WO2006069455A1 - Echtzeitanzeige für eine vorrichtung zur dosierten verabreichung eines produkts - Google Patents
Echtzeitanzeige für eine vorrichtung zur dosierten verabreichung eines produkts Download PDFInfo
- Publication number
- WO2006069455A1 WO2006069455A1 PCT/CH2005/000711 CH2005000711W WO2006069455A1 WO 2006069455 A1 WO2006069455 A1 WO 2006069455A1 CH 2005000711 W CH2005000711 W CH 2005000711W WO 2006069455 A1 WO2006069455 A1 WO 2006069455A1
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- WO
- WIPO (PCT)
- Prior art keywords
- injection device
- dose
- display
- sensor
- coupling
- Prior art date
Links
- 238000002347 injection Methods 0.000 claims abstract description 129
- 239000007924 injection Substances 0.000 claims abstract description 129
- 238000000034 method Methods 0.000 claims abstract description 32
- 239000000126 substance Substances 0.000 claims abstract description 22
- 239000003708 ampul Substances 0.000 claims abstract description 19
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- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
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- 206010012289 Dementia Diseases 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 208000001132 Osteoporosis Diseases 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31525—Dosing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31545—Setting modes for dosing
- A61M5/31548—Mechanically operated dose setting member
- A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31545—Setting modes for dosing
- A61M5/31548—Mechanically operated dose setting member
- A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
- A61M5/31553—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe without axial movement of dose setting member
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
- A61M5/31583—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M2005/3125—Details specific display means, e.g. to indicate dose setting
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M2005/3125—Details specific display means, e.g. to indicate dose setting
- A61M2005/3126—Specific display means related to dosing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/50—General characteristics of the apparatus with microprocessors or computers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
- A61M2205/587—Lighting arrangements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31566—Means improving security or handling thereof
- A61M5/31568—Means keeping track of the total dose administered, e.g. since the cartridge was inserted
Definitions
- the invention relates to a device for metered administration of a product, such as an injection device or pen, with which a metered amount of a fluid product, such as insulin, growth hormones or osteoporosis preparations, by a user can be administered.
- a product such as an injection device or pen
- a metered amount of a fluid product such as insulin, growth hormones or osteoporosis preparations
- the functional elements described below of a real-time electronic or mechanical display and an electronic lifter are used together with an injection pen as described in co-pending patent application "Applicant's Metered Fluid Delivery Apparatus” filed with attorney docket 49 439 XI ,
- the elements and functional assemblies of an injection device described in the patent application with the law file 49 439 XI are incorporated in this application, wherein an erf Injektndungswasher Injedgingspen with respect to the configuration of the dose display described in the referenced patent application and / or sensors, electronics or display elements as follows can distinguish described.
- components of the injection pen may change or deteriorate such as springs or frequently moving components due to the stresses and mechanical stresses and aging processes encountered during use correct functioning and functioning of the pen is impaired.
- a user sets a dose or quantity of a substance to be dispensed by the injection device, for example by displacing the substance from an ampoule inserted in the injection device, then it is advantageous for the user if he can read the currently set dose on a display of the injection device .
- the set dose is displayed in known injection devices and a user can initiate the injection before, for example, by pressing a trigger button, the dose displayed after the injection process from the set dose back to zero or runs back or reset.
- an injection device has at least one sensor in order to detect at least one setting or operating process of the injection device.
- a sensor may be provided as a sensor, a mechanical switch or a pressure switch on the Inj edictions device, for example in the region of a dosing member or an injection button to detect, for example, a first-time operation of the injection device or insertion of an ampoule.
- a sensor or switching element at another point of the injection device such as in the region of a reservoir, in which an ampoule is inserted, or is provided via a connecting member coupled to a component of the injection device, for example, to detect the insertion of an ampoule.
- an encoder or rotary sensor which is coupled, for example, with a dosing member or a piston or threaded rod of the injection device, for example by means of a Zalmradeingriffes for example via a spur gear, a sprocket or about parallel to the central axis or injection device mounted gear may be, so as to detect, for example, a setting or ejection of the injection device.
- any sensor can be used which is suitable for detecting the initial actuation or commissioning of the injection device or with which an operating procedure or actuation process of the injection device, for example for setting a dose to be delivered, for mounting the injection device, for preparing a piercing process, for carrying out a Einstechvorganges, can be detected for dispensing a set dose or for changing an ampoule.
