WO2002072571A8 - Pyridinyl pyrazoles useful for the treatment of copd - Google Patents

Pyridinyl pyrazoles useful for the treatment of copd

Info

Publication number
WO2002072571A8
WO2002072571A8 PCT/EP2002/002316 EP0202316W WO02072571A8 WO 2002072571 A8 WO2002072571 A8 WO 2002072571A8 EP 0202316 W EP0202316 W EP 0202316W WO 02072571 A8 WO02072571 A8 WO 02072571A8
Authority
WO
WIPO (PCT)
Prior art keywords
treatment
copd
pyridinyl
pyrazoles useful
pyrazoles
Prior art date
Application number
PCT/EP2002/002316
Other languages
French (fr)
Other versions
WO2002072571A3 (en
WO2002072571A2 (en
Inventor
Cristina Alonso-Alija
Siegfried Goldmann
Sara Dodd
Mary Fitzgerald
Kevin Nash
Original Assignee
Bayer Ag
Cristina Alonso-Alija
Siegfried Goldmann
Sara Dodd
Mary Fitzgerald
Kevin Nash
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag, Cristina Alonso-Alija, Siegfried Goldmann, Sara Dodd, Mary Fitzgerald, Kevin Nash filed Critical Bayer Ag
Priority to AU2002256638A priority Critical patent/AU2002256638A1/en
Publication of WO2002072571A2 publication Critical patent/WO2002072571A2/en
Publication of WO2002072571A3 publication Critical patent/WO2002072571A3/en
Publication of WO2002072571A8 publication Critical patent/WO2002072571A8/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Abstract

The present invention relates to Pyridinyl pyrazoles of general formula (1) processes for their preparation and their use in medicaments, for the treatment of acute and chronic inflammatory processes, especially for the treatment of COPD.
PCT/EP2002/002316 2001-03-12 2002-03-04 Pyridinyl pyrazoles useful for the treatment of copd WO2002072571A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002256638A AU2002256638A1 (en) 2001-03-12 2002-03-04 Pyridinyl pyrazoles useful for the treatment of copd

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0106061A GB2373245A (en) 2001-03-12 2001-03-12 Pyridinyl pyrazoles and their use for the treatment of COPD
GB0106061.5 2001-03-12

Publications (3)

Publication Number Publication Date
WO2002072571A2 WO2002072571A2 (en) 2002-09-19
WO2002072571A3 WO2002072571A3 (en) 2003-10-30
WO2002072571A8 true WO2002072571A8 (en) 2005-03-17

Family

ID=9910489

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/002316 WO2002072571A2 (en) 2001-03-12 2002-03-04 Pyridinyl pyrazoles useful for the treatment of copd

Country Status (3)

Country Link
AU (1) AU2002256638A1 (en)
GB (1) GB2373245A (en)
WO (1) WO2002072571A2 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2004270733B2 (en) 2003-09-11 2011-05-19 Itherx Pharma, Inc. Cytokine inhibitors
JP2007217322A (en) * 2006-02-15 2007-08-30 Ube Ind Ltd Pharmaceutical composition for treatment or prophylaxis of chronic obstructive pulmonary disease
EA200802050A1 (en) * 2006-04-19 2009-04-28 Лаборатуар Сероно Са NEW HETEROARYLIC-SUBSTITUTED ARYLAMINOPIRIDINE DERIVATIVES AS MEK INHIBITORS
JP2010518014A (en) 2007-01-31 2010-05-27 バーテックス ファーマシューティカルズ インコーポレイテッド 2-Aminopyridine derivatives useful as kinase inhibitors
MX2011000837A (en) 2008-07-23 2011-04-05 Vertex Pharma Tri-cyclic pyrazolopyridine kinase inhibitors.
US8569337B2 (en) 2008-07-23 2013-10-29 Vertex Pharmaceuticals Incorporated Tri-cyclic pyrazolopyridine kinase inhibitors
JP2011529062A (en) 2008-07-23 2011-12-01 バーテックス ファーマシューティカルズ インコーポレイテッド Pyrazolopyridine kinase inhibitor
AU2009279611A1 (en) 2008-08-06 2010-02-11 Vertex Pharmaceuticals Incorporated Aminopyridine kinase inhibitors
CA2760705A1 (en) 2009-05-06 2010-11-11 Vertex Pharmaceuticals Incorporated Pyrazolopyridines
WO2011094290A1 (en) 2010-01-27 2011-08-04 Vertex Pharmaceuticals Incorporated Pyrazolopyrimidine kinase inhibitors
CN102869663A (en) 2010-01-27 2013-01-09 沃泰克斯药物股份有限公司 Pyrazolopyrazine kinase inhibitors
EP2528917B1 (en) 2010-01-27 2016-10-19 Vertex Pharmaceuticals Incorporated Pyrazolopyridines useful for the treatment of autoimmune, inflammatory or (hyper)proliferative diseases
MX2014013407A (en) 2012-05-22 2014-11-26 Hoffmann La Roche Substituted dipyridylamines and uses thereof.
CN103864770B (en) * 2012-12-10 2019-06-11 江苏先声药业有限公司 Aminopyrimidine and pyridyl amine inhibitor as Hedgehog signal transduction
CA2907912A1 (en) 2013-05-01 2014-11-06 F. Hoffmann-La Roche Ag C-linked heterocycloalkyl substituted pyrimidines and their uses
US20190060286A1 (en) 2016-02-29 2019-02-28 University Of Florida Research Foundation, Incorpo Chemotherapeutic Methods
CN114181199B (en) * 2020-09-15 2023-09-26 成都赜灵生物医药科技有限公司 2, 4-disubstituted pyrimidine derivative, preparation method and application thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002514640A (en) * 1998-05-14 2002-05-21 ジー・ディー・サール・アンド・カンパニー 1,5-Diaryl-substituted pyrazoles as p38 kinase inhibitors

Also Published As

Publication number Publication date
AU2002256638A1 (en) 2002-09-24
WO2002072571A3 (en) 2003-10-30
GB2373245A (en) 2002-09-18
WO2002072571A2 (en) 2002-09-19
GB0106061D0 (en) 2001-05-02

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