WO2007080324A3 - Derives de pyrido-pyrimidone, leur preparation, leur application en therapeutique. - Google Patents
Derives de pyrido-pyrimidone, leur preparation, leur application en therapeutique. Download PDFInfo
- Publication number
- WO2007080324A3 WO2007080324A3 PCT/FR2007/000050 FR2007000050W WO2007080324A3 WO 2007080324 A3 WO2007080324 A3 WO 2007080324A3 FR 2007000050 W FR2007000050 W FR 2007000050W WO 2007080324 A3 WO2007080324 A3 WO 2007080324A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- therapeutic use
- derivatives
- preparation
- pyridopyrimidone
- general formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Abstract
L'invention à pour objet des dérivés de pyrido[2,3-d]pyrimidone, leur préparation et leur application en thérapeutique, de formule générale (I) qui suit : (I) à l'état de base ou de sel d'addition à un acide pharmaceutiquement acceptable, à l'état d'hydrates ou de solvates, ainsi que sous forme d'énantiomères, de diastéréoisomères et leur mélange. L'invention a également pour objet leur procédé de préparation, des compositions pharmaceutiques contenant un composé de formule générale (I), et leur utilisation en thérapeutique.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07717935A EP1979352A2 (fr) | 2006-01-13 | 2007-01-12 | Derives de pyrido-pyrimidone, leur preparation, leur application en therapeutique. |
JP2008549907A JP2009523159A (ja) | 2006-01-13 | 2007-01-12 | ピリドピリミドン誘導体、これらの調製、これらの治療上の使用 |
US12/166,431 US7842806B2 (en) | 2006-01-13 | 2008-07-02 | Pyridopyrimidone derivatives, preparation thereof, therapeutic use thereof |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0600298 | 2006-01-13 | ||
FR0600298A FR2896246B1 (fr) | 2006-01-13 | 2006-01-13 | Derives de pyrido-pyrimidone, leur preparation, leur application en therapeutique. |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/166,431 Continuation US7842806B2 (en) | 2006-01-13 | 2008-07-02 | Pyridopyrimidone derivatives, preparation thereof, therapeutic use thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2007080324A2 WO2007080324A2 (fr) | 2007-07-19 |
WO2007080324A3 true WO2007080324A3 (fr) | 2007-08-30 |
Family
ID=36678623
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/FR2007/000050 WO2007080324A2 (fr) | 2006-01-13 | 2007-01-12 | Derives de pyrido-pyrimidone, leur preparation, leur application en therapeutique. |
Country Status (5)
Country | Link |
---|---|
US (1) | US7842806B2 (fr) |
EP (1) | EP1979352A2 (fr) |
JP (1) | JP2009523159A (fr) |
FR (1) | FR2896246B1 (fr) |
WO (1) | WO2007080324A2 (fr) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2873118B1 (fr) | 2004-07-15 | 2007-11-23 | Sanofi Synthelabo | Derives de pyrido-pyrimidine, leur application en therapeutique |
FR2887882B1 (fr) | 2005-07-01 | 2007-09-07 | Sanofi Aventis Sa | Derives de pyrido[2,3-d] pyrimidine, leur preparation, leur application en therapeutique |
FR2910813B1 (fr) | 2006-12-28 | 2009-02-06 | Sanofi Aventis Sa | Nouvelle utilisation therapeutique pour le traitement des leucemies |
WO2015019037A1 (fr) * | 2013-08-05 | 2015-02-12 | Almac Discovery Limited | Composés pharmaceutiques |
GB201322602D0 (en) | 2013-12-19 | 2014-02-05 | Almac Discovery Ltd | Pharmaceutical compounds |
AU2015296322B2 (en) | 2014-07-26 | 2019-09-19 | Sunshine Lake Pharma Co., Ltd. | 2-amino-pyrido[2,3-d]pyrimidin-7(8h)-one derivatives as CDK inhibitors and uses thereof |
