WO2005075457A8 - Derives de phtalazinone utilises en tant qu'inhibiteurs de pde4 - Google Patents

Derives de phtalazinone utilises en tant qu'inhibiteurs de pde4

Info

Publication number
WO2005075457A8
WO2005075457A8 PCT/EP2005/050417 EP2005050417W WO2005075457A8 WO 2005075457 A8 WO2005075457 A8 WO 2005075457A8 EP 2005050417 W EP2005050417 W EP 2005050417W WO 2005075457 A8 WO2005075457 A8 WO 2005075457A8
Authority
WO
WIPO (PCT)
Prior art keywords
phthalazinone
derivatives
pde4 inhibitors
inhibitors
meanings
Prior art date
Application number
PCT/EP2005/050417
Other languages
English (en)
Other versions
WO2005075457A1 (fr
Inventor
Geert Jan Sterk
Armin Hatzelmann
Johannes Barsig
Degenhard Marx
Hans-Peter Kley
Johannes A M Christiaans
Wiro M P B Menge
Original Assignee
Altana Pharma Ag
Geert Jan Sterk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Altana Pharma Ag, Geert Jan Sterk filed Critical Altana Pharma Ag
Priority to EP05701632A priority Critical patent/EP1720854A1/fr
Publication of WO2005075457A1 publication Critical patent/WO2005075457A1/fr
Publication of WO2005075457A8 publication Critical patent/WO2005075457A8/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Abstract

L'invention concerne les composés représentés par la formule (1), dans laquelle R1, R2, R3, R9 et n ont les significations données dans le descriptif. Ces composés sont de nouveaux inhibiteurs efficaces de PDE4.
PCT/EP2005/050417 2004-02-04 2005-02-01 Derives de phtalazinone utilises en tant qu'inhibiteurs de pde4 WO2005075457A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP05701632A EP1720854A1 (fr) 2004-02-04 2005-02-01 Dérivés de phthalazinone comme inhibiteurs de pde4

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04002423 2004-02-04
EP04002423.4 2004-02-04

Publications (2)

Publication Number Publication Date
WO2005075457A1 WO2005075457A1 (fr) 2005-08-18
WO2005075457A8 true WO2005075457A8 (fr) 2006-03-02

Family

ID=34833571

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2005/050417 WO2005075457A1 (fr) 2004-02-04 2005-02-01 Derives de phtalazinone utilises en tant qu'inhibiteurs de pde4

Country Status (2)

Country Link
EP (1) EP1720854A1 (fr)
WO (1) WO2005075457A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2005210042B2 (en) 2004-02-04 2011-04-21 Takeda Gmbh 2-(piperidin-4-yl) -4, 5-dihydro-2H-pyridazin-3-one derivatives as PDE4 inhibitors
ES2374337T3 (es) 2007-05-16 2012-02-15 Nycomed Gmbh Derivados de pirazolona como inhibidores de pde4.
AR074318A1 (es) 2008-11-14 2011-01-05 Nycomed Gmbh Derivados heterociclicos de pirazolona, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de enfermedades de las vias respiratorias.
CN103582644B (zh) 2011-06-17 2016-07-20 塔科达有限责任公司 酞嗪酮-吡咯并嘧啶羧酰胺衍生物

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA200300836A1 (ru) * 2001-02-15 2004-02-26 Алтана Фарма Аг Производные фталазинон-пиперидина в качестве ингибиторов pde4

Also Published As

Publication number Publication date
WO2005075457A1 (fr) 2005-08-18
EP1720854A1 (fr) 2006-11-15

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