PE20070612A1 - NEW CYSTEINE PROTEASE INHIBITORS - Google Patents

NEW CYSTEINE PROTEASE INHIBITORS

Info

Publication number
PE20070612A1
PE20070612A1 PE2006001057A PE2006001057A PE20070612A1 PE 20070612 A1 PE20070612 A1 PE 20070612A1 PE 2006001057 A PE2006001057 A PE 2006001057A PE 2006001057 A PE2006001057 A PE 2006001057A PE 20070612 A1 PE20070612 A1 PE 20070612A1
Authority
PE
Peru
Prior art keywords
saturated
benzohydrazide
alkylen
methylpropyl
pyrimidinyl
Prior art date
Application number
PE2006001057A
Other languages
Spanish (es)
Inventor
Martin Maria Jesus Chaparro
Lopez Jose Miguel Coteron
Roman Jose Maria Fiandor
Martin Maria Marco
Velando Esther Pilar Fernandez
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of PE20070612A1 publication Critical patent/PE20070612A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A61P33/12—Schistosomicides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE R4 ES HALOGENO, R2 ES FENIL-(ALQUILEN-C1-C3)-X, PIRIDIL-FENIL-ALQUILEN C1-C3-X, FENIL-ALQUILEN C1-C3-X-RJ, DONDE FENILO ESTA OPCIONALMENTE SUSTITUIDO POR CF3; RJ ES Z, -ALQUILEN C1-C4-Z, -C(O)Z; X Y Z SON CADA UNO GRUPO HIDROCARBONADO MONOCICLICO SATURADO DE 4 MIEMBROS QUE CONTIENE N, GRUPO HIDROCARBONADO SATURADO MONOCICLICO, PARCIALMENTE SATURADO O AROMATICO DE 6 ATOMOS, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: N'-(5-BROMO-2-CIANO-4-PIRIMIDINIL)-N'-(2-METILPROPIL)-3-[(4-PROPIL-1-PIPERAZINIL)METIL]BENZOHIDRAZIDA; N'-(5-CLORO-2-CIANO-4-PIRIMIDINIL)-4-({4-[3-(DIETILAMINO)PROPIL]-1-PIPERAZINIL}METIL)-N'-(2-METILPROPIL)BENZOHIDRAZIDA; 4-(1-AZETIDINILMETIL)-N'-(5-BROMO-2-CIANO-PIRIMIDINIL)-N'-(2-METILPROPIL)BENZOHIDRAZIDA. REFERIDA TAMBIEN A UN PROCESO Y UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE PROTEASA CON ACTIVIDAD ANTIMALARICAREFERS TO A COMPOUND OF FORMULA I, WHERE R4 IS HALOGEN, R2 IS PHENYL- (ALKYLEN-C1-C3) -X, PYRIDYL-PHENYL-ALKYLEN C1-C3-X, PHENYL-ALKYLEN C1-C3-X-RJ, WHERE FENILO IS OPTIONALLY REPLACED BY CF3; RJ IS Z, -C1-C4-Z ALKYLENE, -C (O) Z; X AND Z ARE EACH SATURATED SATURATED SATURATED HYDROCARBON GROUP OF 4 MEMBERS CONTAINING N, SATURATED SATURATED HYDROCARBON GROUP, PARTIALLY SATURATED OR AROMATIC OF 6 ATOMS, AMONG OTHERS. PREFERRED COMPOUNDS ARE: N '- (5-BROMO-2-CYANO-4-PYRIMIDINYL) -N' - (2-METHYLPROPYL) -3 - [(4-PROPYL-1-PIPERAZINYL) METHYL] BENZOHYDRAZIDE; N '- (5-CHLORO-2-CYANO-4-PYRIMIDINYL) -4 - ({4- [3- (DIETHYLAMINO) PROPYL] -1-PIPERAZINYL} METHYL) -N' - (2-METHYLPROPYL) BENZOHYDRAZIDE; 4- (1-AZETHYDINYLMETHYL) -N '- (5-BROMO-2-CYANE-PYRIMIDINYL) -N' - (2-METHYLPROPYL) BENZOHYDRAZIDE. ALSO REFERRED TO A PROCESS AND A PHARMACEUTICAL COMPOSITION. SAID COMPOUNDS ARE PROTEASE INHIBITORS WITH ANTIMALARIC ACTIVITY

