WO2006089521A1 - Befestigungssystem für wenigstens eine fluidische komponente einer chroma tographieeinrichtung - Google Patents
Befestigungssystem für wenigstens eine fluidische komponente einer chroma tographieeinrichtung Download PDFInfo
- Publication number
- WO2006089521A1 WO2006089521A1 PCT/DE2006/000295 DE2006000295W WO2006089521A1 WO 2006089521 A1 WO2006089521 A1 WO 2006089521A1 DE 2006000295 W DE2006000295 W DE 2006000295W WO 2006089521 A1 WO2006089521 A1 WO 2006089521A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- fastening element
- fastening
- clip
- engagement
- fixed
- Prior art date
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L9/00—Supporting devices; Holding devices
- B01L9/54—Supports specially adapted for pipettes and burettes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L9/00—Supporting devices; Holding devices
- B01L9/02—Laboratory benches or tables; Fittings therefor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L9/00—Supporting devices; Holding devices
- B01L9/04—Retort stands; Retort clamps
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L9/00—Supporting devices; Holding devices
- B01L9/06—Test-tube stands; Test-tube holders
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/28—Control of physical parameters of the fluid carrier
- G01N30/30—Control of physical parameters of the fluid carrier of temperature
- G01N2030/3084—Control of physical parameters of the fluid carrier of temperature ovens
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/60—Construction of the column
- G01N30/6047—Construction of the column with supporting means; Holders
Definitions
- the invention relates to a fastening system for at least one fluidic component of a chromatography device, in particular for holding the at least one fluidic component in a column oven having the features of the preamble of patent claim 1 and a fastening element for such a fastening system having the features of the preamble of claim 8.
- HPLC high-performance liquid chromatography
- the additional fluidic components generally also have to be accommodated in the column oven.
- the separation column and the other fluidic components such as pre-and trap columns are collectively referred to in the text below as "columns".
- corresponding mounting brackets for the columns are provided in known fastening systems for fluidic components in the column oven.
- a difficulty here is that the columns can be quite different in their length and also their diameter, also requires the variety of conceivable applications and different arrangements of the components and interconnections.
- the disadvantage here is that only a few, predetermined positions are available for the mounting brackets.
- the connecting lines from, to and between the individual fluidic components often can not be fixed at all.
- the conversion to another application is complex, since in addition to the fluidic components and the mounting brackets must be rebuilt.
- the invention is therefore based on the object to provide a fastening system for at least one fluidic component of a chromatography device, which can be easily and quickly adapted to different requirements and which makes it possible to fasten the fluidic components in almost any position. Furthermore, the invention has for its object to provide a fastener for such a system with which the fluidic components can be easily and quickly fixed.
- the invention is based on the recognition that by the use of at least one attached to a support member clip on which at least one fastener in a desired position within a mounting region of the clip by frictional or positive locking releasably fixed, a fastening system is formed in which the Position of a fixed with the fastener fluidic
- Component within the attachment region of the clasp is free or at least approximately freely selectable. Since fluidic components, such as columns and the like, usually have to be fixed horizontally, it is advisable to provide the clasps vertically, and to design the fastening elements in such a way that the fluidic elements are held and fixed essentially perpendicular to the course of the attachment regions of the clasps ,
- the clips can be fixed by means of one or more support elements in a predetermined position, wherein also here or the support elements may have a range within which the clips can be held in freely or almost freely selectable positions or at least in a variety of different positions.
- the fluidic elements in a portion of a plane freely or almost freely, but in any case be attached to a variety of different positions without it would be necessary to implement cords consuming.
- Different positions of the fluidic components in the third dimension can be realized by the use of different clasps, the attachment regions of which have a different distance from the carrier element (s). Instead, of course, different length fasteners can be used, which make it possible to fix the fluidic components at different distances to the attachment region of the respective clips.
- the at least one clip can be fixed with its end portions to a respective carrier element, wherein the two carrier elements preferably extend substantially parallel.
- the at least one clip can in each case be fixable with one end region at a plurality of predetermined positions on the relevant carrier element, preferably by means of a form-locking, detachable connection.
- the end portions of the clasps may be held in respective bores of a respective carrier element, wherein the clasps are preferably designed so elastically bendable that they can be released by bending from its fixed position.
- Such clips can be produced very easily, for example by bending a corresponding wire.
