MXPA05004192A - Tetralinas e indanos sustituidos. - Google Patents

Tetralinas e indanos sustituidos.

Info

Publication number
MXPA05004192A
MXPA05004192A MXPA05004192A MXPA05004192A MXPA05004192A MX PA05004192 A MXPA05004192 A MX PA05004192A MX PA05004192 A MXPA05004192 A MX PA05004192A MX PA05004192 A MXPA05004192 A MX PA05004192A MX PA05004192 A MXPA05004192 A MX PA05004192A
Authority
MX
Mexico
Prior art keywords
indanes
substituted tetralins
tetralins
substituted
tetralin
Prior art date
Application number
MXPA05004192A
Other languages
English (en)
Inventor
Jung Lee
Original Assignee
Johnson & Johnson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Johnson & Johnson filed Critical Johnson & Johnson
Publication of MXPA05004192A publication Critical patent/MXPA05004192A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/52Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/48Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06Esters of carbamic acids
    • C07C271/40Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
    • C07C271/56Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/32Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
    • C07C275/34Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/43Y being a hetero atom
    • C07C323/44X or Y being nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/61Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00Systems containing two condensed rings
    • C07C2602/02Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00Systems containing two condensed rings
    • C07C2602/02Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)

Abstract

La invencion tiene como caracteristica compuestos de tetralina e indano, composiciones que los contienen y metodos de uso de los mismos como moduladores del PPAR alfa, para tratar o inhibir la progresion de, por ejemplo, la diabetes.
MXPA05004192A 2002-10-21 2003-10-17 Tetralinas e indanos sustituidos. MXPA05004192A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US42002602P 2002-10-21 2002-10-21
US49578803P 2003-08-15 2003-08-15
PCT/US2003/033371 WO2004037779A1 (en) 2002-10-21 2003-10-17 Substituted tetralins and indanes and their use

Publications (1)

Publication Number Publication Date
MXPA05004192A true MXPA05004192A (es) 2005-09-20

Family

ID=32179777

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA05004192A MXPA05004192A (es) 2002-10-21 2003-10-17 Tetralinas e indanos sustituidos.

Country Status (28)

Country Link
US (2) US20040167211A1 (es)
EP (1) EP1554240B1 (es)
JP (1) JP4411275B2 (es)
KR (1) KR100989394B1 (es)
CN (1) CN100354259C (es)
AT (1) ATE430728T1 (es)
AU (1) AU2003279996B2 (es)
BR (1) BR0315623A (es)
CA (1) CA2502665A1 (es)
CY (1) CY1110326T1 (es)
DE (1) DE60327543D1 (es)
DK (1) DK1554240T3 (es)
EA (1) EA009554B1 (es)
ES (1) ES2325783T3 (es)
HR (1) HRP20050336B1 (es)
IL (1) IL168147A (es)
ME (1) MEP53108A (es)
MX (1) MXPA05004192A (es)
NO (1) NO332352B1 (es)
NZ (1) NZ539451A (es)
PL (1) PL376326A1 (es)
PT (1) PT1554240E (es)
RS (1) RS52079B (es)
SI (1) SI1554240T1 (es)
TW (1) TWI308563B (es)
UA (1) UA80561C2 (es)
WO (1) WO2004037779A1 (es)
ZA (1) ZA200504064B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060094786A1 (en) * 2002-10-21 2006-05-04 Xiaoli Chen Treating syndrome X with substituted tetralins and indanes
KR20050067419A (ko) * 2002-10-21 2005-07-01 얀센 파마슈티카 엔.브이. 치환된 테트라린 및 인단으로의 x 증후군의 치료
US20060247314A1 (en) * 2002-10-21 2006-11-02 Xiaoli Chen Substituted tetralins and indanes
BR0315596A (pt) * 2002-10-21 2005-09-06 Janssen Pharmaceutica Nv Tetralinas e indanos substituìdos
AR048931A1 (es) * 2004-04-21 2006-06-14 Janssen Pharmaceutica Nv Proceso para la preparacion de derivados de tetralina sustituida e indano sustituido y preparacion de intermediarios de sintesis
WO2006044293A2 (en) * 2004-10-12 2006-04-27 Pharmacopeia Drug Discovery, Inc. Bicyclic compounds as selective melanin concentrating hormone receptor antagonists for the treatment of obesity and related disorders
MX2015013365A (es) * 2013-03-20 2016-01-08 Hoffmann La Roche Derivados de urea y su uso como inhibidores de proteina de union de acidos grasos (puag).

