WO2005075457A8 - Phthalazinone-derivatives as pde4 inhibitors - Google Patents

Phthalazinone-derivatives as pde4 inhibitors

Info

Publication number
WO2005075457A8
WO2005075457A8 PCT/EP2005/050417 EP2005050417W WO2005075457A8 WO 2005075457 A8 WO2005075457 A8 WO 2005075457A8 EP 2005050417 W EP2005050417 W EP 2005050417W WO 2005075457 A8 WO2005075457 A8 WO 2005075457A8
Authority
WO
WIPO (PCT)
Prior art keywords
phthalazinone
derivatives
pde4 inhibitors
inhibitors
meanings
Prior art date
Application number
PCT/EP2005/050417
Other languages
French (fr)
Other versions
WO2005075457A1 (en
Inventor
Geert Jan Sterk
Armin Hatzelmann
Johannes Barsig
Degenhard Marx
Hans-Peter Kley
Johannes A M Christiaans
Wiro M P B Menge
Original Assignee
Altana Pharma Ag
Geert Jan Sterk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Altana Pharma Ag, Geert Jan Sterk filed Critical Altana Pharma Ag
Priority to EP05701632A priority Critical patent/EP1720854A1/en
Publication of WO2005075457A1 publication Critical patent/WO2005075457A1/en
Publication of WO2005075457A8 publication Critical patent/WO2005075457A8/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Abstract

The compounds of a certain formula (1), in which R1, R2, R3, R9 and n have the meanings as given in the description, are novel effective PDE4 inhibitors.
PCT/EP2005/050417 2004-02-04 2005-02-01 Phthalazinone-derivatives as pde4 inhibitors WO2005075457A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP05701632A EP1720854A1 (en) 2004-02-04 2005-02-01 Phthalzinone derivatives as pde4 inhibitors

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04002423.4 2004-02-04
EP04002423 2004-02-04

Publications (2)

Publication Number Publication Date
WO2005075457A1 WO2005075457A1 (en) 2005-08-18
WO2005075457A8 true WO2005075457A8 (en) 2006-03-02

Family

ID=34833571

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2005/050417 WO2005075457A1 (en) 2004-02-04 2005-02-01 Phthalazinone-derivatives as pde4 inhibitors

Country Status (2)

Country Link
EP (1) EP1720854A1 (en)
WO (1) WO2005075457A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4778449B2 (en) 2004-02-04 2011-09-21 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング 2- (Piperidin-4-yl) -4,5-dihydro-2H-pyridazin-3-one derivatives as PDE4 inhibitors
US8304436B2 (en) 2007-05-16 2012-11-06 Nycomed Gmbh Pyrazolone derivatives as PDE4 inhibitors
AR074318A1 (en) 2008-11-14 2011-01-05 Nycomed Gmbh HETEROCICLIC DERIVATIVES OF PIRAZOLONA, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND USE OF THE SAME FOR THE TREATMENT OF DISEASES OF RESPIRATORY ROADS.
BR112013031791A2 (en) 2011-06-17 2017-01-31 Takeda Gmbh phthalazinone-pyrrolopyrimidinecarboxamide derivatives

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0303193A3 (en) * 2001-02-15 2007-08-28 Altana Pharma Ag Phthalayinone-piperidino-derivatives as pde4 inhibitors and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
WO2005075457A1 (en) 2005-08-18
EP1720854A1 (en) 2006-11-15

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