- Different positions of the fastening elements on the clasps can be realized in that the fastening elements are displaceable within the fastening region of the clasps against the holding force of the frictional engagement or a locking positive connection.
- a fastening element for such a fastening system can be configured such that a first part is connected to a second part of the fastening element in such a way that the fluidic component to be held and fixed between two
- Clamping areas of the first and second parts can be fixed by frictional engagement or positive locking.
- the two parts can be completely detachable from each other or have such a large adjustment that the fluidic component can be used in a sufficiently wide open position and clamped by axial pushing together of the two parts.
- the fastening element is preferably designed so that at least the usual fluidic components, such as HPLC columns, with a diameter of up to 8 mm can be fixed.
- the first or second part of the fastener engaging and holding means for releasably connecting to the mounting portion of a clip exhibit.
- the fastening means are preferably designed so that a simple attachment to a clip without any assembly tool is possible.
- the engaging and holding means may comprise two arms, which are engageable by a rotational movement of preferably 90 degrees with the mounting portion of the clip.
- the two arms may each extend from opposite areas of the first or second part to each other and parallel to each other and between them include a distance which allows in a radial receiving position to accommodate the attachment region of the clip between the arms to then bring the arms by rotation of the first or second part of the fastener by a predetermined angle about its longitudinal axis into engagement with the mounting portion of the clip
- the first part of the fastening element according to the invention may have a U-shaped connecting region for detachable connection to the second part.
- the second part of the fastening element may comprise a central region, which is connected via one or more webs with a ring surrounding the central region, wherein at least the ring is elastically deformable in the radial direction such that in the deformed state the connection between the first and the second second part is solvable.
- first and second parts of a fastener engage in the connected state of the first and second part, the legs of the U-shaped connecting portion of the first part in the annular space between the central region and the ring of the second part, wherein the connection of the first and second Part by frictional engagement or positive engagement, in particular caused by a locking means positive connection, between the inner wall of the ring of the second part and the outer walls of the legs of the U-shaped connecting portion of the first part is effected.
- first engagement means may be provided in engagement regions of the outer walls of the legs of the U-shaped connection region of the first part, which cooperate with second latching means which are provided in engagement regions on the réellewaiidung of the ring of the second part, for latching connection of the first and second part.
- the two parts of a fastener formed in this way can be assembled without tools and pushed together until a fluidic component inserted into the U-shaped region of the first part is sufficiently clamped and thus fixed.
- the fludidic component is in this case between the base of the U-shaped connection region of the first part and the central region of the second
- Part preferably elastically resilient, clamped fixed when the first part in the axial direction is sufficiently closely engaged with the second part.
- a flexibly deformable pad can be provided on at least one of the surfaces of the first or second part which cause the clamping of the fluidic component.
- Fig. 1 is a perspective view of an embodiment of a fastening system according to the invention
- FIG. 2 shows a clasp of the system in FIG. 1 in an enlarged side view
- Fig. 3 is a perspective view of the fastener in Fig. 1 and
- Fig. 4 is a fragmentary, perspective rear view of the system in Fig. 1 showing a fastener attached to a fastener with the fluidic component held therein.
- the fluidic component mounting system of a chromatography device illustrated in FIG. 1 can be used in particular for holding the fluidic components in a column oven. Since the fluidic components usually have to be kept horizontal, the fastening system shown in FIG. 1 is correspondingly oriented. However, this is not meant to be limiting.
- the fastening system comprises support elements 1, which can also be connected in a manner not shown to a support frame.
- Each possible attachment position defined by the carrier elements 1 or the attachment frame is determined by an upper hole 11 in the upper carrier element, by a groove 12 in the lateral end side of the upper carrier element 1 and a lower hole 13 in the lower carrier element.
- clips 2 are mounted in the support frame or the support elements. As shown enlarged in Fig. 2, the clasps 2 are provided for this purpose with correspondingly shaped end portions, wherein each extending in the vertical direction ends 2a, 2b of the clips in the respective upper and lower
- Hole 11, 13 engages in the upper and lower carrier element 1.
- the clips 2 may for example consist of a resilient wire or plastic.
- Each clasp 2 can be supported by the choice of a corresponding geometry and bias, if necessary, with horizontally extending portions 2c, 2d on the mutually facing surfaces of the carrier elements designed as rails in order to avoid vertical movement or vertical play of the clasps 2. However, this is not absolutely necessary if only the force of gravity is sufficient to ensure a sufficiently stable vertical position of the clasps 2.
