WO2002028821A3 - Propionsäurederivate mit ppar-alpha aktivierenden eigenschaften. - Google Patents
Propionsäurederivate mit ppar-alpha aktivierenden eigenschaften. Download PDFInfo
- Publication number
- WO2002028821A3 WO2002028821A3 PCT/EP2001/011005 EP0111005W WO0228821A3 WO 2002028821 A3 WO2002028821 A3 WO 2002028821A3 EP 0111005 W EP0111005 W EP 0111005W WO 0228821 A3 WO0228821 A3 WO 0228821A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- ppar
- propionic acid
- acid derivatives
- activating properties
- alpha activating
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
- C07C229/18—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C317/28—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Furan Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Priority Applications (15)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NZ525119A NZ525119A (en) | 2000-10-05 | 2001-09-24 | Propionic acid derivatives |
IL15512501A IL155125A0 (en) | 2000-10-05 | 2001-09-24 | Propionic acid derivatives with ppar-alpha activating properties |
AU2001293838A AU2001293838A1 (en) | 2000-10-05 | 2001-09-24 | Propionic acid derivatives with PPAR-alpha activating properties |
KR10-2003-7004828A KR20030059175A (ko) | 2000-10-05 | 2001-09-24 | Ppar-알파 활성화 성질을 갖는 프로피온산 유도체 |
HU0302306A HUP0302306A3 (en) | 2000-10-05 | 2001-09-24 | Propionic acid derivatives with ppar-alpha activating properties |
EEP200300140A EE200300140A (et) | 2000-10-05 | 2001-09-24 | PPAR-alfat aktiveerivate omadustega propaanhappe derivaadid |
BR0114437-5A BR0114437A (pt) | 2000-10-05 | 2001-09-24 | Derivados de acido propiÈnico |
MXPA03002901A MXPA03002901A (es) | 2000-10-05 | 2001-09-24 | Derivados de acido propionico. |
CA002424540A CA2424540A1 (en) | 2000-10-05 | 2001-09-24 | Propionic acid derivatives with ppar-alpha activating properties |
EP01974287A EP1328508A2 (de) | 2000-10-05 | 2001-09-24 | Propionsäurederivate mit ppar-alpha aktivierenden eigenschaften |
JP2002532408A JP2004510757A (ja) | 2000-10-05 | 2001-09-24 | プロピオン酸誘導体 |
SK413-2003A SK4132003A3 (en) | 2000-10-05 | 2001-09-24 | Propionic acid derivatives, the process for their preparation, pharmaceutical composition comprising them, use thereof and intermediates for producing them |
BG107684A BG107684A (bg) | 2000-10-05 | 2003-03-28 | Производни на пропионовата киселина с ppar-алфа активиращи свойства |
NO20031517A NO20031517L (no) | 2000-10-05 | 2003-04-03 | Propionsyrederivater med PPAR-alfa aktiverende egenskaper |
HR20030346A HRP20030346A2 (en) | 2000-10-05 | 2003-05-02 | Propionic acid derivatives |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10049208 | 2000-10-05 | ||
DE10049208.8 | 2000-10-05 | ||
DE10124905.5 | 2001-05-22 | ||
DE10124905A DE10124905A1 (de) | 2000-10-05 | 2001-05-22 | Propionsäurederivate |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2002028821A2 WO2002028821A2 (de) | 2002-04-11 |
WO2002028821A3 true WO2002028821A3 (de) | 2002-08-15 |
Family
ID=26007267
