AR055624A1 - CHEMICAL SUBSTANCE SELECTED BETWEEN HETEROARIL - SUBSTITUTED NITRILS, ITS USE TO PREPARE A MEDICINAL PRODUCT, PHARMACEUTICAL COMPOSITIONS THAT INCLUDE IT AND PROCESSES TO PREPARE SUCH SUBSTANCES - Google Patents

CHEMICAL SUBSTANCE SELECTED BETWEEN HETEROARIL - SUBSTITUTED NITRILS, ITS USE TO PREPARE A MEDICINAL PRODUCT, PHARMACEUTICAL COMPOSITIONS THAT INCLUDE IT AND PROCESSES TO PREPARE SUCH SUBSTANCES

Info

Publication number
AR055624A1
AR055624A1 ARP060103810A ARP060103810A AR055624A1 AR 055624 A1 AR055624 A1 AR 055624A1 AR P060103810 A ARP060103810 A AR P060103810A AR P060103810 A ARP060103810 A AR P060103810A AR 055624 A1 AR055624 A1 AR 055624A1
Authority
AR
Argentina
Prior art keywords
prepare
phenyl
alkyl
substituted
pharmaceutical compositions
Prior art date
Application number
ARP060103810A
Other languages
Spanish (es)
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of AR055624A1 publication Critical patent/AR055624A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A61P33/12—Schistosomicides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Abstract

Sustancia química seleccionada entre compuestos de heteroaril-nitrilos sustituidos de formula (1) en donde: R4 representa halogeno; R2 representa -fenil-alquilen C1-3-X, -piridil-fenil-alquilen C1-3-X o -fenil-alquilen C1-3-X-RJ, en donde fenilo está opcionalmente sustituido con un grupo seleccionado de halogeno o CF3, RJ representa Z, -alquilen C1-3-Z -C(O)Z; X y Z representan, de modo independiente, un grupo hidrocarbonado saturado monocíclico de 6 miembros que contiene uno o dos átomos de N y opcionalmente un átomo de O, que está opcionalmente sustituido con un grupo seleccionado de: alquilo C1-4, alquil C1-4-OH, OH y NRERF; RE y RF independientemente representan H o alquilo C1-4; y sus derivados farmacéuticamente aceptables. Su uso para preparar un medicamento util como inhibidor de cisteína proteasa y tratamiento de la malaria, composiciones farmacéuticas que comprenden estos compuestos y procedimientos para su reparacion.Chemical substance selected from substituted heteroaryl nitrile compounds of formula (1) wherein: R4 represents halogen; R2 represents -phenyl-C1-3-X alkylene, -pyridyl-phenyl-C1-3-X alkylene or -phenyl-C1-3-X-RJ alkylene, wherein phenyl is optionally substituted with a group selected from halogen or CF3 , RJ represents Z, -C 1-3 alkyl-Z-C (O) Z; X and Z independently represent a 6-membered monocyclic saturated hydrocarbon group containing one or two N atoms and optionally an O atom, which is optionally substituted with a group selected from: C1-4 alkyl, C1- alkyl 4-OH, OH and NRERF; RE and RF independently represent H or C1-4 alkyl; and its pharmaceutically acceptable derivatives. Its use to prepare a drug useful as a cysteine protease inhibitor and treatment of malaria, pharmaceutical compositions comprising these compounds and procedures for their repair.

ARP060103810A 2005-09-02 2006-08-31 CHEMICAL SUBSTANCE SELECTED BETWEEN HETEROARIL - SUBSTITUTED NITRILS, ITS USE TO PREPARE A MEDICINAL PRODUCT, PHARMACEUTICAL COMPOSITIONS THAT INCLUDE IT AND PROCESSES TO PREPARE SUCH SUBSTANCES AR055624A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05381043 2005-09-02
EP06110666 2006-03-03

Publications (1)

Publication Number Publication Date
AR055624A1 true AR055624A1 (en) 2007-08-29

Family

ID=37770277

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP060103809A AR057110A1 (en) 2005-09-02 2006-08-31 DERIVATIVES OF HETEROARIL-NITRILOS REPLACED WHICH ARE INHIBITORS OF PROTEASES
ARP060103810A AR055624A1 (en) 2005-09-02 2006-08-31 CHEMICAL SUBSTANCE SELECTED BETWEEN HETEROARIL - SUBSTITUTED NITRILS, ITS USE TO PREPARE A MEDICINAL PRODUCT, PHARMACEUTICAL COMPOSITIONS THAT INCLUDE IT AND PROCESSES TO PREPARE SUCH SUBSTANCES

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ARP060103809A AR057110A1 (en) 2005-09-02 2006-08-31 DERIVATIVES OF HETEROARIL-NITRILOS REPLACED WHICH ARE INHIBITORS OF PROTEASES

Country Status (4)

Country Link
AR (2) AR057110A1 (en)
PE (2) PE20070332A1 (en)
TW (2) TW200804352A (en)
WO (3) WO2007025776A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2030621A1 (en) * 2007-08-21 2009-03-04 Glaxo Group Limited Novel substituted pyrimidines as cysteine protease inhibitors
WO2008052934A1 (en) * 2006-10-30 2008-05-08 Glaxo Group Limited Novel substituted pyrimidines as cysteine protease inhibitors
CN101970007A (en) 2007-06-08 2011-02-09 日本化学医药株式会社 Therapeutic or prophylactic agent for cerebral aneurysm
JPWO2009054454A1 (en) 2007-10-24 2011-03-03 国立大学法人 東京医科歯科大学 Modulator of signal transduction of Toll-like receptor containing cathepsin inhibitor as an active ingredient
DE102008063561A1 (en) * 2008-12-18 2010-08-19 Bayer Cropscience Ag Hydrazides, process for their preparation and their use as herbicides and insecticides
CN102267964B (en) * 2011-06-15 2014-06-18 浙江师范大学 3-hydroxy-2,3-dihydro-benzofuran derivatives as well as synthesis method and application thereof
EP3778576B1 (en) 2018-03-28 2024-04-17 Hanlim Pharmaceutical Co., Ltd. 2-cyanopyrimidin-4-yl carbamate or urea derivative or salt thereof, and pharmaceutical composition including same

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR036375A1 (en) * 2001-08-30 2004-09-01 Novartis Ag PIRROLO [2,3-D] PIRIMIDINE -2- CARBONITRILE COMPOUNDS, A PROCESS FOR THEIR PREPARATION, A PHARMACEUTICAL COMPOSITION AND THE USE OF SUCH COMPOUNDS FOR THE PREPARATION OF MEDICINES

Also Published As

Publication number Publication date
TW200804351A (en) 2008-01-16
WO2007025774A3 (en) 2007-04-26
TW200804352A (en) 2008-01-16
WO2007025776A3 (en) 2007-05-03
AR057110A1 (en) 2007-11-14
WO2007025774A2 (en) 2007-03-08
PE20070332A1 (en) 2007-05-11
PE20070612A1 (en) 2007-06-23
WO2007025775A2 (en) 2007-03-08
WO2007025776A2 (en) 2007-03-08

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