- sensors for qualitative or quantitative detection of operating processes, operating or state parameters, it can be detected, for example, when an injection device was actuated or put into operation for the first time, for example by means provided in the injection device Timer or a timer to start, which outputs a signal according to a manufacturer, for example, given fixed period of, for example, three years to indicate that the life of the injection device, during which the manufacturer of the injection device for the correct operation of the injection device guarantees, has expired.
- a manufacturer for example, given fixed period of, for example, three years to indicate that the life of the injection device, during which the manufacturer of the injection device for the correct operation of the injection device guarantees, has expired.
- Such a timer or a timer can be based, for example, on mechanical or chemical principles, wherein, for example, after a predetermined time in terms of their color changing chemical substance may be provided so that a user can tell from the color of this substance, whether the injection device the intended life has already exceeded or not.
- such a timer or a time control is realized by means of an electronic circuit, which is equipped with at least one of the sensors described above. is bound and receives from one or more of these sensors a start signal, for example, when first pressing the injection device or when inserting a full ampoule to start the timer.
- a start signal for example, when first pressing the injection device or when inserting a full ampoule to start the timer.
- the circuit After the expiration of a time specified or set by the user, for example, by the user or set by the circuit taking into account loads on the injection device, the circuit outputs a signal to a display or a lamp, for example, to indicate to a user the end of the life of the injection device is reached.
- an optical and / or audible and / or tactile or tactile signal can be generated, for example, to indicate to the user that the injection device is no longer safe for safety reasons should be used.
- the injection device can continue to be used, wherein, for example, a corresponding warning signal, such as, for example, the lighting up or blinking of, for example, a red LED or OLED, can be generated during each use procedure.
- an actuator such as an electric motor or a magnetic switch or a locking element
- a data memory may also be provided together with a timer or a clock in which data relating to the adjustment or operating procedures carried out on the injection device, such as data relating to the time of initial startup, can be stored.
- data relating to the adjustment or operating procedures carried out on the injection device such as data relating to the time of initial startup, can be stored. the number and / or time of dose setting and / or dispensing operations and / or the number and / or times of ampoule changes.
- a processor or controller provided in the injection device can, for example, compare the data stored in the memory for use of the injection device with, for example, the manufacturer's fixed preset or adjusted limit values for the maximum permissible use of the injection device, in order to reach or exceed, for example, the maximum permissible number output a signal from vial changes or dispensing operations to generate a warning signal as described above indicating to the user that the maximum number of vial changes or dispensing operations has been reached or exceeded.
- the life span may vary.
- the end of the life is determined taking into account various parameters such that, for example, the life of an unused injection pen ends after a predetermined period of, for example, three years, with each operation detected by one or more sensors Injection device, such as a vial change or a dispensing operation, is subtracted a predetermined time from the maximum life such that a pen frequently used after initial startup, for example, earlier generates a signal indicating that the end of life has been reached a rarely used pen.
- the service life indicator or the life timer is controlled via the number of ampoule changes detected by a sensor, a so-called system check can additionally be carried out. If the ampoule is full, a switch of the life timer is actuated via the threaded rod and a connecting piece, as a result of which the LED briefly lights up in green.
- the indication to a user that the end of life has been reached is preferably a visual indication and may, for example, be indicative of the display of a set value.
- a lamp such as an LED or OLED, may be provided which, for example, first lights up or blinks or changes the color of the emitted light when the end of life of the injection device is reached.
- a multi-colored OLED or LED or a red LED may be provided on or in the injection device, for example, next to a green LED for illuminating a setting display to indicate to a user who is usually looking at the setting display by red light that the injection device should not be used further.
- One or more OLEDs or LEDs may, for example, be provided behind an LCD display or within, for example, coaxially arranged and at least partially or completely transparent counting rings or counting disks for dose display, such that the red light of the LED or OLED through the transparent counting rings or dials shines through.
- a lamp for indicating the end of life another lamp may be provided, which preferably illuminates in a different color and / or light of different brightness compared to the life indicator lamp emits, so that, for example, a green LED behind a electronic or mechanical indicator lights up when it is detected by a sensor that a user actuates an adjustment or actuation element of the injection device, whereby the user can read the set dose even in darkness or low light conditions.
- this lamp may be permanently turned off or switched to emitting differently colored light so that the life-termination indicator or lamp flashes or illuminates, for example, permanently or after user detection or adjustment of the injection device such that a user does not see the green light normally perceived by him during a setting procedure, but can recognize from the then generated red light and / or a flashing light that the end of life of the injection projection direction is reached and therefore should not be used, even if the continued use of I ⁇ jetechnischsvorraum is possible in principle.
- a battery such as a button cell or accumulator may be provided which can be charged, and the above-described optical display elements may also be used to alert a user that the battery should be recharged.