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2001/011005 WO2002028821A2 (de) | 2000-10-05 | 2001-09-24 | Propionsäurederivate mit ppar-alpha aktivierenden eigenschaften. |
Country Status (22)
Country | Link |
---|---|
EP (1) | EP1328508A2 (de) |
JP (1) | JP2004510757A (de) |
CN (1) | CN1479716A (de) |
AU (1) | AU2001293838A1 (de) |
BG (1) | BG107684A (de) |
BR (1) | BR0114437A (de) |
CA (1) | CA2424540A1 (de) |
CZ (1) | CZ2003964A3 (de) |
EE (1) | EE200300140A (de) |
HN (1) | HN2001000223A (de) |
HR (1) | HRP20030346A2 (de) |
HU (1) | HUP0302306A3 (de) |
IL (1) | IL155125A0 (de) |
MA (1) | MA25917A1 (de) |
MX (1) | MXPA03002901A (de) |
NO (1) | NO20031517L (de) |
NZ (1) | NZ525119A (de) |
PL (1) | PL361162A1 (de) |
RU (1) | RU2003112968A (de) |
SK (1) | SK4132003A3 (de) |
UY (1) | UY26951A1 (de) |
WO (1) | WO2002028821A2 (de) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10151390A1 (de) * | 2001-10-18 | 2003-05-08 | Bayer Ag | Essigsäurederivate |
GB0214254D0 (en) * | 2002-06-20 | 2002-07-31 | Glaxo Group Ltd | Chemical compounds |
KR20050067419A (ko) * | 2002-10-21 | 2005-07-01 | 얀센 파마슈티카 엔.브이. | 치환된 테트라린 및 인단으로의 x 증후군의 치료 |
BR0315596A (pt) * | 2002-10-21 | 2005-09-06 | Janssen Pharmaceutica Nv | Tetralinas e indanos substituìdos |
MXPA05004192A (es) * | 2002-10-21 | 2005-09-20 | Johnson & Johnson | Tetralinas e indanos sustituidos. |
EP1583754A1 (de) * | 2003-01-06 | 2005-10-12 | Eli Lilly And Company | Thiophenderivate ppar modulatoren |
BRPI0413923A (pt) | 2003-08-29 | 2006-11-07 | Ono Pharmaceutical Co | composto capaz de ligar o receptor de s1p e uso farmacêutico do mesmo |
AR048931A1 (es) | 2004-04-21 | 2006-06-14 | Janssen Pharmaceutica Nv | Proceso para la preparacion de derivados de tetralina sustituida e indano sustituido y preparacion de intermediarios de sintesis |
CN100344618C (zh) | 2004-05-24 | 2007-10-24 | 北京摩力克科技有限公司 | 作为hPPARα和hPPARγ激动剂的N-芳丙烯酰基取代的酪氨酸衍生物 |
KR100699928B1 (ko) | 2004-10-05 | 2007-03-26 | 재단법인서울대학교산학협력재단 | 퍼록시솜 증식자 활성화 수용체 알파 리간드를 제조하기위한 중간체의 제조방법 |
ATE541830T1 (de) | 2004-12-13 | 2012-02-15 | Ono Pharmaceutical Co | Aminocarbonsäurederivat und dessen medizinische verwendung |
CN101054372B (zh) * | 2006-04-11 | 2010-10-13 | 中国科学院上海药物研究所 | 嘧啶取代苯丙酸衍生化合物、其制法和在治疗多囊肾疾病中的用途 |
AU2009323367B2 (en) | 2008-12-01 | 2013-05-23 | Mitsubishi Tanabe Pharma Corporation | Carboxylic acid derivative containing thiazole ring and pharmaceutical use thereof |
JP5436941B2 (ja) * | 2009-06-03 | 2014-03-05 | あすか製薬株式会社 | ラクタム化合物又はその塩及びppar活性化剤 |
UY34200A (es) | 2011-07-21 | 2013-02-28 | Bayer Ip Gmbh | 3-(fluorovinil)pirazoles y su uso |
WO2016091746A1 (en) * | 2014-12-11 | 2016-06-16 | Dsm Sinochem Pharmaceuticals Netherlands B.V. | Method for acylating a cyclic peptide |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3912756A (en) * | 1973-04-21 | 1975-10-14 | Boehringer Mannheim Gmbh | New phenoxyalkyl-carboxylic acid compounds and therapeutic compositions |
WO2000023407A2 (en) * | 1998-10-16 | 2000-04-27 | Glaxo Group Limited | Ureido-thiobutyric acid derivatives as ppar-agonists |
-
2001
- 2001-09-24 HU HU0302306A patent/HUP0302306A3/hu unknown