PE2006001057A 2005-09-02 2006-08-31 NEW CYSTEINE PROTEASE INHIBITORS PE20070612A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05381043 2005-09-02
EP06110666 2006-03-03

Publications (1)

Publication Number Publication Date
PE20070612A1 true PE20070612A1 (en) 2007-06-23

Family

ID=37770277

Family Applications (2)

Application Number Title Priority Date Filing Date
PE2006001057A PE20070612A1 (en) 2005-09-02 2006-08-31 NEW CYSTEINE PROTEASE INHIBITORS
PE2006001056A PE20070332A1 (en) 2005-09-02 2006-08-31 HETEROARYL-NITRILE COMPOUNDS SUBSTITUTED AS INHIBITORS OF CYSTEINE PROTEASES

Family Applications After (1)

Application Number Title Priority Date Filing Date
PE2006001056A PE20070332A1 (en) 2005-09-02 2006-08-31 HETEROARYL-NITRILE COMPOUNDS SUBSTITUTED AS INHIBITORS OF CYSTEINE PROTEASES

Country Status (4)

Country Link
AR (2) AR057110A1 (en)
PE (2) PE20070612A1 (en)
TW (2) TW200804351A (en)
WO (3) WO2007025774A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010508322A (en) * 2006-10-30 2010-03-18 グラクソ グループ リミテッド Novel substituted pyridine derivatives as cysteine protease inhibitors
EP2030621A1 (en) * 2007-08-21 2009-03-04 Glaxo Group Limited Novel substituted pyrimidines as cysteine protease inhibitors
US20110092484A1 (en) 2007-06-08 2011-04-21 Nippon Chemiphar Co., Ltd. Therapeutic or prophylactic agent for cerebral aneurysm
JPWO2009054454A1 (en) 2007-10-24 2011-03-03 国立大学法人 東京医科歯科大学 Modulator of signal transduction of Toll-like receptor containing cathepsin inhibitor as an active ingredient
DE102008063561A1 (en) * 2008-12-18 2010-08-19 Bayer Cropscience Ag Hydrazides, process for their preparation and their use as herbicides and insecticides
CN102267964B (en) * 2011-06-15 2014-06-18 浙江师范大学 3-hydroxy-2,3-dihydro-benzofuran derivatives as well as synthesis method and application thereof
AU2019243099B2 (en) * 2018-03-28 2022-04-07 Hanlim Pharmaceutical Co., Ltd. 2-cyanopyrimidin-4-yl carbamate or urea derivative or salt thereof, and pharmaceutical composition including same

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR036375A1 (en) * 2001-08-30 2004-09-01 Novartis Ag PIRROLO [2,3-D] PIRIMIDINE -2- CARBONITRILE COMPOUNDS, A PROCESS FOR THEIR PREPARATION, A PHARMACEUTICAL COMPOSITION AND THE USE OF SUCH COMPOUNDS FOR THE PREPARATION OF MEDICINES

Also Published As

Publication number Publication date
WO2007025776A3 (en) 2007-05-03
TW200804351A (en) 2008-01-16
WO2007025774A2 (en) 2007-03-08
PE20070332A1 (en) 2007-05-11
WO2007025776A2 (en) 2007-03-08
TW200804352A (en) 2008-01-16
AR057110A1 (en) 2007-11-14
WO2007025775A2 (en) 2007-03-08
AR055624A1 (en) 2007-08-29
WO2007025774A3 (en) 2007-04-26

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