- the invention further relates to a method for determining the lifetime of an injection device, wherein a start of the life interval is determined by a sensor by detecting a user's operation, and wherein the sensor generates a signal which defines or defines a time at which the life interval starts to run. After determining that the predetermined lifetime interval or a recalculated life span shortened by operations has expired, an optical and / or audible signal is generated immediately or at a next detected operation that may indicate the end of life to a user.
- the invention relates to a computer program or an algorithm with which a program as described above can be carried out, for example a lifetime calculation taking into account the service life shortening operating processes, such as injection processes or ampoule replacement.
- the invention relates to an injection device with a real-time display for the continuous display of a dose set and yet to be dispensed by the injection device.
- An injection device according to the invention in which a substance to be dispensed is contained or can be placed in an ampoule, has an adjusting element, such as a dosing button or a dosing member, with which, for example, by turning or Moving, such as by pulling out, a set for delivery or injection dose can be set or fixed.
- At least one sensor is provided, which is connected directly or indirectly to the adjusting element or a setting device of the ejection device of the injection device or is coupled, for example via gears, in order to detect the quantity of a dose available for dispensing a substance from the injection device.
- An evaluation unit such as an electrical circuit or a processor, which is connected to the at least one sensor, on the basis of the signals from the at least one sensor directly, that is directly from the signals, or from the time course of the signals, that is taking into account previous signals of the at least one sensor, determine which dose is currently set, or which dose is still released for delivery by the injection device due to the setting.
- the evaluation unit also determines the amount of the adjusted dose that is still available for dispensing or dispensing but not yet dispensed during dispensing of the substance contained in the injection device.
- a display connected to the evaluation unit can represent the dose set by a user, for example as a numerical value, so that the set dose can be read, for example, on an LCD or by means of mechanically coupled counting wheels or rings.
- a backward running dose or number may be displayed on the display during dispensing of a substance.
- a mechanical or electronic display of the injection device can always display the current value of the already dispensed substance amount or the not yet distributed dose or the state of the mechanism as a real-time display.
- a user can determine what quantity of a substance he has already injected or what dose he still has to inject.
- an electronic unit of the injection device is modular, that is, the injection device is designed so that it can be determined only during assembly, whether a mechanical or electronic display provided and For example, used or snapped, whereby subsequently different housing shells can be used. However, it is not necessary that the injection device be rebuilt to integrate either a mechanical or electronic display in the injection device.
- an electronic unit may be provided as an assembly for direct mounting in the injection device, whereby it is possible that plastic parts and their assembly steps can be eliminated.
- contemporary real-time display can thus be displayed both the setting or correction of a dose, as well as the distribution and, if necessary, the correction of a set dose during a dispensing process.
- a sensor for detecting the dose still to be delivered is preferably coupled or connected to an adjustment element or a dispensing mechanism of the injection mechanism, such as a piston rod or a coupling element as described in the above-mentioned patent application 49 439 XI and preferably continuously detects the current operating state the injection device or information and parameters, such as' a rotation angle or the Number of revolutions of a unit provided for setting or dispensing a dose in the injection device, such as a clutch, piston rod or rack.
- the sensor may be a rotary switch or encoder, which preferably has no stop. Such an encoder is used, for example, by the Alps Electric Co., Ltd. made in Tokyo, Japan.
- an encoder for example, a rotational movement of a setting element or dosing member directly or the rotation of a coupling sleeve or with the coupling sleeve engaged spur gear or gear can be detected, wherein the signal detected by the encoder processed by an electronics contained in the injection device and to a LCD for reading by the user can be passed.
- an encoder can also be used as a sensor for a life timer described above for detecting the start of the life or an adjustment or dispensing operation.
- the display used to display the shared even for distribution dose may be an LCD display, which is provided for example in an electronic assembly or in an E-modulus of the injection device and can be illuminated by an above 'lamp or LED described or will be screened.
- a mechanical display may be provided, for example, in the form of one, two or more counting rings, as described, for example, in EP 0 554 996 B1 or EP 0 897 728 A1, the teachings of which relating to the mechanical design and coupling of single and multiple rings Tens counting rings is included in this application.
- a real-time display of the injection device may be provided with mechanical elements, for example, as a coaxial display of two or more juxtaposed counting rings, for example circumferentially labeled with numerals from “0" to "9", such as for example motor vehicle odometer or registers in cassette machines is known.