- 2001-09-24 EP EP01974287A patent/EP1328508A2/de not_active Withdrawn
- 2001-09-24 JP JP2002532408A patent/JP2004510757A/ja active Pending
- 2001-09-24 MX MXPA03002901A patent/MXPA03002901A/es unknown
- 2001-09-24 CN CNA018200885A patent/CN1479716A/zh active Pending
- 2001-09-24 SK SK413-2003A patent/SK4132003A3/sk not_active Application Discontinuation
- 2001-09-24 CA CA002424540A patent/CA2424540A1/en not_active Abandoned
- 2001-09-24 RU RU2003112968/04A patent/RU2003112968A/ru not_active Application Discontinuation
- 2001-09-24 AU AU2001293838A patent/AU2001293838A1/en not_active Abandoned
- 2001-09-24 WO PCT/EP2001/011005 patent/WO2002028821A2/de active IP Right Grant
- 2001-09-24 BR BR0114437-5A patent/BR0114437A/pt not_active IP Right Cessation
- 2001-09-24 EE EEP200300140A patent/EE200300140A/xx unknown
- 2001-09-24 CZ CZ2003964A patent/CZ2003964A3/cs unknown
- 2001-09-24 PL PL01361162A patent/PL361162A1/xx not_active Application Discontinuation
- 2001-09-24 NZ NZ525119A patent/NZ525119A/en unknown
- 2001-09-24 IL IL15512501A patent/IL155125A0/xx unknown
- 2001-10-03 UY UY26951A patent/UY26951A1/es not_active Application Discontinuation
- 2001-10-04 HN HN2001000223A patent/HN2001000223A/es unknown
-
2003
- 2003-03-28 BG BG107684A patent/BG107684A/bg unknown
- 2003-04-03 NO NO20031517A patent/NO20031517L/no not_active Application Discontinuation
- 2003-04-04 MA MA27091A patent/MA25917A1/fr unknown
- 2003-05-02 HR HR20030346A patent/HRP20030346A2/hr not_active Application Discontinuation
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3912756A (en) * | 1973-04-21 | 1975-10-14 | Boehringer Mannheim Gmbh | New phenoxyalkyl-carboxylic acid compounds and therapeutic compositions |
WO2000023407A2 (en) * | 1998-10-16 | 2000-04-27 | Glaxo Group Limited | Ureido-thiobutyric acid derivatives as ppar-agonists |
Non-Patent Citations (1)
Title |
---|
BROWN P J ET AL: "A Ureido-Thiobutyric Acid (GW9578) is a subtype-Selective PPARalpha Agonist with Potent lipid-Lowering Activity", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 42, no. 19, 9 April 1999 (1999-04-09), pages 3785 - 3788, XP002128791, ISSN: 0022-2623 * |
Also Published As
Publication number | Publication date |
---|---|
NO20031517D0 (no) | 2003-04-03 |
HUP0302306A2 (hu) | 2003-10-28 |
PL361162A1 (en) | 2004-09-20 |
CA2424540A1 (en) | 2003-04-02 |
EP1328508A2 (de) | 2003-07-23 |
HN2001000223A (es) | 2001-10-25 |
WO2002028821A2 (de) | 2002-04-11 |
BG107684A (bg) | 2003-10-31 |
HUP0302306A3 (en) | 2005-02-28 |
EE200300140A (et) | 2003-08-15 |
AU2001293838A1 (en) | 2002-04-15 |
RU2003112968A (ru) | 2004-09-20 |
IL155125A0 (en) | 2003-10-31 |
JP2004510757A (ja) | 2004-04-08 |
NZ525119A (en) | 2005-04-29 |
NO20031517L (no) | 2003-05-28 |
UY26951A1 (es) | 2002-06-20 |
HRP20030346A2 (en) | 2005-04-30 |
SK4132003A3 (en) | 2004-02-03 |
MA25917A1 (fr) | 2003-10-01 |
CN1479716A (zh) | 2004-03-03 |
CZ2003964A3 (cs) | 2003-08-13 |
BR0114437A (pt) | 2003-07-01 |
MXPA03002901A (es) | 2003-10-15 |
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