WO2005083441A3 - Diagnostic and therapeutics for diseases associated with proto-oncogene tyrosine-protein kinase (fyn) - Google Patents

Diagnostic and therapeutics for diseases associated with proto-oncogene tyrosine-protein kinase (fyn) Download PDF

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Publication number
WO2005083441A3
WO2005083441A3 PCT/EP2005/001419 EP2005001419W WO2005083441A3 WO 2005083441 A3 WO2005083441 A3 WO 2005083441A3 EP 2005001419 W EP2005001419 W EP 2005001419W WO 2005083441 A3 WO2005083441 A3 WO 2005083441A3
Authority
WO
WIPO (PCT)
Prior art keywords
diseases
fyn
proto
therapeutics
diagnostic
Prior art date
Application number
PCT/EP2005/001419
Other languages
French (fr)
Other versions
WO2005083441A2 (en
Inventor
Stefan Golz
Ulf Brueggemeier
Andreas Geerts
Ralf Thiele
Holger Summer
Original Assignee
Bayer Healthcare Ag
Stefan Golz
Ulf Brueggemeier
Andreas Geerts
Ralf Thiele
Holger Summer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare Ag, Stefan Golz, Ulf Brueggemeier, Andreas Geerts, Ralf Thiele, Holger Summer filed Critical Bayer Healthcare Ag
Publication of WO2005083441A2 publication Critical patent/WO2005083441A2/en
Publication of WO2005083441A3 publication Critical patent/WO2005083441A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/45—Transferases (2)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

Abstract

The invention provides a human FYN which is associated with cardiovascular diseases, endocrinological diseases, metabolic diseases, gastroenterological diseases, inflammation, hematological diseases, respiratory diseases, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, endocrinological diseases, metabolic diseases, gastroenterological diseases, inflammation, hematological diseases, respiratory diseases, neurological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of FYN as well as pharmaceutical compositions comprising such compounds.
PCT/EP2005/001419 2004-02-26 2005-02-12 Diagnostic and therapeutics for diseases associated with proto-oncogene tyrosine-protein kinase (fyn) WO2005083441A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04004313.5 2004-02-26
EP04004313 2004-02-26

Publications (2)

Publication Number Publication Date
WO2005083441A2 WO2005083441A2 (en) 2005-09-09
WO2005083441A3 true WO2005083441A3 (en) 2005-11-10

Family

ID=34895951

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2005/001419 WO2005083441A2 (en) 2004-02-26 2005-02-12 Diagnostic and therapeutics for diseases associated with proto-oncogene tyrosine-protein kinase (fyn)

Country Status (1)

Country Link
WO (1) WO2005083441A2 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995029185A1 (en) * 1994-04-22 1995-11-02 Sugen, Inc. Novel megakaryocytic protein tyrosine kinases
US6506607B1 (en) * 1997-12-24 2003-01-14 Millennium Pharmaceuticals, Inc. Methods and compositions for the identification and assessment of prostate cancer therapies and the diagnosis of prostate cancer
WO2003081210A2 (en) * 2002-03-21 2003-10-02 Sunesis Pharmaceuticals, Inc. Identification of kinase inhibitors

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995029185A1 (en) * 1994-04-22 1995-11-02 Sugen, Inc. Novel megakaryocytic protein tyrosine kinases
US6506607B1 (en) * 1997-12-24 2003-01-14 Millennium Pharmaceuticals, Inc. Methods and compositions for the identification and assessment of prostate cancer therapies and the diagnosis of prostate cancer
WO2003081210A2 (en) * 2002-03-21 2003-10-02 Sunesis Pharmaceuticals, Inc. Identification of kinase inhibitors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MARAFIOTI T ET AL.: "Expression of intracellular signaling molecules in classical and lymphocyte predominance Hodgkin disease", BLOOD, vol. 103, no. 1, 1 January 2004 (2004-01-01), pages 188 - 193, XP002338561, ISSN: 0006-4971 *

Also Published As

Publication number Publication date
WO2005083441A2 (en) 2005-09-09

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