WO2005093092A3 - Diagnostics and therapeutics for diseases associated with g-protein coupled receptor 44 (gpr44) - Google Patents

Diagnostics and therapeutics for diseases associated with g-protein coupled receptor 44 (gpr44) Download PDF

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Publication number
WO2005093092A3
WO2005093092A3 PCT/EP2005/002600 EP2005002600W WO2005093092A3 WO 2005093092 A3 WO2005093092 A3 WO 2005093092A3 EP 2005002600 W EP2005002600 W EP 2005002600W WO 2005093092 A3 WO2005093092 A3 WO 2005093092A3
Authority
WO
WIPO (PCT)
Prior art keywords
diseases
gpr44
therapeutics
diagnostics
diseases associated
Prior art date
Application number
PCT/EP2005/002600
Other languages
French (fr)
Other versions
WO2005093092A2 (en
Inventor
Stefan Golz
Ulf Brueggemeier
Andreas Geerts
Original Assignee
Bayer Healthcare Ag
Stefan Golz
Ulf Brueggemeier
Andreas Geerts
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare Ag, Stefan Golz, Ulf Brueggemeier, Andreas Geerts filed Critical Bayer Healthcare Ag
Publication of WO2005093092A2 publication Critical patent/WO2005093092A2/en
Publication of WO2005093092A3 publication Critical patent/WO2005093092A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57488—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds identifable in body fluids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2821—Alzheimer

Abstract

The invention provides a human GPR44 which is associated with the cardiovascular diseases, gastroenterological diseases, cancer, inflammation, metabolic diseases, hematological diseases, respiratory diseases, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, gastroenterological diseases, cancer, inflammation, metabolic diseases, hematological diseases, respiratory diseases, neurological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of GPR44 as well as pharmaceutical compositions comprising such compounds.
PCT/EP2005/002600 2004-03-26 2005-03-11 Diagnostics and therapeutics for diseases associated with g-protein coupled receptor 44 (gpr44) WO2005093092A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04007435.3 2004-03-26
EP04007435 2004-03-26

Publications (2)

Publication Number Publication Date
WO2005093092A2 WO2005093092A2 (en) 2005-10-06
WO2005093092A3 true WO2005093092A3 (en) 2005-11-17

Family

ID=34961889

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2005/002600 WO2005093092A2 (en) 2004-03-26 2005-03-11 Diagnostics and therapeutics for diseases associated with g-protein coupled receptor 44 (gpr44)

Country Status (1)

Country Link
WO (1) WO2005093092A2 (en)

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WO2015061441A1 (en) * 2013-10-23 2015-04-30 Genentech, Inc. Methods of diagnosing and treating eosinophilic disorders
CA2975852A1 (en) 2015-02-04 2016-08-11 Twist Bioscience Corporation Methods and devices for de novo oligonucleic acid assembly
WO2016172377A1 (en) 2015-04-21 2016-10-27 Twist Bioscience Corporation Devices and methods for oligonucleic acid library synthesis
TWI726897B (en) * 2015-07-15 2021-05-11 日商協和麒麟股份有限公司 Antibodies that specifically bind to human CRTH2
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WO2017053450A1 (en) 2015-09-22 2017-03-30 Twist Bioscience Corporation Flexible substrates for nucleic acid synthesis
JP6871364B2 (en) 2016-09-21 2021-05-12 ツイスト バイオサイエンス コーポレーション Nucleic acid-based data storage
SG11201907713WA (en) 2017-02-22 2019-09-27 Twist Bioscience Corp Nucleic acid based data storage
WO2018231864A1 (en) 2017-06-12 2018-12-20 Twist Bioscience Corporation Methods for seamless nucleic acid assembly
CN111566209A (en) 2017-06-12 2020-08-21 特韦斯特生物科学公司 Seamless nucleic acid assembly method
US11407837B2 (en) 2017-09-11 2022-08-09 Twist Bioscience Corporation GPCR binding proteins and synthesis thereof
KR20240024357A (en) 2017-10-20 2024-02-23 트위스트 바이오사이언스 코포레이션 Heated nanowells for polynucleotide synthesis
KR20210013128A (en) 2018-05-18 2021-02-03 트위스트 바이오사이언스 코포레이션 Polynucleotides, reagents and methods for nucleic acid hybridization
SG11202109283UA (en) 2019-02-26 2021-09-29 Twist Bioscience Corp Variant nucleic acid libraries for antibody optimization
EP3987019A4 (en) 2019-06-21 2023-04-19 Twist Bioscience Corporation Barcode-based nucleic acid sequence assembly

Citations (4)

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EP0851030A1 (en) * 1996-06-05 1998-07-01 BML Inc. PROTEIN SPECIFIC TO HUMAN Th2, GENE (B19) ENCODING THE SAME, AND TRANSFORMANT, RECOMBINANT VECTOR AND MONOCLONAL ANTIBODY RELATING THERETO
EP1170594A2 (en) * 2000-07-07 2002-01-09 Pfizer Products Inc. Methods for the identification of compounds useful for the treatment of disease states mediated by Prostaglandin D2
US20020052330A1 (en) * 1998-02-23 2002-05-02 David Michalovich Molecular cloning of a chemokine receptor (SBELEVTM)
US20050038070A1 (en) * 2003-07-09 2005-02-17 Amgen Inc. Asthma and allergic inflammation modulators

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0851030A1 (en) * 1996-06-05 1998-07-01 BML Inc. PROTEIN SPECIFIC TO HUMAN Th2, GENE (B19) ENCODING THE SAME, AND TRANSFORMANT, RECOMBINANT VECTOR AND MONOCLONAL ANTIBODY RELATING THERETO
US20020052330A1 (en) * 1998-02-23 2002-05-02 David Michalovich Molecular cloning of a chemokine receptor (SBELEVTM)
EP1170594A2 (en) * 2000-07-07 2002-01-09 Pfizer Products Inc. Methods for the identification of compounds useful for the treatment of disease states mediated by Prostaglandin D2
US20020022218A1 (en) * 2000-07-07 2002-02-21 Baiyong Li Methods for the identification of compounds useful for the treatment of disease states medicated by prostaglandin D2
US20050038070A1 (en) * 2003-07-09 2005-02-17 Amgen Inc. Asthma and allergic inflammation modulators

Also Published As

Publication number Publication date
WO2005093092A2 (en) 2005-10-06

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