ZA201004214B - Dipeptidyl peptidase-iv inhibiting compounds,methods of preparing the same,and pharmaceutical compositions containing the same as active agent - Google Patents

Dipeptidyl peptidase-iv inhibiting compounds,methods of preparing the same,and pharmaceutical compositions containing the same as active agent

Info

Publication number
ZA201004214B
ZA201004214B ZA2010/04214A ZA201004214A ZA201004214B ZA 201004214 B ZA201004214 B ZA 201004214B ZA 2010/04214 A ZA2010/04214 A ZA 2010/04214A ZA 201004214 A ZA201004214 A ZA 201004214A ZA 201004214 B ZA201004214 B ZA 201004214B
Authority
ZA
South Africa
Prior art keywords
same
preparing
methods
pharmaceutical compositions
active agent
Prior art date
Application number
ZA2010/04214A
Inventor
Changhee Min
Wan Su Park
Hee Bong Lee
Sung-Hack Lee
Jaeick Lee
Kyoung-Hee Kim
Chang-Seok Lee
Hyeon Joo Yim
Kyu Woong Lee
Original Assignee
Lg Life Sciences Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lg Life Sciences Ltd filed Critical Lg Life Sciences Ltd
Publication of ZA201004214B publication Critical patent/ZA201004214B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
ZA2010/04214A 2007-12-21 2010-06-14 Dipeptidyl peptidase-iv inhibiting compounds,methods of preparing the same,and pharmaceutical compositions containing the same as active agent ZA201004214B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20070134887 2007-12-21
PCT/KR2008/007543 WO2009082134A2 (en) 2007-12-21 2008-12-19 Dipeptidyl peptidase-iv inhibiting compounds, methods of preparing the same, and pharmaceutical compositions containing the same as active agent

Publications (1)

Publication Number Publication Date
ZA201004214B true ZA201004214B (en) 2011-04-28

Family

ID=40801676

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA2010/04214A ZA201004214B (en) 2007-12-21 2010-06-14 Dipeptidyl peptidase-iv inhibiting compounds,methods of preparing the same,and pharmaceutical compositions containing the same as active agent

Country Status (14)

Country Link
US (1) US8470836B2 (en)
EP (1) EP2220086A4 (en)
JP (1) JP5358585B2 (en)
KR (1) KR101105607B1 (en)
CN (1) CN101903386B (en)
AU (1) AU2008341352B2 (en)
BR (1) BRPI0819719B8 (en)
CA (1) CA2710109C (en)
CO (1) CO6300861A2 (en)
EA (1) EA201070635A1 (en)
MA (1) MA31919B1 (en)
UA (1) UA103181C2 (en)
WO (1) WO2009082134A2 (en)
ZA (1) ZA201004214B (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011107494A1 (en) 2010-03-03 2011-09-09 Sanofi Novel aromatic glycoside derivatives, medicaments containing said compounds, and the use thereof
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
CA2810393C (en) * 2010-09-03 2016-04-12 Lg Life Sciences Ltd. Method of preparing 3-amino-4-(2-oxo-piperidin-1-yl)-butyric acid derivative for synthesizing medicament
CN102617566B (en) * 2011-01-30 2015-03-04 山东轩竹医药科技有限公司 Pyrazolo alkylimidazole derivative
CN102875567B (en) * 2011-07-15 2015-03-11 天津药物研究院 Piperazine compound and preparation and usage thereof
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP2760862B1 (en) 2011-09-27 2015-10-21 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
KR101539761B1 (en) * 2012-02-03 2015-07-28 주식회사 엘지생명과학 Method for preparing compounds through a novel Michael-addition reaction using water or various acids as additives
CN105142621A (en) 2012-10-24 2015-12-09 国家健康科学研究所 Tpl2 kinase inhibitors for preventing or treating diabetes and for promoting Beta-cell survival
CN105017244A (en) * 2014-04-16 2015-11-04 上海药明康德新药开发有限公司 Cis/trans-tert-butyl-4-O-hexahydro-1H-pyrrole[3,4-c]pyridine-2(3H)-tert-butyl carboxylate synthesis method
CN104447511A (en) * 2014-11-12 2015-03-25 江苏中邦制药有限公司 Synthetic method of N-t-butyloxycarboryl-3-piperidone
EP3273981B1 (en) 2015-03-24 2020-04-29 INSERM - Institut National de la Santé et de la Recherche Médicale Method and pharmaceutical composition for use in the treatment of diabetes
CN111247127B (en) * 2017-11-16 2024-02-06 株式会社Lg化学 Process for the production of intermediate compounds for the synthesis of medicaments

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CO5150173A1 (en) 1998-12-10 2002-04-29 Novartis Ag COMPOUNDS N- (REPLACED GLYCLE) -2-DIPEPTIDYL-IV PEPTIDASE INHIBITING CYANOPIRROLIDINS (DPP-IV) WHICH ARE EFFECTIVE IN THE TREATMENT OF CONDITIONS MEDIATED BY DPP-IV INHIBITION
UA74912C2 (en) 2001-07-06 2006-02-15 Merck & Co Inc Beta-aminotetrahydroimidazo-(1,2-a)-pyrazines and tetratriazolo-(4,3-a)-pyrazines as inhibitors of dipeptylpeptidase for the treatment or prevention of diabetes
US6861440B2 (en) 2001-10-26 2005-03-01 Hoffmann-La Roche Inc. DPP IV inhibitors
US7307164B2 (en) 2002-03-25 2007-12-11 Merck & Co., Inc. β-amino heterocyclic dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
CA2512546A1 (en) * 2003-01-17 2004-08-05 Merck & Co., Inc. 3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
WO2004089362A1 (en) * 2003-04-11 2004-10-21 Novo Nordisk A/S 2-cyanopyrroles and their analogues as ddp-iv inhibitors
TWI357902B (en) * 2005-04-01 2012-02-11 Lg Life Science Ltd Dipeptidyl peptidase-iv inhibiting compounds, meth

Also Published As

Publication number Publication date
CA2710109A1 (en) 2009-07-02
US20100274013A1 (en) 2010-10-28
EA201070635A1 (en) 2010-12-30
EP2220086A2 (en) 2010-08-25
AU2008341352A1 (en) 2009-07-02
AU2008341352B2 (en) 2013-08-01
JP2011507832A (en) 2011-03-10
US8470836B2 (en) 2013-06-25
CN101903386A (en) 2010-12-01
BRPI0819719A2 (en) 2015-06-16
CN101903386B (en) 2015-04-22
CA2710109C (en) 2016-07-19
WO2009082134A2 (en) 2009-07-02
MA31919B1 (en) 2010-12-01
CO6300861A2 (en) 2011-07-21
KR20090068156A (en) 2009-06-25
BRPI0819719A8 (en) 2015-09-22
KR101105607B1 (en) 2012-01-18
WO2009082134A3 (en) 2009-09-24
EP2220086A4 (en) 2010-12-22
JP5358585B2 (en) 2013-12-04
BRPI0819719B8 (en) 2021-05-25
BRPI0819719B1 (en) 2020-09-24
UA103181C2 (en) 2013-09-25

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