WO2008140421A3 - Heterocycloalkyl substituted pyrimidine derivatives - Google Patents

Heterocycloalkyl substituted pyrimidine derivatives Download PDF

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Publication number
WO2008140421A3
WO2008140421A3 PCT/SG2008/000180 SG2008000180W WO2008140421A3 WO 2008140421 A3 WO2008140421 A3 WO 2008140421A3 SG 2008000180 W SG2008000180 W SG 2008000180W WO 2008140421 A3 WO2008140421 A3 WO 2008140421A3
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
disorders
heterocycloalkyl substituted
substituted pyrimidine
pyrimidine derivatives
Prior art date
Application number
PCT/SG2008/000180
Other languages
French (fr)
Other versions
WO2008140421A2 (en
Inventor
Haishan Wang
Original Assignee
S Bio Pte Ltd
Haishan Wang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by S Bio Pte Ltd, Haishan Wang filed Critical S Bio Pte Ltd
Publication of WO2008140421A2 publication Critical patent/WO2008140421A2/en
Publication of WO2008140421A3 publication Critical patent/WO2008140421A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

Abstract

The present invention relates to pyrimidine compounds that are useful as agents for the treatment of kinase related disorders such as proliferative disorders. More particularly, the present invention relates to heterocycloalkyl substituted pyrimidine compounds, methods for their preparation, pharmaceutical compositions containing these compounds and uses of these compounds in the treatment of proliferative disorders. These compounds may be useful as medicaments for the treatment of a number of kinase related disorders such as proliferative disorders including tumours and cancers as well as other disorders or conditions related to or associated with kinases.
PCT/SG2008/000180 2007-05-15 2008-05-14 Heterocycloalkyl substituted pyrimidine derivatives WO2008140421A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92444107P 2007-05-15 2007-05-15
US60/924,441 2007-05-15

Publications (2)

Publication Number Publication Date
WO2008140421A2 WO2008140421A2 (en) 2008-11-20
WO2008140421A3 true WO2008140421A3 (en) 2009-04-30

Family

ID=40002774

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/SG2008/000180 WO2008140421A2 (en) 2007-05-15 2008-05-14 Heterocycloalkyl substituted pyrimidine derivatives

Country Status (1)

Country Link
WO (1) WO2008140421A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102617599B (en) * 2012-04-10 2014-04-16 江苏先声药物研究有限公司 Macrocyclic compound and application thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002096888A1 (en) * 2001-05-29 2002-12-05 Schering Aktiengesellschaft Cdk inhibiting pyrimidines, production thereof and their use as medicaments
WO2004078682A2 (en) * 2003-03-05 2004-09-16 Irm Llc Cyclic compounds and compositions as protein kinase inhibitors

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002096888A1 (en) * 2001-05-29 2002-12-05 Schering Aktiengesellschaft Cdk inhibiting pyrimidines, production thereof and their use as medicaments
WO2004078682A2 (en) * 2003-03-05 2004-09-16 Irm Llc Cyclic compounds and compositions as protein kinase inhibitors

Also Published As

Publication number Publication date
WO2008140421A2 (en) 2008-11-20

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