WO2000069841A3 - Benzofuranylaminoalcohols - Google Patents

Benzofuranylaminoalcohols Download PDF

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Publication number
WO2000069841A3
WO2000069841A3 PCT/EP2000/004015 EP0004015W WO0069841A3 WO 2000069841 A3 WO2000069841 A3 WO 2000069841A3 EP 0004015 W EP0004015 W EP 0004015W WO 0069841 A3 WO0069841 A3 WO 0069841A3
Authority
WO
WIPO (PCT)
Prior art keywords
benzofuranylaminoalcohols
medicaments
preparation
treatment
general formula
Prior art date
Application number
PCT/EP2000/004015
Other languages
French (fr)
Other versions
WO2000069841A2 (en
Inventor
Gabriele Braeunlich
Mazen Es-Sayed
Ruediger Fischer
Burkhard Fugmann
Rolf Henning
Stephan Schneider
Michael Sperzel
Karl-Heinz Schlemmer
Graham Sturton
Mary Fitzgerald
Barbara Briggs
Arnel Conception
William Bullock
Original Assignee
Bayer Ag
Gabriele Braeunlich
Es Sayed Mazen
Ruediger Fischer
Burkhard Fugmann
Rolf Henning
Stephan Schneider
Michael Sperzel
Schlemmer Karl Heinz
Graham Sturton
Mary Fitzgerald
Barbara Briggs
Arnel Conception
William Bullock
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag, Gabriele Braeunlich, Es Sayed Mazen, Ruediger Fischer, Burkhard Fugmann, Rolf Henning, Stephan Schneider, Michael Sperzel, Schlemmer Karl Heinz, Graham Sturton, Mary Fitzgerald, Barbara Briggs, Arnel Conception, William Bullock filed Critical Bayer Ag
Priority to AU45616/00A priority Critical patent/AU4561600A/en
Publication of WO2000069841A2 publication Critical patent/WO2000069841A2/en
Publication of WO2000069841A3 publication Critical patent/WO2000069841A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Benzofuranylaminoalcohols of general formula (I), process for their preparation and their use in medicaments, especially for the treatment of inflammatory processes.
PCT/EP2000/004015 1999-05-17 2000-05-04 Benzofuranylaminoalcohols WO2000069841A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU45616/00A AU4561600A (en) 1999-05-17 2000-05-04 Benzofuranylaminoalcohols

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9911453A GB2350110A (en) 1999-05-17 1999-05-17 Pharmaceutically active benzofurans
GB9911453.0 1999-05-17

Publications (2)

Publication Number Publication Date
WO2000069841A2 WO2000069841A2 (en) 2000-11-23
WO2000069841A3 true WO2000069841A3 (en) 2002-05-02

Family

ID=10853621

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2000/004015 WO2000069841A2 (en) 1999-05-17 2000-05-04 Benzofuranylaminoalcohols

Country Status (3)

Country Link
AU (1) AU4561600A (en)
GB (1) GB2350110A (en)
WO (1) WO2000069841A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7153871B2 (en) 2001-01-22 2006-12-26 Memory Pharmaceuticals Corporation Phosphodiesterase 4 inhibitors, including aminoindazole and aminobenzofuran analogs
JP2006507215A (en) 2002-02-22 2006-03-02 バイエル・フアーマシユーチカルズ・コーポレーシヨン Benzofuran and benzothiophene derivatives useful for the treatment of hyperproliferative disorders
US7144885B2 (en) 2002-02-22 2006-12-05 Bayer Pharmaceuticals Corporation Fused tricyclic heterocycles useful for treating hyper-proliferative disorders
CN100381425C (en) * 2002-07-19 2008-04-16 记忆药物公司 6-amino-1H-indazole and 4-aminobenzofuran compounds as phosphodiesterase 4 inhibitors
JP2006504656A (en) 2002-07-19 2006-02-09 メモリー・ファーマシューティカルズ・コーポレイション Phosphodiesterase 4 inhibitors comprising N-substituted anilines and diphenylamine analogues
US7087625B2 (en) 2002-11-19 2006-08-08 Memory Pharmaceuticals Corporation Phosphodiesterase 4 inhibitors
EP3137454A1 (en) 2014-04-28 2017-03-08 Pfizer Inc. Heteroaromatic compounds and their use as dopamine d1 ligands

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0146243A1 (en) * 1983-10-31 1985-06-26 Merck Frosst Canada Inc. Lipoxygenase inhibitors
EP0731099A1 (en) * 1995-03-06 1996-09-11 Bayer Ag N-(3-benzofuranyl)urea-derivatives
EP0779291A1 (en) * 1995-12-11 1997-06-18 Bayer Ag Heterocyclylcarbonyl substituted benzofuranyl-ureas
WO1998002440A1 (en) * 1996-07-12 1998-01-22 Bayer Aktiengesellschaft 3-ureido-pyridofurans and -pyridothiophenes for the treatment of inflammatory processes

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4056626A (en) * 1971-05-13 1977-11-01 Kakenyaku Kako Co., Ltd. Pharmaceutical composition containing benzofuran derivative

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0146243A1 (en) * 1983-10-31 1985-06-26 Merck Frosst Canada Inc. Lipoxygenase inhibitors
EP0731099A1 (en) * 1995-03-06 1996-09-11 Bayer Ag N-(3-benzofuranyl)urea-derivatives
EP0779291A1 (en) * 1995-12-11 1997-06-18 Bayer Ag Heterocyclylcarbonyl substituted benzofuranyl-ureas
WO1998002440A1 (en) * 1996-07-12 1998-01-22 Bayer Aktiengesellschaft 3-ureido-pyridofurans and -pyridothiophenes for the treatment of inflammatory processes

Also Published As

Publication number Publication date
AU4561600A (en) 2000-12-05
GB9911453D0 (en) 1999-07-14
GB2350110A (en) 2000-11-22
WO2000069841A2 (en) 2000-11-23

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