- Such an example consisting of coaxially juxtaposed Zählringen and / or Zählin display can be coaxially provided on the injection device, such as in the rear of the injection device in the vicinity of a knob or dosing and coupled with such a knob or dosing, so that always , if For example, a dosing or metering wheel is moved, which rotates the mechanical display both during the dosing, dose correction or during distribution.
- the mechanical display is coupled with an adjustment and / or dispensing or dispensing mechanism of the injection device, that the amount of still to be distributed dose is always represented by the mechanical display during the dispensing, that is, the mechanical display counts during the distribution of in the injection device contained substance backwards.
- the mechanical counter is provided with a planetary drive for rotating the counter wheels.
- a planetary drive for rotating the counter wheels.
- These planet gears engage in a toothing provided on the outside of a one-counting ring and thus drive the Einser- counting ring.
- a perforation is provided in the circumferential direction only within a range of, for example, 36 degrees, which corresponds to approximately one counting step, so that the one-counting ring engages in this toothing after each full handling Coupling or Kochträgszahnrad can drive, which in each case after a full revolution of the one-counting ring coaxially to the one counting ring provided tens counting ring drives so that it is further rotated by a predetermined value of, for example, 36 degrees, for example, one on the Tens digit ring to the position of an adjacent digit to rotate back or forth.
- a ring gear can serve as a carrier for the one and ten-counting rings and has on its inside a toothing, in which the planetary gears which drive the one-counter wheel, engage.
- the coupling gear can be mounted in the ring gear.
- the ring gear is mounted against rotation in the housing of the injection device or integrated into it.
- the transmission ratio of the drive disc can be set to the one-counting ring, so that it is possible, for example, that during a revolution of the drive disc, the one-counting ring 2.4
- other transmission ratios can be realized by correspondingly changed Zahnungsabround or diameter variations of intermeshing gears or rotating rows of teeth.
- the counting rings may be made of a nontransparent or transparent material as described above so that the light from one or more lamps or LEDs disposed within the counting rings may pass outwardly through the counting rings to allow a user to read a set dose to allow in the dark.
- the invention further relates to a method for displaying a dose to be delivered by an injection device after a setting operation, wherein a set dose is detected and displayed, and during a dispensing and dispensing operation the amount of the still to be dispensed dose is continuously measured or determined and displayed that during a dispensing operation, a returning display can be realized.
- the indication is reset to "0" when the ampoule is changed or when the set dose has been released or, for example, detected by a sensor, for example, by a stop of a component on another component of the injection device upon completion of a dispensing operation, that no further dose can be distributed without further adjustment.
- a display can be automatically zeroed after each payout and / or ampoule change to ensure that the display or electronics of the injection device does not lose count steps and is available again from a defined initial state for a new adjustment operation.
- a mechanical display can be automatically turned back to "0" from a drive member as shown in FIGS. 1A to 1C, for example a rotary or spiral spring, when the pen is screwed on to change the ampoule.
- An electronic display of the injection device and / or a lighting of an electronic or mechanical display, such as an LED, can be turned on when an operation or movement of the injection device is detected by a sensor and can be turned off again when a predetermined period of time from Example 30 seconds has elapsed or if it is determined that within a given period of time, no actuation of the injection device was made or if it is determined that a discharge is completed.
- Figures 1A to 1C are cross-sectional views of one embodiment of an injection device as described in the above-referenced Patent Application 49,339 XI;
- FIGS. 2 and 3 show a sensor for an electronic life timer in the dosing button in a cross-sectional and exploded view
- Figure 4 shows an embodiment of an electronic real-time display with a spur gear for coupling the sensor with the setting and Aus contain mechanism
- FIGS. 5A to 5C show an embodiment of an electronic real-time display with an encoder arranged offset to a dosing element as a sensor;
- Figure 6 is a driven by a planetary gear coaxial real-time display
- FIG. 7 shows a mechanical coaxial real-time display with life timer
- FIG. 8 shows a cross-sectional view of a section of the device shown in FIG
- Figures 9 and 10 are sectional views of the section shown in Figure 8.
- FIG. 11 shows a detailed view of the region designated by X in FIG.
- FIGS. 1A to 1C show in cross-section an embodiment of an injection device in which a life timer and / or an electronic or mechanical real-time display can be integrated.
- Figures IA to IC show the described in the parallel patent application with the Attorney Docket 49 439 XI third embodiment of an injection device in which the driving force for the product distribution is not applied manually, but by a drive member 25 which is formed as a drive spring when administered.
- the drive member 25 is acting as a torsion spring coil spring with spring coils which rotate around the threaded axis of the threaded engagement between the coupling output member 9 and the piston rod 15.
