WO2007025774A3 - Cysteine protease inhibitors - Google Patents

Cysteine protease inhibitors Download PDF

Info

Publication number
WO2007025774A3
WO2007025774A3 PCT/EP2006/008578 EP2006008578W WO2007025774A3 WO 2007025774 A3 WO2007025774 A3 WO 2007025774A3 EP 2006008578 W EP2006008578 W EP 2006008578W WO 2007025774 A3 WO2007025774 A3 WO 2007025774A3
Authority
WO
WIPO (PCT)
Prior art keywords
protease inhibitors
cysteine protease
compounds
processes
formula
Prior art date
Application number
PCT/EP2006/008578
Other languages
French (fr)
Other versions
WO2007025774A2 (en
Inventor
Alvaro Isabel Castellote
Lopez Jose Miguel Coteron
Velando Esther Pilar Fernandez
Roman Jose Maria Fiandor
De Francisco Esther Porras
Original Assignee
Glaxo Group Ltd
Alvaro Isabel Castellote
Lopez Jose Miguel Coteron
Velando Esther Pilar Fernandez
Roman Jose Maria Fiandor
De Francisco Esther Porras
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd, Alvaro Isabel Castellote, Lopez Jose Miguel Coteron, Velando Esther Pilar Fernandez, Roman Jose Maria Fiandor, De Francisco Esther Porras filed Critical Glaxo Group Ltd
Publication of WO2007025774A2 publication Critical patent/WO2007025774A2/en
Publication of WO2007025774A3 publication Critical patent/WO2007025774A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A61P33/12—Schistosomicides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Abstract

Substituted heteroaryl nitrile derivatives of Formula (I), processes for their preparation, pharmaceutical compositions comprising such compounds and use of the compounds as cysteine protease inhibitors are provided.
PCT/EP2006/008578 2005-09-02 2006-08-31 Cysteine protease inhibitors WO2007025774A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP05381043 2005-09-02
EP05381043.8 2005-09-02
EP06110666.2 2006-03-03
EP06110666 2006-03-03

Publications (2)

Publication Number Publication Date
WO2007025774A2 WO2007025774A2 (en) 2007-03-08
WO2007025774A3 true WO2007025774A3 (en) 2007-04-26

Family

ID=37770277

Family Applications (3)

Application Number Title Priority Date Filing Date
PCT/EP2006/008580 WO2007025776A2 (en) 2005-09-02 2006-08-31 Cysteine protease inhibitors
PCT/EP2006/008578 WO2007025774A2 (en) 2005-09-02 2006-08-31 Cysteine protease inhibitors
PCT/EP2006/008579 WO2007025775A2 (en) 2005-09-02 2006-08-31 Cysteine protease inhibitors

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/EP2006/008580 WO2007025776A2 (en) 2005-09-02 2006-08-31 Cysteine protease inhibitors

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/EP2006/008579 WO2007025775A2 (en) 2005-09-02 2006-08-31 Cysteine protease inhibitors

Country Status (4)

Country Link
AR (2) AR057110A1 (en)
PE (2) PE20070332A1 (en)
TW (2) TW200804352A (en)
WO (3) WO2007025776A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7271566B2 (en) 2018-03-28 2023-05-11 ハンリム ファーマシューティカル カンパニー リミテッド 2-cyanopyrimidin-4-yl carbamate derivative or urea derivative or salt thereof and pharmaceutical composition containing same

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2030621A1 (en) * 2007-08-21 2009-03-04 Glaxo Group Limited Novel substituted pyrimidines as cysteine protease inhibitors
US20100009956A1 (en) * 2006-10-30 2010-01-14 Glaxo Group Limited , a corporation Novel substituted pyrimidines as cysteine protease inhibitors
CN101970007A (en) 2007-06-08 2011-02-09 日本化学医药株式会社 Therapeutic or prophylactic agent for cerebral aneurysm
US20100331545A1 (en) 2007-10-24 2010-12-30 Nippon Chemiphar Co., Ltd. Regulator for signaling toll-like receptor, which comprises cathepsin inhibitor as active ingredient
DE102008063561A1 (en) * 2008-12-18 2010-08-19 Bayer Cropscience Ag Hydrazides, process for their preparation and their use as herbicides and insecticides
CN102267964B (en) * 2011-06-15 2014-06-18 浙江师范大学 3-hydroxy-2,3-dihydro-benzofuran derivatives as well as synthesis method and application thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040249153A1 (en) * 2001-08-30 2004-12-09 Eva Altmann Cysteine protease inhibitors with 2-cyano-4-amino-pyrimidine structure and cathepsin k inhibitory activity for the treatment of inflammations and other diseases

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040249153A1 (en) * 2001-08-30 2004-12-09 Eva Altmann Cysteine protease inhibitors with 2-cyano-4-amino-pyrimidine structure and cathepsin k inhibitory activity for the treatment of inflammations and other diseases

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7271566B2 (en) 2018-03-28 2023-05-11 ハンリム ファーマシューティカル カンパニー リミテッド 2-cyanopyrimidin-4-yl carbamate derivative or urea derivative or salt thereof and pharmaceutical composition containing same

Also Published As

Publication number Publication date
AR057110A1 (en) 2007-11-14
AR055624A1 (en) 2007-08-29
PE20070612A1 (en) 2007-06-23
WO2007025775A2 (en) 2007-03-08
WO2007025774A2 (en) 2007-03-08
TW200804351A (en) 2008-01-16
WO2007025776A2 (en) 2007-03-08
WO2007025776A3 (en) 2007-05-03
TW200804352A (en) 2008-01-16
PE20070332A1 (en) 2007-05-11

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