WO2008103068A3 - Способ получения 2-aнилинoпиpимидинoв или их солей - Google Patents

Способ получения 2-aнилинoпиpимидинoв или их солей Download PDF

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Publication number
WO2008103068A3
WO2008103068A3 PCT/RU2008/000037 RU2008000037W WO2008103068A3 WO 2008103068 A3 WO2008103068 A3 WO 2008103068A3 RU 2008000037 W RU2008000037 W RU 2008000037W WO 2008103068 A3 WO2008103068 A3 WO 2008103068A3
Authority
WO
WIPO (PCT)
Prior art keywords
producing
anilinopyrimidines
salts
novel
treating
Prior art date
Application number
PCT/RU2008/000037
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English (en)
French (fr)
Other versions
WO2008103068A2 (ru
Inventor
Yury Iosifovich Kopyrin
Original Assignee
Yury Iosifovich Kopyrin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yury Iosifovich Kopyrin filed Critical Yury Iosifovich Kopyrin
Publication of WO2008103068A2 publication Critical patent/WO2008103068A2/ru
Publication of WO2008103068A3 publication Critical patent/WO2008103068A3/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Изобретение относится к новому способу получения производных 2- анилинопиримидинов и их солей, которые могут найти применение для приготовления лекарственных средств при лечении различных заболеваний, в частности соединений с противоопухолевой активностью. Согласно предлагаемому способу может быть получен также иматиниб, известный как средство для лечения лейкемии, церебральной ишемии, сосудистого стеноза. Способ позволяет получить также новые промежуточные продукты и новые производные 2- анилинопиримидинов.
PCT/RU2008/000037 2007-02-20 2008-01-25 Способ получения 2-aнилинoпиpимидинoв или их солей WO2008103068A2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RU2007106105/04A RU2329260C1 (ru) 2007-02-20 2007-02-20 Способ получения 2-анилинопиримидинов или их солей (варианты)
RU2007106105 2007-02-20

Publications (2)

Publication Number Publication Date
WO2008103068A2 WO2008103068A2 (ru) 2008-08-28
WO2008103068A3 true WO2008103068A3 (ru) 2008-10-16

Family

ID=39710618

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/RU2008/000037 WO2008103068A2 (ru) 2007-02-20 2008-01-25 Способ получения 2-aнилинoпиpимидинoв или их солей

Country Status (2)

Country Link
RU (1) RU2329260C1 (ru)
WO (1) WO2008103068A2 (ru)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2480086A4 (en) 2009-09-25 2013-03-20 N30 Pharmaceuticals Inc NOVEL DIHYDROPYRIMIDINE-2 (1H) -ONES COMPOUNDS AS INHIBITORS OF S-NITROSOGLUTATHION REDUCTASE
WO2012039718A1 (en) 2010-09-24 2012-03-29 N30 Pharmaceuticals, Llc Novel dihydropyrimidin-2(1h)-one compounds as neurokinin-3 receptor antagonists
CN102796110B (zh) * 2011-05-23 2016-03-30 复旦大学 苯胺嘧啶化合物及其制备方法和用途
RU2486180C1 (ru) * 2011-11-02 2013-06-27 Общество с ограниченной ответственностью "ТехноХим" (ООО "ТехноХим") Способ получения 2-ариламино-4-гетарилпиримидинов
WO2013120852A1 (en) 2012-02-13 2013-08-22 Grindeks, A Joint Stock Company Intermediates for a novel process of preparing imatinib and related tyrosine kinase inhibitors
BR112017024229A2 (pt) * 2015-05-12 2018-07-17 Ecolab Usa Inc composição, métodos para formar uma composição injetável e para recuperar compostos de hidrocarboneto, e, uso de uma composição.
CN105801559B (zh) * 2016-04-28 2019-03-01 北京化工大学 4-甲基-3-[[4-(3-吡啶基)-2-嘧啶基]氨基]苯甲酸乙酯的制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0812832A1 (en) * 1996-04-10 1997-12-17 Rohm And Haas Company Improved process for pyrimidinone compounds
RU2125992C1 (ru) * 1992-04-03 1999-02-10 Новартис Аг Производные n-фенил-2-пиримидинамина или их соли и фармацевтическая композиция на их основе, обладающая противоопухолевой активностью
RU2005129100A (ru) * 2003-02-18 2006-06-10 Сипла Лтд. (In) Способ получения иматиниба, и иматиниб, полученный данным способом

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2125992C1 (ru) * 1992-04-03 1999-02-10 Новартис Аг Производные n-фенил-2-пиримидинамина или их соли и фармацевтическая композиция на их основе, обладающая противоопухолевой активностью
EP0812832A1 (en) * 1996-04-10 1997-12-17 Rohm And Haas Company Improved process for pyrimidinone compounds
RU2005129100A (ru) * 2003-02-18 2006-06-10 Сипла Лтд. (In) Способ получения иматиниба, и иматиниб, полученный данным способом

Also Published As

Publication number Publication date
RU2329260C1 (ru) 2008-07-20
WO2008103068A2 (ru) 2008-08-28

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