- each clip 2 can be easily inserted into the holes 11 and 13 of the support elements 1.
- Fasteners 3 are connected to the clasps at the desired height, which hold a fluidic element 4 to be held and fixed, for example a chromatography column, in the desired position. As shown in FIG. 1, a fluidic element can also be fixed by two or more fastening elements 3.
- Fig. 3 shows a specific Aus collirungsbeispiel a ' fastener 3 for the fastening system shown in Fig. 1.
- the fastening element 3 consists of a first part 31, two cushioning elements 32 and a second part 33.
- the first part 31 can be fastened by means of fastening means, which comprise two arms 35, to one of the clips 2 with a rotational movement and can, if necessary , in vertical
- the second part 33 consists of a resilient ring 33a, which is connected via four webs 33c to a central region 33b. In the annular space between the webs 33 c engage two legs 31 a of a U-shaped portion of the first part 31 a. In order to connect the first and second parts 31, 33, the limbs of the U-shaped region of the first part 31 have latching means 34 on their outer sides, which interact with counter-latching means on the associated inner surfaces of the ring 33a of the second part 33.
- the ring 33a By compressing the ring 33a in the direction of the drawn arrows (Fig. 3), the ring increases in the direction perpendicular thereto, so that the latching attachment is released and the ring can be removed. In this way, the fluidic element 4 can be inserted into the U-shaped region of the first part 31 and then fixed by pushing on the second part 33.
- the latching means 34 and the counter-latching means can be designed so that a collapse of the first and second part is possible up to the desired clamping position without the ring 33a of the second part 33 must be compressed, however, a pulling apart of the two parts only by a Squeezing the ring 33a allows becomes light. This can be achieved for example by a suitable choice of the angle of the locking teeth.
- a pad 32 may be connected to the base of the U-shaped area of the first part 31 and to the surface of the central area of the second part facing it. These pads 32 secure by their additional spring effect, the fluidic component against slipping and protect at the same time sensitive fluidic elements, such as capillary columns, from damage.
- FIG. 4 shows the rear view of a fastening element 3, which is fastened to a clip 2 and fixes a fluidic component 4.
- the fastening means for fastening the fastening element 3 on the clasp 2 are clearly visible.
- the two arms 35 each extend from opposite outer regions of the cross section of the first element 3 in the direction of the respective opposite outer region substantially parallel to the back of the first part 31. The distance between the back of the part 31 and the arms 35 is so chosen that the attachment portion 2e (Fig. 2) of the clasp 2 between the back of the part
- the force of the frictional engagement is preferably selected so that the part 31 and thus also the entire fastening element 3 can still be displaced on the clasp 2 in the clamped state.
- a distance h is held, which makes it possible to use the clasp 2 or its attachment region 2e between the two arms 35 or the fastener or at least the first part 31 with the arms 35 on the Attachment area 2e of the clasp 2 set when the first part 31 is rotated so that the two arms 35 are parallel to the mounting portion 2e.
- the part 31 After placing the part 31 on the fastening area 2e of the clasp 2, the part 31 (or the entire fastening element) can be rotated by about 90 ° so that the clamping position shown in FIG. 4 is achieved.
- the fasteners 3 With the fixing system described so far, shown in the drawing, the fasteners 3 can be arranged arbitrarily in a two-dimensional plane. Thus, one or more fluidic components of different lengths can be fixed in the most favorable position.
- the clasps 2 can be used in several Aus pressurellrept with different depths, i. different clips 2 have different distances between the attachment regions 2e of the support elements 1.
- the fastening system according to the invention thus enables the arrangement and attachment of the fluidic components 4 at virtually any desired position. Due to the flexible arrangement of the fastening elements, fluidic components of different sizes, e.g. Columns of different lengths, to be held reliably. At the same time, the flexible arrangement allows better space utilization in a column oven. Therefore, more components can be arranged in the same space, or for a given number of components, a smaller column oven is sufficient.
- the fastening means of the fastening elements 3 on the clasps 2 reliably prevent inadvertent release of the connection compared with a normal snap connection, since the fastening elements 3 are fixed in their respective angular position by the installed fluidic components 4. Therefore, equipped with this mounting system column oven with built fluidic components 4 transport safe.
- the latching closure and the upholstery 32 of the fastening elements 3 allow the reliable fixing of fluidic components 4 with different outer diameters or outer dimensions and cross sections.
