WO2003048202A3 - Nf-kappab activating genes - Google Patents
Nf-kappab activating genes Download PDFInfo
- Publication number
- WO2003048202A3 WO2003048202A3 PCT/JP2002/012644 JP0212644W WO03048202A3 WO 2003048202 A3 WO2003048202 A3 WO 2003048202A3 JP 0212644 W JP0212644 W JP 0212644W WO 03048202 A3 WO03048202 A3 WO 03048202A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- protein
- dna
- activating
- recombinant vector
- activation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Abstract
Provided are proteins capable of activating NF-κB, which are used for diagnosing, treating or preventing diseases associated with the excessive activation or inhibition of NF-κB. Using plasmid pNFκB-Luc, cDNA encoding a protein capable of activating NF-κB has been cloned from a cDNA library constructed from human lung fibroblasts and the like, and the DNA sequence and the deduced amino acid sequence determined. The protein, the DNA encoding the protein, a recombinant vector containing the DNA, and a transformant containing the recombinant vector are useful for screening a substance inhibiting or promoting NF-κB activation.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2002349784A AU2002349784A1 (en) | 2001-12-03 | 2002-12-03 | Nf-kappab activating genes |
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2001-368692 | 2001-12-03 | ||
JP2001368692A JP2006166701A (en) | 2001-12-03 | 2001-12-03 | NF-kappaB ACTIVATING GENE |
US33582901P | 2001-12-05 | 2001-12-05 | |
US60/335,829 | 2001-12-05 | ||
JP2002291302A JP2006166705A (en) | 2002-10-03 | 2002-10-03 | NF-kappaB ACTIVATING GENE |
JP2002-291302 | 2002-10-03 | ||
US41576902P | 2002-10-04 | 2002-10-04 | |
US60/415,769 | 2002-10-04 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2003048202A2 WO2003048202A2 (en) | 2003-06-12 |
WO2003048202A3 true WO2003048202A3 (en) | 2004-07-01 |
Family
ID=27482716
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2002/012644 WO2003048202A2 (en) | 2001-12-03 | 2002-12-03 | Nf-kappab activating genes |
Country Status (2)
Country | Link |
---|---|
AU (1) | AU2002349784A1 (en) |
WO (1) | WO2003048202A2 (en) |
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2002
- 2002-12-03 AU AU2002349784A patent/AU2002349784A1/en not_active Abandoned
- 2002-12-03 WO PCT/JP2002/012644 patent/WO2003048202A2/en active Application Filing
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9562049B2 (en) | 2012-12-21 | 2017-02-07 | Medimmune Limited | Pyrrolobenzodiazepines and conjugates thereof |
US9567340B2 (en) | 2012-12-21 | 2017-02-14 | Medimmune Limited | Unsymmetrical pyrrolobenzodiazepines-dimers for use in the treatment of proliferative and autoimmune diseases |
Also Published As
Publication number | Publication date |
---|---|
AU2002349784A8 (en) | 2003-06-17 |
WO2003048202A2 (en) | 2003-06-12 |
AU2002349784A1 (en) | 2003-06-17 |
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