PL3191099T3 (pl) * | 2014-09-12 | 2019-07-31 | Biolab Sanus Farmacéutica Ltda | Pochodne pirydopirymidyn |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996034867A1 (fr) * | 1995-05-03 | 1996-11-07 | Warner-Lambert Company | PYRIDO[2,3-d]PYRIMIDINES DESTINEES A INHIBER LA PROLIFERATION CELLULAIRE INDUITE PAR LES TYROSINES KINASES |
WO2002012238A2 (fr) * | 2000-08-04 | 2002-02-14 | Warner-Lambert Company | 2-(4-pyridyl)amino-6-dialcoxyphenyl-pyrido[2,3-d]pyrimidine-7-ones |
WO2004063195A1 (fr) * | 2003-01-03 | 2004-07-29 | Sloan-Kettering Institute For Cancer Research | Inhibiteurs de kinases a base de pyridopyrimidine |
WO2005105097A2 (fr) * | 2004-04-28 | 2005-11-10 | Gpc Biotech Ag | Derives de pyridopyrimidine |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1171218A (en) * | 1967-11-09 | 1969-11-19 | Parke Davis & Co | New Heterocyclic Amine Compounds and Methods for their Production |
IL115256A0 (en) * | 1994-11-14 | 1995-12-31 | Warner Lambert Co | 6-Aryl pyrido (2,3-d) pyrimidines and naphthyridines and their use |
MX9702245A (es) | 1994-11-14 | 1997-06-28 | Warner Lambert Co | Seis-aril-pirido(2,3-d)pirimidinas y naftiridinas para inhibir la proliferacion celular mediada por la proteina cinasa tirosina. |
US5620981A (en) * | 1995-05-03 | 1997-04-15 | Warner-Lambert Company | Pyrido [2,3-D]pyrimidines for inhibiting protein tyrosine kinase mediated cellular proliferation |
AU7315700A (en) | 1999-09-20 | 2001-04-24 | Takeda Chemical Industries Ltd. | Melanin concentrating hormone antagonist |
AR030044A1 (es) | 2000-01-25 | 2003-08-13 | Warner Lambert Co | Pirido (2,3-d ) pirimidin-2,7-diaminas inhibidores de quinasas |
EE200200506A (et) | 2000-03-06 | 2004-02-16 | Warner-Lambert Company | 5-alküülpürido[2,3-d]pürimidiinid kui türosiinkinaasi inhibiitorid |
WO2003000011A2 (fr) | 2001-06-21 | 2003-01-03 | Ariad Pharmaceuticals, Inc. | Nouvelles pyridopyrimidines et leur utilisation |
TW200502236A (en) | 2003-03-28 | 2005-01-16 | Hoffmann La Roche | Novel pyrido[2,3-d]pyrimidin-7-carboxylic acid derivatives, their manufacture and use as pharmaceutical agents |
FR2873118B1 (fr) | 2004-07-15 | 2007-11-23 | Sanofi Synthelabo | Derives de pyrido-pyrimidine, leur application en therapeutique |
PE20060569A1 (es) | 2004-07-16 | 2006-06-22 | Boehringer Ingelheim Int | Compuestos de indol carbonilamino como inhibidores de la polimerasa ne5b del vhc |
FR2887882B1 (fr) | 2005-07-01 | 2007-09-07 | Sanofi Aventis Sa | Derives de pyrido[2,3-d] pyrimidine, leur preparation, leur application en therapeutique |
-
2006
- 2006-01-13 FR FR0600298A patent/FR2896246B1/fr not_active Expired - Fee Related
-
2007
- 2007-01-12 JP JP2008549907A patent/JP2009523159A/ja not_active Withdrawn
- 2007-01-12 EP EP07717935A patent/EP1979352A2/fr not_active Withdrawn
- 2007-01-12 WO PCT/FR2007/000050 patent/WO2007080324A2/fr active Application Filing
-
2008
- 2008-07-02 US US12/166,431 patent/US7842806B2/en not_active Expired - Fee Related
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996034867A1 (fr) * | 1995-05-03 | 1996-11-07 | Warner-Lambert Company | PYRIDO[2,3-d]PYRIMIDINES DESTINEES A INHIBER LA PROLIFERATION CELLULAIRE INDUITE PAR LES TYROSINES KINASES |
WO2002012238A2 (fr) * | 2000-08-04 | 2002-02-14 | Warner-Lambert Company | 2-(4-pyridyl)amino-6-dialcoxyphenyl-pyrido[2,3-d]pyrimidine-7-ones |
WO2004063195A1 (fr) * | 2003-01-03 | 2004-07-29 | Sloan-Kettering Institute For Cancer Research | Inhibiteurs de kinases a base de pyridopyrimidine |