Landscapes
- Health & Medical Sciences (AREA)
- Clinical Laboratory Science (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Clamps And Clips (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06722504A EP1851448A1 (de) | 2005-02-23 | 2006-02-17 | Befestigungssystem für wenigstens eine fluidische komponente einer chromatographieeinrichtung |
US11/816,958 US20080149547A1 (en) | 2005-02-23 | 2006-02-17 | Fixing System for at Least One Fluidic Component of a Chromatography Device |
JP2007555450A JP2008531986A (ja) | 2005-02-23 | 2006-02-17 | クロマトグラフィー装置における少なくとも一つの液体構成要素用固定システム |
CA002600582A CA2600582A1 (en) | 2005-02-23 | 2006-02-17 | Fixing system for at least one fluidic component of a chromatography device |
AU2006217315A AU2006217315B2 (en) | 2005-02-23 | 2006-02-17 | Fixing system for at least one fluidic component of a chromatography device |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102005008620.9 | 2005-02-23 | ||
DE102005008620A DE102005008620B3 (de) | 2005-02-23 | 2005-02-23 | Befestigungssystem für wenigstens eine fluidische Komponente einer Chromatographieeinrichtung |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2006089521A1 true WO2006089521A1 (de) | 2006-08-31 |
Family
ID=36498828
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/DE2006/000295 WO2006089521A1 (de) | 2005-02-23 | 2006-02-17 | Befestigungssystem für wenigstens eine fluidische komponente einer chroma tographieeinrichtung |
Country Status (7)
Country | Link |
---|---|
US (1) | US20080149547A1 (de) |
EP (1) | EP1851448A1 (de) |
JP (1) | JP2008531986A (de) |
AU (1) | AU2006217315B2 (de) |
CA (1) | CA2600582A1 (de) |
DE (1) | DE102005008620B3 (de) |
WO (1) | WO2006089521A1 (de) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2336764A1 (de) * | 2008-09-02 | 2011-06-22 | GL Sciences Incorporated | Flüssigchromatograf |
EP2425239A1 (de) * | 2009-04-28 | 2012-03-07 | GE Healthcare Bio-Sciences AB | Befestigungsanordnung für einen säulenhalter |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102018128261A1 (de) * | 2018-11-12 | 2020-05-14 | Sartorius Stedim Biotech Gmbh | Konfigurierbare Vorrichtungsanordnung für die Durchführung wenigstens einer Grundoperation in einem biopharmazeutischen Prozess |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
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US3123353A (en) * | 1964-03-03 | Adjustable instrument bench | ||
US4582204A (en) * | 1982-07-02 | 1986-04-15 | Amicon Wright Limited | Column systems for chromatography and the like |
US4732672A (en) * | 1987-03-26 | 1988-03-22 | Kiang Chih Hen | Universally applicable mounting apparatus for high pressure liquid chromatography columns |
Family Cites Families (24)
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US2579694A (en) * | 1946-04-15 | 1951-12-25 | Jack M Pari | Garment clasp |
US2535641A (en) * | 1947-10-16 | 1950-12-26 | Lawrence L Levy | Pin clasp |
US3112973A (en) * | 1960-09-26 | 1963-12-03 | Hubbell Inc Harvey | Locking three-wire electrical cord connector |
US3266554A (en) * | 1963-11-29 | 1966-08-16 | Possis Machine Corp | Apparatus for preparing specimens for chromatographic analysis |
US4147466A (en) * | 1973-06-29 | 1979-04-03 | Bbc Brown, Boveri & Company Limited | Arrangement for maintaining optimum minimum operating clearance between rotor and stator components of fluid-flow machines and the like |
US4313828A (en) * | 1979-03-26 | 1982-02-02 | Brownlee Labs, Inc. | High pressure tubing coupler |
FI61766C (fi) * | 1980-11-10 | 1982-09-10 | Orion Yhtymae Oy | Foervarings- och faeststaellning foer en gaskromatografkolonn |
US4452695A (en) * | 1983-07-14 | 1984-06-05 | Energy Extension Industries | Full-flow and by-pass filter conversion system for internal combustion engines |
