WO2008081659A1 - 内視鏡システム - Google Patents

内視鏡システム Download PDF

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Publication number
WO2008081659A1
WO2008081659A1 PCT/JP2007/072725 JP2007072725W WO2008081659A1 WO 2008081659 A1 WO2008081659 A1 WO 2008081659A1 JP 2007072725 W JP2007072725 W JP 2007072725W WO 2008081659 A1 WO2008081659 A1 WO 2008081659A1
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WO
WIPO (PCT)
Prior art keywords
fluorescence
information
unit
concentration
observation mode
Prior art date
Application number
PCT/JP2007/072725
Other languages
English (en)
French (fr)
Inventor
Masaya Nakaoka
Koki Morishita
Original Assignee
Olympus Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Olympus Corporation filed Critical Olympus Corporation
Priority to US12/521,224 priority Critical patent/US8313426B2/en
Priority to CN2007800480187A priority patent/CN101573068B/zh
Priority to EP07832450A priority patent/EP2098156A4/en
Publication of WO2008081659A1 publication Critical patent/WO2008081659A1/ja

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
    • A61B1/05—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances characterised by the image sensor, e.g. camera, being in the distal end portion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
    • A61B1/043—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances for fluorescence imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/06—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements
    • A61B1/0638—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements providing two or more wavelengths
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/06—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements
    • A61B1/0655—Control therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/2823—Imaging spectrometer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/44—Raman spectrometry; Scattering spectrometry ; Fluorescence spectrometry
    • G01J3/4406—Fluorescence spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
    • G01N2021/6441—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks with two or more labels

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Surgery (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Optics & Photonics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Endoscopes (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)

Abstract

　混合状態で取得された蛍光画像から各蛍光薬剤毎の蛍光の分布画像を取得することを可能とし、癌細胞の診断能を向上する。光学特性の異なる２種類以上の蛍光薬剤を励起させるために分光特性の異なる２種類以上の励起光を選択的に照射する光源部と、体腔内に入れられる部位に設けられ、各励起光により観察対象から放射される２種類以上の蛍光の波長帯域に受光感度を有する撮像部と、蛍光強度と各蛍光薬剤の濃度との相対関係情報を記憶する記憶部と、撮像部により撮影された２以上の画像の蛍光強度と記憶部に記憶されている相対関係情報とに基づいて、各蛍光薬剤の濃度情報を演算して出力する濃度情報演算部と、撮像部により取得された少なくとも１つの蛍光強度画像を提示する第１の蛍光観察モードと、濃度情報演算部により演算された各蛍光薬剤の濃度情報を提示する第２の蛍光観察モードとを切替可能なモード切替部とを備える内視鏡システムを提供する。
PCT/JP2007/072725 2006-12-28 2007-11-26 内視鏡システム WO2008081659A1 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US12/521,224 US8313426B2 (en) 2006-12-28 2007-11-26 Endoscope system
CN2007800480187A CN101573068B (zh) 2006-12-28 2007-11-26 内窥镜***
EP07832450A EP2098156A4 (en) 2006-12-28 2007-11-26 ENDOSCOPE SYSTEM

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2006-356139 2006-12-28
JP2006356139A JP2008161550A (ja) 2006-12-28 2006-12-28 内視鏡システム

Publications (1)

Publication Number Publication Date
WO2008081659A1 true WO2008081659A1 (ja) 2008-07-10

Family

ID=39588343

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2007/072725 WO2008081659A1 (ja) 2006-12-28 2007-11-26 内視鏡システム

Country Status (5)