- the spring coils are arranged one above the other radially to the thread axis; they have the slope of zero to the thread axis.
- An inner end of the spring coils is fixed to the clutch input member 6 ', and an outer end is fixed to a mounting structure 26 movably connected to the housing member 4 in the direction of clutch movement X but secured against twisting.
- the attachment structure 26 is non-movably connected to the clutch input member 6 'in and against the direction of the clutch movement X.
- the clutch input member 6 ' is rotatable relative to the mounting structure 26 about the threaded axis.
- the clutch 6'-I l 'in its operation corresponds to that of the second embodiment of the parallel patent application with the Attorney's Record 49 439 XI, so that for the coupling members 6'-10 and the decoupling member 11', the same reference numerals are used.
- the local coupling sleeve 8 ' is omitted.
- the coupling Slider member 7 ' is directly with the coupling output member 9 in a rotational drive movement of the clutch input member 6' on the coupling output member 9 engaging engagement.
- the holding device is formed in the embodiment shown in Figures IA to IC in a third variant. It comprises a return element 19, furthermore the coupling receptacle, which again forms the linear guide 4a for the piston rod 15, and a support structure 6d, which is not movably connected to the coupling input element 6 'at least in and against the direction of the coupling movement X;
- the clutch input member 6 'and the support structure 6d are formed in one piece.
- the drive spring 25 is axially surrounded by the support structures 6d and 26.
- the return element 19 is supported in the direction of the coupling movement via the coupling receptacle on the housing part 4 and against the direction of the coupling movement X on the support structure 6d.
- the return element 19 exerts on the clutch input member 6 'an acting against the coupling movement X elastic restoring force. It acts again as a compression spring.
- the tensioned between the piston rod 15 and the connecting part 33 compensating spring 17 supports the return element 19.
- the compensating spring 17 could replace the return element 19 for the disengagement of the coupling members 6 ', 7' and 9 basically. However, it is preferably so weak that, at least after a partial relaxation, it can no longer hold the coupling members 6'-9 with sufficient certainty in the holding position and thus the clutch in the disengaged state.
- FIG. 1A shows the housing part 4 with the parts of the injection device accommodated therein in an idle state, in which the device can be stored or the product dose can be adjusted.
- a rotational lock is formed between the clutch housing 6' and the housing part 4.
- the rotation lock consists in the illustrated holding position of the coupling members 6 ', T and 9 between a first locking member 24 and a second locking member 34.
- the locking member 24 is torsion and 29iebegeschreibt connected to the clutch input member 6'.
- the locking member 34 is secured against rotation with the housing part 4, but movable relative to the housing part 4 and the coupling input member 6 'in and against the direction of the coupling movement X.
- the locking members 24 and 34 form with their locking engagement with one another contacting faces a ratchet that allows the drive member 25 exciting rotational movement of the clutch input member 6 'and prevents rotation in the opposite direction.
- the locking member 24 is provided for a secondary function in connection with the metering and distribution on a jacket outer surface with a thread whose threaded axis with the threaded axis of the piston rod 15 is coaxial.
- a stop member 27 engages.
- the stop member 27 is guided linearly movable parallel to the threaded axis of the locking member 24, in Ausf ⁇ hrungsbeispiel in an axial groove on the inner circumferential surface of the housing part 4.
- the locking member 24 forms for the stop member 27 is a rotational stop, the propulsion of the piston rod 15 causing rotational movement of the clutch input member 6'- limited. It forms for the stop member 27 a further rotation stop, which determines the distributable and adjustable maximum dose.
- a trigger element 28 is provided for the triggering of the drive member 25, a trigger element 28 is provided.
- the trigger element 28 is relative to the housing part 4 in the direction of the coupling movement X in the exemplary embodiment, the advancing direction V and distal direction, translational and about the axis of rotation of the coupling input member 6 ', which coincides in the embodiment with the threaded axis of the piston rod 15, rotatably movable and is guided by the housing part 4 in these two movements.
- the triggering element 28 forms in a further function the dosing member of the third exemplary embodiment.
- the product dose which can be released with the next discharge operation is set via several intermediate links. From the zero dose position, which is shown in Figure IA and by stop of the stop member 27 on which the drive movement of the clutch input member 6 'limiting rotational stop of the locking member 24 is determined, the dose can be adjusted by rotating the trigger element 28 in the direction of the marked direction of rotation arrow.
- the rotary dosing movement of the trigger element 28 is transmitted via an inner part 29, which is rotationally and non-displaceably connected to the trigger element 28 or formed integrally therewith, and a connecting part 33 is transmitted to the clutch input member 6 '.