WO2005105097A2 (fr) * | 2004-04-28 | 2005-11-10 | Gpc Biotech Ag | Derives de pyridopyrimidine |
Non-Patent Citations (1)
Title |
---|
PALMER B D ET AL: "Structure-activity relationships for 2-anilino-6-phenylpyrido[2,3-d]p yrimidin-7(8H)-ones as inhibitors of the cellular checkpoint kinase Wee1", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 15, no. 7, 1 April 2005 (2005-04-01), pages 1931 - 1935, XP004789411, ISSN: 0960-894X * |
Also Published As
Publication number | Publication date |
---|---|
WO2007080324A2 (fr) | 2007-07-19 |
FR2896246A1 (fr) | 2007-07-20 |
JP2009523159A (ja) | 2009-06-18 |
EP1979352A2 (fr) | 2008-10-15 |
US7842806B2 (en) | 2010-11-30 |
FR2896246B1 (fr) | 2008-08-15 |
US20090048277A1 (en) | 2009-02-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2006016067A3 (fr) | Derives de pyrido-pyrimidine, leur preparation, leur application dans le traitement du cancer | |
WO2006042954A8 (fr) | Dérivés de 2-amido-4-phenylthiazole, leur préparation et leur application en thérapeutique | |
WO2008002244A3 (fr) | Nouveaux composés 384 | |
WO2007040438A3 (fr) | Derives d'imidazo(4,5-b) pyridine utilises comme inhibiteurs de la glycogene synthase kinase 3 pour le traitement de la demence et de troubles neurodegeneratifs | |
WO2008002245A8 (fr) | Nouveaux composés 385 | |
WO2006077025A3 (fr) | Morpholines en tant qu'agonistes de 5ht2c | |
WO2007138472A3 (fr) | Dérivés de la triazolopyridazine | |
TW200626553A (en) | Novel compounds | |
WO2006011050A3 (fr) | Derives de pyridine | |
WO2008120725A1 (fr) | Nouveau dérivé de pyrrolinone et composition médicale le contenant | |
ZA200707901B (en) | Novel imidazo[1,5-a]pyridine derivatives, method for preparing same and pharmaceutical compositions containing same | |
MX2009006018A (es) | Derivados de quinuclidinol como antagonistas de receptores muscarinicos. | |
HK1135964A1 (en) | Derivatives of imidazo[1,2-a]pyridine-2-carboxamides, preparation method thereof and use of same in therapeutics | |
WO2007080324A3 (fr) | Derives de pyrido-pyrimidone, leur preparation, leur application en therapeutique. | |
MX2009010165A (es) | Nuevas imidazo[4,5-b]piridina-7-carboxamidas 704. | |
UA99447C2 (ru) | Способ получения силденафила | |
WO2009140341A3 (fr) | Compositions d'atorvastatine | |
WO2008006795A3 (fr) | Composés d'indole | |
PL1730144T3 (pl) | Podstawione pochodne 1,4,8-triazaspiro[4.5]dekan-2-onu | |
PL1869038T3 (pl) | Podstawione pochodne 5,6,7,8-tetrahydro-imidazo[1,2-a]pirydyn-2-yloaminy i ich zastosowanie do wytwarzania środków leczniczych | |
WO2011009714A3 (fr) | Dérivés de sel de benzoquinolizinium comme agents anti-cancéreux | |
WO2006072000A3 (fr) | Compositions pharmaceutiques a base de derives d'acide xanthurenique et methodes associees | |
WO2004083185A3 (fr) | Composes imidazole | |
WO2006074919A3 (fr) | Amides d'acide 3-amino-6-aryl-thieno[2,3-b]pyridine-2-carboxylique, preparations pharmaceutiques contenant ces composes et utilisation desdits composes comme inhibiteurs de la liberation de tnf$g(a) | |
WO2008039894A3 (fr) | Compositions pharmaceutiques d'atorvastatine |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
WWE | Wipo information: entry into national phase |
Ref document number: 2007717935 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2008549907 Country of ref document: JP |
|
NENP | Non-entry into the national phase |
Ref country code: DE |