Country Link
US (1) US8313426B2 (ja)
EP (1) EP2098156A4 (ja)
JP (1) JP2008161550A (ja)
CN (1) CN101573068B (ja)
WO (1) WO2008081659A1 (ja)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2322075A1 (en) * 2009-03-30 2011-05-18 Olympus Medical Systems Corp. Fluorescence observation device
CN103654700A (zh) * 2013-12-31 2014-03-26 中国人民武装警察部队总医院 荧光内窥成像***及成像方法
WO2019081833A1 (fr) * 2017-10-26 2019-05-02 Fluoptics Procédé et dispositif de suivi de la fluorescence émise à la surface d'un tissu biologique
CN111122855A (zh) * 2020-01-10 2020-05-08 上海泰辉生物科技有限公司 荧光免疫层析试纸条即时检测***
CN115825032A (zh) * 2023-02-08 2023-03-21 之江实验室 一种数字化荧光仿生模体成像方法及***

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US8498695B2 (en) 2006-12-22 2013-07-30 Novadaq Technologies Inc. Imaging system with a single color image sensor for simultaneous fluorescence and color video endoscopy
EP2268194B1 (en) 2008-03-18 2016-08-31 Novadaq Technologies Inc. Imaging system for combined full-color reflectance and near-infrared imaging
JP5389380B2 (ja) 2008-05-28 2014-01-15 オリンパス株式会社 信号処理システム及び信号処理プログラム
DE602009001103D1 (de) * 2008-06-04 2011-06-01 Fujifilm Corp Beleuchtungsvorrichtung zur Verwendung in Endoskopen
JP5216429B2 (ja) * 2008-06-13 2013-06-19 富士フイルム株式会社 光源装置および内視鏡装置
JP4717103B2 (ja) 2008-07-18 2011-07-06 オリンパス株式会社 信号処理システム及び信号処理プログラム
JP4773583B2 (ja) * 2009-10-20 2011-09-14 オリンパスメディカルシステムズ株式会社 蛍光観察装置
JP2011104199A (ja) * 2009-11-19 2011-06-02 Fujifilm Corp 内視鏡装置
JP5721959B2 (ja) * 2010-03-16 2015-05-20 オリンパス株式会社 蛍光内視鏡装置
JP5432793B2 (ja) * 2010-03-29 2014-03-05 オリンパス株式会社 蛍光内視鏡装置
US9211058B2 (en) 2010-07-02 2015-12-15 Intuitive Surgical Operations, Inc. Method and system for fluorescent imaging with background surgical image composed of selective illumination spectra
US10682198B2 (en) 2010-07-02 2020-06-16 Intuitive Surgical Operations, Inc. Method and system for fluorescent imaging with background surgical image composed of selective illumination spectra
JP2012016545A (ja) * 2010-07-09 2012-01-26 Fujifilm Corp 内視鏡装置
US9115862B2 (en) * 2010-08-24 2015-08-25 Osram Gmbh Colour-tunable light source unit with phosphor element
JP5685406B2 (ja) * 2010-09-06 2015-03-18 富士フイルム株式会社 画像撮像装置およびその作動方法
JP5525991B2 (ja) * 2010-10-21 2014-06-18 富士フイルム株式会社 電子内視鏡システム、電子内視鏡システムのプロセッサ装置、及び電子内視鏡システムの作動方法
EP2596739A4 (en) * 2010-12-13 2017-08-16 Olympus Corporation Medical apparatus
JP5405445B2 (ja) 2010-12-17 2014-02-05 富士フイルム株式会社 内視鏡装置
JP5309120B2 (ja) 2010-12-20 2013-10-09 富士フイルム株式会社 内視鏡装置
RU2016149820A (ru) 2011-03-08 2018-11-05 Новадак Текнолоджис Инк. Светодиодное осветительное устройство полного спектра
EP2599428B1 (en) * 2011-03-15 2017-09-06 Olympus Corporation Medical apparatus
CN103153155B (zh) 2011-03-15 2014-09-10 奥林巴斯医疗株式会社 医疗装置
JP2012217673A (ja) * 2011-04-11 2012-11-12 Fujifilm Corp 内視鏡診断装置
US20140213898A1 (en) 2011-09-02 2014-07-31 Ttaas Thommo's Training & Assessment Systems Pty Ltd Method for detecting fluid injection in a patient
CA3105924C (en) * 2011-12-21 2022-06-28 Catherine M. Shachaf System for imaging lesions aligning tissue surfaces
DE102011122602A1 (de) * 2011-12-30 2013-07-04 Karl Storz Gmbh & Co. Kg Vorrichtung und Verfahren zur endoskopischen Fluoreszenzdetektion
US11433147B2 (en) 2014-02-10 2022-09-06 Quaker Chemical (Australasia) Pty Ltd Fluorescent fluid for detecting fluid injection
JP2014161500A (ja) * 2013-02-25 2014-09-08 Canon Inc 画像処理装置、眼科撮影装置及び方法、並びにプログラム
EP2982289A4 (en) * 2013-05-29 2016-10-05 ENDOSCOPE SYSTEM
JP5789348B2 (ja) * 2013-07-11 2015-10-07 オリンパス株式会社 光源装置
CN106687025A (zh) * 2014-09-19 2017-05-17 奥林巴斯株式会社 光发送单元、光发送模块与发送侧光连接器的连接方法以及内窥镜***
WO2017068908A1 (ja) * 2015-10-22 2017-04-27 オリンパス株式会社 内視鏡システム
CN113648067A (zh) 2015-11-13 2021-11-16 史赛克欧洲运营有限公司 用于目标的照明和成像的***和方法
EP3408654B1 (en) 2016-01-26 2022-08-03 Stryker European Operations Limited Fluorescence imaging system and method for fluorescence imaging
USD916294S1 (en) 2016-04-28 2021-04-13 Stryker European Operations Limited Illumination and imaging device
WO2017214730A1 (en) 2016-06-14 2017-12-21 Novadaq Technologies Inc. Methods and systems for adaptive imaging for low light signal enhancement in medical visualization
WO2018083879A1 (ja) * 2016-11-01 2018-05-11 オリンパス株式会社 生体観察システム
CA3049922A1 (en) 2017-02-10 2018-08-16 Novadaq Technologies ULC Open-field handheld fluorescence imaging systems and methods
JP6956805B2 (ja) * 2017-12-22 2021-11-02 オリンパス株式会社 内視鏡システム、内視鏡システムの制御方法
CN111565620A (zh) * 2017-12-27 2020-08-21 爱惜康有限责任公司 缺光环境中的荧光成像
EP3886680A1 (en) * 2018-11-30 2021-10-06 Intuitive Surgical Operations, Inc. Medical imaging systems and methods that facilitate use of different fluorescence imaging agents