- the inner part 29 and the connecting part 33 are engaged with each other in a rotationally secured engagement, and the connecting part 33 is connected to the clutch input member 6 'secured against rotation.
- the connecting part 33 is connected to the clutch input member 6 'further axially not movable.
- the inner part 29 and the connecting part 33 are provided with an internal toothing 29a and an external toothing 33a, which engage in one another in the resting state of the device and are axially displaceable against each other.
- the triggering element 28 is arranged in the proximal end region of the housing part 4 in a user-friendly way. Its outer sleeve part surrounds the housing part 4. A bottom of the trigger element 28 forms a distal end of the injection device.
- the trigger element 28 can be operated like a rotary knob and has a corrugation on its outer lateral surface for this purpose.
- it can be operated like a push-button. From the in ⁇ enteil 29 projects a stop element 29b to a proximal end face of the connecting part 33.
- the locking member 31 is supported for this purpose in the direction of the coupling movement X on the locking member 34 and the coupling movement X against a housing part 30 from which fixedly connected to the housing part 4 is.
- the user adjusts the dose by rotating the trigger element 28 in the direction of the rotation arrow.
- the trigger element 28 takes in this rotary dosing over the rotation 29a, 33a, the connecting part 33, which in turn carries the clutch input member 6 ', which thus performs the same rotational dosing movement as the trigger element 28.
- the drive member 25 is tensioned.
- the stop member 27 moves in engagement with the thread of the locking member 24 from the zero dose determining stop of the thread in the direction of the maximum dose determining stop.
- the user If the user has inadvertently set too high a dose, he can correct the dose by turning back the clutch input member 6 '. For the dose correction, he pulls the trigger element 28 in the proximal direction.
- the inner part 29 and the locking member 34 are in the resting state of the device with respect to a movement in the proximal direction in a driving engagement.
- the corresponding drivers are designated 29c and 34a.
- the driver 29c formed by the inner part 29 and the driver 34a formed by the locking member 34 engage behind each other and form a Movement of the trigger element 28 in the proximal direction an entanglement.
- the user can by means of translational dosing of the trigger element 28 and the still existing rotation-secured engagement of the inner part 29 with the connecting part 33 to correct the dose.
- the user releases the trigger element 28 it snaps back together with the locking member 34 under the action of the locking spring 31 in the distal direction and the locking member 34 thereby again in locking engagement with the locking member 24.
- the return movement of the user expediently continues to hold the trigger element 28 fixed, but only to prevent relative rotational movement in the housing part 4. Basically, he can also snap it back.
- the device After setting the desired dose, the device is placed on the skin at the desired point of administration and the injection needle is inserted.
- the user For the insertion of the needle, the user must push the trigger element 28 in the distal direction.
- a needle protection sleeve is correspondingly coupled to the triggering element 28.
- the drive member 25 can be triggered by further pressure on the trigger element 28 and the distribution can be effected.
- the trigger member 28 and thus the inner member 29 is pressed against the pressure of the spring 32 relative to the connecting member 33 further in the distal direction, so that the rotation lock 29a, 33a triggers.
- the trigger element 28 can rotate empty.
- the stop element 29b comes into abutting contact with the connecting part 33.
- the tripping element 28 presses the connecting element 33 via the stop element 29b and thus the coupling input element 6 'in the direction of Coupling movement X 5 in the exemplary embodiment in the advancing direction V.
- the clutch input member 6 enters the clutch engagement with the Coupling intermediate member 7 '.
- Figure IB shows the injection device in the case of setting a zero dose in the engaged state after the release of the anti-rotation lock 24, 34, i. after the triggering dement 28 has completed the release movement.
- the triggering sequence described above runs automatically in advantageously continuously applied to the triggering element pressure, from piercing to the complete distribution of the set dose; for piercing the housing 1, 4 must be pressed against the skin surface.
- Figure IC shows the injection device after emptying of the reservoir 2.
- the housing part 1 has already been removed from the housing part 4.
- the piston rod 15 assumes its most distal position.
- the decoupling member 11 ' blocks the coupling input member 6' in the position withdrawn from the intermediate coupling member 7 '.
- the operation of the decoupling member 11 ' corresponds to that in the other embodiments.
- the housing part 1 and the decoupling member 11 ' are not directly connected to one another in a guide unit. but via an adapter structure 40.
- the adapter structure 40 is a sleeve which is fixed in the housing part 4 in which connecting portion in and against the direction of the coupling movement X, but can rotate about the central longitudinal axis of the housing part 4.
