraction
Object 15wt%, edible adjuvant 30wt%.
Film-making agent：Raw material is weighed by above-mentioned formula, is uniformly mixed, the tablet of 0.6g/ pieces is made.
(2) efficacy validation is tested
110 patients took the anti-trioxypurine composition of the present embodiment after 8 weeks, and 44% patient's blood uric acid recovers normal,
29% patient's blood uric acid is substantially reduced, and anti-trioxypurine effective percentage reaches 73%.
Embodiment 8：A kind of composition of anti-trioxypurine
(1) composition pulvis is prepared
Formula：Ocean fish oligopeptide powder 22wt%, leaf of Moringa powder 30wt%, acerola concentrate concentrate 5wt%, green plum extraction
Object 6wt%, edible adjuvant 37wt%.
Pulvis processed：Raw material is weighed by above-mentioned formula, is uniformly mixed, 2g/ bags of pulvis is made.
(2) efficacy validation is tested
98 patients took the anti-trioxypurine composition of the present embodiment after 8 weeks, and 51% patient's blood uric acid recovers normal,
25% patient's blood uric acid is substantially reduced, and anti-trioxypurine effective percentage reaches 76%.
Embodiment 9：A kind of composition of anti-trioxypurine
(1) composition pulvis is prepared
Formula：Ocean fish oligopeptide powder 32wt%, leaf of Moringa powder 8wt%, acerola concentrate concentrate 15wt%, green plum extraction
Object 30wt%, edible adjuvant 15wt%.
Pulvis processed：Raw material is weighed by above-mentioned formula, is uniformly mixed, 2g/ bags of pulvis is made.
(2) efficacy validation is tested
101 patients took the anti-trioxypurine composition of the present embodiment after 8 weeks, and 49% patient's blood uric acid recovers normal,
23% patient's blood uric acid is substantially reduced, and anti-trioxypurine effective percentage reaches 72%.
Embodiment 10：A kind of composition of anti-trioxypurine
(1) composition hard shell capsules are prepared
Formula：Ocean fish oligopeptide powder 15wt%, leaf of Moringa powder 25wt%, acerola concentrate concentrate 10wt%, green plum carry
Take object 25wt%, edible adjuvant 25wt%.
Hard shell capsules processed：Raw material is weighed by above-mentioned formula, is uniformly mixed, the hard shell capsules of 0.5g/ are made.
(2) efficacy validation is tested
97 patients took the anti-trioxypurine composition of the present embodiment after 8 weeks, and 44% patient's blood uric acid recovers normal,
25% patient's blood uric acid is substantially reduced, and anti-trioxypurine effective percentage reaches 69%.
Embodiment 11：A kind of composition of anti-trioxypurine
(1) composition hard shell capsules are prepared
Formula：Ocean fish oligopeptide powder 12wt%, leaf of Moringa powder 30wt%, acerola concentrate concentrate 8wt%, green plum extraction
Object 15wt%, edible adjuvant 35wt%.
Hard shell capsules processed：Raw material is weighed by above-mentioned formula, is uniformly mixed, the hard shell capsules of 0.5g/ are made.
(2) efficacy validation is tested
107 patients took the anti-trioxypurine composition of the present embodiment after 8 weeks, and 38% patient's blood uric acid recovers normal,
26% patient's blood uric acid is substantially reduced, and anti-trioxypurine effective percentage reaches 64%.
It can be seen from the above embodiments that, the present invention is with ocean fish oligopeptide powder, leaf of Moringa powder, acerola concentrate concentrate
For Effect raw material and rational proportion is carried out with plum extract, and scientific compatibility has played synergistic effect between each component, rationally taken
With edible adjuvant, can be made into notable anti-trioxypurine effect and the health products such as tablet without side-effects, hard shell capsules, pulvis or in
Medicine preparation etc. should can make patient after this anti-trioxypurine composition is taken 8 weeks with the composition of the effect of notable anti-trioxypurine,
The effective percentage of anti-trioxypurine can reach more than 97%.
Applicant states that the present invention illustrates the process of the present invention, but not office of the invention by above-described embodiment
It is limited to above-mentioned processing step, that is, does not mean that the present invention has to rely on above-mentioned processing step and could implement.Technical field
Technical staff it will be clearly understood that any improvement in the present invention, equivalence replacement and auxiliary element to raw material selected by the present invention
Addition, selection of concrete mode etc., all fall within protection scope of the present invention and the open scope.
Claims (7)
1. a kind of composition of anti-trioxypurine, which is characterized in that composition percentage composition by weight is made of following component：Sea
Foreign fish oligopeptide powder 10-30%, leaf of Moringa powder 10-25%, acerola concentrate concentrate 4-12%, plum extract 5-15%.
2. composition according to claim 1, which is characterized in that composition percentage composition by weight is by following component
It is made：Ocean fish oligopeptide powder 25-30%, leaf of Moringa powder 15-20%, acerola concentrate concentrate 8-10%, plum extract 10-
15%.
3. composition according to claim 1 or 2, which is characterized in that the composition also contains edible adjuvant.
4. composition according to claim 3, which is characterized in that the edible adjuvant is excipient, stabilizer, flavoring agent
In color stabilizer any one or at least two mixture.
5. a kind of Chinese medicine preparation, which is characterized in that the Chinese medicine preparation contains claim 1-4 any one of them such as and combines
Object.
6. Chinese medicine preparation according to claim 5, which is characterized in that the dosage form of the preparation for tablet, capsule, pulvis,
Pill or granule.
7. according to application of the claim 1-4 any one of them composition in the food or drug for anti-trioxypurine is prepared.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510642189.9A CN105126067B (en) | 2015-09-30 | 2015-09-30 | A kind of composition of anti-trioxypurine and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510642189.9A CN105126067B (en) | 2015-09-30 | 2015-09-30 | A kind of composition of anti-trioxypurine and application thereof |
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| CN107951022A (en) * | 2017-12-28 | 2018-04-24 | 陆淼兴 | A kind of marine fish oligopeptide mixture and its preparation and preparation method |
| CN108185434A (en) * | 2018-01-19 | 2018-06-22 | 长江师范学院 | A kind of health food for preventing hyperuricemia and gout |
| CN109122859A (en) * | 2018-11-01 | 2019-01-04 | 威海健康生生物科技有限公司 | Anti-trioxypurine composition and the preparation method and application thereof |
| CN109172806A (en) * | 2018-11-07 | 2019-01-11 | 张玉龙 | A kind of composition and preparation method thereof reducing uric acid level |
| CN109567070A (en) * | 2018-12-12 | 2019-04-05 | 海南热带海洋学院 | A kind of acerola concentrate sea cucumber composite chewable tablet and preparation method thereof |
| CN110038119A (en) * | 2019-04-28 | 2019-07-23 | 杭州泽健医药科技有限公司 | A kind of pharmaceutical composition with anti-trioxypurine and antifatigue effect |
| CN111617231B (en) * | 2019-11-01 | 2023-02-24 | 北京同仁堂健康药业股份有限公司 | Uric acid-reducing and gout-resisting composition as well as preparation method and application thereof |
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