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Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2322075A1 (en) * 2009-03-30 2011-05-18 Olympus Medical Systems Corp. Fluorescence observation device
CN102164530A (zh) * 2009-03-30 2011-08-24 奥林巴斯医疗株式会社 荧光观察装置
EP2322075A4 (en) * 2009-03-30 2011-10-26 Olympus Medical Systems Corp FLUORESCENCE OBSERVATION DEVICE
CN103654700A (zh) * 2013-12-31 2014-03-26 中国人民武装警察部队总医院 荧光内窥成像***及成像方法
CN103654700B (zh) * 2013-12-31 2016-08-31 中国人民武装警察部队总医院 荧光内窥成像***及成像方法
WO2019081833A1 (fr) * 2017-10-26 2019-05-02 Fluoptics Procédé et dispositif de suivi de la fluorescence émise à la surface d'un tissu biologique
CN111122855A (zh) * 2020-01-10 2020-05-08 上海泰辉生物科技有限公司 荧光免疫层析试纸条即时检测***
CN111122855B (zh) * 2020-01-10 2023-04-11 上海泰辉生物科技有限公司 荧光免疫层析试纸条即时检测***
CN115825032A (zh) * 2023-02-08 2023-03-21 之江实验室 一种数字化荧光仿生模体成像方法及***

Also Published As

Publication number Publication date
CN101573068A (zh) 2009-11-04
JP2008161550A (ja) 2008-07-17
US20100094136A1 (en) 2010-04-15
CN101573068B (zh) 2011-01-26
EP2098156A1 (en) 2009-09-09
US8313426B2 (en) 2012-11-20
EP2098156A4 (en) 2011-05-11

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