- the adapter structure 40 forms a guide curve 40a either as a recess or aperture in its the decoupling member 11 'facing lateral surface.
- the guide curve 40a has the course of a threaded portion.
- the length measured along the circumference and the slope of the guide curve 40a measured with respect to the central longitudinal axis of the housing part 4 are dimensioned such that when the adapter structure 40 is rotated by a quarter to half turn relative to the decoupling member IT, it is shown in FIG Uncoupling position is moved.
- the movement of the decoupling member 11 ' has an axial length which corresponds to the length X of the complete coupling movement. For the generation of the axial movement, the decoupling member 11 'engages with its engagement element 12 in the guide curve 40a.
- the adapter structure 40 forms when connecting the housing parts 1 and 4, a linear guide for the housing part 1.
- the housing part 1 is inserted into the adapter structure 40, wherein preferably a slight frictional engagement and, accordingly, a sliding guide for the housing part 1.
- the housing part 1 is not rotatable relative to the adapter structure 40 about the central longitudinal axis of the housing part 4. The correspondingly rotationally secured engagement is produced at the beginning of the insertion of the housing part 1 into the adapter structure 40.
- the housing part 1 After the housing part 1 has been pushed in abutment against the housing part 4, namely its Riepplungsfact at 4a, the housing part 1 is rotated relative to the housing part 4 and takes in this rotational movement, the adapter structure 40 with, until the engagement member 12 of the decoupling element IT the end of the guide curve 40a reaches the stop.
- the rotational movement of the housing part 1 is preferably possible only in its axial stop position, for which an effective against rotation into the stop position against rotation between the housing parts 1 and 4 may be formed.
- FIG. 2 shows, as in FIG. 3, a life timer 100 integrated in the trigger element or dosing button 28 in cross-section, which is connected by means of a connecting piece 101 the threaded or piston rod 15 is connected. If the ampoule inserted in the injection device is full, the switch 102 of the lifter can be actuated via the threaded rod 15 and the connecting piece 101, so that the LED 103a briefly lights up, for example, green. To evaluate the signals generated by the contact switch 102 and to drive the LED 103a, a chip 104 is provided on the printed circuit board 105a.
- the required current is provided by a battery 106 which is fastened to the printed circuit board 105a by means of a contact clip 107, the life timer comprising the components 102 to 107 being mounted in the receptacle 108.
- the elements of the first embodiment of the life-timer shown in cross-section in FIG. 2 are shown individually in FIG.
- a time detection unit is integrated, which is started after the first detection of an operation by a signal from the switch 102. After expiration of, for example, 3 years stored in the maximum lifetime of the chip, for example, the LED 103a is controlled so that it glows red or flashing to signal a user that he should stop using the injection device and must replace. Additionally or alternatively, the number of ampoule changes, which can also be detected with the switch 102, be used to determine the end of life.
- FIG. 4 shows an electronic module integrated into the injection device with an LCD display 110, which is illuminated from the back with a green light LED 103b, if the injection pen is still illuminated within the service life and with red light, if the injection pen is outside a fixed one or service-dependent determined life is operated.
- a spur gear or ' ring gear 1 1 1 meshes with a toothing of the coupling sleeve or the ' coupling input member 6, 6 'and transmits a rotational movement of the coupling sleeve 6, 6' to the encoder 112 a, wherein the signal generated by the encoder 112 a processed by an electronics and for display on the LCD 110 for reading by the user.
- a sensor or encoder can also be coupled or connected directly or indirectly with other elements of the pen provided for metering or dispensing movement, such as a counting ring 23a, 23b, the blocking member 24 or the connecting member 33.
- Figure 5A shows a perspective view of a in Figure 5B in cross section and in Figure 5C in plan view shown another embodiment of a real-time electronic display, wherein on a setting or dosing of the Inj tion device, not shown, a ring gear 1 14 is provided, in which a with a non-impact encoder or rotary encoder 112b coupled gear 113 engages to detect a rotational movement of the dosing and display a rotational movement corresponding dose on the LCD display 110.
- the encoder 112b could also be coupled to the clutch input member 6, 6 'by means of a gear, as shown in FIG.
- Figure 6 shows an embodiment of a mechanical coaxial real-time display with a one-count ring 23a and a ten-count ring 23b as briefly described above.
- the drive pulley 120 connected to the coupling sleeve 6, 6 '(not shown in FIG. 6) has, in the illustrated embodiment, three supports 120a for planetary gears 121, which are driven by the drive pulley 120.
- the planets 121 drive the one-counting ring 23a, which has an outer toothing 23c serving as a sun gear, which is coaxially offset and has a smaller diameter than the one-counting ring 23a.