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU632809B2 (en) * 1989-05-25 1993-01-14 Takeda Chemical Industries Ltd. Benzocycloalkane benzopyran and benzothiopyran urea derivatives and production thereof
GB9027023D0 (en) 1990-12-12 1991-01-30 Wellcome Found Anti-atherosclerotic aryl compounds
EP0712387B1 (en) 1993-08-06 1999-12-08 PHARMACIA & UPJOHN COMPANY 2-aminoindans as selective dopamine d3 ligands
GB9606805D0 (en) 1996-03-30 1996-06-05 Glaxo Wellcome Inc Medicaments
US6146872A (en) 1996-06-13 2000-11-14 Fukisawa Pharmaceutical Co., Ltd. Cyclic lipopeptide acylase
GB9822473D0 (en) * 1998-10-16 1998-12-09 Glaxo Group Ltd Chemical compounds
US6300339B1 (en) * 1998-10-21 2001-10-09 Novo Nordisk A/S Compounds, their preparation and use
TWI234557B (en) 1999-05-26 2005-06-21 Telik Inc Novel naphthalene ureas as glucose uptake enhancers
EP1259494A4 (en) * 2000-02-18 2004-09-15 Merck & Co Inc ARYLOXY ACETIC ACIDS FOR DIABETES AND LIPID DISEASES
HUP0302306A3 (en) * 2000-10-05 2005-02-28 Bayer Ag Propionic acid derivatives with ppar-alpha activating properties
JPWO2002044129A1 (ja) * 2000-11-29 2004-04-02 杏林製薬株式会社 置換カルボン酸誘導体
AU2002222573A1 (en) * 2000-12-05 2002-06-18 Kyorin Pharmaceutical Co. Ltd. Substituted carboxylic acid derivatives
JP2004517100A (ja) * 2000-12-20 2004-06-10 グラクソ グループ リミテッド hPPARアルファアゴニストとしての置換オキサゾールおよびチアゾール
TWI241190B (en) 2001-02-13 2005-10-11 Aventis Pharma Gmbh 4-Fluoro-N-indan-2-yl benzamide and its use as pharmaceutical
JP2004520397A (ja) 2001-02-15 2004-07-08 ファイザー・プロダクツ・インク 増殖性アクチベータ受容体(ppar)化合物
BR0207285A (pt) 2001-02-15 2004-02-10 Pfizer Producs Inc Agonistas de ppar
US6548538B2 (en) * 2001-05-22 2003-04-15 Bayer Aktiengesellschaft Propionic acid derivatives
UA82835C2 (en) * 2001-12-03 2008-05-26 Reddys Lab Ltd Dr ?-aryl-?-oxysubstituted propionuc acid derivatives and pharmaceutical composition based thereon
US20060094786A1 (en) * 2002-10-21 2006-05-04 Xiaoli Chen Treating syndrome X with substituted tetralins and indanes
BR0315596A (pt) * 2002-10-21 2005-09-06 Janssen Pharmaceutica Nv Tetralinas e indanos substituìdos
US20060247314A1 (en) * 2002-10-21 2006-11-02 Xiaoli Chen Substituted tetralins and indanes
KR20050067419A (ko) * 2002-10-21 2005-07-01 얀센 파마슈티카 엔.브이. 치환된 테트라린 및 인단으로의 x 증후군의 치료
AR048931A1 (es) * 2004-04-21 2006-06-14 Janssen Pharmaceutica Nv Proceso para la preparacion de derivados de tetralina sustituida e indano sustituido y preparacion de intermediarios de sintesis

Also Published As

Publication number Publication date
MEP53108A (en) 2011-05-10
US20040167211A1 (en) 2004-08-26
PT1554240E (pt) 2009-06-17
KR20050071597A (ko) 2005-07-07
AU2003279996A1 (en) 2004-05-13
US7351857B2 (en) 2008-04-01
EA009554B1 (ru) 2008-02-28
CN1726187A (zh) 2006-01-25
UA80561C2 (en) 2007-10-10
SI1554240T1 (sl) 2009-10-31
EA200500516A1 (ru) 2005-10-27
DE60327543D1 (de) 2009-06-18
CA2502665A1 (en) 2004-05-06
IL168147A (en) 2010-11-30
EP1554240B1 (en) 2009-05-06
ZA200504064B (en) 2006-09-27
US20060074130A1 (en) 2006-04-06
NO20052280L (no) 2005-06-24
RS52079B (sr) 2012-06-30
HRP20050336B1 (hr) 2013-06-30
BR0315623A (pt) 2005-08-23
JP2006503917A (ja) 2006-02-02
ES2325783T3 (es) 2009-09-17
CN100354259C (zh) 2007-12-12
JP4411275B2 (ja) 2010-02-10
EP1554240A1 (en) 2005-07-20
RS20050320A (en) 2007-11-15
KR100989394B1 (ko) 2010-10-25
PL376326A1 (en) 2005-12-27
DK1554240T3 (da) 2009-08-17
TW200418774A (en) 2004-10-01
CY1110326T1 (el) 2015-01-14
TWI308563B (en) 2009-04-11
ATE430728T1 (de) 2009-05-15
AU2003279996B2 (en) 2009-07-09
WO2004037779A1 (en) 2004-05-06
NO332352B1 (no) 2012-09-03
NZ539451A (en) 2008-03-28
HRP20050336A2 (en) 2006-11-30

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