WO2006124874A3 - Inhibitors of b-raf kinase - Google Patents

Inhibitors of b-raf kinase Download PDF

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Publication number
WO2006124874A3
WO2006124874A3 PCT/US2006/018885 US2006018885W WO2006124874A3 WO 2006124874 A3 WO2006124874 A3 WO 2006124874A3 US 2006018885 W US2006018885 W US 2006018885W WO 2006124874 A3 WO2006124874 A3 WO 2006124874A3
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Prior art keywords
inhibitors
raf kinase
raf
dermatologic
hematopoiesis
Prior art date
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PCT/US2006/018885
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French (fr)
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WO2006124874A2 (en
Inventor
Timothy C Gahman
Hengyuan Lang
Robert L Davis
Shawn A Scranton
Original Assignee
Kalypsys Inc
Timothy C Gahman
Hengyuan Lang
Robert L Davis
Shawn A Scranton
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Application filed by Kalypsys Inc, Timothy C Gahman, Hengyuan Lang, Robert L Davis, Shawn A Scranton filed Critical Kalypsys Inc
Publication of WO2006124874A2 publication Critical patent/WO2006124874A2/en
Publication of WO2006124874A3 publication Critical patent/WO2006124874A3/en

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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P35/00—Antineoplastic agents
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    • C07C225/02—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C225/14—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated
    • C07C225/16—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
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Abstract

The present invention relates to compounds and methods useful as inhibitors of B-Raf for the treatment or prevention of cancer, including hematological and non-hematologic malignancies, hematopoiesis, autoimmune diseases, dermatologic and ophthalmologic conditions.
PCT/US2006/018885 2005-05-12 2006-05-11 Inhibitors of b-raf kinase WO2006124874A2 (en)

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US68028805P 2005-05-12 2005-05-12
US68029205P 2005-05-12 2005-05-12
US68029005P 2005-05-12 2005-05-12
US60/680,294 2005-05-12
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