- a bearing for a coupling gear 123 is provided, which engages after each full handling of the one-counting ring 23a provided in only a portion of the one-toothed ring 23a internal toothing 23d to turn the tens counter ring 23b by 36 degrees.
- the ring gear 123 serves as a carrier of the unit shown in Figure 6 and is held in the housing of the injection device.
- the direction of rotation of the one-counting ring 23a and the tens counting ring 23b corresponds to the direction of rotation of the drive disc 120 coupled or connected to the coupling sleeve 6, 6 ', so that a mechanical real-time display can be realized, which during the adjustment process, any corrections of the setting and during the distribution continuously counted and displays the amount of ready after the setting for the distribution dose in real time.
- FIG. 7 shows an exemplary embodiment in which the concept described with reference to FIG. 4 is implemented not with an electronic but with a mechanical display.
- the external toothing of the coupling sleeve 6, 6 ' is coupled to a gear 130 formed as a driver, which transmits the rotational movement of the coupling sleeve 6, 6' on an internal toothing 23e of the one-counting ring 23a, wherein the one-counting ring 23a by means of only a part internal gear teeth 23d, as described with reference to FIG.
- the one and ten counting rings 23a and 23b are transparent, so that a red or green light emitted by the LED 103 for indicating whether the injection device can still be used (green) or whether the life has expired (red), from a User can be perceived when reading the setting on the counting rings 23a, 23b.
- FIG. 8 shows the device shown in FIG. 7 in cross-section in the assembled state, with a section being taken along the line III-III in FIG. 9 and along the line designated IV-IV in FIG. Detail detail X of FIG. 9 is shown in FIG.
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Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
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JP2007547133A JP2008523930A (ja) | 2004-12-31 | 2005-11-30 | 製剤の投薬分の投与装置用実時間ディスプレイ |
EP05804273A EP1833534A1 (de) | 2004-12-31 | 2005-11-30 | Echtzeitanzeige f]r eine vorrichtung zur dosierten verabreichung eines produkts |
AU2005321732A AU2005321732B9 (en) | 2004-12-31 | 2005-11-30 | Real-time display for a device for the dosed administration of a product |
US11/769,227 US20080033369A1 (en) | 2004-12-31 | 2007-06-27 | Real-time display for a device for the dosed administration of a product |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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DE102004063664A DE102004063664A1 (de) | 2004-12-31 | 2004-12-31 | Echtzeitanzeige für eine Vorrichtung zur dosierten Verabreichung eines Produkts |
DE102004063664.8 | 2004-12-31 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
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US11/769,227 Continuation US20080033369A1 (en) | 2004-12-31 | 2007-06-27 | Real-time display for a device for the dosed administration of a product |
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WO2006069455A1 true WO2006069455A1 (de) | 2006-07-06 |
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Application Number | Title | Priority Date | Filing Date |
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PCT/CH2005/000711 WO2006069455A1 (de) | 2004-12-31 | 2005-11-30 | Echtzeitanzeige für eine vorrichtung zur dosierten verabreichung eines produkts |
Country Status (7)
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US (1) | US20080033369A1 (de) |
EP (1) | EP1833534A1 (de) |
JP (1) | JP2008523930A (de) |
CN (1) | CN101107030A (de) |
AU (1) | AU2005321732B9 (de) |
DE (1) | DE102004063664A1 (de) |
WO (1) | WO2006069455A1 (de) |
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US11857770B2 (en) | 2018-02-22 | 2024-01-02 | Eli Lilly And Company | Medication delivery device with a sensed element |
WO2021191095A1 (de) * | 2020-03-26 | 2021-09-30 | Ypsomed Ag | Autoinjektor mit ausschüttdetektion |
EP3930793B1 (de) * | 2020-03-26 | 2023-11-08 | Ypsomed AG | Autoinjektor mit ausschüttdetektion |
EP4289456A3 (de) * | 2020-03-26 | 2024-03-20 | Ypsomed AG | Autoinjektor mit ausschüttdetektion |
Also Published As
Publication number | Publication date |
---|---|
AU2005321732B2 (en) | 2009-08-06 |
DE102004063664A1 (de) | 2006-07-20 |
JP2008523930A (ja) | 2008-07-10 |
US20080033369A1 (en) | 2008-02-07 |
CN101107030A (zh) | 2008-01-16 |
AU2005321732A1 (en) | 2006-07-06 |
EP1833534A1 (de) | 2007-09-19 |
AU2005321732B9 (en) | 2009-12-10 |
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