WO2006040047A3 - Diagnostics and therapeutics for diseases associated with rho/rac-interacting citron kinase (cit) - Google Patents

Diagnostics and therapeutics for diseases associated with rho/rac-interacting citron kinase (cit) Download PDF

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Publication number
WO2006040047A3
WO2006040047A3 PCT/EP2005/010700 EP2005010700W WO2006040047A3 WO 2006040047 A3 WO2006040047 A3 WO 2006040047A3 EP 2005010700 W EP2005010700 W EP 2005010700W WO 2006040047 A3 WO2006040047 A3 WO 2006040047A3
Authority
WO
WIPO (PCT)
Prior art keywords
diseases
cit
rac
rho
therapeutics
Prior art date
Application number
PCT/EP2005/010700
Other languages
French (fr)
Other versions
WO2006040047A2 (en
Inventor
Stefan Golz
Ulf Brueggemeier
Andreas Geerts
Original Assignee
Bayer Healthcare Ag
Stefan Golz
Ulf Brueggemeier
Andreas Geerts
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare Ag, Stefan Golz, Ulf Brueggemeier, Andreas Geerts filed Critical Bayer Healthcare Ag
Publication of WO2006040047A2 publication Critical patent/WO2006040047A2/en
Publication of WO2006040047A3 publication Critical patent/WO2006040047A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

Abstract

The invention provides a human CIT which is associated with cardiovascular diseases, respiratory diseases, dermatological diseases, endocrinological diseases, metabolic diseases, inflammation, gastroenterological diseases, cancer, hematological diseases, muscle skeleton diseases, neuro­logical diseases, urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, respiratory diseases, dermatological diseases, endocrinological diseases, metabolic diseases, inflammation, gastro­enterological diseases, cancer, hematological diseases, muscle skeleton diseases, neurological diseases, urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of CIT as well as pharmaceutical compositions comprising such compounds.
PCT/EP2005/010700 2004-10-15 2005-10-05 Diagnostics and therapeutics for diseases associated with rho/rac-interacting citron kinase (cit) WO2006040047A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04024671.2 2004-10-15
EP04024671 2004-10-15

Publications (2)

Publication Number Publication Date
WO2006040047A2 WO2006040047A2 (en) 2006-04-20
WO2006040047A3 true WO2006040047A3 (en) 2006-06-22

Family

ID=35618297

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2005/010700 WO2006040047A2 (en) 2004-10-15 2005-10-05 Diagnostics and therapeutics for diseases associated with rho/rac-interacting citron kinase (cit)

Country Status (1)

Country Link
WO (1) WO2006040047A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100537769C (en) * 2006-11-10 2009-09-09 上海人类基因组研究中心 People Citron gene, its proteins encoded and application
CN104232744B (en) * 2013-06-09 2017-05-17 上海吉凯基因化学技术有限公司 Application of human CIT gene and EGFR gene in curing tumors and related drugs

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001038503A2 (en) * 1999-11-24 2001-05-31 Sugen, Inc. Novel human protein kinases and protein kinase-like enzymes
US6479268B1 (en) * 2000-02-29 2002-11-12 Millennium Pharmaceuticals, Inc. 7970, a novel ATPase-like molecule and uses thereof
WO2003004629A2 (en) * 2001-07-02 2003-01-16 Bayer Aktiengesellschaft Regulation of human citron rho/rac-interacting kinase-short kinase
WO2003004523A1 (en) * 2001-07-02 2003-01-16 Bayer Aktiengesellschaft Regulation of human citron rho/rac-interacting kinase
WO2003029424A2 (en) * 2001-10-02 2003-04-10 Curagen Corporation Novel proteins and nucleic acids encoding same
WO2003083096A2 (en) * 2002-03-28 2003-10-09 Qlt Inc. Cancer associated protein kinases and their uses
WO2004006838A2 (en) * 2002-07-15 2004-01-22 Sugen, Inc. Novel kinases

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001038503A2 (en) * 1999-11-24 2001-05-31 Sugen, Inc. Novel human protein kinases and protein kinase-like enzymes
US6479268B1 (en) * 2000-02-29 2002-11-12 Millennium Pharmaceuticals, Inc. 7970, a novel ATPase-like molecule and uses thereof
WO2003004629A2 (en) * 2001-07-02 2003-01-16 Bayer Aktiengesellschaft Regulation of human citron rho/rac-interacting kinase-short kinase
WO2003004523A1 (en) * 2001-07-02 2003-01-16 Bayer Aktiengesellschaft Regulation of human citron rho/rac-interacting kinase
WO2003029424A2 (en) * 2001-10-02 2003-04-10 Curagen Corporation Novel proteins and nucleic acids encoding same
WO2003083096A2 (en) * 2002-03-28 2003-10-09 Qlt Inc. Cancer associated protein kinases and their uses
WO2004006838A2 (en) * 2002-07-15 2004-01-22 Sugen, Inc. Novel kinases

Also Published As

Publication number Publication date
WO2006040047A2 (en) 2006-04-20

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