WO2008140421A3 - Dérivés de pyrimidine à substitution hétérocycloalkyle - Google Patents

Dérivés de pyrimidine à substitution hétérocycloalkyle Download PDF

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Publication number
WO2008140421A3
WO2008140421A3 PCT/SG2008/000180 SG2008000180W WO2008140421A3 WO 2008140421 A3 WO2008140421 A3 WO 2008140421A3 SG 2008000180 W SG2008000180 W SG 2008000180W WO 2008140421 A3 WO2008140421 A3 WO 2008140421A3
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
disorders
heterocycloalkyl substituted
substituted pyrimidine
pyrimidine derivatives
Prior art date
Application number
PCT/SG2008/000180
Other languages
English (en)
Other versions
WO2008140421A2 (fr
Inventor
Haishan Wang
Original Assignee
S Bio Pte Ltd
Haishan Wang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by S Bio Pte Ltd, Haishan Wang filed Critical S Bio Pte Ltd
Publication of WO2008140421A2 publication Critical patent/WO2008140421A2/fr
Publication of WO2008140421A3 publication Critical patent/WO2008140421A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

Abstract

La présente invention concerne des composés à base de pyrimidine qui sont utiles comme agents de traitement de troubles liés aux kinases, tels que des troubles évolutifs. La présente invention concerne plus précisément des composés de pyrimidine à substitution hétérocycloalkyle, leurs méthodes de préparation, des compositions pharmaceutiques contenant ces composés et des usages de ces composés dans le traitement de troubles évolutifs. Ces composés peuvent être utiles comme médicaments pour le traitement de plusieurs troubles liés aux kinases, tels que des troubles évolutifs, y compris des tumeurs et des cancers, ainsi que d'autres troubles ou états pathologiques associés ou liés aux kinases.
PCT/SG2008/000180 2007-05-15 2008-05-14 Dérivés de pyrimidine à substitution hétérocycloalkyle WO2008140421A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92444107P 2007-05-15 2007-05-15
US60/924,441 2007-05-15

Publications (2)

Publication Number Publication Date
WO2008140421A2 WO2008140421A2 (fr) 2008-11-20
WO2008140421A3 true WO2008140421A3 (fr) 2009-04-30

Family

ID=40002774

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/SG2008/000180 WO2008140421A2 (fr) 2007-05-15 2008-05-14 Dérivés de pyrimidine à substitution hétérocycloalkyle

Country Status (1)

Country Link
WO (1) WO2008140421A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102617599B (zh) * 2012-04-10 2014-04-16 江苏先声药物研究有限公司 大环类化合物及其应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002096888A1 (fr) * 2001-05-29 2002-12-05 Schering Aktiengesellschaft Pyrimidine inhibitrice de la cdk, sa production et son utilisation comme medicament
WO2004078682A2 (fr) * 2003-03-05 2004-09-16 Irm Llc Composes cycliques et compositions servant d'inhibiteurs de proteines-kinases

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002096888A1 (fr) * 2001-05-29 2002-12-05 Schering Aktiengesellschaft Pyrimidine inhibitrice de la cdk, sa production et son utilisation comme medicament
WO2004078682A2 (fr) * 2003-03-05 2004-09-16 Irm Llc Composes cycliques et compositions servant d'inhibiteurs de proteines-kinases

Also Published As

Publication number Publication date
WO2008140421A2 (fr) 2008-11-20

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