US4512899A (en) * | 1984-03-19 | 1985-04-23 | Milton Roy Company | Liquid chromatography tube connections |
US4863596A (en) * | 1988-02-29 | 1989-09-05 | Amoco Corporation | Cell alignment frame assembly |
US4879028A (en) * | 1988-08-30 | 1989-11-07 | John Gibson | Debris diverting boom |
US5167524A (en) * | 1991-09-19 | 1992-12-01 | Robert Falcon | Coupling restraints for electrical connectors |
US6405826B1 (en) * | 2000-11-01 | 2002-06-18 | Trampass N. Bass | Hanger with swivel arm |
DE10101478C2 (de) * | 2001-01-12 | 2003-03-27 | Biedermann Motech Gmbh | Verbindungselement |
DE10136162B4 (de) * | 2001-07-25 | 2016-05-12 | Biedermann Technologies Gmbh & Co. Kg | Verbindungselement zum Verbinden zweier zur Knochen- und Wirbelsäulenstabilisierung eingesetzter stabförmiger Elemente |
US6641586B2 (en) * | 2002-02-01 | 2003-11-04 | Depuy Acromed, Inc. | Closure system for spinal fixation instrumentation |
US6935607B2 (en) * | 2002-10-23 | 2005-08-30 | Western Forms, Inc. | Forming panel with extruded elongated threaded slot for receiving threaded attachment members |
US7156849B2 (en) * | 2003-06-16 | 2007-01-02 | Depuy Spine, Inc. | Rod reduction nut and driver tool |
US20060052783A1 (en) * | 2004-08-17 | 2006-03-09 | Dant Jack A | Polyaxial device for spine stabilization during osteosynthesis |
US20060052786A1 (en) * | 2004-08-17 | 2006-03-09 | Zimmer Spine, Inc. | Polyaxial device for spine stabilization during osteosynthesis |
US9463554B2 (en) * | 2004-08-25 | 2016-10-11 | Illinois Tool Works Inc. | Plastic clamp and method of manufacturing the same |
US7651502B2 (en) * | 2004-09-24 | 2010-01-26 | Jackson Roger P | Spinal fixation tool set and method for rod reduction and fastener insertion |
WO2006057837A1 (en) * | 2004-11-23 | 2006-06-01 | Jackson Roger P | Spinal fixation tool attachment structure |
US7798240B2 (en) * | 2006-04-03 | 2010-09-21 | Honda Motor Co., Ltd. | Waste recovery station structure for beach cleaner and beach cleaner structure |
-
2005
- 2005-02-23 DE DE102005008620A patent/DE102005008620B3/de not_active Expired - Fee Related
-
2006
- 2006-02-17 CA CA002600582A patent/CA2600582A1/en not_active Abandoned
- 2006-02-17 US US11/816,958 patent/US20080149547A1/en not_active Abandoned
- 2006-02-17 JP JP2007555450A patent/JP2008531986A/ja not_active Withdrawn
- 2006-02-17 AU AU2006217315A patent/AU2006217315B2/en not_active Expired - Fee Related
- 2006-02-17 WO PCT/DE2006/000295 patent/WO2006089521A1/de active Application Filing
- 2006-02-17 EP EP06722504A patent/EP1851448A1/de not_active Withdrawn
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3123353A (en) * | 1964-03-03 | Adjustable instrument bench | ||
US4582204A (en) * | 1982-07-02 | 1986-04-15 | Amicon Wright Limited | Column systems for chromatography and the like |
US4732672A (en) * | 1987-03-26 | 1988-03-22 | Kiang Chih Hen | Universally applicable mounting apparatus for high pressure liquid chromatography columns |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2336764A1 (de) * | 2008-09-02 | 2011-06-22 | GL Sciences Incorporated | Flüssigchromatograf |
EP2336764A4 (de) * | 2008-09-02 | 2011-09-28 | Gl Sciences Inc | Flüssigchromatograf |
EP2425239A1 (de) * | 2009-04-28 | 2012-03-07 | GE Healthcare Bio-Sciences AB | Befestigungsanordnung für einen säulenhalter |
EP2425239A4 (de) * | 2009-04-28 | 2013-09-25 | Ge Healthcare Bio Sciences Ab | Befestigungsanordnung für einen säulenhalter |
Also Published As
Publication number | Publication date |
---|---|
US20080149547A1 (en) | 2008-06-26 |
CA2600582A1 (en) | 2006-08-31 |
AU2006217315B2 (en) | 2010-07-15 |
AU2006217315A1 (en) | 2006-08-31 |
JP2008531986A (ja) | 2008-08-14 |
EP1851448A1 (de) | 2007-11-07 |
DE102005008620B3 (de) | 2006-09-28 |
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